{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:03:57Z","timestamp":1762509837384,"version":"build-2065373602"},"reference-count":83,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012900","name":"High-Level Talents Introduction Program of Qingdao Agricultural University","doi-asserted-by":"publisher","award":["1121021"],"award-info":[{"award-number":["1121021"]}],"id":[{"id":"10.13039\/100012900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Sour soup, a traditional fermented specialty from Northeast China, is renowned for its distinctive aroma and various health benefits. Here, we report the probiotic properties of Lactiplantibacillus plantarum Z45\u2014a strain isolated from sour soup broth\u2014along with its fermentative potential in sour soup production. This strain is suitable for food fermentation due to its absence of biogenic amine production and non-hemolytic activity. It exhibited strong tolerance to simulated gastrointestinal conditions and demonstrated high adherence capability to Caco-2 cells. Additionally, the strain displayed antioxidant and antimicrobial activities. Whole-genome sequencing revealed that Z45 carries no virulence or antibiotic resistance genes. It also harbors multiple carbohydrate-active enzymes and a complete folate biosynthesis pathway, alongside genes associated with stress response, antioxidant activity, and adhesion. Subsequently, Z45 was employed as a starter culture for sour soup fermentation, and its effects on the physicochemical and sensory properties of the product were evaluated. The results indicated that fermentation with Z45 did not alter the physicochemical properties of sour soup but significantly enhanced its sensory attributes. Compared to spontaneous fermentation, Z45-fermented sour soup showed reduced levels of harmful biogenic amines, improved flavor and overall sensory quality, notable enrichment of Lactobacillus and Oscillospirales in the microbial community, and upregulation of beneficial metabolites such as flavonoids and glycerophosphocholine. In summary, Lactiplantibacillus plantarum Z45 is safe, demonstrates probiotic potential, and holds promise for improving the quality and functional properties of fermented foods.<\/jats:p>","DOI":"10.3390\/foods14213803","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:14:45Z","timestamp":1762506885000},"page":"3803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactiplantibacillus plantarum Z45 from Sour Soup Improves Flavor and Safety of Fermented Corn: Insights from Genomic and Metabolomic Approaches"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-8270","authenticated-orcid":false,"given":"Mengdi","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"},{"name":"College of Animal Science and Technology, Shandong Agricultural University, Taian 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-6295","authenticated-orcid":false,"given":"Guangyu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-023-06378-w","article-title":"Synergy and oxygen adaptation for development of next-generation probiotics","volume":"620","author":"Khan","year":"2023","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"142549","DOI":"10.1016\/j.foodchem.2024.142549","article-title":"Effects of postbiotics produced by Lactobacillus plantarum JM015 isolated from traditional fermented dairy products on Salmonella-induced intestinal inflammation: A preventive strategy","volume":"469","author":"Pang","year":"2025","journal-title":"Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41575-019-0173-3","article-title":"Probiotics and prebiotics in intestinal health and disease: From biology to the clinic","volume":"16","author":"Daniel","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12602-017-9360-0","article-title":"Newly Isolated Lactobacilli strains from Algerian Human Vaginal Microbiota: Lactobacillus fermentum Strains Relevant Probiotic\u2019s Candidates","volume":"11","author":"Ouarabi","year":"2019","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1039\/C8FO00547H","article-title":"Anticancer potential against cervix cancer (HeLa) cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk","volume":"9","author":"Rajoka","year":"2018","journal-title":"Food Funct."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.tifs.2021.05.034","article-title":"Probiotic microorganisms from non-dairy traditional fermented foods","volume":"118","author":"Ilango","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"141892","DOI":"10.1016\/j.foodchem.2024.141892","article-title":"Correlation between microbial communities and flavor compounds in Suantangzi dough from Liaoning Province, China","volume":"464","author":"Song","year":"2025","journal-title":"Food Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1080\/10408398.2020.1858269","article-title":"Role of lactic acid bacteria in flavor development in traditional Chinese fermented foods: A review","volume":"62","author":"Hu","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.46234\/ccdcw2020.264","article-title":"A Foodborne Bongkrekic Acid Poisoning Incident\u2014Heilongjiang Province, 2020","volume":"2","author":"Yuan","year":"2020","journal-title":"China CDC Wkly."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fm.2016.08.009","article-title":"Advances in the genomics and metabolomics of dairy lactobacilli: A review","volume":"61","author":"Stefanovic","year":"2017","journal-title":"Food Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1093\/advances\/nmab014","article-title":"Pro-biomics: Omics Technologies to Unravel the Role of Probiotics in Health and Disease","volume":"12","author":"Kiousi","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.tifs.2008.03.003","article-title":"Metabolomics: Applications to food science and nutrition research","volume":"19","author":"Wishart","year":"2008","journal-title":"Trends Food Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"116039","DOI":"10.1016\/j.lwt.2024.116039","article-title":"Whole genome sequencing and analysis of probiotic characteristics for Lactiplantibacillus plantarum EL2 isolated from yak yogurt","volume":"198","author":"Zheng","year":"2024","journal-title":"LWT"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1292\/jvms.19-0523","article-title":"Distribution and epidemiological relatedness of methicillin-resistant Staphylococcus aureus isolated from companion dogs, owners, and environments","volume":"82","author":"Oh","year":"2020","journal-title":"J. Vet. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s12602-023-10187-y","article-title":"Complete Genome Sequence and Probiotic Properties of Pediococcus acidilactici CLP03 Isolated from Healthy Felis catus","volume":"17","author":"Zhao","year":"2023","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"116288","DOI":"10.1016\/j.lwt.2024.116288","article-title":"Screening and genome analysis of potential probiotic lactic acid bacteria with broad-spectrum antibacterial activity from Sichuan sun-dried vinegar grains (Cupei)","volume":"202","author":"Shu","year":"2024","journal-title":"LWT"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhao, M., Li, Y., Zhang, Y., and Li, G. (2024). Genomic analysis and functional properties of Lactobacillus johnsonii GJ231 isolated from healthy beagles. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1437036"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhao, M., Liu, K., Zhang, Y., Li, Y., Zhou, N., and Li, G. (2023). Probiotic characteristics and whole-genome sequence analysis of Pediococcus acidilactici isolated from the feces of adult beagles. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1179953"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Adimpong, D.B., Nielsen, D.S., S\u00f8rensen, K.I., Derkx, P.M., and Jespersen, L. (2012). Genotypic characterization and safety assessment of lactic acid bacteria from indigenous African fermented food products. BMC Microbiol., 12.","DOI":"10.1186\/1471-2180-12-75"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijfoodmicro.2004.05.011","article-title":"Antibiotic susceptibility profiles of new probiotic Lactobacillus and Bifidobacterium strains","volume":"98","author":"Zhou","year":"2005","journal-title":"Int. J. Food Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhao, M., Zhang, Y., Li, Y., and Li, G. (2025). Developing Gut-Healthy Strains for Pets: Probiotic Potential and Genomic Insights of Canine-Derived Lactobacillus acidophilus GLA09. Microorganisms, 13.","DOI":"10.3390\/microorganisms13020350"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109820","DOI":"10.1016\/j.foodres.2020.109820","article-title":"Determination of the microbial communities of Guizhou Suantang, a traditional Chinese fermented sour soup, and correlation between the identified microorganisms and volatile compounds","volume":"138","author":"Wang","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhao, M., Zhang, Y., Li, Y., Liu, K., Bao, K., and Li, G. (2024). Impact of Pediococcus acidilactici GLP06 supplementation on gut microbes and metabolites in adult beagles: A comparative analysis. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1369402"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1039\/C8FO00365C","article-title":"Strain-specific properties of Lactobacillus plantarum for prevention of Salmonella infection","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ngamsomchat, A., Kaewkod, T., Konkit, M., Tragoolpua, Y., Bovonsombut, S., and Chitov, T. (2022). Characterisation of Lactobacillus plantarum of Dairy-Product Origin for Probiotic Ch\u00e8vre Cheese Production. Foods, 11.","DOI":"10.3390\/foods11070934"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1801944","DOI":"10.1080\/19490976.2020.1801944","article-title":"Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: A systematic review","volume":"12","author":"Feng","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"112847","DOI":"10.1016\/j.lwt.2021.112847","article-title":"Assessing the safety and probiotic characteristics of Bacillus coagulans 13002 based on complete genome and phenotype analysis","volume":"155","author":"Wu","year":"2022","journal-title":"LWT"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"399S","DOI":"10.1093\/ajcn\/73.2.399s","article-title":"Probiotics: Determinants of survival and growth in the gut","volume":"73","author":"Bezkorovainy","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"116386","DOI":"10.1016\/j.lwt.2024.116386","article-title":"Assessment of the safety and probiotic properties of Lactiplantibacillus plantarum HYY-DB9 based on comprehensive genomic and phenotypic analysis","volume":"203","author":"Lu","year":"2024","journal-title":"LWT"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.copbio.2006.02.005","article-title":"Towards understanding molecular modes of probiotic action","volume":"17","author":"Marco","year":"2006","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106177","DOI":"10.1016\/j.micpath.2023.106177","article-title":"Assessing the protection mechanisms on Enterobacter aerogenes ATCC 13048 by potentially probiotic strain Lacticaseibacillus casei XN18: An experimental and modeling study","volume":"181","author":"Taki","year":"2023","journal-title":"Microb. Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1038\/s41598-024-66597-7","article-title":"Probiotic evaluation, adherence capability and safety assessment of Lactococcus lactis strain isolated from an important herb \u201cMurraya koenigii\"","volume":"14","author":"Shivani","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"103677","DOI":"10.1016\/j.micpath.2019.103677","article-title":"Inhibition of Escherichia coli adhesion to human intestinal Caco-2 cells by probiotic candidate Lactobacillus plantarum strain L15","volume":"136","author":"Noshad","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Goel, A., Halami, P.M., and Tamang, J.P. (2020). Genome Analysis of Lactobacillus plantarum Isolated From Some Indian Fermented Foods for Bacteriocin Production and Probiotic Marker Genes. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00040"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/1574-6976.12067","article-title":"Bacterial insertion sequences: Their genomic impact and diversity","volume":"38","author":"Siguier","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/1751-7915.13972","article-title":"Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage-encoded holin-lysin system","volume":"15","author":"Liu","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"114759","DOI":"10.1016\/j.lwt.2023.114759","article-title":"Evaluation of the safety and probiotic properties of Lactobacillus gasseri LGZ1029 based on whole genome analysis","volume":"184","author":"Wu","year":"2023","journal-title":"LWT"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"111778","DOI":"10.1016\/j.lwt.2021.111778","article-title":"Whole genome sequencing of Lactobacillus plantarum DMDL 9010 and its effect on growth phenotype under nitrite stress","volume":"149","author":"Huang","year":"2021","journal-title":"LWT"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113129","DOI":"10.1016\/j.lwt.2022.113129","article-title":"Analysis of the probiotic characteristics and adaptability of Lactiplantibacillus plantarum DMDL 9010 to gastrointestinal environment by complete genome sequencing and corresponding phenotypes","volume":"158","author":"Liu","year":"2022","journal-title":"LWT"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lu, J., Mao, Y., Ma, T., Liu, X., Cheng, X., Bai, Y., and Li, S. (2023). Screening and genome analysis of lactic acid bacteria with high exopolysaccharide production and good probiotic properties. Food Biosci., 56.","DOI":"10.1016\/j.fbio.2023.103211"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1021\/jacs.5b01156","article-title":"Reaction Mechanisms in Carbohydrate-Active Enzymes: Glycoside Hydrolases and Glycosyltransferases. Insights from ab Initio Quantum Mechanics\/Molecular Mechanics Dynamic Simulations","volume":"137","author":"Rovira","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1038\/s41467-020-18990-9","article-title":"Exploring and applying the substrate promiscuity of a C-glycosyltransferase in the chemo-enzymatic synthesis of bioactive C-glycosides","volume":"11","author":"Xie","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.3168\/jds.2019-18047","article-title":"Physiological function analysis of Lactobacillus plantarum Y44 based on genotypic and phenotypic characteristics","volume":"103","author":"Gao","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1074\/mcp.M110.002741","article-title":"Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG","volume":"10","author":"Koskenniemi","year":"2011","journal-title":"Mol. Cell. Proteom."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, J., Mu, G., and Tuo, Y. (2023). Phenotypic Traits and Probiotic Functions of Lactiplantibacillus plantarum Y42 in Planktonic and Biofilm Forms. Foods, 12.","DOI":"10.3390\/foods12071516"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.micres.2011.07.001","article-title":"Inactivation of the ftsH gene of Lactobacillus plantarum WCFS1: Effects on growth, stress tolerance, cell surface properties and biofilm formation","volume":"167","author":"Bove","year":"2012","journal-title":"Microbiol. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1016\/j.jmb.2016.08.003","article-title":"Molecular Mechanisms of Two-Component Signal Transduction","volume":"428","author":"Zschiedrich","year":"2016","journal-title":"J. Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"116229","DOI":"10.1016\/j.lwt.2024.116229","article-title":"Physicochemical, microbiological and sensory characterization of yogurt fermented by Weissella confusa SW1 and traditional starters","volume":"201","author":"Zou","year":"2024","journal-title":"LWT"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"117600","DOI":"10.1016\/j.foodres.2025.117600","article-title":"Transcriptional analysis of oxidative-tolerant and temperature-sensitive genes of Bifidobacterium animalis BF052 during freeze-drying process and development of its soymilk-synbiotic product containing banana and jicama powders","volume":"221","author":"Jantama","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S933","DOI":"10.14309\/01.ajg.0000709264.10195.c6","article-title":"S1804 Gut Friend or Foe: A Case of Lactobacillus Rhamnosus Endocarditis from Probiotic Use","volume":"115","author":"Bergagnini","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"160461","DOI":"10.1016\/j.scitotenv.2022.160461","article-title":"Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health","volume":"860","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1093\/molbev\/msu223","article-title":"Perturbation of iron homeostasis promotes the evolution of antibiotic resistance","volume":"31","author":"Bogos","year":"2014","journal-title":"Mol. Biol. Evol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Gueimonde, M., S\u00e1nchez, B., de los Reyes-Gavil\u00e1n, C.G., and Margolles, A. (2013). Antibiotic resistance in probiotic bacteria. Front. Microbiol., 4.","DOI":"10.3389\/fmicb.2013.00202"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00284-019-01769-7","article-title":"Antibiotic Resistance of LACTOBACILLUS Strains","volume":"76","author":"Anisimova","year":"2019","journal-title":"Curr. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0168-1605(00)00522-5","article-title":"Antimicrobial susceptibility of starter culture bacteria used in Norwegian dairy products","volume":"67","author":"Katla","year":"2001","journal-title":"Int. J. Food Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.nbt.2022.05.001","article-title":"Comparative genomics reveals the organic acid biosynthesis metabolic pathways among five lactic acid bacterial species isolated from fermented vegetables","volume":"70","author":"Okoye","year":"2022","journal-title":"New Biotechnol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"153626","DOI":"10.1016\/j.phymed.2021.153626","article-title":"Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action","volume":"90","author":"Micol","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Perricone, M., Arace, E., Corbo, M.R., Sinigaglia, M., and Bevilacqua, A. (2015). Bioactivity of essential oils: A review on their interaction with food components. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00076"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodres.2016.07.013","article-title":"Folates: Chemistry, analysis, occurrence, biofortification and bioavailability","volume":"89","author":"Saini","year":"2016","journal-title":"Food Res. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1039\/C8FO01952E","article-title":"Transcriptomic analysis of de novo folate biosynthetic genes in Lactobacillus plantarum strain 4_3 in fermented soybean","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1111\/1541-4337.13162","article-title":"A systematic review on the flavor of soy-based fermented foods: Core fermentation microbiome, multisensory flavor substances, key enzymes, and metabolic pathways","volume":"22","author":"An","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s10068-023-01388-w","article-title":"Characterization of fermented pomegranate juice: ACE inhibitory activity under in vitro digestion, antioxidant capacity, phenolics composition, chemical properties and sensory evaluation","volume":"33","author":"Chen","year":"2024","journal-title":"Food Sci. Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1038\/ejcn.2010.218","article-title":"Biogenic amines in fermented foods","volume":"64","author":"Spano","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.17221\/197\/2014-CJFS","article-title":"Improved screening procedure for biogenic amine production by lactic acid bacteria and Enterobacteria","volume":"33","author":"Shiling","year":"2015","journal-title":"Czech J. Food Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Capozzi, V., Russo, P., Ladero, V., Fernandez, M., Fiocco, D., Alvarez, M.A., Grieco, F., and Spano, G. (2012). Biogenic Amines Degradation by Lactobacillus plantarum: Toward a Potential Application in Wine. Front. Microbiol., 3.","DOI":"10.3389\/fmicb.2012.00122"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.foodcont.2013.01.029","article-title":"Reduction of biogenic amine accumulation in silver carp sausage by an amine-negative Lactobacillus plantarum","volume":"32","author":"Zhang","year":"2013","journal-title":"Food Control"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"130351","DOI":"10.1016\/j.foodchem.2021.130351","article-title":"Study on the nutritional characteristics and antioxidant activity of dealcoholized sequentially fermented apple juice with Saccharomyces cerevisiae and Lactobacillus plantarum fermentation","volume":"363","author":"Li","year":"2021","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"141635","DOI":"10.1016\/j.foodchem.2024.141635","article-title":"Lactic acid bacteria sequential fermentation improves viable counts and quality of fermented apple juice via generating two logarithmic phases","volume":"464","author":"Yang","year":"2025","journal-title":"Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"110668","DOI":"10.1016\/j.foodres.2021.110668","article-title":"Effects of the main ingredients of the fermented food, kimchi, on bacterial composition and metabolite profile","volume":"149","author":"Song","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"126481","DOI":"10.1016\/j.foodchem.2020.126481","article-title":"Microbial niches in raw ingredients determine microbial community assembly during kimchi fermentation","volume":"318","author":"Song","year":"2020","journal-title":"Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Palmn\u00e4s-B\u00e9dard, M., de Santa Izabel, A., Dicksved, J., and Landberg, R. (2023). Characterization of the Bacterial Composition of 47 Fermented Foods in Sweden. Foods, 12.","DOI":"10.3390\/foods12203827"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-S\u00e1nchez, R., Hern\u00e1ndez-Oaxaca, D., Escobar-Zepeda, A., Ramos Cerrillo, B., L\u00f3pez-Mungu\u00eda, A., and Segovia, L. (2023). Analysing the dynamics of the bacterial community in pozol, a Mexican fermented corn dough. Microbiology, 169.","DOI":"10.1099\/mic.0.001355"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1987783","DOI":"10.1080\/19490976.2021.1987783","article-title":"Oscillospira\u2014A candidate for the next-generation probiotics","volume":"13","author":"Yang","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Shang, Q., Liu, S., Liu, H., Mahfuz, S., and Piao, X. (2021). Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation. J. Anim. Sci. Biotechnol., 12.","DOI":"10.1186\/s40104-021-00573-3"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Imran, M., Rauf, A., Abu-Izneid, T., Nadeem, M., Shariati, M.A., Khan, I.A., Imran, A., Orhan, I.E., Rizwan, M., and Atif, M. (2019). Luteolin, a flavonoid, as an anticancer agent: A review. Biomed. Pharmacother., 112.","DOI":"10.1016\/j.biopha.2019.108612"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0891-5849(98)00190-7","article-title":"Quantitative structure-activity relationship analysis of phenolic antioxidants","volume":"26","author":"Lien","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ijbiomac.2021.04.063","article-title":"Development of active packaging films based on chitosan and nano-encapsulated luteolin","volume":"182","author":"Bi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Punia Bangar, S., Kajla, P., Chaudhary, V., Sharma, N., and Ozogul, F. (2023). Luteolin: A flavone with myriads of bioactivities and food applications. Food Biosci., 52.","DOI":"10.1016\/j.fbio.2023.102366"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Liu, J.Y., Zheng, R.Q., Wang, Y., Liu, Y.H., Jiang, S., Wang, X.-Z., He, K., Pan, X., Zhou, T., and Li, T. (2022). The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in Caenorhabditis elegans. Metabolites, 12.","DOI":"10.3390\/metabo12020177"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.116.022993","article-title":"Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents","volume":"134","author":"Syme","year":"2016","journal-title":"Circulation"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1021\/acs.jafc.2c00530","article-title":"Preparation and Taste Characteristics of Kokumi N-Lactoyl Phenylalanine in the Presence of Phenylalanine and Lactate","volume":"70","author":"Wu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41586-022-04828-5","article-title":"An exercise-inducible metabolite that suppresses feeding and obesity","volume":"606","author":"Li","year":"2022","journal-title":"Nature"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/21\/3803\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T10:00:09Z","timestamp":1762509609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/21\/3803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":83,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["foods14213803"],"URL":"https:\/\/doi.org\/10.3390\/foods14213803","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]}}}