{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:17:42Z","timestamp":1788290262410,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Science and Technology Program of Guangzhou, China","award":["202002020006"],"award-info":[{"award-number":["202002020006"]}]},{"name":"the Science and Technology Program of Guangzhou, China","award":["2017YFC1703102"],"award-info":[{"award-number":["2017YFC1703102"]}]},{"name":"the Science and Technology Program of Guangzhou, China","award":["[2022]2"],"award-info":[{"award-number":["[2022]2"]}]},{"name":"the Science and Technology Program of Guangzhou, China","award":["RCJD2020-21"],"award-info":[{"award-number":["RCJD2020-21"]}]},{"name":"the National Key R&amp;D Program of China","award":["202002020006"],"award-info":[{"award-number":["202002020006"]}]},{"name":"the National Key R&amp;D Program of China","award":["2017YFC1703102"],"award-info":[{"award-number":["2017YFC1703102"]}]},{"name":"the National Key R&amp;D Program of China","award":["[2022]2"],"award-info":[{"award-number":["[2022]2"]}]},{"name":"the National Key R&amp;D Program of China","award":["RCJD2020-21"],"award-info":[{"award-number":["RCJD2020-21"]}]},{"name":"the Science and Technology Program of Bijie","award":["202002020006"],"award-info":[{"award-number":["202002020006"]}]},{"name":"the Science and Technology Program of Bijie","award":["2017YFC1703102"],"award-info":[{"award-number":["2017YFC1703102"]}]},{"name":"the Science and Technology Program of Bijie","award":["[2022]2"],"award-info":[{"award-number":["[2022]2"]}]},{"name":"the Science and Technology Program of Bijie","award":["RCJD2020-21"],"award-info":[{"award-number":["RCJD2020-21"]}]},{"name":"the Guizhou Province Talent Base Construction Project","award":["202002020006"],"award-info":[{"award-number":["202002020006"]}]},{"name":"the Guizhou Province Talent Base Construction Project","award":["2017YFC1703102"],"award-info":[{"award-number":["2017YFC1703102"]}]},{"name":"the Guizhou Province Talent Base Construction Project","award":["[2022]2"],"award-info":[{"award-number":["[2022]2"]}]},{"name":"the Guizhou Province Talent Base Construction Project","award":["RCJD2020-21"],"award-info":[{"award-number":["RCJD2020-21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Cili (Rosa roxburghii Tratt) fruit is a nutrient-rich edible plant known for its antioxidant and hepatoprotective properties. However, conventional extraction methods often lead to the degradation of its bioactive compounds. In this study, we developed a low-temperature homogenate-assisted high-pressure disruption extraction (HHPD) method to obtain a phytochemically enriched cili fruit extract (HHPD-CFE). The chemical characterization of the HHPD-CFE showed that it contained higher levels of polyphenols, polysaccharides, and superoxide dismutase (SOD) than those in conventional squeeze extraction. The hepatoprotective effects of the HHPD-CFE were evaluated in oxidative stress-induced liver injury and hepatic fibrosis models. The HHPD-CFE mitigated oxidative damage by reducing malondialdehyde while enhancing SOD and glutathione activity. Additionally, the HHPD-CFE inhibited the activation of hepatic stellate cells (HSC-T6) and reduced collagen deposition, suggesting a protective role against liver fibrosis. These findings support that the HHPD-CFE is a promising botanical extract with enriched bioactive compounds and liver-protective properties. This study supports the potential application of optimized extraction techniques to preserve thermosensitive compounds and improve the efficacy of functional foods for liver health.<\/jats:p>","DOI":"10.3390\/foods14081301","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T07:49:02Z","timestamp":1744184942000},"page":"1301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Phytochemical Characterization of a Cili (Rosa roxburghii) Fruit Low-Temperature Extract with Hepatoprotective Effects"],"prefix":"10.3390","volume":"14","author":[{"given":"Rifeng","family":"He","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Lian","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Bijie Institute of Traditional Chinese Medicine, Bijie 551700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Bijie Institute of Traditional Chinese Medicine, Bijie 551700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-6889","authenticated-orcid":false,"given":"Hang","family":"Ma","sequence":"additional","affiliation":[{"name":"Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Kingston, RI 02881, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahuan","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, M.-H., Zhang, Q., Zhang, Y.-H., Lu, X.-Y., Fu, W.-M., and He, J.-Y. 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