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This article systematically reviews the core applications of AI in the orbit of food safety. First, in the production and quality control of primary food sources, the integration of spectral data with AI efficiently identifies pest and disease, food spoilage, and pesticide and veterinary drug residues. Secondly, during food processing, sensors combined with machine learning algorithms are utilized to ensure regulatory compliance and monitor production parameters. AI also works together with blockchain to build an immutable and end-point traceability system. Furthermore, multi-source data fusion can provide personalized nutrition and dietary recommendations. The integration of AI technologies with traditional food detection methods has significantly improved the accuracy and sensitivity of food analytical methods. Finally, in the future, to address the increasing food safety issues, Food Industry 4.0 will expand the application of AI with lightweight edge computing, multi-modal large models, and global data sharing to create a more intelligent, adaptive and flexible food safety system.<\/jats:p>","DOI":"10.3390\/foods14111973","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:09:12Z","timestamp":1748840952000},"page":"1973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["AI-Powered Innovations in Food Safety from Farm to Fork"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0484-4951","authenticated-orcid":false,"given":"Binfeng","family":"Yin","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-0689","authenticated-orcid":false,"given":"Rashid","family":"Muhammad","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Suqian Product Quality Supervision and Inspection Institute, Suqian 223800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Bi","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e28361","DOI":"10.1016\/j.heliyon.2024.e28361","article-title":"A comprehensive review of mycotoxins: Toxicology, detection, and effective mitigation approaches","volume":"10","author":"Khan","year":"2024","journal-title":"Heliyon"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e51069","DOI":"10.15252\/embr.202051069","article-title":"Healthy soils for healthy plants for healthy humans How beneficial microbes in the soil, food and gut are interconnected and how agriculture can contribute to human health","volume":"21","author":"Hirt","year":"2020","journal-title":"Embo Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"109832","DOI":"10.1016\/j.foodcont.2023.109832","article-title":"Food safety risk behavior and social Co-governance in the food supply chain","volume":"152","author":"Gao","year":"2023","journal-title":"Food Control"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112505","DOI":"10.1016\/j.ecolind.2024.112505","article-title":"Risk evaluation, spatiotemporal evolution, and driving factors of provincial food safety in China","volume":"166","author":"Qin","year":"2024","journal-title":"Ecol. 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