{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:41:22Z","timestamp":1760060482802,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42177439"],"award-info":[{"award-number":["42177439"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Cyanide, a highly toxic compound, may exist in trace amounts in distilled Chinese liquor, a traditional spirit consumed by over a billion people. To enhance the efficiency and reliability of cyanide detection, we propose a rapid, fully automated method integrating steam distillation with a continuous flow analyzer. This system combines sample pretreatment, fast distillation, and colorimetric detection using the isonicotinic-barbituric acid chromogenic system based on Lambert\u2013Beer law (measuring at 600 nm). The standard curve exhibits an excellent linear relationship and a correlation coefficient r = 0.99959. The detection limit (0.2519 \u00b5g\/L) was derived from 11 replicate blank measurements. When applied to three types of Chinese liquor, the method yields spike recovery rates ranging from 91.530% to 98.485%, and precision values between 1.177% and 1.525%. A paired t-test confirms no significant difference between this method and the national standard spectrophotometric method (t = 0.535, p = 0.615). Overall, this method offers outstanding repeatability, high accuracy, rapid analysis, and minimal manual intervention, establishing it as a reliable tool for cyanide determination and contributing to the assurance of food safety in alcoholic beverages.<\/jats:p>","DOI":"10.3390\/foods14173045","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T16:18:15Z","timestamp":1756484295000},"page":"3045","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trace Determination of Cyanide in Chinese Liquor by Coupling Automatic Distillation with the Flow Analysis Method"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7290-1770","authenticated-orcid":false,"given":"Lingyi","family":"Zhao","sequence":"first","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4803-6243","authenticated-orcid":false,"given":"Youquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lvbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Fang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bai, Y., Miao, Z., Yan, R., Wang, X., Cheng, Z., Yang, J., Wang, B., Sun, J., Li, Z., and Zhang, Y. 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