{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:07:21Z","timestamp":1793326041841,"version":"4.5.0"},"reference-count":137,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&D Program Projects in Guangdong, P.R. China","award":["2024B0202010001"],"award-info":[{"award-number":["2024B0202010001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Obesity is closely linked to dyslipidemia, hepatic injury, and chronic inflammation through disturbances in the gut\u2013liver axis. Here, we evaluated the anti-obesity effects of L. rhamnosus (Lacticaseibacillus rhamnosus) CU262 in a high-fat diet (HFD) mouse model and elucidated mechanisms using an integrated multi-omics strategy. Male C57BL\/6 mice received CU262 during 12 weeks of HFD feeding. Phenotypes, serum\/liver biochemistry, gut microbiota (16S rRNA sequencing), fecal short-chain fatty acids (SCFAs), and hepatic transcriptomes (RNA-seq) were assessed. CU262 significantly attenuated weight gain and adiposity; improved serum TC, TG, LDL-C and HDL-C; lowered ALT\/AST and FFA; and mitigated oxidative stress and inflammatory imbalance (\u2193 IL-6\/TNF-\u03b1, \u2191 IL-10). CU262 restored alpha diversity, reduced the Firmicutes\/Bacteroidetes ratio, enriched beneficial taxa (e.g., Akkermansia), and increased acetate and butyrate. Liver transcriptomics showed CU262 reversed HFD-induced activation of cholesterol\/steroid biosynthesis and endoplasmic reticulum stress, with downregulation of key genes (Mvk, Mvd, Fdps, Nsdhl, and Dhcr7) and Pcsk9, yielding negative enrichment of steroid and terpenoid backbone pathways and enhancement of oxidative phosphorylation and glutathione metabolism. Correlation analyses linked Akkermansia and SCFAs with improved lipid\/inflammatory indices and repression of cholesterol-synthetic and stress-response genes. These findings demonstrate that CU262 alleviates HFD-induced metabolic derangements via microbiota-SCFA-hepatic gene network reprogramming along the gut\u2013liver axis, supporting its potential as a functional probiotic for obesity management.<\/jats:p>","DOI":"10.3390\/foods15020332","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:39:37Z","timestamp":1768563577000},"page":"332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lacticaseibacillus rhamnosus CU262 Attenuates High-Fat Diet\u2013Induced Obesity via Gut\u2013Liver Axis Reprogramming"],"prefix":"10.3390","volume":"15","author":[{"given":"Hezixian","family":"Guo","sequence":"first","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-8218","authenticated-orcid":false,"given":"Linhao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongjian","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyi","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Liao","sequence":"additional","affiliation":[{"name":"College of Food Science, South China Agriculture University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide Trends in Underweight and Obesity from 1990 to 2022: A Pooled Analysis of 3663 Population-Representative Studies with 222 Million Children, Adolescents, and Adults","volume":"403","author":"Phelps","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102958","DOI":"10.1016\/j.eclinm.2024.102958","article-title":"Burden of Disease Attributable to High Body Mass Index: An Analysis of Data from the Global Burden of Disease Study 2021","volume":"78","author":"Zhou","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","article-title":"A 2022 Update on the Epidemiology of Obesity and a Call to Action: As Its Twin COVID-19 Pandemic Appears to Be Receding, the Obesity and Dysmetabolism Pandemic Continues to Rage On","volume":"133","author":"Boutari","year":"2022","journal-title":"Metabolism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41575-023-00867-z","article-title":"Gut Microbiota in Overweight and Obesity: Crosstalk with Adipose Tissue","volume":"21","author":"Cani","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut Microbiota, Intestinal Permeability, and Systemic Inflammation: A Narrative Review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s11427-022-2283-4","article-title":"High-Fat Diet Impairs Gut Barrier through Intestinal Microbiota-Derived Reactive Oxygen Species","volume":"67","author":"Zeng","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Hu, Y., Gao, M., Chenghuang, J., and Bao, R. (2025). Insights into the Gut-Liver Axis: Mechanisms and Emerging Therapies in Hepatocellular Carcinoma. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1595853"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.clnu.2024.04.004","article-title":"Optimal Probiotic Combinations for Treating Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis","volume":"43","author":"Yang","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e13667","DOI":"10.1111\/obr.13667","article-title":"Beneficial Effects of the Probiotics and Synbiotics Supplementation on Anthropometric Indices and Body Composition in Adults: A Systematic Review and Meta-Analysis","volume":"25","author":"Saadati","year":"2024","journal-title":"Obes. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejim.2023.10.002","article-title":"Gut Microbes in Metabolic Disturbances. Promising Role for Therapeutic Manipulations?","volume":"119","author":"Portincasa","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Dmytriv, T.R., Storey, K.B., and Lushchak, V.I. (2024). Intestinal Barrier Permeability: The Influence of Gut Microbiota, Nutrition, and Exercise. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1380713"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wang, S.-P., Ba, L., Lv, X.-R., Qi, Y.-X., Wang, X., Zhang, J., and Xu, X. (2025). Protective Effects of Lactobacillus Rhamnosus GG Supernatant on Metabolic Associated Fatty Liver Disease through Intestinal Barrier Restoration and Regulation of the Regenerating Gene 3\u03b3. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1580171"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chayanupatkul, M., Machchimapiro, P., Chuaypen, N., Wanpiyarat, N., Tumwasorn, S., Siriviriyakul, P., and Werawatganon, D. (2024). Single and Mixed Strains of Probiotics Reduced Hepatic Fat Accumulation and Inflammation and Altered Gut Microbiome in a Nonalcoholic Steatohepatitis Rat Model. Biomedicines, 12.","DOI":"10.3390\/biomedicines12081847"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., De Barba, C., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., and Ruffolo, C. (2024). Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications. Life, 14.","DOI":"10.20944\/preprints202403.1638.v1"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s13213-018-1360-0","article-title":"Screening of Lactic Acid Bacteria with Cholesterol-Lowering and Triglyceride-Lowering Activity In Vitro and Evaluation of Probiotic Function","volume":"68","author":"Gao","year":"2018","journal-title":"Ann. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liu, H., Fan, D., Wang, J., Wang, Y., Li, A., Wu, S., Zhang, B., Liu, J., and Wang, S. (2024). Lactobacillus rhamnosus NKU FL1-8 Isolated from Infant Feces Ameliorates the Alcoholic Liver Damage by Regulating the Gut Microbiota and Intestinal Barrier in C57BL\/6J Mice. Nutrients, 16.","DOI":"10.3390\/nu16132139"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Agolino, G., Cristofolini, M., Vaccalluzzo, A., Tagliazucchi, D., Cattivelli, A., Pino, A., Caggia, C., Solieri, L., and Randazzo, C.L. (2025). Genome Mining and Characterization of Two Novel Lacticaseibacillus rhamnosus Probiotic Candidates with Bile Salt Hydrolase Activity. Biomolecules, 15.","DOI":"10.3390\/biom15010086"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41538-023-00199-x","article-title":"\u2018Multi-Omics\u2019 Data Integration: Applications in Probiotics Studies","volume":"7","author":"Kwoji","year":"2023","journal-title":"npj Sci. Food"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wu, J., Singleton, S.S., Bhuiyan, U., Krammer, L., and Mazumder, R. (2024). Multi-Omics Approaches to Studying Gastrointestinal Microbiome in the Context of Precision Medicine and Machine Learning. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1337373"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/gutjnl-2024-332602","article-title":"Multiomics of the Intestine-Liver-Adipose Axis in Multiple Studies Unveils a Consistent Link of the Gut Microbiota and the Antiviral Response with Systemic Glucose Metabolism","volume":"74","author":"Puig","year":"2025","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"bbaf502","DOI":"10.1093\/bib\/bbaf502","article-title":"Multi-Omics Time-Series Analysis in Microbiome Research: A Systematic Review","volume":"26","author":"Sherwani","year":"2025","journal-title":"Brief Bioinform."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5009\/gnl240539","article-title":"Gut-Liver Axis: The Role of Intestinal Microbiota and Their Metabolites in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease","volume":"19","author":"Cui","year":"2025","journal-title":"Gut Liver"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104425","DOI":"10.1016\/j.tifs.2024.104425","article-title":"Research Progress on Improving the Freeze-Drying Resistance of Probiotics: A Review","volume":"147","author":"Ge","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Milhem, F., Skates, E., Wilson, M., and Komarnytsky, S. (2024). Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism. Nutrients, 16.","DOI":"10.3390\/nu16010171"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"03000605241259682","DOI":"10.1177\/03000605241259682","article-title":"Comparison of Staining Quality between Rapid and Routine Hematoxylin and Eosin Staining of Frozen Breast Tissue Sections: An Observational Study","volume":"52","author":"Ma","year":"2024","journal-title":"J. Int. Med. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"du Sert, N.P., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., and Dirnagl, U. (2020). The ARRIVE Guidelines 2.0: Updated Guidelines for Reporting Animal Research. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000410"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.4254\/wjh.v13.i11.1688","article-title":"Abnormal Liver Enzymes: A Review for Clinicians","volume":"13","author":"Kalas","year":"2021","journal-title":"World J. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Smith, M., Polite, L., Christy, A., Edirisinghe, I., Burton-Freeman, B., and Sandhu, A. (2023). An Improved Validated Method for the Determination of Short-Chain Fatty Acids in Human Fecal Samples by Gas Chromatography with Flame Ionization Detection (GC-FID). Metabolites, 13.","DOI":"10.3390\/metabo13111106"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of General 16S Ribosomal RNA Gene PCR Primers for Classical and Next-Generation Sequencing-Based Diversity Studies","volume":"41","author":"Klindworth","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1002\/cpbi.100","article-title":"QIIME 2 Enables Comprehensive End-to-End Analysis of Diverse Microbiome Data and Comparative Studies with Publicly Available Data","volume":"70","author":"Estaki","year":"2020","journal-title":"Curr. Protoc. Bioinform."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41598-024-77864-y","article-title":"Key Features and Guidelines for the Application of Microbial Alpha Diversity Metrics","volume":"15","author":"Cassol","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-Based Genome Alignment and Genotyping with HISAT2 and HISAT-Genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-Seq Data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"The Gene Ontology Consortium (2019). The Gene Ontology Resource: 20 Years and Still GOing Strong. Nucleic Acids Res., 47, D330\u2013D338.","DOI":"10.1093\/nar\/gky1055"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene Set Enrichment Analysis: A Knowledge-Based Approach for Interpreting Genome-Wide Expression Profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"28520","DOI":"10.1021\/acsomega.4c02514","article-title":"Lactobacillus rhamnosus 069 and Lactobacillus Brevis 031: Unraveling Strain-Specific Pathways for Modulating Lipid Metabolism and Attenuating High-Fat-Diet-Induced Obesity in Mice","volume":"9","author":"Ho","year":"2024","journal-title":"ACS Omega"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2100348","DOI":"10.1002\/mnfr.202100348","article-title":"Lactobacillus rhamnosus Strain LRH05 Intervention Ameliorated Body Weight Gain and Adipose Inflammation via Modulating the Gut Microbiota in High-Fat Diet-Induced Obese Mice","volume":"66","author":"Chen","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Chen, T., Wang, J., and Liu, Z. (2024). Effect of Supplementation with Probiotics or Synbiotics on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1282699"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pan, Y., Yang, Y., Wu, J., Zhou, H., and Yang, C. (2024). Efficacy of Probiotics, Prebiotics, and Synbiotics on Liver Enzymes, Lipid Profiles, and Inflammation in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. BMC Gastroenterol., 24.","DOI":"10.1186\/s12876-024-03356-y"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.clnesp.2023.07.087","article-title":"Anti-Inflammatory Effects of Probiotics and Synbiotics on Patients with Non-Alcoholic Fatty Liver Disease: An Umbrella Study on Meta-Analyses","volume":"57","author":"Mahapatro","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Arellano-Garc\u00eda, L., Trepiana, J., Mart\u00ednez, J.A., Portillo, M.P., and Milton-Laskibar, I. (2023). Beneficial Effects of Viable and Heat-Inactivated Lactobacillus rhamnosus GG Administration on Oxidative Stress and Inflammation in Diet-Induced NAFLD in Rats. Antioxidants, 12.","DOI":"10.3390\/antiox12030717"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13568-024-01731-2","article-title":"Vinpocetine and Lactobacillus Improve Fatty Liver in Rats: Role of Adiponectin and Gut Microbiome","volume":"14","author":"Shata","year":"2024","journal-title":"AMB Express"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5540686","DOI":"10.1155\/grp\/5540686","article-title":"Lactobacillus rhamnosus Ameliorates Dyslipidemia and Liver Steatosis in a Rat Model Fed High-Fat Diet","volume":"2025","author":"Liao","year":"2025","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jhep.2021.12.003","article-title":"Promises of Microbiome-Based Therapies","volume":"76","author":"Bajaj","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The Intestinal Barrier: A Pivotal Role in Health, Inflammation, and Cancer","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jcmgh.2021.05.006","article-title":"Sodium Butyrate Supplementation Inhibits Hepatic Steatosis by Stimulating Liver Kinase B1 and Insulin-Induced Gene","volume":"12","author":"Zhao","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Fogacci, F., Giovannini, M., Di Micoli, V., Grandi, E., Borghi, C., and Cicero, A.F.G. (2024). Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Nutrients, 16.","DOI":"10.3390\/nu16152454"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1038\/s41598-024-52852-4","article-title":"Temporal Variations in the Gut Microbial Diversity in Response to High-Fat Diet and Exercise","volume":"14","author":"Imdad","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Chaiyasut, C., Sivamaruthi, B.S., Thangaleela, S., Sisubalan, N., Bharathi, M., Khongtan, S., Kesika, P., Sirilun, S., Choeisoongnern, T., and Peerajan, S. (2024). Influence of Lactobacillus rhamnosus Supplementation on the Glycaemic Index, Lipid Profile, and Microbiome of Healthy Elderly Subjects: A Preliminary Randomized Clinical Trial. Foods, 13.","DOI":"10.3390\/foods13091293"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kara\u010di\u0107, A., Renko, I., Krznari\u0107, \u017d., Klobu\u010dar, S., and Liberati Pr\u0161o, A.-M. (2024). The Association between the Firmicutes\/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia. Biomedicines, 12.","DOI":"10.3390\/biomedicines12102263"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1038\/s41467-024-48355-5","article-title":"Gut Microbiome Remodeling and Metabolomic Profile Improves in Response to Protein Pacing with Intermittent Fasting versus Continuous Caloric Restriction","volume":"15","author":"Mohr","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"L\u00fctzh\u00f8ft, D.O., B\u00e6kg\u00e5rd, C., Wimborne, E., Straarup, E.M., Pedersen, K.-M., Swann, J.R., Pedersen, H.D., Kristensen, K., Morgills, L., and Nielsen, D.S. (2024). High Fat Diet Is Associated with Gut Microbiota Dysbiosis and Decreased Gut Microbial Derived Metabolites Related to Metabolic Health in Young G\u00f6ttingen Minipigs. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0298602"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/jgh.16747","article-title":"Role of Akkermansia muciniphila in Insulin Resistance","volume":"40","author":"Zeng","year":"2025","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1038\/s41467-024-47275-8","article-title":"The Secreted Protein Amuc_1409 from Akkermansia muciniphila Improves Gut Health through Intestinal Stem Cell Regulation","volume":"15","author":"Kang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1038\/s41467-024-50660-y","article-title":"A Male Mouse Model for Metabolic Dysfunction-Associated Steatotic Liver Disease and Hepatocellular Carcinoma","volume":"15","author":"Jeong","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12946","DOI":"10.1038\/s41598-023-38530-x","article-title":"Lactobacillus Oris Improves Non-Alcoholic Fatty Liver in Mice and Inhibits Endogenous Cholesterol Biosynthesis","volume":"13","author":"Zhao","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s43856-024-00465-3","article-title":"Transcriptomics-Driven Metabolic Pathway Analysis Reveals Similar Alterations in Lipid Metabolism in Mouse MASH Model and Human","volume":"4","author":"Tsouka","year":"2024","journal-title":"Commun. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhang, X.-Y., Lu, Q.-Q., Li, Y.-J., Shi, S.-R., Ma, C.-N., Miao, M., and Guo, S.-D. (2025). Conditional Knockdown of Hepatic PCSK9 Ameliorates High-Fat Diet-Induced Liver Inflammation in Mice. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1528250"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13099-024-00635-7","article-title":"The Influence of Akkermansia muciniphila on Intestinal Barrier Function","volume":"16","author":"Mo","year":"2024","journal-title":"Gut Pathog."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jian, E., Wang, M., Zhang, Z., Heng, Y., Zhang, C., Chen, Q., Yu, X., Zhu, Y., and Cai, P. (2025). The Metabolic Endotoxemia and Gut Microbiota: Research Trajectories and Hot Trends across the Centuries (1999\u20132024). Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1634803"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1038\/s41598-024-56308-7","article-title":"Helicobacter pylori Components Increase the Severity of Metabolic Syndrome and Its Hepatic Manifestations Induced by a High Fat Diet","volume":"14","author":"Tomaszewska","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apsb.2024.10.010","article-title":"Akkermansia muciniphila-Derived Acetate Activates the Hepatic AMPK\/SIRT1\/PGC-1\u03b1 Axis to Alleviate Ferroptosis in Metabolic-Associated Fatty Liver Disease","volume":"15","author":"Zhuge","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Meiners, F., Ortega-Matienzo, A., Fuellen, G., and Barrantes, I. (2025). Gut Microbiome-Mediated Health Effects of Fiber and Polyphenol-Rich Dietary Interventions. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1647740"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Luo, Y., Jin, Y., Wang, H., Wang, G., Lin, Y., Chen, H., Li, X., and Wang, M. (2024). Effects of Clostridium tyrobutyricum on Lipid Metabolism, Intestinal Barrier Function, and Gut Microbiota in Obese Mice Induced by High-Fat Diet. Nutrients, 16.","DOI":"10.3390\/nu16040493"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s40364-024-00664-z","article-title":"Heat Shock Proteins (HSPs) in Non-Alcoholic Fatty Liver Disease (NAFLD): From Molecular Mechanisms to Therapeutic Avenues","volume":"12","author":"Nie","year":"2024","journal-title":"Biomark. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.ajpath.2023.08.007","article-title":"The Role of Endoplasmic Reticulum in Lipotoxicity during Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Pathogenesis","volume":"193","author":"Venkatesan","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Fan, Y., Liu, Y., Shao, C., Jiang, C., Wu, L., Xiao, J., and Tang, L. (2025). Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26125486"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"109409","DOI":"10.1016\/j.jnutbio.2023.109409","article-title":"Butyrate Restores the Fat\/Lean Mass Ratio Balance and Energy Metabolism and Reinforces the Tight Junction-Mediated Intestinal Epithelial Barrier in Prediabetic Mice Independently of Its Anti-Inflammatory and Epigenetic Actions","volume":"120","author":"Matheus","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"100810","DOI":"10.1016\/j.crfs.2024.100810","article-title":"Impact of Probiotics on Weight Loss, Glucose and Lipid Metabolism in Overweight or Obese Women: A Meta-Analysis of Randomized Controlled Trials","volume":"9","author":"Cao","year":"2024","journal-title":"Curr. Res. Food Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Hou, S., Li, R., Zhang, Y., Liang, P., Yang, H., He, H., Wang, L., Sun, Y., Jin, T., and Liu, Z. (2025). Supplementation of Mixed Lactobacillus Alleviates Metabolic Impairment, Inflammation, and Dysbiosis of the Gut Microbiota in an Obese Mouse Model. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1554996"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41575-023-00771-6","article-title":"Gut\u2013Liver Axis: Barriers and Functional Circuits","volume":"20","author":"Pabst","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/s42255-025-01356-0","article-title":"Dietary Fibre-Adapted Gut Microbiome Clears Dietary Fructose and Reverses Hepatic Steatosis","volume":"7","author":"Jung","year":"2025","journal-title":"Nat. Metab."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2024.12.010","article-title":"Akkermansia muciniphila Supplementation in Patients with Overweight\/Obese Type 2 Diabetes: Efficacy Depends on Its Baseline Levels in the Gut","volume":"37","author":"Zhang","year":"2025","journal-title":"Cell Metab."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mamun, M.A.A., Rakib, A., Mandal, M., and Singh, U.P. (2025). Impact of a High-Fat Diet on the Gut Microbiome: A Comprehensive Study of Microbial and Metabolite Shifts During Obesity. Cells, 14.","DOI":"10.3390\/cells14060463"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"14204","DOI":"10.1038\/s41598-025-96893-9","article-title":"Gut Microbiota Diversity in Obese Rats Treated with Intermittent Fasting, Probiotic-Fermented Camel Milk with or without Dates and Their Combinations","volume":"15","author":"Aljutaily","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Khalili, L., Park, G., Nagpal, R., and Salazar, G. (2024). The Role of Akkermansia muciniphila on Improving Gut and Metabolic Health Modulation: A Meta-Analysis of Preclinical Mouse Model Studies. Microorganisms, 12.","DOI":"10.2139\/ssrn.4771341"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2375555","DOI":"10.1080\/21505594.2024.2375555","article-title":"Akkermansia muciniphila: A Promising Probiotic against Inflammation and Metabolic Disorders","volume":"15","author":"Zhao","year":"2024","journal-title":"Virulence"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"17898","DOI":"10.1038\/s41598-021-95738-5","article-title":"Comparative Effects of Alive and Pasteurized Akkermansia muciniphila on Normal Diet-Fed Mice","volume":"11","author":"Ashrafian","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12964-023-01219-9","article-title":"Short-Chain Fatty Acids in Diseases","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"139856","DOI":"10.1016\/j.foodchem.2024.139856","article-title":"Probing the Alterations in Mice Cecal Content Due to High-Fat Diet","volume":"455","author":"Trouki","year":"2024","journal-title":"Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1007\/s11694-023-02056-7","article-title":"Investigating the Effect of Addition of Probiotic Microorganisms (Bacteria or Yeast) to Yoghurt on the Viability and Volatile Aromatic Profiles","volume":"17","author":"Niamah","year":"2023","journal-title":"Food Meas."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wang, X., Lv, X., Qi, Y., Wang, S., Yang, M., Wang, B., Cao, H., Zhang, J., and Xu, X. (2025). Lactobacillus rhamnosus GG Supernatant Improves GLP-1 Secretion Through Attenuating L Cell Lipotoxicity and Modulating Gut Microbiota in Obesity. Probiotics Antimicrob. Proteins, 1\u201316.","DOI":"10.1007\/s12602-025-10564-9"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Liu, X., Shao, J., Liao, Y.-T., Wang, L.-N., Jia, Y., Dong, P., Liu, Z., He, D., Li, C., and Zhang, X. (2023). Regulation of Short-Chain Fatty Acids in the Immune System. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1186892"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/eurheartj\/ehab644","article-title":"Propionate Attenuates Atherosclerosis by Immune-Dependent Regulation of Intestinal Cholesterol Metabolism","volume":"43","author":"Haghikia","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tim.2023.07.014","article-title":"Beyond Butyrate: Microbial Fiber Metabolism Supporting Colonic Epithelial Homeostasis","volume":"32","author":"Fagundes","year":"2024","journal-title":"Trends Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1038\/s41467-023-40874-x","article-title":"Gut Microbiota and Fecal Short Chain Fatty Acids Differ with Adiposity and Country of Origin: The METS-Microbiome Study","volume":"14","author":"Maseng","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e0096525","DOI":"10.1128\/msystems.00965-25","article-title":"Multi-Omics Analysis Reveals the Mechanism of Lactobacillus plantarum in Alleviating Metabolic Disorders in Type 2 Diabetic Mice through the Gut-Liver Axis","volume":"10","author":"Zhang","year":"2025","journal-title":"mSystems"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Chen, J., Rao, H., and Zheng, X. (2024). Identification of Novel Targets Associated with Cholesterol Metabolism in Nonalcoholic Fatty Liver Disease: A Comprehensive Study Using Mendelian Randomization Combined with Transcriptome Analysis. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1464865"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1530\/REP-21-0164","article-title":"Contribution of High-Fat Diet-Induced PCSK9 Upregulation to a Mouse Model of PCOS Is Mediated Partly by SREBP2","volume":"162","author":"Guo","year":"2021","journal-title":"Reproduction"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1074\/jbc.RA119.008094","article-title":"Diet-Induced Hepatic Steatosis Abrogates Cell-Surface LDLR by Inducing de Novo PCSK9 Expression in Mice","volume":"294","author":"Lebeau","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e70227","DOI":"10.1111\/1751-7915.70227","article-title":"Lactiplantibacillus plantarum Attenuates Diet-Induced Obesity and Insulin Resistance Through Gut Microbiota-Driven PPAR\/PI3K-Axis Modulation","volume":"18","author":"Gao","year":"2025","journal-title":"Microb. Biotechnol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1007\/s11010-025-05344-6","article-title":"Effects of Lacticaseibacillus rhamnosus LB1.5 as Potential Probiotic Supplement on the Liver and Adipose Tissue of Adult Male Mice to a High-Fat Diet","volume":"480","author":"Schmidt","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Huang, X., Gao, Y., Cao, H., Li, J., Mo, S., Li, T., Wu, J., Guo, K., Wei, R., and Zhang, K. (2022). Effects of Scoparone on Non-Alcoholic Fatty Liver Disease Revealed by RNA Sequencing. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1004284"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e70076","DOI":"10.1002\/btm2.70076","article-title":"Engineered Probiotic Ameliorates Hyperlipidemia and Atherosclerosis by Secreting PCSK9 Nanobodies and Regulating Gut Microbiota","volume":"10","author":"Wang","year":"2025","journal-title":"Bioeng. Transl. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e70174","DOI":"10.1002\/hsr2.70174","article-title":"PCSK9 Inhibitors: The Evolving Future","volume":"7","author":"Jeswani","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"ar59","DOI":"10.1091\/mbc.E24-01-0012","article-title":"Loss of Grp170 Results in Catastrophic Disruption of Endoplasmic Reticulum Function","volume":"35","author":"Mann","year":"2024","journal-title":"Mol. Biol. Cell"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic Reticulum Stress: Molecular Mechanism and Therapeutic Targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/CIRCULATIONAHA.124.072336","article-title":"PCSK9 Promotes LDLR Degradation by Preventing SNX17-Mediated LDLR Recycling","volume":"151","author":"Guan","year":"2025","journal-title":"Circulation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107694","DOI":"10.1016\/j.phrs.2025.107694","article-title":"Probiotics for the Treatment of Hyperlipidemia: Focus on Gut-Liver Axis and Lipid Metabolism","volume":"214","author":"You","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_100","first-page":"2077","article-title":"Lactobacillus Plantarum ST-III Culture Supernatant Protects against Acute Alcohol-Induced Liver and Intestinal Injury","volume":"16","author":"Xu","year":"2023","journal-title":"Aging"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Deng, M., Zhang, S., Wu, S., Jiang, Q., Teng, W., Luo, T., Ouyang, Y., Liu, J., and Gu, B. (2024). Lactiplantibacillus plantarum N4 Ameliorates Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Rats. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1390293"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"105476","DOI":"10.1016\/j.psj.2025.105476","article-title":"Sodium Butyrate Attenuates Lipid Metabolism Disorder via Improving Mitochondrial Function and Activating Autophagy in LMH Cells","volume":"104","author":"Miao","year":"2025","journal-title":"Poult. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"M\u00fcnte, E., and Hartmann, P. (2025). The Role of Short-Chain Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Metabolic Diseases. Biomolecules, 15.","DOI":"10.3390\/biom15040469"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Zhu, J., Liu, X., Liu, N., Zhao, R., and Wang, S. (2024). Lactobacillus plantarum Alleviates High-Fat Diet-Induced Obesity by Altering the Structure of Mice Intestinal Microbial Communities and Serum Metabolic Profiles. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1425764"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e2300672","DOI":"10.1002\/mnfr.202300672","article-title":"A Mix of Probiotic Strains Prevents Hepatic Steatosis, and Improves Oxidative Stress Status and Gut Microbiota Composition in Obese Mice","volume":"68","author":"Guo","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wang, X., Wei, Z., Xiang, Q., Tang, L., and Xie, W. (2025). Therapeutic Potential of Probiotics in Metabolic Dysfunction-Associated Steatohepatitis: A Comprehensive Review. Microorganisms, 13.","DOI":"10.3390\/microorganisms13081894"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s00394-019-02117-y","article-title":"Anti-Obesity Effect of Lactobacillus rhamnosus LS-8 and Lactobacillus crustorum MN047 on High-Fat and High-Fructose Diet Mice Base on Inflammatory Response Alleviation and Gut Microbiota Regulation","volume":"59","author":"Wang","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1186\/s12967-025-07228-1","article-title":"Lactobacillus rhamnosus B16 Regulates Lipid Metabolism Homeostasis by Producing Acetic Acid","volume":"23","author":"Che","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"104997","DOI":"10.1016\/j.idairyj.2021.104997","article-title":"Anti-Obesity Effects of Lactobacillus rhamnosus 4B15, and Its Synergy with Hydrolysed Lactose Skim Milk Powder","volume":"123","author":"Kim","year":"2021","journal-title":"Int. Dairy J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e2116","DOI":"10.1002\/biof.2116","article-title":"Comparative Effects of Viable Lact. Rhamnosus GG and Its Heat-Inactivated Paraprobiotic in the Prevention of High-Fat High-Fructose Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats","volume":"51","author":"Portillo","year":"2025","journal-title":"BioFactors"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The Gut\u2013Liver Axis and Gut Microbiota in Health and Liver Disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1038\/s41598-025-90820-8","article-title":"Effects of Oral Supplementation of Probiotics on Body Weight and Visceral Fat in Obese Patients: A Meta-Analysis and Systematic Review","volume":"15","author":"Guo","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1038\/s41467-023-38778-x","article-title":"Host-Diet-Gut Microbiome Interactions Influence Human Energy Balance: A Randomized Clinical Trial","volume":"14","author":"Corbin","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.cmet.2023.07.011","article-title":"Hyodeoxycholic Acid Alleviates Non-Alcoholic Fatty Liver Disease through Modulating the Gut-Liver Axis","volume":"35","author":"Kuang","year":"2023","journal-title":"Cell Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1210\/endrev\/bnae033","article-title":"The Microbiota and Evolution of Obesity","volume":"46","author":"Saad","year":"2025","journal-title":"Endocr. Rev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e2346872","DOI":"10.1001\/jamanetworkopen.2023.46872","article-title":"Recommendations to Improve Quality of Probiotic Systematic Reviews With Meta-Analyses","volume":"6","author":"McFarland","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zuo, J., Huang, D., Liu, J., Wang, Z., Ren, Y., Su, Y., and Ma, Y. (2025). Effect of Probiotics Containing Lactobacillus plantarum on Blood Lipids: Systematic Review, Meta-Analysis, and Network Pharmacological Analysis. Foods, 14.","DOI":"10.3390\/foods14193300"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis, K., Allende, A., Alvarez-Ord\u00f3\u00f1ez, A., Bolton, D., Bover-Cid, S., Chemaly, M., De Cesare, A., Hilbert, F., and Lindqvist, R. (2023). Update of the List of Qualified Presumption of Safety (QPS) Recommended Microbiological Agents Intentionally Added to Food or Feed as Notified to EFSA 17: Suitability of Taxonomic Units Notified to EFSA until September 2022. EFSA J., 21, e07746.","DOI":"10.2903\/j.efsa.2023.7746"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12986-024-00826-8","article-title":"The Effects of Probiotic Supplementation and Exercise Training on Liver Enzymes and Cardiometabolic Markers in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"21","author":"Kazeminasab","year":"2024","journal-title":"Nutr. Metab."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/nutrit\/nuad042","article-title":"Short-Chain Fatty Acids and Insulin Sensitivity: A Systematic Review and Meta-Analysis","volume":"82","author":"Pham","year":"2024","journal-title":"Nutr. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Gurunathan, S., Thangaraj, P., and Kim, J.-H. (2023). Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases. Foods, 13.","DOI":"10.3390\/foods13010089"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2386412","DOI":"10.1080\/19476337.2024.2386412","article-title":"Role of Postbiotics in Food and Health: A Comprehensive Review","volume":"22","author":"Islam","year":"2024","journal-title":"CyTA J. Food"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"100024","DOI":"10.1016\/j.fnutr.2025.100024","article-title":"Comprehensive Insights into Postbiotics: Bridging the Gap to Real-World Application","volume":"1","author":"Meena","year":"2025","journal-title":"Food Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1016\/j.cell.2024.07.011","article-title":"Translational Potential of Mouse Models of Human Metabolic Disease","volume":"187","author":"Farooqi","year":"2024","journal-title":"Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40635-024-00603-0","article-title":"Sepsis and Obesity: A Scoping Review of Diet-Induced Obesity Murine Models","volume":"12","author":"Eng","year":"2024","journal-title":"Intensive Care Med. Exp."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41467-023-37055-1","article-title":"Microbiota Alters the Metabolome in an Age- and Sex-Dependent Manner in Mice","volume":"14","author":"Brown","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41522-024-00561-1","article-title":"Transient Colonizing Microbes Promote Gut Dysbiosis and Functional Impairment","volume":"10","author":"Lee","year":"2024","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41575-025-01041-3","article-title":"A Consensus Statement on Establishing Causality, Therapeutic Applications and the Use of Preclinical Models in Microbiome Research","volume":"22","author":"Metwaly","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"116735","DOI":"10.1016\/j.biopha.2024.116735","article-title":"GPR41 and GPR43: From Development to Metabolic Regulation","volume":"175","author":"Lee","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Bui, T.N.Y., Paul, A., Guleria, S., O\u2019Sullivan, J.M., and Toldi, G. (2025). Short-Chain Fatty Acids\u2014A Key Link between the Gut Microbiome and T-Lymphocytes in Neonates?. Pediatr. Res., 1\u20139.","DOI":"10.1038\/s41390-025-04075-0"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Ponomarenko, E.A., Krasnov, G.S., Kiseleva, O.I., Kryukova, P.A., Arzumanian, V.A., Dolgalev, G.V., Ilgisonis, E.V., Lisitsa, A.V., and Poverennaya, E.V. (2023). Workability of mRNA Sequencing for Predicting Protein Abundance. Genes, 14.","DOI":"10.3390\/genes14112065"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/phar.4635","article-title":"Current and Emerging PCSK9-directed Therapies to Reduce LDL-C and ASCVD Risk: A State-of-the-art Review","volume":"45","author":"Garwood","year":"2025","journal-title":"Pharmacotherapy"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile Acid Metabolism and Signaling in Health and Disease: Molecular Mechanisms and Therapeutic Targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Almada, G., Mej\u00eda-Le\u00f3n, M.E., and Salazar-L\u00f3pez, N.J. (2024). Probiotic, Postbiotic, and Paraprobiotic Effects of Lactobacillus rhamnosus as a Modulator of Obesity-Associated Factors. Foods, 13.","DOI":"10.3390\/foods13223529"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Figueroa, R.H., L\u00f3pez-Malo, A., and Mani-L\u00f3pez, E. (2025). Lactic Acid Bacteria-Derived Exopolysaccharides: Dual Roles as Functional Ingredients and Fermentation Agents in Food Applications. Fermentation, 11.","DOI":"10.3390\/fermentation11090538"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Rahmati, R., Zarimeidani, F., Ghanbari Boroujeni, M.R., Sadighbathi, S., Kashaniasl, Z., Saleh, M., and Alipourfard, I. (2025). CRISPR-Assisted Probiotic and In Situ Engineering of Gut Microbiota: A Prospect to Modification of Metabolic Disorders. Probiotics Antimicrob. 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