{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:39:01Z","timestamp":1791589141719,"version":"4.3.4"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32072182"],"award-info":[{"award-number":["32072182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hongliu Outstanding Youth program 2023","award":["062402"],"award-info":[{"award-number":["062402"]}]},{"name":"Key Research and Development Program of Gannan Prefecture","award":["2025ZY1No07"],"award-info":[{"award-number":["2025ZY1No07"]}]},{"name":"Science and Technology Planning Project of Chengguan District, Lanzhou City","award":["2024RCCX0022"],"award-info":[{"award-number":["2024RCCX0022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Fructose dietary intake is one of the most common risk factors for hyperuricemia, which is a critical threat to human health, and the lack of an effective biological intervention method is the main problem in preventing hyperuricemia caused by fructose intake. Lacticaseibacillus rhamnosus Fmb14 (L. rhamnosus Fmb14) has a fructose-metabolizing ability to produce extracellular polysaccharides (EPSs), and the yield of EPSs reached 0.50 and 0.42 g\/L after 48 h of fermentation in liquid media of glucose-MRS and fructose-MRS. Six pure polysaccharide components were obtained after purification. A hyperuricemic mouse model was subsequently established by feeding a 60% high-fructose diet with potassium oxyazinate for 8 weeks, and the results revealed that L. rhamnosus Fmb14 and fructose-derived EPS (F-EPS) intervention significantly reduced the serum uric acid level of the model mice from 133.6 \u03bcmol\/L to 106.7 to 111.0 \u03bcmol\/L. The content of XOD in the liver decreased from 2188.1 ng\/L in the model group to 1797.9 ng\/L in the H-Fmb14 group and 1906.6 ng\/L in the H-F-EPS group, alleviating fatty liver degeneration and improving intestinal barrier (increasing OCLN and ZO1 expression in colon). The abundances of allobaculum, bacteroides, Lactobacilli prevotella, and clostridium, the new potential biomarkers of fructose-induced hyperuricemia, were found to be modulated after Fmb14 and F-EPS intervention. The effects of Fmb14 and F-EPS in reducing uric acid synthesis and protecting the intestinal tract are very promising as food intervention agents in the prevention of hyperuricemia caused by fructose dietary.<\/jats:p>","DOI":"10.3390\/foods15030409","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:35:56Z","timestamp":1769193356000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exopolysaccharides from Lacticaseibacillus rhamnosus Fmb14 Ameliorate Fructose-Induced Hyperuricemia and Fatty Liver via Gut Modulation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-9767","authenticated-orcid":false,"given":"Hongyuan","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China"},{"name":"College of Food Science & Technology, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"Gansu Hualing Dairy Co., Ltd., Hezuo 747000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science & Technology, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China"},{"name":"College of Agriculture, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Food Science & Technology, Nanjing Agricultural University, Nanjing 210095, China"},{"name":"College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Gansu Hualing Dairy Co., Ltd., Hezuo 747000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-7419","authenticated-orcid":false,"given":"Zhaoxin","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Food Science & Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Food Science & Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1039\/D1FO03206B","article-title":"The potential of probiotics in the amelioration of hyperuricemia","volume":"13","author":"Zhao","year":"2022","journal-title":"Food Funct."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/rheumatology\/kez128","article-title":"The effects of fruit consumption in patients with hyperuricaemia or gout","volume":"58","author":"Nakagawa","year":"2019","journal-title":"Rheumatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"110795","DOI":"10.1016\/j.biopha.2020.110795","article-title":"Recent advances in fructose intake and risk of hyperuricemia","volume":"131","author":"Zhang","year":"2020","journal-title":"Biomed. 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