{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T04:11:26Z","timestamp":1794370286292,"version":"4.9.0"},"reference-count":213,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is the second most common neurodegenerative disease, characterized by motor and non-motor symptoms that significantly impact patients\u2019 quality of life. Beyond pharmacological treatments, nutrition plays a crucial role in the prevention and management of the disease. Nutritional interventions represent a pivotal strategy for improving clinical outcomes and quality of life in PD patients, addressing issues such as delayed gastric emptying, constipation, weight loss, malnutrition, and chewing or swallowing difficulties. A plant-based diet is particularly suitable for such patients, due to its high fiber content which can enhance gastrointestinal motility, thereby improving levodopa bioavailability, and potentially ameliorateing PD symptoms. For this reason, alongside neurological support, PD patients should receive nutritional counseling. Moreover, food choices can influence the risk of developing the disease: a high consumption of dairy products has been associated with an increased risk of PD; conversely, many plant foods could elicit neuroprotective effects thanks to beneficial phytochemicals such as flavonoids, especially anthocyanins. Furthermore, a moderate coffee consumption could reduce PD risk and progression. The aim of this review is to explore the impact of dietary factors on the risk and progression of PD, evaluate the therapeutic potential of specific foods and dietary patterns in disease management, and highlight the clinical significance of nutritional interventions, specifically focusing on plant-based diets.<\/jats:p>","DOI":"10.3390\/foods15030514","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T15:38:12Z","timestamp":1770046692000},"page":"514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Role of Food and Food-Related Compounds in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-1021","authenticated-orcid":false,"given":"Ilaria","family":"Trezzi","sequence":"first","affiliation":[{"name":"Scientific Society for Vegetarian Nutrition-SSNV, 30171 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-0621","authenticated-orcid":false,"given":"Gianluca","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Scientific Society for Vegetarian Nutrition-SSNV, 30171 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-9132","authenticated-orcid":false,"given":"Francesca","family":"Giampieri","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Odontostomatological Sciences, University Polytechnic of Marche, 60131 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-1782","authenticated-orcid":false,"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Odontostomatological Sciences, University Polytechnic of Marche, 60131 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5263-6084","authenticated-orcid":false,"given":"Luciana","family":"Baroni","sequence":"additional","affiliation":[{"name":"Scientific Society for Vegetarian Nutrition-SSNV, 30171 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Attuquayefio, T., Stevenson, R.J., Oaten, M.J., and Francis, H.M. (2017). A Four-Day Western-Style Dietary Intervention Causes Reductions in Hippocampal-Dependent Learning and Memory and Interoceptive Sensitivity. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172645"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3945\/ajcn.113.079624","article-title":"Dietary Lipids Are Differentially Associated with Hippocampal-Dependent Relational Memory in Prepubescent Children","volume":"99","author":"Baym","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Gibson, E.L., Barr, S., and Jeanes, Y.M. (2013). Habitual Fat Intake Predicts Memory Function in Younger Women. Front. Hum. Neurosci., 7.","DOI":"10.3389\/fnhum.2013.00838"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/alz.12421","article-title":"Mediterranean and Western Diet Effects on Alzheimer\u2019s Disease Biomarkers, Cerebral Perfusion, and Cognition in Mid-Life: A Randomized Trial","volume":"18","author":"Hoscheidt","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Knight, E., Geetha, T., Burnett, D., and Babu, J.R. (2022). The Role of Diet and Dietary Patterns in Parkinson\u2019s Disease. Nutrients, 14.","DOI":"10.3390\/nu14214472"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s Disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The Epidemiology of Parkinson\u2019s Disease: Risk Factors and Prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of Brain Pathology Related to Sporadic Parkinson\u2019s Disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1038\/s41598-022-08076-5","article-title":"Transcellular Propagation of Fibrillar \u03b1-Synuclein from Enteroendocrine to Neuronal Cells Requires Cell-to-Cell Contact and Is Rab35-Dependent","volume":"12","author":"Rodrigues","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ana.24448","article-title":"Vagotomy and Subsequent Risk of Parkinson\u2019s Disease","volume":"78","author":"Svensson","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/1028415X.2022.2073107","article-title":"The Role of Nutrition on Parkinson\u2019s Disease: A Systematic Review","volume":"26","author":"Bianchi","year":"2023","journal-title":"Nutr. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S1474-4422(25)00305-9","article-title":"The Role of Lifestyle Interventions in Symptom Management and Disease Modification in Parkinson\u2019s Disease","volume":"25","author":"Trinh","year":"2026","journal-title":"Lancet Neurol."},{"key":"ref_13","first-page":"694","article-title":"The Future of Parkinson\u2019s Disease Research: A New Paradigm of Human-Specific Investigation Is Necessary\u2026 and Possible","volume":"39","author":"Cassotta","year":"2022","journal-title":"ALTEX"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Georgiou, A., Demetriou, C.A., Christou, Y.P., Heraclides, A., Leonidou, E., Loukaides, P., Yiasoumi, E., Pantziaris, M., Kleopa, K.A., and Papacostas, S.S. (2019). Genetic and Environmental Factors Contributing to Parkinson\u2019s Disease: A Case-Control Study in the Cypriot Population. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.01047"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1177\/17423953211039789","article-title":"Effect of Modifiable Risk Factors in Parkinson\u2019s Disease: A Case-Control Study Looking at Common Dietary Factors, Toxicants, and Anti-Inflammatory Medications","volume":"18","author":"Shermon","year":"2022","journal-title":"Chronic Illn."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/mds.29778","article-title":"Contribution of Nutritional, Lifestyle, and Metabolic Risk Factors to Parkinson\u2019s Disease","volume":"39","author":"Veronese","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/ije\/28.6.1102","article-title":"Adult Nutrient Intake as a Risk Factor for Parkinson\u2019s Disease","volume":"28","author":"Johnson","year":"1999","journal-title":"Int. J. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.parkreldis.2013.09.023","article-title":"Dietary Fat Intake, Pesticide Use, and Parkinson\u2019s Disease","volume":"20","author":"Kamel","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-022-00863-8","article-title":"Dietary Fat Intake and Risk of Parkinson Disease: Results from the Swedish National March Cohort","volume":"37","author":"Hantikainen","year":"2022","journal-title":"Eur. J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2006.10.018","article-title":"Formation and Biochemistry of Carcinogenic Heterocyclic Aromatic Amines in Cooked Meats","volume":"168","author":"Turesky","year":"2007","journal-title":"Toxicol. Lett."},{"key":"ref_21","first-page":"90","article-title":"Mutagenic Potency of Food-Derived Heterocyclic Amines","volume":"616","author":"Felton","year":"2007","journal-title":"Mutat. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/toxsci\/kfu060","article-title":"2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) Is Selectively Toxic to Primary Dopaminergic Neurons in Vitro","volume":"140","author":"Griggs","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/jcsm.12121","article-title":"The Human Skeletal Muscle Proteome Project: A Reappraisal of the Current Literature","volume":"8","author":"Semba","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Jackson, A., Forsyth, C.B., Shaikh, M., Voigt, R.M., Engen, P.A., Ramirez, V., and Keshavarzian, A. (2019). Diet in Parkinson\u2019s Disease: Critical Role for the Microbiome. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.01245"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"149975","DOI":"10.1016\/j.brainres.2025.149975","article-title":"Parkinson\u2019s Disease and the Gut-Brain Connection: Unveiling Pathways, Mechanisms and Promising Therapies","volume":"1868","author":"Hajare","year":"2025","journal-title":"Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejphar.2017.05.042","article-title":"The Gut-Brain Axis in Parkinson\u2019s Disease: Possibilities for Food-Based Therapies","volume":"817","author":"Kliest","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"112444","DOI":"10.1016\/j.exger.2024.112444","article-title":"Association between Increased and Decreased Gut Microbiota Abundance and Parkinson\u2019s Disease: A Systematic Review and Subgroup Meta-Analysis","volume":"191","author":"Bai","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N.D., and Kahleova, H. (2019). The Effects of Vegetarian and Vegan Diets on Gut Microbiota. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00047"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated Fatty Acids and Their Metabolites in Brain Function and Disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"McCarty, M.F., and Lerner, A. (2020). Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103624"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Avallone, R., Vitale, G., and Bertolotti, M. (2019). Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials. Int. J. Mol. Sci., 20.","DOI":"10.20944\/preprints201907.0289.v1"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Liu, B., Zhang, Y., Yang, Z., Liu, M., Zhang, C., Zhao, Y., and Song, C. (2021). \u03c9-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1\/M2 Polarizations through Inhibiting NF-\u03baB\/MAPK P38 Signaling and Activating Neuron-BDNF-PI3K\/AKT Pathways. Mar. Drugs, 19.","DOI":"10.3390\/md19110587"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lin, F., Shi, Y., Zheng, J., Li, Y., Chen, X., Zou, X., Hong, Y., Chen, K., Zeng, Y., and Ye, Q. (2023). Fish Oil Supplementation, Physical Activity and Risk of Incident Parkinson\u2019s Disease: Results of Longitudinal Analysis from the UK Biobank. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1304629"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2026.01.001","article-title":"Cytokine Associated Neuroinflammation in Parkinson\u2019s Disease: Molecular Pathways, Therapeutic Targets, and Translational Insights","volume":"88","author":"Dhapola","year":"2026","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2100339","DOI":"10.1002\/mnfr.202100339","article-title":"N-3 PUFA-Deficiency in Early Life Exhibits Aggravated MPTP-Induced Neurotoxicity in Old Age While Supplementation with DHA\/EPA-Enriched Phospholipids Exerts a Neuroprotective Effect","volume":"65","author":"Wu","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"107976","DOI":"10.1016\/j.neuropharm.2020.107976","article-title":"Docosahexaenoic Acid Protects Motor Function and Increases Dopamine Synthesis in a Rat Model of Parkinson\u2019s Disease via Mechanisms Associated with Increased Protein Kinase Activity in the Striatum","volume":"167","author":"Chitre","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cbpc.2017.11.008","article-title":"The Neurological Toxicity of Heavy Metals: A Fish Perspective","volume":"208","author":"Green","year":"2018","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_38","first-page":"239","article-title":"Occupational Exposure to Manganese, Copper, Lead, Iron, Mercury and Zinc and the Risk of Parkinson\u2019s Disease","volume":"20","author":"Gorell","year":"1999","journal-title":"Neurotoxicology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/0006-2952(85)90710-5","article-title":"Effects of Heavy Metal Cations, Sulfhydryl Reagents and Other Chemical Agents on Striatal D2 Dopamine Receptors","volume":"34","author":"Scheuhammer","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"ref_40","first-page":"31","article-title":"Parkinsonism in chronic occupational metallic mercury intoxication","volume":"37","author":"Miller","year":"2003","journal-title":"Neurol. Neurochir. Pol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/toxsci\/kfq266","article-title":"Characterization of Developmental Neurotoxicity of As, Cd, and Pb Mixture: Synergistic Action of Metal Mixture in Glial and Neuronal Functions","volume":"118","author":"Rai","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.etap.2016.09.016","article-title":"Heavy Metals (Pb, Cd, As and MeHg) as Risk Factors for Cognitive Dysfunction: A General Review of Metal Mixture Mechanism in Brain","volume":"48","author":"Karri","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/10408398.2011.596292","article-title":"Bioavailability and Potential Uses of Vegetarian Sources of Omega-3 Fatty Acids: A Review of the Literature","volume":"54","author":"Lane","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1212\/WNL.0000000000004057","article-title":"Intake of Dairy Foods and Risk of Parkinson Disease","volume":"89","author":"Hughes","year":"2017","journal-title":"Neurology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ana.10381","article-title":"Diet and Parkinson\u2019s Disease: A Potential Role of Dairy Products in Men","volume":"52","author":"Chen","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1017\/S0007114512000955","article-title":"A Cohort Study on Diet and the Risk of Parkinson\u2019s Disease: The Role of Food Groups and Diet Quality","volume":"109","author":"Knekt","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10654-012-9760-0","article-title":"Dietary and Lifestyle Variables in Relation to Incidence of Parkinson\u2019s Disease in Greece","volume":"28","author":"Kyrozis","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/aje\/kwk089","article-title":"Consumption of Dairy Products and Risk of Parkinson\u2019s Disease","volume":"165","author":"Chen","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10654-014-9921-4","article-title":"Dairy Foods Intake and Risk of Parkinson\u2019s Disease: A Dose-Response Meta-Analysis of Prospective Cohort Studies","volume":"29","author":"Jiang","year":"2014","journal-title":"Eur. J. Epidemiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/02652039609374401","article-title":"Detection of Some Organochlorine Pesticides in Cow\u2019s Milk","volume":"13","author":"Waliszewski","year":"1996","journal-title":"Food Addit. Contam."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/oemed-2013-101394","article-title":"The Association between Ambient Exposure to Organophosphates and Parkinson\u2019s Disease Risk","volume":"71","author":"Wang","year":"2014","journal-title":"Occup. Environ. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1212\/WNL.0000000000002254","article-title":"Midlife Milk Consumption and Substantia Nigra Neuron Density at Death","volume":"86","author":"Abbott","year":"2016","journal-title":"Neurology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10661-010-1849-x","article-title":"Organochlorine Pesticide (OCP) Residues in Cow\u2019s, Buffalo\u2019s, and Sheep\u2019s Milk from Afyonkarahisar Region, Turkey","volume":"181","author":"Bulut","year":"2011","journal-title":"Environ. Monit. Assess."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1081\/PFC-120004473","article-title":"Pesticide Residues in Cow Milk Consumed in S\u00e3o Paulo City (Brazil)","volume":"37","author":"Ciscato","year":"2002","journal-title":"J. Environ. Sci. Health B"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/19393210.2024.2414088","article-title":"Metals in Honey, Cow\u2019s Milk and Eggs in North-East Algeria and Health Risk","volume":"18","author":"Chebli","year":"2025","journal-title":"Food Addit. Contam. Part B Surveill."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kistner, A., and Krack, P. (2014). Parkinson\u2019s Disease: No Milk Today?. Front. Neurol., 5.","DOI":"10.3389\/fneur.2014.00172"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jprot.2015.09.024","article-title":"Characterization of the Bovine Milk Proteome in Early-Lactation Holstein and Jersey Breeds of Dairy Cows","volume":"130","author":"Tacoma","year":"2016","journal-title":"J. Proteom."},{"key":"ref_58","unstructured":"(2025, September 29). Milk and Parkinson Disease: Could Galactose Be the Missing Link\u2014Anna Rita Sarni, Luciana Baroni, 2019. Available online: https:\/\/journals.sagepub.com\/doi\/10.3233\/MNM-180234."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJMoa035700","article-title":"Purine-Rich Foods, Dairy and Protein Intake, and the Risk of Gout in Men","volume":"350","author":"Choi","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/aje\/kwm127","article-title":"Plasma Urate and Risk of Parkinson\u2019s Disease","volume":"166","author":"Weisskopf","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/aje\/kwg073","article-title":"Dietary Intakes of Fat and Risk of Parkinson\u2019s Disease","volume":"157","author":"Chen","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ana.410390113","article-title":"Dietary Lipids and Antioxidants in Parkinson\u2019s Disease: A Population-Based, Case-Control Study","volume":"39","author":"Logroscino","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cnr.2006.09.006","article-title":"Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson\u2019s Disease","volume":"6","author":"Mosley","year":"2006","journal-title":"Clin. Neurosci. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"175950","DOI":"10.1016\/j.ejphar.2023.175950","article-title":"Neuroprotective Effect of Chlorogenic Acid on Parkinson\u2019s Disease like Symptoms through Boosting the Autophagy in Zebrafish","volume":"956","author":"Gao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1212\/01.WNL.0000166038.67153.9F","article-title":"Dietary Fatty Acids and the Risk of Parkinson Disease: The Rotterdam Study","volume":"64","author":"Bornebroek","year":"2005","journal-title":"Neurology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"iii30","DOI":"10.1007\/s00415-003-1306-7","article-title":"Environmental, Life-Style, and Physical Precursors of Clinical Parkinson\u2019s Disease: Recent Findings from the Honolulu-Asia Aging Study","volume":"250","author":"Abbott","year":"2003","journal-title":"J. Neurol."},{"key":"ref_67","first-page":"86","article-title":"Dietary Cholesterol, Fats and Risk of Parkinson\u2019s Disease in the Singapore Chinese Health Study","volume":"87","author":"Tan","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1212\/WNL.57.3.456","article-title":"Frequency of Bowel Movements and the Future Risk of Parkinson\u2019s Disease","volume":"57","author":"Abbott","year":"2001","journal-title":"Neurology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/aje\/kwr119","article-title":"A Prospective Study of Bowel Movement Frequency and Risk of Parkinson\u2019s Disease","volume":"174","author":"Gao","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yrtph.2018.05.005","article-title":"Pesticide Exposure and Risk of Parkinson\u2019s Disease: Dose-Response Meta-Analysis of Observational Studies","volume":"96","author":"Yan","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1289\/ehp.1002839","article-title":"Rotenone, Paraquat, and Parkinson\u2019s Disease","volume":"119","author":"Tanner","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-444-62627-1.00009-3","article-title":"The Neurotoxicity of Organochlorine and Pyrethroid Pesticides","volume":"131","author":"Costa","year":"2015","journal-title":"Handb. Clin. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2478\/intox-2013-0018","article-title":"Exposure to Lipophilic Chemicals as a Cause of Neurological Impairments, Neurodevelopmental Disorders and Neurodegenerative Diseases","volume":"6","author":"Zeliger","year":"2013","journal-title":"Interdiscip. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1089\/gtmb.2013.0313","article-title":"Pesticide-Induced Gene Mutations and Parkinson Disease Risk: A Meta-Analysis","volume":"17","author":"Liu","year":"2013","journal-title":"Genet. Test. Mol. Biomark."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/01652176.2014.980934","article-title":"In Vitro Dopaminergic Neurotoxicity of Pesticides: A Link with Neurodegeneration?","volume":"34","author":"Heusinkveld","year":"2014","journal-title":"Vet. Q."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3233\/JPD-230206","article-title":"Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson\u2019s Disease","volume":"13","author":"Kulcsarova","year":"2023","journal-title":"J. Parkinson\u2019s Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.scitotenv.2014.03.022","article-title":"Dioxins and PCBs in Feed and Food--Review from European Perspective","volume":"491\u2013492","author":"Malisch","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/0045-6535(94)90393-X","article-title":"Dioxins in U.S. Food and Estimated Daily Intake","volume":"29","author":"Schecter","year":"1994","journal-title":"Chemosphere"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/152873901750128326","article-title":"Intake of Dioxins and Related Compounds from Food in the U.S. Population","volume":"63","author":"Schecter","year":"2001","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0048-9697(98)00062-X","article-title":"Hong Kong Male Subfertility Links to Mercury in Human Hair and Fish","volume":"214","author":"Dickman","year":"1998","journal-title":"Sci. Total Environ."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/1091581815583561","article-title":"Groundwater Pesticide Levels and the Association with Parkinson Disease","volume":"34","author":"James","year":"2015","journal-title":"Int. J. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wen, M., Zhou, B., Chen, Y.-H., Ma, Z.-L., Gou, Y., Zhang, C.-L., Yu, W.-F., and Jiao, L. (2017). Serum Uric Acid Levels in Patients with Parkinson\u2019s Disease: A Meta-Analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173731"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Gra\u017cy\u0144ska, A., Adamczewska, K., Antoniuk, S., Bie\u0144, M., To\u015b, M., Kufel, J., Urba\u015b, W., and Siuda, J. (2021). The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson\u2019s Disease and Atypical Parkinsonisms-A Systematic Review. Medicina, 57.","DOI":"10.3390\/medicina57090972"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/mds.29209","article-title":"Uric Acid in Parkinson\u2019s Disease: What Is the Connection?","volume":"37","author":"Seifar","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Parkinson Study Group SURE-PD3 Investigators, Schwarzschild, M.A., Ascherio, A., Casaceli, C., Curhan, G.C., Fitzgerald, R., Kamp, C., Lungu, C., Macklin, E.A., and Marek, K. (2021). Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial. JAMA, 326, 926\u2013939.","DOI":"10.1001\/jama.2021.10207"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric Acid Provides an Antioxidant Defense in Humans against Oxidant- and Radical-Caused Aging and Cancer: A Hypothesis","volume":"78","author":"Ames","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/bj2350747","article-title":"Uric Acid-Iron Ion Complexes. A New Aspect of the Antioxidant Functions of Uric Acid","volume":"235","author":"Davies","year":"1986","journal-title":"Biochem. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.expneurol.2017.06.017","article-title":"Targeting Urate to Reduce Oxidative Stress in Parkinson Disease","volume":"298","author":"Crotty","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0404.1965.tb04277.x","article-title":"Uric Acid in the Cerebrospinal Fluid in Cerebral Atrophy","volume":"41","author":"Farstad","year":"1965","journal-title":"Acta Neurol. Scand."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000346370","article-title":"Postmortem Brain Levels of Urate and Precursors in Parkinson\u2019s Disease and Related Disorders","volume":"12","author":"McFarland","year":"2013","journal-title":"Neurodegener. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/jcp.45.2.110","article-title":"Importance of Diurnal Variations on Clinical Value and Interpretation of Serum Urate Measurements","volume":"45","author":"Devgun","year":"1992","journal-title":"J. Clin. Pathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1096\/fasebj.4.9.2189777","article-title":"Metabolic Effects of Dietary Fructose","volume":"4","author":"Hallfrisch","year":"1990","journal-title":"FASEB J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1056\/NEJM198212233072602","article-title":"Ethanol-Induced Hyperuricemia: Evidence for Increased Urate Production by Activation of Adenine Nucleotide Turnover","volume":"307","author":"Faller","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1248\/bpb.b13-00967","article-title":"Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperuricemia","volume":"37","author":"Kaneko","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11926-010-0160-8","article-title":"Effects of Dairy Intake on Hyperuricemia and Gout","volume":"13","author":"Dalbeth","year":"2011","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_96","first-page":"1239","article-title":"Acute Effect of Soy and Soy Products on Serum Uric Acid Concentration among Healthy Chinese Men","volume":"27","author":"Zhang","year":"2018","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0002-9343(87)90441-4","article-title":"Asymptomatic Hyperuricemia. Risks and Consequences in the Normative Aging Study","volume":"82","author":"Campion","year":"1987","journal-title":"Am. J. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2459\/JCM.0b013e3283595adc","article-title":"Hyperuricaemia: More than Just a Cause of Gout?","volume":"14","author":"Katsiki","year":"2013","journal-title":"J. Cardiovasc. Med."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Schmidt, J.A., Crowe, F.L., Appleby, P.N., Key, T.J., and Travis, R.C. (2013). Serum Uric Acid Concentrations in Meat Eaters, Fish Eaters, Vegetarians and Vegans: A Cross-Sectional Analysis in the EPIC-Oxford Cohort. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056339"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zgaga, L., Theodoratou, E., Kyle, J., Farrington, S.M., Agakov, F., Tenesa, A., Walker, M., McNeill, G., Wright, A.F., and Rudan, I. (2012). The Association of Dietary Intake of Purine-Rich Vegetables, Sugar-Sweetened Beverages and Dairy with Plasma Urate, in a Cross-Sectional Study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038123"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/rheumatology\/ken416","article-title":"The Effect of Calcium Supplementation on Serum Urate: Analysis of a Randomized Controlled Trial","volume":"48","author":"Dalbeth","year":"2009","journal-title":"Rheumatology"},{"key":"ref_102","first-page":"650794","article-title":"Effects of Various Flavonoids on the \u03b1-Synuclein Fibrillation Process","volume":"2010","author":"Meng","year":"2010","journal-title":"Parkinson\u2019s Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"177829","DOI":"10.1016\/j.ejphar.2025.177829","article-title":"Therapeutic Potential of Flavonoids against \u03b1-Synuclein Aggregation in Parkinson\u2019s Disease: Integrative in Silico and in Vitro Analysis","volume":"1002","author":"Khorsand","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.1021\/bi900506b","article-title":"Molecular Mechanisms Underlying the Flavonoid-Induced Inhibition of Alpha-Synuclein Fibrillation","volume":"48","author":"Meng","year":"2009","journal-title":"Biochemistry"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wu, S., Li, Q., Lang, W., Li, W., Jiang, X., Wan, Z., Chen, J., and Wang, H. (2022). Epigallocatechin-3-Gallate: A Phytochemical as a Promising Drug Candidate for the Treatment of Parkinson\u2019s Disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.977521"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Javed, H., Ojha, S., Javed, H., and Ojha, S. (2019). Therapeutic Potential of Baicalein in Parkinson\u2019s Disease: Focus on Inhibition of \u03b1-Synuclein Oligomerization and Aggregation. Synucleins-Biochemistry and Role in Diseases, IntechOpen.","DOI":"10.5772\/intechopen.83589"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1471-4159.2010.06752.x","article-title":"Baicalein Reduces E46K Alpha-Synuclein Aggregation in Vitro and Protects Cells against E46K Alpha-Synuclein Toxicity in Cell Models of Familiar Parkinsonism","volume":"114","author":"Jiang","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jocn.2019.02.005","article-title":"Baicalein Enhances the Effect of Low Dose Levodopa on the Gait Deficits and Protects Dopaminergic Neurons in Experimental Parkinsonism","volume":"64","author":"Zheng","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.4103\/1673-5374.139476","article-title":"Effects of Naringin, a Flavanone Glycoside in Grapefruits and Citrus Fruits, on the Nigrostriatal Dopaminergic Projection in the Adult Brain","volume":"9","author":"Jung","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Silva Dos Santos, J., Gon\u00e7alves Cirino, J.P., de Oliveira Carvalho, P., and Ortega, M.M. (2020). The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.565700"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"101911","DOI":"10.1016\/j.redox.2021.101911","article-title":"Kaempferol Alleviates LD-Mitochondrial Damage by Promoting Autophagy: Implications in Parkinson\u2019s Disease","volume":"41","author":"Han","year":"2021","journal-title":"Redox Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"115215","DOI":"10.1016\/j.biopha.2023.115215","article-title":"Kaempferol, a Potential Neuroprotective Agent in Neurodegenerative Diseases: From Chemistry to Medicine","volume":"165","author":"Jin","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2014.01.047","article-title":"Neuroprotective Effects of Anthocyanin- and Proanthocyanidin-Rich Extracts in Cellular Models of Parkinson\u05f3s Disease","volume":"1555","author":"Strathearn","year":"2014","journal-title":"Brain Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1212\/WNL.0b013e31824f7fc4","article-title":"Habitual Intake of Dietary Flavonoids and Risk of Parkinson Disease","volume":"78","author":"Gao","year":"2012","journal-title":"Neurology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2011.04.032","article-title":"Metabolic Conversion of Dietary Flavonoids Alters Their Anti-Inflammatory and Antioxidant Properties","volume":"51","author":"Lotito","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuroscience.2025.02.007","article-title":"Synaptic Plasticity and Neuroprotection: The Molecular Impact of Flavonoids on Neurodegenerative Disease Progression","volume":"569","author":"Kopalli","year":"2025","journal-title":"Neuroscience"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Pokimica, B., and Garc\u00eda-Conesa, M.-T. (2018). Critical Evaluation of Gene Expression Changes in Human Tissues in Response to Supplementation with Dietary Bioactive Compounds: Moving Towards Better-Quality Studies. Nutrients, 10.","DOI":"10.3390\/nu10070807"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Cheatham, C.L., Nieman, D.C., Neilson, A.P., and Lila, M.A. (2022). Enhancing the Cognitive Effects of Flavonoids with Physical Activity: Is There a Case for the Gut Microbiome?. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.833202"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Westfall, S., and Pasinetti, G.M. (2019). The Gut Microbiota Links Dietary Polyphenols with Management of Psychiatric Mood Disorders. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01196"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1038\/s41598-018-29744-5","article-title":"Gut Microbiota Modulation Accounts for the Neuroprotective Properties of Anthocyanins","volume":"8","author":"Marques","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s10068-019-00656-y","article-title":"Interactions of Tea Catechins with Intestinal Microbiota and Their Implication for Human Health","volume":"28","author":"Guo","year":"2019","journal-title":"Food Sci. Biotechnol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"115788","DOI":"10.1016\/j.biopha.2023.115788","article-title":"Flavonoids: Their Putative Neurologic Roles, Epigenetic Changes, and Gut Microbiota Alterations in Parkinson\u2019s Disease","volume":"168","author":"Capasso","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Martini, D., Del Bo\u2019, C., Tassotti, M., Riso, P., Del Rio, D., Brighenti, F., and Porrini, M. (2016). Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies. Molecules, 21.","DOI":"10.3390\/molecules21080979"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3934\/publichealth.2016.2.407","article-title":"Beneficial Role of Coffee and Caffeine in Neurodegenerative Diseases: A Minireview","volume":"3","author":"Yenisetti","year":"2016","journal-title":"AIMS Public Health"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/mds.27577","article-title":"The Association between Lifestyle Factors and Parkinson\u2019s Disease Progression and Mortality","volume":"34","author":"Paul","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e209201","DOI":"10.1212\/WNL.0000000000209201","article-title":"Association of Coffee Consumption and Prediagnostic Caffeine Metabolites with Incident Parkinson Disease in a Population-Based Cohort","volume":"102","author":"Zhao","year":"2024","journal-title":"Neurology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"104671","DOI":"10.1016\/j.nbd.2019.104671","article-title":"Modifiable Risk and Protective Factors in Disease Development, Progression and Clinical Subtypes of Parkinson\u2019s Disease: What Do Prospective Studies Suggest?","volume":"134","author":"Belvisi","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Hong, C.T., Chan, L., and Bai, C.-H. (2020). The Effect of Caffeine on the Risk and Progression of Parkinson\u2019s Disease: A Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12061860"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/ggi.12123","article-title":"Dose-Response Meta-Analysis on Coffee, Tea and Caffeine Consumption with Risk of Parkinson\u2019s Disease","volume":"14","author":"Qi","year":"2014","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11302-020-09694-2","article-title":"The Belated US FDA Approval of the Adenosine A2A Receptor Antagonist Istradefylline for Treatment of Parkinson\u2019s Disease","volume":"16","author":"Chen","year":"2020","journal-title":"Purinergic Signal."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2174\/0113895575306884240604065754","article-title":"A Review of the Protective Effects of Alkaloids against Alpha-Synuclein Toxicity in Parkinson\u2019s Disease","volume":"25","author":"Khodadadi","year":"2025","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1039\/C4FO00042K","article-title":"Coffee: Biochemistry and Potential Impact on Health","volume":"5","author":"Ludwig","year":"2014","journal-title":"Food Funct."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/1574-6968.12142","article-title":"Influence of Coffee (Coffea Arabica) and Galacto-Oligosaccharide Consumption on Intestinal Microbiota and the Host Responses","volume":"343","author":"Nakayama","year":"2013","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1007\/s00394-020-02415-w","article-title":"Association between Coffee Consumption and Total Dietary Caffeine Intake with Cognitive Functioning: Cross-Sectional Assessment in an Elderly Mediterranean Population","volume":"60","author":"Babio","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.parkreldis.2018.02.016","article-title":"Association of Coffee Consumption and Non-Motor Symptoms in Drug-Na\u00efve, Early-Stage Parkinson\u2019s Disease","volume":"50","author":"Cho","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Cho, B.-H., Choi, S.-M., and Kim, B.C. (2019). Gender-Dependent Effect of Coffee Consumption on Tremor Severity in de Novo Parkinson\u2019s Disease. BMC Neurol., 19.","DOI":"10.1186\/s12883-019-1427-y"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1212\/WNL.0b013e318263570d","article-title":"Caffeine for Treatment of Parkinson Disease: A Randomized Controlled Trial","volume":"79","author":"Postuma","year":"2012","journal-title":"Neurology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1212\/WNL.0000000000004568","article-title":"Caffeine as Symptomatic Treatment for Parkinson Disease (Caf\u00e9-PD): A Randomized Trial","volume":"89","author":"Postuma","year":"2017","journal-title":"Neurology"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.archger.2015.08.004","article-title":"Association between Cigarette Smoking and Parkinson\u2019s Disease: A Meta-Analysis","volume":"61","author":"Li","year":"2015","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/mds.24012","article-title":"Environmental Tobacco Smoke and Parkinson\u2019s Disease","volume":"27","author":"Gallagher","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"107022","DOI":"10.1016\/j.parkreldis.2024.107022","article-title":"Smoking Exposure and Parkinson\u2019s Disease: A UK Brain Bank Pathology-Validated Case-Control Study","volume":"125","author":"Pecoraro","year":"2024","journal-title":"Park. Relat. Disord."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/mds.29707","article-title":"Clearing the Smoke: What Protects Smokers from Parkinson\u2019s Disease?","volume":"39","author":"Rose","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0161-813X(03)00107-4","article-title":"Tobacco Leaf, Smoke and Smoking, MAO Inhibitors, Parkinson\u2019s Disease and Neuroprotection; Are There Links?","volume":"25","author":"Castagnoli","year":"2004","journal-title":"Neurotoxicology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"105831","DOI":"10.1016\/j.neuint.2024.105831","article-title":"Monoamine Oxidase and Neurodegeneration: Mechanisms, Inhibitors and Natural Compounds for Therapeutic Intervention","volume":"179","author":"Banerjee","year":"2024","journal-title":"Neurochem. Int."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tins.2004.06.008","article-title":"Smoking, Nicotine and Parkinson\u2019s Disease","volume":"27","author":"Quik","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbapap.2008.09.026","article-title":"Smoking and Parkinson\u2019s Disease: Does Nicotine Affect Alpha-Synuclein Fibrillation?","volume":"1794","author":"Hong","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)-Proteins Proteom."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ana.23884","article-title":"Nicotine from Edible Solanaceae and Risk of Parkinson Disease","volume":"74","author":"Nielsen","year":"2013","journal-title":"Ann. Neurol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/13547500902898164","article-title":"Analysis of Myosmine, Cotinine and Nicotine in Human Toenail, Plasma and Saliva","volume":"14","author":"Heppel","year":"2009","journal-title":"Biomarkers"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1021\/jf990089w","article-title":"Determination of the Nicotine Content of Various Edible Nightshades (Solanaceae) and Their Products and Estimation of the Associated Dietary Nicotine Intake","volume":"47","author":"Siegmund","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archpsyc.63.8.907","article-title":"Cigarette Smoking Saturates Brain Alpha 4 Beta 2 Nicotinic Acetylcholine Receptors","volume":"63","author":"Brody","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejphar.2012.11.017","article-title":"Anti-Inflammatory Activity of Anatabine via Inhibition of STAT3 Phosphorylation","volume":"698","author":"Paris","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1271\/bbb.90570","article-title":"Assessment of the Biological Similarity of Three Capsaicin Analogs (Capsinoids) Found in Non-Pungent Chili Pepper (CH-19 Sweet) Fruits","volume":"74","author":"Sasahara","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/mds.25028","article-title":"Nicotine as a Potential Neuroprotective Agent for Parkinson\u2019s Disease","volume":"27","author":"Quik","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1017\/S0007114521002476","article-title":"Mediterranean Diet Scoring Systems: Understanding the Evolution and Applications for Mediterranean and Non-Mediterranean Countries","volume":"128","author":"Bales","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/1028415X.2023.2233727","article-title":"A Comprehensive Examination of the Evidence for Whole of Diet Patterns in Parkinson\u2019s Disease: A Scoping Review","volume":"27","author":"Rees","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1468-1331.2011.03600.x","article-title":"Dietary Patterns and Risk of Parkinson\u2019s Disease: A Case-Control Study in Japan","volume":"19","author":"Okubo","year":"2012","journal-title":"Eur. J. Neurol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Bohnen, J.L.B., Albin, R.L., and Bohnen, N.I. (2023). Ketogenic Interventions in Mild Cognitive Impairment, Alzheimer\u2019s Disease, and Parkinson\u2019s Disease: A Systematic Review and Critical Appraisal. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1123290"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Norwitz, N.G., Hu, M.T., and Clarke, K. (2019). The Mechanisms by Which the Ketone Body D-\u03b2-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson\u2019s Disease. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00063"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.maturitas.2022.06.001","article-title":"Ketogenic Therapy for Parkinson\u2019s Disease: A Systematic Review and Synthesis without Meta-Analysis of Animal and Human Trials","volume":"163","author":"Grammatikopoulou","year":"2022","journal-title":"Maturitas"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2217\/nmt-2021-0033","article-title":"Effects of an Low Carbohydrate\/Healthy Fat\/Ketogenic Diet on Biomarkers of Health and Symptoms, Anxiety and Depression in Parkinson\u2019s Disease: A Pilot Study","volume":"12","author":"Tidman","year":"2022","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_161","first-page":"41","article-title":"Nutritional Ketosis for Mild Cognitive Impairment in Parkinson\u2019s Disease: A Controlled Pilot Trial","volume":"1","author":"Krikorian","year":"2019","journal-title":"Clin. Park. Relat. Disord."},{"key":"ref_162","first-page":"358","article-title":"Adherence to the MIND Diet Is Associated with 12-Year All-Cause Mortality in Older Adults","volume":"25","author":"Corley","year":"2022","journal-title":"Public Health Nutr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1080\/10408398.2021.1925220","article-title":"MIND Diet and Cognitive Performance in Older Adults: A Systematic Review","volume":"62","author":"Kheirouri","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/mds.28464","article-title":"MIND and Mediterranean Diets Associated with Later Onset of Parkinson\u2019s Disease","volume":"36","author":"Yu","year":"2021","journal-title":"Mov. Disord."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Fox, D.J., Park, S.J., and Mischley, L.K. (2022). Comparison of Associations between MIND and Mediterranean Diet Scores with Patient-Reported Outcomes in Parkinson\u2019s Disease. Nutrients, 14.","DOI":"10.3390\/nu14235185"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1001\/jamainternmed.2013.6473","article-title":"Vegetarian Dietary Patterns and Mortality in Adventist Health Study 2","volume":"173","author":"Orlich","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1054\/mehy.2000.1321","article-title":"Does a Vegan Diet Reduce Risk for Parkinson\u2019s Disease?","volume":"57","author":"McCarty","year":"2001","journal-title":"Med. Hypotheses"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/mds.29580","article-title":"Plant-Based Dietary Patterns and Parkinson\u2019s Disease: A Prospective Analysis of the UK Biobank","volume":"38","author":"Thompson","year":"2023","journal-title":"Mov. Disord."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"107125","DOI":"10.1016\/j.parkreldis.2024.107125","article-title":"Total Physical Activity, Plant-Based Diet and Neurodegenerative Diseases: A Prospective Cohort Study of the UK Biobank","volume":"128","author":"Zheng","year":"2024","journal-title":"Park. Relat. Disord."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Hegelmaier, T., Lebbing, M., Duscha, A., Tomaske, L., T\u00f6nges, L., Holm, J.B., Bj\u00f8rn Nielsen, H., Gatermann, S.G., Przuntek, H., and Haghikia, A. (2020). Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson\u2019s Disease. Cells, 9.","DOI":"10.3390\/cells9020376"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/advances\/nmaa112","article-title":"Perspective: Low Risk of Parkinson\u2019s Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin","volume":"12","author":"McCarty","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/ajcn\/86.5.1486","article-title":"Prospective Study of Dietary Pattern and Risk of Parkinson Disease","volume":"86","author":"Gao","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/174313211X12966635733231","article-title":"Pilot Dietary Study with Normoproteic Protein-Redistributed Plant-Food Diet and Motor Performance in Patients with Parkinson\u2019s Disease","volume":"14","author":"Baroni","year":"2011","journal-title":"Nutr. Neurosci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1021\/jf9909860","article-title":"High Content of Dopamine, a Strong Antioxidant, in Cavendish Banana","volume":"48","author":"Kanazawa","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Briguglio, M., Dell\u2019Osso, B., Panzica, G., Malgaroli, A., Banfi, G., Zanaboni Dina, C., Galentino, R., and Porta, M. (2018). Dietary Neurotransmitters: A Narrative Review on Current Knowledge. Nutrients, 10.","DOI":"10.3390\/nu10050591"},{"key":"ref_176","first-page":"681","article-title":"Broad Bean (Vicia faba) Consumption and Parkinson\u2019s Disease","volume":"60","author":"Rabey","year":"1993","journal-title":"Adv. Neurol."},{"key":"ref_177","first-page":"375","article-title":"Broad Bean (Vicia faba) Consumption and Parkinson\u2019s Disease: A Natural Source of L-Dopa to Consider","volume":"30","author":"Romaskevych","year":"2015","journal-title":"Neurologia"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/jnnp.55.8.725","article-title":"Improvement of Parkinsonian Features Correlate with High Plasma Levodopa Values after Broad Bean (Vicia faba) Consumption","volume":"55","author":"Rabey","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01088335","article-title":"Variation of Favism-Inducing Factors (Vicine, Convicine and L-DOPA) during Pod Development in Vicia faba L.","volume":"47","author":"Burbano","year":"1995","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0308-8146(95)00024-D","article-title":"The Effect of Cooking, Autoclaving and Germination on the Nutritional Quality of Faba Beans","volume":"54","author":"Khalil","year":"1995","journal-title":"Food Chemistry"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/mds.20380","article-title":"Case of Neuroleptic Malignant-like Syndrome Precipitated by Abrupt Fava Bean Discontinuance","volume":"20","author":"Ladha","year":"2005","journal-title":"Mov. Disord."},{"key":"ref_182","first-page":"1004","article-title":"Simultaneous Determination of Levodopa and Carbidopa from Fava Bean, Green Peas and Green Beans by High Performance Liquid Gas Chromatography","volume":"7","author":"SM","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/1381612822666151112151653","article-title":"Oxidative Stress and Parkinson\u2019s Disease: New Hopes in Treatment with Herbal Antioxidants","volume":"22","author":"Sarrafchi","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_184","first-page":"1349509","article-title":"Knowing Your Beans in Parkinson\u2019s Disease: A Critical Assessment of Current Knowledge about Different Beans and Their Compounds in the Treatment of Parkinson\u2019s Disease and in Animal Models","volume":"2019","author":"Rijntjes","year":"2019","journal-title":"Park. Dis."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"947","DOI":"10.7164\/antibiotics.28.947","article-title":"Isolation of Isoflavones Inhibiting DOPA Decarboxylase from Fungi and Streptomyces","volume":"28","author":"Umezawa","year":"1975","journal-title":"J. Antibiot."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jns.2016.01.005","article-title":"Effects of Soybean Ingestion on Pharmacokinetics of Levodopa and Motor Symptoms of Parkinson\u2019s Disease--In Relation to the Effects of Mucuna pruriens","volume":"361","author":"Nagashima","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s00415-012-6527-1","article-title":"Comparison of Chocolate to Cacao-Free White Chocolate in Parkinson\u2019s Disease: A Single-Dose, Investigator-Blinded, Placebo-Controlled, Crossover Trial","volume":"259","author":"Wolz","year":"2012","journal-title":"J. Neurol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1007\/s11064-022-03591-3","article-title":"Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases","volume":"47","author":"Zahra","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.parkreldis.2010.04.015","article-title":"A Water Extract of Mucuna pruriens Provides Long-Term Amelioration of Parkinsonism with Reduced Risk for Dyskinesias","volume":"16","author":"Lieu","year":"2010","journal-title":"Park. Relat. Disord."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s13205-020-02532-7","article-title":"Mucuna pruriens in Parkinson\u2019s and in Some Other Diseases: Recent Advancement and Future Prospective","volume":"10","author":"Rai","year":"2020","journal-title":"3 Biotech"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.2169\/internalmedicine.3171-23","article-title":"Japanese Mucuna pruriens (Hasshou Beans) Showed Fast-Acting and Long-Lasting Effects in Parkinson\u2019s Disease","volume":"63","author":"Sakata","year":"2024","journal-title":"Intern. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1136\/jnnp.2003.028761","article-title":"Mucuna pruriens in Parkinson\u2019s Disease: A Double Blind Clinical and Pharmacological Study","volume":"75","author":"Katzenschlager","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1212\/WNL.0000000000004175","article-title":"Mucuna pruriens in Parkinson Disease: A Double-Blind, Randomized, Controlled, Crossover Study","volume":"89","author":"Cilia","year":"2017","journal-title":"Neurology"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.parkreldis.2018.01.014","article-title":"Daily Intake of Mucuna pruriens in Advanced Parkinson\u2019s Disease: A 16-Week, Noninferiority, Randomized, Crossover, Pilot Study","volume":"49","author":"Cilia","year":"2018","journal-title":"Park. Relat. Disord."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"106983","DOI":"10.1016\/j.parkreldis.2024.106983","article-title":"Mucuna pruriens to Treat Parkinson\u2019s Disease in Low-Income Countries: Recommendations and Practical Guidelines from the Farmer to Clinical Trials. Paving the Way for Future Use in Clinical Practice","volume":"124","author":"Caronni","year":"2024","journal-title":"Park. Relat. Disord."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1021\/jf950776x","article-title":"Chemical Composition and Protein Quality of the Little-Known Legume, Velvet Bean (Mucuna pruriens (L.) DC.)","volume":"44","author":"Siddhuraju","year":"1996","journal-title":"J. Agric. Food Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ptr.1514","article-title":"Neuroprotective Effects of the Antiparkinson Drug Mucuna pruriens","volume":"18","author":"Manyam","year":"2004","journal-title":"Phytother. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/09637480020027264","article-title":"Some Nutritional Properties of the Seeds of Three Mucuna Species","volume":"52","author":"Prakash","year":"2001","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"113518","DOI":"10.1016\/j.jep.2020.113518","article-title":"Mucuna pruriens (L.) DC. Seed Extract Inhibits Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells","volume":"267","author":"Rachsee","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2125.1993.tb05691.x","article-title":"The Effect of L-Leucine on the Absorption of Levodopa, Studied by Regional Jejunal Perfusion in Man","volume":"35","author":"Nilsson","year":"1993","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.parkreldis.2003.10.004","article-title":"The Effects of a Normal Protein Diet on Levodopa Plasma Kinetics in Advanced Parkinson\u2019s Disease","volume":"10","author":"Simon","year":"2004","journal-title":"Park. Relat. Disord."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000116649","article-title":"Protein Redistribution Diet and Antiparkinsonian Response to Levodopa","volume":"31","author":"Bracco","year":"1991","journal-title":"Eur. Neurol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00002826-199210000-00004","article-title":"Clinical and Pharmacokinetic Effects of a Diet Rich in Insoluble Fiber on Parkinson Disease","volume":"15","author":"Astarloa","year":"1992","journal-title":"Clin. Neuropharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archneur.1987.00520220012007","article-title":"Plasma Levels of Amino Acids Correlate with Motor Fluctuations in Parkinsonism","volume":"44","author":"Pincus","year":"1987","journal-title":"Arch. Neurol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-Synuclein in Lewy Bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The Pathogenesis of Parkinson\u2019s Disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"ref_207","first-page":"461","article-title":"The Role of Oxidative Stress in Parkinson\u2019s Disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Park. Dis."},{"key":"ref_208","first-page":"1817","article-title":"Damage to Dopaminergic Neurons by Oxidative Stress in Parkinson\u2019s Disease (Review)","volume":"41","author":"Guo","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Lucchesi, M., Biso, L., Bonaso, M., Longoni, B., Buchignani, B., Battini, R., Santorelli, F.M., Doccini, S., and Scarselli, M. (2025). Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson\u2019s Disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094451"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.04.004","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Parkinson\u2019s Disease","volume":"106\u2013107","author":"Subramaniam","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Navarro-Romero, A., Montpey\u00f3, M., and Martinez-Vicente, M. (2020). The Emerging Role of the Lysosome in Parkinson\u2019s Disease. Cells, 9.","DOI":"10.3390\/cells9112399"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/mds.25462","article-title":"Lysosomal Impairment in Parkinson\u2019s Disease","volume":"28","author":"Dehay","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/nan.12297","article-title":"Review: Parkinson\u2019s Disease: From Synaptic Loss to Connectome Dysfunction","volume":"42","author":"Bellucci","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/3\/514\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:02:19Z","timestamp":1770048139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/3\/514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":213,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["foods15030514"],"URL":"https:\/\/doi.org\/10.3390\/foods15030514","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}