{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:21:12Z","timestamp":1793046072119,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Foundation of Hubei Key Laboratory of Selenium Resource Research and Biological Application","award":["PT10202302"],"award-info":[{"award-number":["PT10202302"]}]},{"name":"Open Foundation of Hubei Key Laboratory of Selenium Resource Research and Biological Application","award":["2023BBB005"],"award-info":[{"award-number":["2023BBB005"]}]},{"name":"Open Foundation of Hubei Key Laboratory of Selenium Resource Research and Biological Application","award":["2024AFD079"],"award-info":[{"award-number":["2024AFD079"]}]},{"name":"Key Research and Development Program of Hubei Province","award":["PT10202302"],"award-info":[{"award-number":["PT10202302"]}]},{"name":"Key Research and Development Program of Hubei Province","award":["2023BBB005"],"award-info":[{"award-number":["2023BBB005"]}]},{"name":"Key Research and Development Program of Hubei Province","award":["2024AFD079"],"award-info":[{"award-number":["2024AFD079"]}]},{"name":"Hubei Province Natural Science Foundation","award":["PT10202302"],"award-info":[{"award-number":["PT10202302"]}]},{"name":"Hubei Province Natural Science Foundation","award":["2023BBB005"],"award-info":[{"award-number":["2023BBB005"]}]},{"name":"Hubei Province Natural Science Foundation","award":["2024AFD079"],"award-info":[{"award-number":["2024AFD079"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Dihydromyricetin, the predominant bioactive constituent in vine tea, manifests diverse bioactivities, including anti-tumoral and anti-inflammatory effects. However, the deep processing of vine tea remains underdeveloped, thereby curtailing its economic benefits. Concurrently, as the demand for organic selenium products escalates, the exploration and development of selenium-containing compounds bearing synergistic effects has emerged as a research frontier. In this investigation, dihydromyricetin underwent selenium modification through a SeO2- and HCl-catalyzed reaction, leading to the successful synthesis of selenium-modified dihydromyricetin. A comprehensive array of characterization techniques\u2014encompassing Fourier-transform infrared spectroscopy and solid-state nuclear magnetic resonance\u2014was employed for structural elucidation. The results demonstrated that selenium was covalently tethered to the 4\u2019-hydroxyl group of the B-ring of dihydromyricetin via an O-Se-O bond. Activity assays revealed that selenium-modified dihydromyricetin exhibited significantly augmented inhibitory effects on \u03b1-amylase and \u03b1-glucosidase (p &lt; 0.05) relative to dihydromyricetin, with IC50 values of 0.0459 mg\/mL and 0.01728 mg\/mL, respectively. Moreover, selenium-modified dihydromyricetin exerted marked inhibitory effects on the proliferation of HepG2 and A549 cells, with IC50 values of 49.05 \u03bcg\/mL and 515.60 \u03bcg\/mL, respectively. These findings collectively furnish experimental evidence underpinning the potential application of selenium-modified dihydromyricetin as a functional food ingredient, particularly within blood glucose regulation.<\/jats:p>","DOI":"10.3390\/foods14101735","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:31:49Z","timestamp":1747135909000},"page":"1735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structural Characterization and Bioactivity Evaluation of Selenium-Modified Dihydromyricetin from Vine Tea"],"prefix":"10.3390","volume":"14","author":[{"given":"Kaixuan","family":"Cheng","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Selenium Resource Research and Biological Application, Hubei Minzu University, Enshi 445000, China"},{"name":"College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqian","family":"Hou","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Selenium Resource Research and Biological Application, Hubei Minzu University, Enshi 445000, China"},{"name":"College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqi","family":"Mei","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Selenium Resource Research and Biological Application, Hubei Minzu University, Enshi 445000, China"},{"name":"College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Gao","sequence":"additional","affiliation":[{"name":"Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Hubei Minzu University, Enshi 445000, China"},{"name":"Hubei Provincial Clinical Medical Research Center for Nephropathy, Minda Hospital of Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Selenium Resource Research and Biological Application, Hubei Minzu University, Enshi 445000, China"},{"name":"College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-3308","authenticated-orcid":false,"given":"Longchen","family":"Shang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Selenium Resource Research and Biological Application, Hubei Minzu University, Enshi 445000, China"},{"name":"College of Biological and Food Engineering, Hubei Minzu University, Enshi 445000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7910-2303","authenticated-orcid":false,"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, J., Xiang, H., Ding, P., Wu, T., and Ji, G. 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