{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:48:41Z","timestamp":1788835721260,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minas Gerais State Research Support Foun-dation","award":["APQ-04299-22"],"award-info":[{"award-number":["APQ-04299-22"]}]},{"name":"Minas Gerais State Research Support Foun-dation","award":["APQ-02221-24"],"award-info":[{"award-number":["APQ-02221-24"]}]},{"name":"National Council for Sci-entific and Technological Development","award":["422096-2021-0"],"award-info":[{"award-number":["422096-2021-0"]}]},{"name":"National Council for Sci-entific and Technological Development","award":["304302-2025-2"],"award-info":[{"award-number":["304302-2025-2"]}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya","award":["2023 BP 00050"],"award-info":[{"award-number":["2023 BP 00050"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2022\/09526-4"],"award-info":[{"award-number":["2022\/09526-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The Norway spruce (Picea abies) is a forest resource whose by-products contain bioactive compounds such as galactoglucomannan (GGM), catechin, and epicatechin, recognized for their antioxidant and chemopreventive potential. Within a food-related valorization context, we evaluated the antiproliferative, antimetastatic, genotoxic, and antimalarial activities of the Norway spruce by-product extract (NSBE). Considering its chemical composition and multifunctional bioactive profile, NSBE is investigated for its potential application as a functional food ingredient. NSBE exhibited concentration-dependent antiproliferative and antimetastatic effects two cancer cell lines (A549 and HCT-8), reducing cell adhesion by 33.96% in A549 cells and 40.15% in HCT-8 cells, and suppressing clonogenic capacity by up to 90% and 75%, respectively. The extract preserved basal chromosomal integrity and demonstrated a cytoprotective effect at 10 \u00b5g GAE\/mL, reducing cisplatin-induced genotoxicity. Additionally, in antiplasmodial assays, NSBE showed potent inhibition of two Plasmodium falciparum strains: W2 (chloroquine-resistant) and 3D7 (chloroquine-sensitive) strains, with IC50 values below 3.5 \u00b5g GAE\/mL. This activity was supported by a selectivity index (SI) of 13, exceeding the recommended threshold for natural antimalarial candidates. Altogether, these findings highlight the NSBE as a sustainable and multifunctional food ingredient with relevant antiproliferative and antiplasmodial properties, supporting its cytoprotective and chemopreventive potential within a functional food framework.<\/jats:p>","DOI":"10.3390\/foods15020264","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:30:34Z","timestamp":1768203034000},"page":"264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Forestry By-Product to Functional Food Ingredient Innovation: Antiproliferative, Antimetastatic and Antiplasmodial Activities of Norway Spruce Sawdust Extract"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4904-5579","authenticated-orcid":false,"given":"Julia","family":"Carvalho Cardoso Consentini","sequence":"first","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6579-971X","authenticated-orcid":false,"given":"Gabriela","family":"Furlaneto","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia","family":"Alves Bento","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3865-1364","authenticated-orcid":false,"given":"Thaise","family":"Caputo Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Vitor Vieira","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0982-0123","authenticated-orcid":false,"given":"Petri","family":"Kilpelainen","sequence":"additional","affiliation":[{"name":"Natural Resources Institute Finland (Luke), Latokartanonkaari 9, FI-00790 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2959-4856","authenticated-orcid":false,"given":"Giselly Karoline","family":"Paiva da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Bofill Verdaguer","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-5471","authenticated-orcid":false,"given":"Marcell","family":"Crispim","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas 37130-001, MG, Brazil"},{"name":"Barcelona Institute for Global Health (ISGlobal), Hospital Cl\u00ednic-Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"dos Santos Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0502-4090","authenticated-orcid":false,"given":"Luciana","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicology Analysis In Vitro and In Vivo, Federal University of Alfenas, Alfenas 37133-840, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhao, H., Mikkonen, K.S., Kilpel\u00e4inen, P.O., and Lehtonen, M.I. 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