{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T15:56:56Z","timestamp":1791734216828,"version":"4.3.4"},"reference-count":61,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"special project of the key research and development task of Xinjiang Autonomous Region","award":["2023B02028"],"award-info":[{"award-number":["2023B02028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Sea buckthorn pomace (SBP) is a rich source of flavonoid compounds with potential healthy properties. This study optimized ultrasonic-enzymatic-assisted extraction (UEAE) of flavonoids from SBP and investigated its chemical composition and biological activities. Under the optimal conditions (pectinase addition of 1500 U\/g, ultrasonic power of 300 W, ethanol concentration of 48%, liquid\u2013solid ratio of 34:1, extract temperature of 50 \u00b0C, and extraction time of 28 min), the yield of SBP flavonoid extracts (SBFEs) was 21.57 \u00b1 0.45 mg\/g, well-matched with the predicted value (21.72 mg\/g). The chemical composition was detected by ultrahigh-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MSE) and mainly including isorhamnetin, kaempferol, and quercetin\u2019s derivatives. After purification with AB-8 macroporous resin, the purified product (PSBFE) exhibited a significantly enhanced scavenging capability for 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) (947.17 \u00b1 3.85 and 427.33 \u00b1 0.67 \u03bcmol Trolox\/g, respectively) and ferric reducing antioxidant power (2.68 \u00b1 0.01 mmol FeSO4\u00b77H2O\/g). Moreover, PSBFE possessed a pronounced inhibitory rate on \u03b1-glucosidase and \u03b1-amylase, with the IC50 at 52.89 \u00b1 0.09 and 97.81 \u00b1 0.42 \u03bcg\/mL, respectively. These findings indicate that it is a reliable, optimal extraction method to obtain potential antioxidant and hypoglycemic flavonoids from SBP for comprehensive development in functional food.<\/jats:p>","DOI":"10.3390\/foods14101656","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:47:15Z","timestamp":1746686835000},"page":"1656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Optimization of Ultrasonic-Enzymatic-Assisted Extraction of Flavonoids from Sea Buckthorn (Hippophae rhamnoides L.) Pomace: Chemical Composition and Biological Activities"],"prefix":"10.3390","volume":"14","author":[{"given":"Wenyu","family":"Suo","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"},{"name":"Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajing","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Work of Forestry Administrative Station of Kirgiz Autonomous Prefecture, Artush 845350, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-0636","authenticated-orcid":false,"given":"Wuyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, S., Xiao, P., Kuang, Y., Hao, J., Huang, T., and Liu, E. 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