{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T09:06:13Z","timestamp":1762938373408,"version":"3.45.0"},"reference-count":42,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Innovation Project of Yantai City, Shandong Province","award":["2023YT06000829"],"award-info":[{"award-number":["2023YT06000829"]}]},{"name":"Yantai Science and Technology Program","award":["2022XDRH012"],"award-info":[{"award-number":["2022XDRH012"]}]},{"name":"Innovation Project for graduate students of Ludong University","award":["IPGS2025-081"],"award-info":[{"award-number":["IPGS2025-081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Long-term excessive intake of alcohol can cause serious damage to the liver, and the study of natural active ingredients with hepatoprotective effects is of great significance for the prevention and treatment of alcoholic liver injury. This study explored the ameliorative effects of high F-value oligopeptides (HFOPs) from Chlamys farreri, Pueraria lobata extract (PL), and their complex (HFOPs + PL) on alcoholic liver injury. Results showed HFOPs + PL significantly reduced alanine aminotransferase (ALT) and aspartate aminotransferase (AST) leakage, increased superoxide dismutase (SOD) and glutathione (GSH) activities, and decreased the production of malondialdehyde (MDA) and inflammatory factors in alcohol-induced HepG2 cells. In mice, it prolonged intoxication time, shortened detoxification time, enhanced hepatic ADH and aldehyde dehydrogenase (ALDH) activities, reduced serum AST and ALT levels, and improved antioxidant capacity. Its effects were better than PL alone and comparable to HFOPs alone. HFOPs and PL alleviate alcoholic liver injury by enhancing ethanol metabolism, reducing oxidative stress, and suppressing inflammation, providing theoretical support for their combined use in alcohol detoxification and liver protection.<\/jats:p>","DOI":"10.3390\/foods14223859","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T14:28:59Z","timestamp":1762871339000},"page":"3859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Alcohol-Induced Hepatoprotective Effects of the High Fischer Ratio Oligopeptides with\/Without Half Substitution by Pueraria lobata"],"prefix":"10.3390","volume":"14","author":[{"given":"Yongke","family":"Deng","sequence":"first","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-6815","authenticated-orcid":false,"given":"Hongbing","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haimei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Ludong University, Yantai 264025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/add.15204","article-title":"Alcohol Use Disorder and the Liver","volume":"116","author":"Buchanan","year":"2021","journal-title":"Addiction"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hyun, J., Han, J., Lee, C., Yoon, M., and Jung, Y. 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