{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:08:34Z","timestamp":1778029714249,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2025YFF1107300"],"award-info":[{"award-number":["2025YFF1107300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472321"],"award-info":[{"award-number":["32472321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Projects of Tianjin"},{"name":"Key Technology Research Project of Taiyuan","award":["2024TYJB0146"],"award-info":[{"award-number":["2024TYJB0146"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Monascus vinegar (MV) is a functional food containing various bioactive components, which has attracted significant research attention due to the unique health benefits conferred by these active functional ingredients. This study aimed to investigate the mechanism by which Monascus vinegar polysaccharides (MVPs) prevent hyperlipidemia. We established a hyperlipidemia mouse model using a high-fat diet (HFD) and conducted an 8-week intervention experiment. Results showed that MVP significantly reduced serum and liver lipid levels in mice, increased the activity of liver antioxidant enzymes, and downregulated the expression of serum proinflammatory cytokines. Hematoxylin and eosin (H&amp;E) staining revealed that MVP significantly improved liver histopathological abnormalities. Enrichment analysis of key differential metabolites identified four potential metabolic pathways and mapped them to the MVP and model groups. The analysis revealed the involvement of pathways related to arachidonic acid metabolism, glutathione metabolism, alanine\u2013aspartate\u2013glutamate metabolism, and pyrimidine metabolism. After MVP intervention, key metabolites within these pathways were significantly improved. MVP may influence lipid metabolism through modulation of these pathways. This study provides theoretical support for the application and development of MVP in the functional food sector.<\/jats:p>","DOI":"10.3390\/foods15040654","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:25:49Z","timestamp":1770816349000},"page":"654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolomics-Based Elucidation of the Lipid-Lowering Mechanisms of Monascus Vinegar Polysaccharides"],"prefix":"10.3390","volume":"15","author":[{"given":"Yanhua","family":"Liu","sequence":"first","affiliation":[{"name":"College of Sciences, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyue","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senzhen","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3706-0364","authenticated-orcid":false,"given":"Bingning","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-2121","authenticated-orcid":false,"given":"Jia","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-4065","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio-Based Fiber Materials, School of Biological Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.fct.2009.10.048","article-title":"Antidiabetic and antihyperlipidemic activity of ethyl acetate:Isopropanol (1:1) fraction of vernonia anthelmintica seeds in streptozotocin induced diabetic rats","volume":"48","author":"Fatima","year":"2010","journal-title":"Food Chem. 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