{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:03:07Z","timestamp":1793746987081,"version":"4.6.1"},"reference-count":90,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory and oxidative stress markers and uremic toxins among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and explored its molecular effects in LLC-PK1 renal cells. A randomized, controlled clinical trial was conducted with 27 patients (55.0 [19.5] years, BMI 24.3 [3.8] kg\/m2) on regular HD. Participants were allocated to receive the jaboticaba peel formulation (3.3 g\/day, equivalent to ~667 mg of phenolic compounds) for 3 weeks or to routine treatment (control). Plasma levels of interleukin (IL)-1\u03b2 and IL-17E (ELISA), lipid peroxidation (TBARS), protein carbonylation, and plasma levels of uremic were analyzed. LLC-PK1 cells were treated with 100 \u00b5L of jaboticaba peel formulation at different concentrations, and a panel of inflammatory genes was evaluated. While plasma IL-1\u03b2 and IL-17E concentrations were increased in the control group, the jaboticaba group exhibited no significant changes, suggesting anti-inflammatory protection. Transcriptomic analysis revealed downregulation of key components of the TLR\u2013MYD88\u2013NF-\u03baB\u2013IL-1 axis after cell treatment. Additionally, cells treated with jaboticaba formulation (1.5%) showed reduced ROS levels, indicating antioxidant capacity. In conclusion, supplementation with jaboticaba peel attenuated the increase in pro-inflammatory markers in HD patients. These results suggest that jaboticaba peel holds promise as an adjuvant nutritional intervention for chronic inflammation in CKD.<\/jats:p>","DOI":"10.3390\/foods14234030","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T08:50:20Z","timestamp":1764060620000},"page":"4030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of the Brazilian Native Fruit Jaboticaba (Plinia cauliflora) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-2439","authenticated-orcid":false,"given":"Ligia Soares","family":"Lima","sequence":"first","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-3027","authenticated-orcid":false,"given":"Jessyca Sousa de","family":"Brito","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-3364","authenticated-orcid":false,"given":"Marcelo","family":"Ribeiro-Alves","sequence":"additional","affiliation":[{"name":"HIV\/AIDS Clinical Research Center, National Institute of Infectious Diseases Evandro Chagas (INI\/Fiocruz), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-1237","authenticated-orcid":false,"given":"Karen Salve","family":"Coutinho-Wolino","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo dos Santos P.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-814X","authenticated-orcid":false,"given":"Rafael Hospodar Felippe","family":"Valverde","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-1174","authenticated-orcid":false,"given":"Marcelo","family":"Einicker-Lamas","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-1301","authenticated-orcid":false,"given":"Andresa A.","family":"Berretta","sequence":"additional","affiliation":[{"name":"Chair Propolis Working Group, International Honey Commission (IHC), Ribeir\u00e3o Preto 14020-670, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8219-3421","authenticated-orcid":false,"given":"Carmen Luc\u00eda","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba 81531-980, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-6350","authenticated-orcid":false,"given":"Lia S.","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba 81531-980, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-4820","authenticated-orcid":false,"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, 141 86 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-6056","authenticated-orcid":false,"given":"Denise","family":"Mafra","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil"},{"name":"Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niter\u00f3i 24070-090, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41581-020-00345-8","article-title":"Food as Medicine: Targeting the Uraemic Phenotype in Chronic Kidney Disease","volume":"17","author":"Mafra","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1053\/j.jrn.2023.08.002","article-title":"Protect the Kidneys and Save the Heart Using the Concept of Food as Medicine","volume":"33","author":"Cardozo","year":"2023","journal-title":"J. Ren. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1080\/10408398.2017.1422111","article-title":"Superfruits: Phytochemicals, Antioxidant Efficacies, and Health Effects\u2013A Comprehensive Review","volume":"59","author":"Chang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"110518","DOI":"10.1016\/j.foodres.2021.110518","article-title":"Jaboticaba Berry: A Comprehensive Review on Its Polyphenol Composition, Health Effects, Metabolism, and the Development of Food Products","volume":"147","author":"Inada","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Resende, L.M., and Franca, A.S. (2022). Jabuticaba (Plinia sp.) Peel as a Source of Pectin: Characterization and Effect of Different Extraction Methods. Foods, 12.","DOI":"10.3390\/foods12010117"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tifs.2021.03.044","article-title":"Jaboticaba (Myrtaceae cauliflora) Fruit and Its by-Products: Alternative Sources for New Foods and Functional Components","volume":"112","author":"Benvenutti","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"113611","DOI":"10.1016\/j.jep.2020.113611","article-title":"Anti-Inflammatory, Hypoglycemic, Hypolipidemic, and Analgesic Activities of Plinia cauliflora (Mart.) Kausel (Brazilian Grape) Epicarp","volume":"268","author":"Nascimento","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"110139","DOI":"10.1016\/j.foodres.2021.110139","article-title":"Phenolic Compounds from Jaboticaba (Plinia jaboticaba (Vell.) Berg) Ameliorate Intestinal Inflammation and Associated Endotoxemia in Obesity","volume":"141","author":"Rodrigues","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Soares, E., Soares, A.C., Trindade, P.L., Monteiro, E.B., Martins, F.F., Forgie, A.J., Inada, K.O.P., de Bem, G.F., Resende, A., and Perrone, D. (2021). Jaboticaba (Myrciaria jaboticaba) Powder Consumption Improves the Metabolic Profile and Regulates Gut Microbiome Composition in High-Fat Diet-Fed Mice. Biomed. Pharmacother., 144.","DOI":"10.1016\/j.biopha.2021.112314"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1017\/S0007114512005090","article-title":"Freeze-Dried Jaboticaba Peel Powder Improves Insulin Sensitivity in High-Fat-Fed Mice","volume":"110","author":"Dragano","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrneph.2017.52","article-title":"The Systemic Nature of CKD","volume":"13","author":"Zoccali","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Deng, L., Guo, S., Liu, Y., Zhou, Y., Liu, Y., Zheng, X., Yu, X., and Shuai, P. (2025). Global, Regional, and National Burden of Chronic Kidney Disease and Its Underlying Etiologies from 1990 to 2021: A Systematic Analysis for the Global Burden of Disease Study 2021. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-21851-z"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global Burden of 369 Diseases and Injuries in 204 Countries and Territories, 1990\u20132019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Abbafati","year":"2020","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, Regional, and National Burden of Chronic Kidney Disease, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","article-title":"Global Incidence, Prevalence, Years Lived with Disability (YLDs), Disability-Adjusted Life-Years (DALYs), and Healthy Life Expectancy (HALE) for 371 Diseases and Injuries in 204 Countries and Territories and 811 Subnational Locations, 1990\u20132021: A Systematic Analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Ferrari","year":"2024","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41581-023-00747-4","article-title":"Diagnosis of Cardiovascular Disease in Patients with Chronic Kidney Disease","volume":"19","author":"Zoccali","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.ekir.2021.04.023","article-title":"Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2","volume":"6","author":"Stenvinkel","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kadatane, S.P., Satariano, M., Massey, M., Mongan, K., and Raina, R. (2023). The Role of Inflammation in CKD. Cells, 12.","DOI":"10.3390\/cells12121581"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s00018-024-05532-5","article-title":"Gut Microbiota Regulates Oxidative Stress and Inflammation: A Double-Edged Sword in Renal Fibrosis","volume":"81","author":"Li","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, Y., and Gao, L. (2022). Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.800950"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/eurheartj\/ehaa1049","article-title":"The Cardiovascular\u2013Dialysis Nexus: The Transition to Dialysis Is a Treacherous Time for the Heart","volume":"42","author":"Chan","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Granata, S., Masola, V., Zoratti, E., Scupoli, M.T., Baruzzi, A., Messa, M., Sallustio, F., Gesualdo, L., Lupo, A., and Zaza, G. (2015). NLRP3 Inflammasome Activation in Dialyzed Chronic Kidney Disease Patients. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122272"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"F938","DOI":"10.1152\/ajprenal.00256.2017","article-title":"Inflammation and Premature Aging in Advanced Chronic Kidney Disease","volume":"313","author":"Kooman","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2741\/4595","article-title":"Uremic Toxins Are Conditional Danger- or Homeostasis-Associated Molecular Patterns","volume":"23","author":"Sun","year":"2018","journal-title":"Front. Biosci.-Landmark"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s40620-021-01153-4","article-title":"The Innate Immune System in Human Kidney Inflammaging","volume":"35","author":"Sepe","year":"2021","journal-title":"J. Nephrol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Plonsky-Toder, M., Magen, D., and Pollack, S. (2023). Innate Immunity and CKD: Is There a Significant Association?. Cells, 12.","DOI":"10.3390\/cells12232714"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cestari, A.P., Gasparotto, F.M., Kassuya, C.A.L., Lacerda, T.M.R., Donadel, G., Moura, C.S., Ceranto, D.B., Jacomassi, E., Alberton, O., and Tramontini, S.B. (2024). Ateroprotective Effects of Plinia cauliflora in. New Zealand Rabbits: Beyond the Lipid-Lowering Effect. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1244632"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1007\/s11033-020-05873-x","article-title":"Ellagic Acid Prevents Kidney Injury and Oxidative Damage via Regulation of Nrf-2\/NF-\u039aB Signaling in Carbon Tetrachloride Induced Rats","volume":"47","author":"Aslan","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1016\/j.clnu.2020.03.007","article-title":"Impact of Curcumin Supplementation on Expression of Inflammatory Transcription Factors in Hemodialysis Patients: A Pilot Randomized, Double-Blind, Controlled Study","volume":"39","author":"Alvarenga","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s13197-017-2769-3","article-title":"Jabuticaba (Myrciaria jaboticaba) Juice Obtained by Steam-Extraction: Phenolic Compound Profile, Antioxidant Capacity, Microbiological Stability, and Sensory Acceptability","volume":"55","author":"Inada","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.foodchem.2016.04.142","article-title":"Characterization of Antioxidant Polyphenols from Myrciaria jaboticaba Peel and Their Effects on Glucose Metabolism and Antioxidant Status: A Pilot Clinical Study","volume":"211","author":"Plaza","year":"2016","journal-title":"Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.foodres.2017.08.044","article-title":"Effect of Clarified Brazilian Native Fruit Juices on Postprandial Glycemia in Healthy Subjects","volume":"100","author":"Balisteiro","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_34","unstructured":"USFDA (2025, November 20). Guidance for Industry. Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers, Available online: https:\/\/www.fda.gov\/media\/72309\/download."},{"key":"ref_35","unstructured":"Association of Official Analytical Chemists Official Methods of Analysis (2005). AOAC-Official Methods of Analysis of AOAC INTERNATIONAL, AOAC International."},{"key":"ref_36","first-page":"7","article-title":"Extraction, Isolation, and Purification of Anthocyanins","volume":"Volume 2","author":"Wrolstad","year":"2005","journal-title":"Handbook of Food Analytical Chemistry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"F1.2.1","DOI":"10.1002\/0471142913.faf0102s00","article-title":"Characterization and Measurement of Anthocyanins by UV-Visible Spectroscopy","volume":"00","author":"Giusti","year":"2001","journal-title":"Curr. Protoc. Food Anal. Chem."},{"key":"ref_38","unstructured":"AOAC (2025, November 12). Official Method of Analysis. 18th Edition, Association of Officiating Analytical Chemists, Washington DC, Method 935.14 and 992.24. Available online: https:\/\/www.scirp.org\/reference\/ReferencesPapers?ReferenceID=2033299."},{"key":"ref_39","unstructured":"WHO (2000). Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation, World Health Organization."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for Lipid Peroxides in Animal Tissues by Thiobarbituric Acid Reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"[49] Determination of Carbonyl Content in Oxidatively Modified Proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/ndt\/gfr672","article-title":"Novel Method for Simultaneous Determination of p-Cresylsulphate and p-Cresylglucuronide: Clinical Data and Pathophysiological Implications","volume":"27","author":"Meert","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.jrn.2016.07.005","article-title":"Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in Chronic Kidney Disease","volume":"26","author":"Borges","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Melo, M.N.D.O., Ochioni, A.C., Zancan, P., Oliveira, A.P., Grazi, M., Garrett, R., Holandino, C., and Baumgartner, S. (2022). Viscum album Mother Tinctures: Harvest Conditions and Host Trees Influence the Plant Metabolome and the Glycolytic Pathway of Breast Cancer Cells. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1027931"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bonaterra, G.A., Schmitt, J., Schneider, K., Schwarzbach, H., Aziz-Kalbhenn, H., Kelber, O., M\u00fcller, J., and Kinscherf, R. (2022). Phytohustil\u00ae and Root Extract of Althaea Officinalis L. Exert Anti-Inflammatory and Anti-Oxidative Properties and Improve the Migratory Capacity of Endothelial Cells in Vitro. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.948248"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.nutres.2024.02.008","article-title":"Jaboticaba Peel Improves Postprandial Glucose and Inflammation: A Randomized Controlled Trial in Adults with Metabolic Syndrome","volume":"125","author":"Geraldi","year":"2024","journal-title":"Nutr. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1039\/D4FO01907E","article-title":"Jaboticaba Berry (Myrciaria jaboticaba) Supplementation Protects against Micro- and Macrovascular Dysfunction Induced by Eccentric Exercise: A Randomized Clinical Trial","volume":"15","author":"Tavares","year":"2024","journal-title":"Food Funct."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00394-025-03767-x","article-title":"Jaboticaba Berry (Myrciaria jaboticaba) Consumption Improves Plasma GSH Levels and Accelerates Muscle Recovery Following Exercise-Induced Muscle Damage: A Randomized, Placebo-Controlled Trial","volume":"64","author":"Junior","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Frountzas, M., Karanikki, E., Toutouza, O., Sotirakis, D., Schizas, D., Theofilis, P., Tousoulis, D., and Toutouzas, K.G. (2023). Exploring the Impact of Cyanidin-3-Glucoside on Inflammatory Bowel Diseases: Investigating New Mechanisms for Emerging Interventions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119399"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molimm.2021.08.007","article-title":"Ellagic Acid Protects Rats from Chronic Renal Failure via MiR-182\/FOXO3a Axis","volume":"138","author":"Chen","year":"2021","journal-title":"Mol. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s10753-019-01120-z","article-title":"Ellagic Acid Ameliorates Renal Ischemic-Reperfusion Injury Through NOX4\/JAK\/STAT Signaling Pathway","volume":"43","author":"Liu","year":"2020","journal-title":"Inflammation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2963540","DOI":"10.1155\/2020\/2963540","article-title":"Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia","volume":"2020","author":"He","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.1021\/acs.jafc.1c05239","article-title":"Ellagic Acid Exerts Beneficial Effects on Hyperuricemia by Inhibiting Xanthine Oxidase and NLRP3 Inflammasome Activation","volume":"69","author":"Sun","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00394-024-03577-7","article-title":"Ellagic Acid Alleviates DSS\u2013Induced Ulcerative Colitis by Inhibiting ROS\/NLRP3 Pathway Activation and Modulating Gut Microbiota in Mice","volume":"64","author":"Xiong","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12011-020-02034-w","article-title":"Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats","volume":"198","author":"Mohammed","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9364364","DOI":"10.1155\/2018\/9364364","article-title":"Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK\/NF-\u039aB and Akt\/AMPK\/Nrf2 Pathways","volume":"2018","author":"Tanaka","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.intimp.2018.11.049","article-title":"Gallic Acid Improved Inflammation via NF-\u039aB Pathway in TNBS-Induced Ulcerative Colitis","volume":"67","author":"Zhu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lin, Y., Luo, T., Weng, A., Huang, X., Yao, Y., Fu, Z., Li, Y., Liu, A., Li, X., and Chen, D. (2020). Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.580593"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Naghibi, N., Sadeghi, A., Movahedinia, S., Rahimi Naiini, M., Rajizadeh, M.A., Bahri, F., and Nazari-Robati, M. (2023). Ellagic Acid Ameliorates Aging-Induced Renal Oxidative Damage through Upregulating SIRT1 and NRF2. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-03907-y"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.intimp.2014.07.005","article-title":"Ellagic Acid Protects Lipopolysaccharide\/d-Galactosamine-Induced Acute Hepatic Injury in Mice","volume":"22","author":"Gu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"104148","DOI":"10.1016\/j.jff.2020.104148","article-title":"Cyanidin-3-Glucoside Protects Liver from Oxidative Damage through AMPK\/Nrf2 Mediated Signaling Pathway in Vivo and in Vitro","volume":"73","author":"Yu","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"9233","DOI":"10.1080\/21655979.2022.2059995","article-title":"Ellagic Acid Attenuates Interleukin-1\u03b2-Induced Oxidative Stress and Exerts Protective Effects on Chondrocytes through the Kelch-like ECH-Associated Protein 1 (Keap1)\/Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Pathway","volume":"13","author":"Zhu","year":"2022","journal-title":"Bioengineered"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Mallamaci, R., Barbarossa, A., Carocci, A., and Meleleo, D. (2024). Evaluation of the Potential Protective Effect of Ellagic Acid against Heavy Metal (Cadmium, Mercury, and Lead) Toxicity in SH-SY5Y Neuroblastoma Cells. Foods, 13.","DOI":"10.3390\/foods13030419"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Al-Zharani, M., Mubarak, M., Rudayni, H.A., Al-Doaiss, A.A., Abd-Elwahab, M.M., and Al-Eissa, M.S. (2023). Quercetin as a Dietary Supplementary Flavonoid Alleviates the Oxidative Stress Induced by Lead Toxicity in Male Wistar Rats. Nutrients, 15.","DOI":"10.3390\/nu15081888"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Qi, W., Qi, W., Xiong, D., and Long, M. (2022). Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy. Molecules, 27.","DOI":"10.3390\/molecules27196545"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zhang, W., Zheng, Y., Yan, F., Dong, M., and Ren, Y. (2023). Research Progress of Quercetin in Cardiovascular Disease. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1203713"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Rapa, S.F., Di Iorio, B.R., Campiglia, P., Heidland, A., and Marzocco, S. (2020). Inflammation and Oxidative Stress in Chronic Kidney Disease\u2014Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010263"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the Mechanism of IL-1\u03b2 Secretion","volume":"22","author":"Brough","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1681\/ASN.2016020177","article-title":"Of Inflammasomes and Alarmins: IL-1\u03b2 and IL-1\u03b1 in Kidney Disease","volume":"27","author":"Anders","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41420-024-01996-3","article-title":"Renal Macrophages and NLRP3 Inflammasomes in Kidney Diseases and Therapeutics","volume":"10","author":"Islamuddin","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41392-022-01036-5","article-title":"Signaling Pathways of Chronic Kidney Diseases, Implications for Therapeutics","volume":"7","author":"Yuan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1681\/ASN.2010070693","article-title":"IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease","volume":"22","author":"Cao","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1681\/ASN.2014050479","article-title":"IL-25 Elicits Innate Lymphoid Cells and Multipotent Progenitor Type 2 Cells That Reduce Renal Ischemic\/Reperfusion Injury","volume":"26","author":"Huang","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"F87","DOI":"10.1152\/ajprenal.00209.2022","article-title":"Chronic Treatment with IL-25 Increases Renal M2 Macrophages and Reduces Renal Injury in Obese Dahl Salt-Sensitive Rats during the Prepubescent Stage","volume":"325","author":"Poudel","year":"2023","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_75","first-page":"151","article-title":"The Expression of Interleukin-25 Increases in Human Coronary Artery Disease and Is Associated with the Severity of Coronary Stenosis","volume":"23","author":"Xu","year":"2020","journal-title":"Anatol. J. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yuan, Q., Peng, N., Xiao, F., Shi, X., Zhu, B., Rui, K., Tian, J., and Lu, L. (2023). New Insights into the Function of Interleukin-25 in Disease Pathogenesis. Biomark. Res., 11.","DOI":"10.1186\/s40364-023-00474-9"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Polak-Szczyby\u0142o, E., and Tabarkiewicz, J. (2022). IL-17A, IL-17E and IL-17F as Potential Biomarkers for the Intensity of Low-Grade Inflammation and the Risk of Cardiovascular Diseases in Obese People. Nutrients, 14.","DOI":"10.3390\/nu14030643"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaci.2020.12.628","article-title":"IL-25 (IL-17E) in Epithelial Immunology and Pathophysiology","volume":"148","author":"Borowczyk","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/procel\/pwae010","article-title":"CARM1 Drives Triple-Negative Breast Cancer Progression by Coordinating with HIF1A","volume":"15","author":"Feng","year":"2024","journal-title":"Protein Cell"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Qiu, S., Zhong, C., Zhao, B., Li, G., Wang, J., Jehan, S., Li, J., Zhao, X., Li, D., and Sui, G. (2021). Transcriptome Analysis of Signaling Pathways Targeted by Ellagic Acid in Hepatocellular Carcinoma Cells. Biochim. Biophys. Acta Gen. Subj., 1865.","DOI":"10.1016\/j.bbagen.2021.129911"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13668-025-00645-0","article-title":"Urolithin as a Metabolite of Ellagitannins and Ellagic Acid from Fruits and Nuts Produced by the Gut Microbiota: Its Role on Non-Communicable Diseases","volume":"14","author":"Ribeiro","year":"2025","journal-title":"Curr. Nutr. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-\u039aB\/P65 Antagonizes Nrf2-ARE Pathway by Depriving CBP from Nrf2 and Facilitating Recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta BBA-Mol. Cell Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.redox.2016.12.028","article-title":"Cross-Talk between Lipid and Protein Carbonylation in a Dynamic Cardiomyocyte Model of Mild Nitroxidative Stress","volume":"11","author":"Griesser","year":"2017","journal-title":"Redox Biol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Gianazza, E., Brioschi, M., Fernandez, A.M., and Banfi, C. (2019). Lipoxidation in Cardiovascular Diseases. Redox Biol., 23.","DOI":"10.1016\/j.redox.2019.101119"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"708","DOI":"10.33963\/v.phj.100609","article-title":"Elevated Carbonylated Proteins Are Associated with Major Cardiovascular Events in Patients with Chronic Coronary Syndrome: A Cohort Study","volume":"82","author":"Paszek","year":"2024","journal-title":"Kardiol. Pol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9794629","DOI":"10.1155\/2018\/9794629","article-title":"The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol\/Disulfide Redox State through the Upregulation of Glutathione Synthesis","volume":"2018","author":"Quatrin","year":"2018","journal-title":"J. Nutr. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Calloni, C., Mart\u00ednez, L.S., Gil, D.F., da Silva, D.M., Rosales, P.F., Agostini, F., Moura e Silva, S., Parmegiani Jahn, M., and Salvador, M. (2020). Jabuticaba (Plinia trunciflora (O. Berg) Kausel) Improved the Lipid Profile and Immune System and Reduced Oxidative Stress in Streptozotocin-Induced Diabetic Rats. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13383"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1002\/jcp.26213","article-title":"Quercetin Protects against Radiocontrast Medium Toxicity in Human Renal Proximal Tubular Cells","volume":"233","author":"Andreucci","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Erjavec, L.C., Parra, L.G., Sendyk, D.E., Recabarren, M., Herb\u00f3n, C., Favale, N.O., Tulino, S., Carballo, M., L\u00f3pez Nigro, M., and Magnani, N. (2025). Non-Beneficial Effects of Resveratrol on Renal Epithelial Cell Cultures: Implications in Cell Differentiation. BioFactors, 51.","DOI":"10.1002\/biof.70018"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/23\/4030\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:27:33Z","timestamp":1764134853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/23\/4030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":90,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["foods14234030"],"URL":"https:\/\/doi.org\/10.3390\/foods14234030","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]}}}