{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:36:13Z","timestamp":1788413773045,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022960","name":"Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams","doi-asserted-by":"crossref","award":["2024CXTD10"],"award-info":[{"award-number":["2024CXTD10"]}],"id":[{"id":"10.13039\/100022960","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Talent Training Program of Guangdong Academy of Agricultural Sciences","award":["R2022PY-QY009"],"award-info":[{"award-number":["R2022PY-QY009"]}]},{"name":"Construction of the High-Level Academy of Agricultural Sciences","award":["NYQS202623"],"award-info":[{"award-number":["NYQS202623"]}]},{"name":"Guangdong Provincial Talent Project","award":["NYLJ202505"],"award-info":[{"award-number":["NYLJ202505"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Finger Citron (Citrus medica L. var. sarcodactylis Swingle) holds significant potential as both a culinary ingredient and a traditional medicinal remedy; however, its precise molecular mechanisms of action remain largely unexplored. This study investigates the anti-inflammatory properties of Finger Citron extract (FCE) in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS). Using UPLC-ESI-QTF-MS, we analyzed the extract\u2019s composition, revealing a rich presence of polyphenols and polysaccharides, with hesperidin, melitidin, and hesperetin as the predominant polyphenolic compounds. Additionally, the study elucidated the monosaccharide composition profile of polysaccharides in the extract. Furthermore, Finger Citron extract markedly suppressed the production of key inflammatory mediators, including TNF-\u03b1, IL-6, and NO. The inhibition of protein phosphorylation levels of inhibiting the mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-\u03baB) signaling was also observed, indicating that the anti-inflammatory effects of Finger Citron extract may involve the NF-\u03baB and MAPK signaling pathway. Given these findings, Finger Citron extract has the potential to act as a natural product with anti-inflammatory activity.<\/jats:p>","DOI":"10.3390\/foods15040688","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:52:21Z","timestamp":1770979941000},"page":"688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Inflammatory Effect of Finger Citron Extract on RAW264.7 Macrophages via NF-\u03baB and MAPK Signaling Pathways"],"prefix":"10.3390","volume":"15","author":[{"given":"Jiateng","family":"Hu","sequence":"first","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"},{"name":"College of Food Science and Technology, South China University of Technology, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanshan","family":"Yu","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"},{"name":"College of Food Science and Technology, South China University of Technology, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Bu","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"},{"name":"College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Wu","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"},{"name":"College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengsheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-0388","authenticated-orcid":false,"given":"Bo","family":"Zou","sequence":"additional","affiliation":[{"name":"Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Dong Guanzhuang Yiheng RD, Tianhe District, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"ref_1","first-page":"239","article-title":"Inflammation and Aging: Signaling Pathways and Intervention Therapies","volume":"8","author":"Li","year":"2023","journal-title":"Inflamm. Aging Signal. Pathw. Interv. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jacc.2021.12.017","article-title":"Inflammation, Aging, and Cardiovascular Disease","volume":"79","author":"Liberale","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.trecan.2022.07.002","article-title":"Inflammation: The Incubator of the Tumor Microenvironment","volume":"8","author":"Denk","year":"2022","journal-title":"Trends Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2023.12.009","article-title":"Nutritional Regulation of Microbiota-Derived Metabolites: Implications for Immunity and Inflammation","volume":"57","author":"Arifuzzaman","year":"2024","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-pharmtox-051921-084536","article-title":"Pharmacology of Intestinal Inflammation and Repair","volume":"65","author":"Deraison","year":"2025","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.cmet.2024.08.003","article-title":"Defying \u201cIL-11ness\u201d by Inhibiting Inflammation: Strategy for Health and Longevity","volume":"36","author":"Kim","year":"2024","journal-title":"Cell Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.semcancer.2025.07.007","article-title":"Obesity-Driven Inflammation and Cancer Risk: A Comprehensive Review","volume":"114","author":"Lamabadusuriya","year":"2025","journal-title":"Semin. Cancer Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41423-025-01310-w","article-title":"NF-\u039aB in Inflammation and Cancer","volume":"22","author":"Mao","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1158\/0008-5472.CAN-23-1200","article-title":"Tumor Cell-Intrinsic P38 MAPK Signaling Promotes IL1\u237a-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer","volume":"84","author":"Singh","year":"2024","journal-title":"Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"117056","DOI":"10.1016\/j.biopha.2024.117056","article-title":"Sulforaphane-Mediated Immune Regulation through Inhibition of NF-KB and MAPK Signaling Pathways in Human Dendritic Cells","volume":"177","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-023-01512-7","article-title":"Reactive Oxygen Species (ROS) Scavenging Biomaterials for Anti-Inflammatory Diseases: From Mechanism to Therapy","volume":"16","author":"Liu","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant Flavonoids: Classification, Distribution, Biosynthesis, and Antioxidant Activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Karp, D., and Hu, X. (2023). The Citron (Citrus medica L.) in China. The Citron Compendium, Springer.","DOI":"10.1007\/978-3-031-25775-9_8"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.indcrop.2013.02.015","article-title":"Variation in the components and antioxidant activity of Citrus medica L. var. sarcodactylis essential oils at different stages of maturity","volume":"46","author":"Wu","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.12691\/jfnr-6-7-10","article-title":"Bioactive Compounds and Functional Benefits of the Foshou Fruit: A Review","volume":"6","author":"Wang","year":"2018","journal-title":"J. Food Nutr. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"136640","DOI":"10.1016\/j.ijbiomac.2024.136640","article-title":"Review of Polysaccharides from Citrus medica L. var. sarcodactylis. (Fingered citron): Their Extraction, Purification, Structural Characteristics, Bioactivity and Potential Applications","volume":"282","author":"Sun","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tan, T., Xu, M., Hong, X., Li, Z., Li, J., Jiao, B., and Zhao, X. (2025). Quantitative Analysis of Flavonoids and Coumarins from Fingered Citron in Different Growth Periods and Their Regulatory Effects on Oxidative Stress. Foods, 14.","DOI":"10.3390\/foods14020180"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"103559","DOI":"10.1016\/j.fochx.2026.103559","article-title":"A Novel Polysaccharide of Citrus medica L. var. sarcodactylis Swingle: Purification, Structural Characterization, and Hypolipidemic Effects","volume":"33","author":"Wu","year":"2026","journal-title":"Food Chem. X"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Luo, X., Wang, J., Chen, H., Zhou, A., Song, M., Zhong, Q., Chen, H., and Cao, Y. (2020). Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities. Front. Nutr., 7.","DOI":"10.3389\/fnut.2020.584900"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s10068-019-00567-y","article-title":"Protein and polyphenols involved in sediment formation in cloudy litchi juice","volume":"28","author":"Zeng","year":"2019","journal-title":"Food Sci. Biotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0021-9258(18)74048-9","article-title":"The isolation of the components of streptococcal nucleoproteins in serologically active form","volume":"124","author":"Sevag","year":"1938","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric Method for Determination of Sugars and Related Substances","volume":"28","author":"DuBois","year":"1956","journal-title":"Anal. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijbiomac.2022.09.195","article-title":"The variation on structure and immunomodulatory activity of polysaccharide during the longan pulp fermentation","volume":"222","author":"Hu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"01674","DOI":"10.1016\/j.fbio.2022.101674","article-title":"Structural identification and antioxidant potency evaluation of pomelo vinegar polyphenols","volume":"47","author":"Zou","year":"2022","journal-title":"Food Biosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1440-1711.2001.01002.x","article-title":"Real-time reverse transcriptase\u2013polymerase chain reaction (RT\u2013PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I","volume":"79","author":"Yin","year":"2001","journal-title":"Immunol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.foodchem.2018.02.028","article-title":"Persimmon vinegar polyphenols protect against hydrogen peroxide-induced cellular oxidative stress via Nrf2 signalling pathway","volume":"255","author":"Zou","year":"2018","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10068-017-0099-x","article-title":"Evolution of the antioxidant capacity and phenolic contents of persimmon during fermentation","volume":"26","author":"Zou","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tu, H., and Li, Y. (2023). Inflammation Balance in Skeletal Muscle Damage and Repair. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1133355"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116438","DOI":"10.1016\/j.biopha.2024.116438","article-title":"Tolperisone Hydrochloride Improves Motor Functions in Parkinson\u2019s Disease via MMP-9 Inhibition and by Downregulating P38 MAPK and ERK1\/2 Signaling Cascade","volume":"174","author":"Zaman","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/ard-2023-224878","article-title":"Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-\u03b1 in rheumatoid arthritis","volume":"83","author":"Hu","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104090","DOI":"10.1016\/j.drudis.2024.104090","article-title":"Lipid- and polymer-based formulations containing TNF-\u03b1 inhibitors for the treatment of inflammatory bowel diseases","volume":"29","author":"Voci","year":"2024","journal-title":"Drug Discov. Today"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1053\/j.gastro.2024.07.007","article-title":"Inflammatory Markers at Birth and Risk of Early-Onset Inflammatory Bowel Disease","volume":"167","author":"Rudbaek","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_33","first-page":"e118","article-title":"Effect of Apremilast on Hand and Whole-Body MRI Assessments of Inflammation in Patients with Psoriatic Arthritis (MOSAIC): A Phase 4, Multicentre, Single-Arm, Open-Label Study","volume":"7","author":"Boesen","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"ref_34","first-page":"6623379","article-title":"Finger Citron Extract Ameliorates Glycolipid Metabolism and Inflammation by Regulating GLP-1 Secretion via TGR5 Receptors in Obese Rats","volume":"2021","author":"Yang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"115445","DOI":"10.1016\/j.jep.2022.115445","article-title":"Ziziphus mauritiana Lam attenuates inflammation via downregulating NF\u03baB pathway in LPS-stimulated RAW 264.7 macrophages & OVA-induced airway inflammation in mice models","volume":"295","author":"Ramachandran","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1039\/D4MD00011K","article-title":"Identification of chalcone analogues as anti-inflammatory agents through the regulation of NF-\u03baB and JNK activation","volume":"15","author":"Zhang","year":"2024","journal-title":"RSC Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"105650","DOI":"10.1016\/j.arabjc.2024.105650","article-title":"Novel modified probiotic gold nanoparticles loaded with ginsenoside CK exerts an anti-inflammation effect via NF-\u03baB\/MAPK signaling pathways","volume":"17","author":"Kim","year":"2024","journal-title":"Arab. J. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.phanu.2015.10.001","article-title":"Characterization of flavonoids in Citrus bergamia (Bergamot) polyphenolic fraction by liquid chromatography\u2013High resolution mass spectrometry (LC\/HRMS)","volume":"4","author":"Salerno","year":"2016","journal-title":"PharmaNutrition"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106527","DOI":"10.1016\/j.jff.2024.106527","article-title":"Ilex asprella-derived polysaccharide activates macrophage via TLR4-mediated NF-\u03baB and MAPK signaling pathways","volume":"122","author":"Wang","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"107279","DOI":"10.1016\/j.ultsonch.2025.107279","article-title":"Flavonoids from sour jujube leaves: Ultrasound-assisted extraction, UPLC-QQQ-MS\/MS quantification, and ameliorative effect on DSS-induced ulcerative colitis in mice","volume":"114","author":"Wei","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"111617","DOI":"10.1016\/j.indcrop.2019.111617","article-title":"Structural characterization and immunoregulatory activity of a novel heteropolysaccharide from bergamot (Citrus medica L. var. sarcodactylis) by alkali extraction","volume":"140","author":"Peng","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"124491","DOI":"10.1016\/j.ijbiomac.2023.124491","article-title":"Structural characterization and immunomodulatory activity of a polysaccharide from finger citron extracted by continuous phase-transition extraction","volume":"240","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"123381","DOI":"10.1016\/j.carbpol.2025.123381","article-title":"Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata","volume":"356","author":"Xu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"103076","DOI":"10.1016\/j.copbio.2024.103076","article-title":"Anti-inflammatory and immunomodulatory properties of polysaccharides in mushrooms","volume":"86","author":"Mizuno","year":"2024","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.fshw.2022.10.025","article-title":"Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-\u03baB and MAPK pathways","volume":"12","author":"Hu","year":"2022","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"113062","DOI":"10.1016\/j.fct.2022.113062","article-title":"Jujube peel polyphenols synergistically inhibit lipopolysaccharide-induced inflammation through multiple signaling pathways in RAW 264.7 cells","volume":"164","author":"Shen","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105044","DOI":"10.1016\/j.jff.2022.105044","article-title":"Anti-inflammatory effect of lentil hull (Lens culinaris) extract via MAPK\/NF-\u03baB signaling pathways and effects of digestive products on intestinal barrier and inflammation in Caco-2 and Raw264.7 co-culture","volume":"92","author":"Peng","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1021\/jf902143x","article-title":"Insulin Secretagogue Bioactivity of Finger Citron Fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)","volume":"57","author":"Peng","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Borgatti, M., Mancini, I., Bianchi, N., Guerrini, A., Lampronti, I., Rossi, D., Sacchetti, G., and Gambari, R. (2011). Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC Biochem., 12.","DOI":"10.1186\/1471-2091-12-15"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.phrs.2012.10.010","article-title":"Negative regulation of inflammation by SIRT1","volume":"67","author":"Xie","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1021\/jf1008605","article-title":"In Vitro Protective Effects of Two Extracts from Bergamot Peels on Human Endothelial Cells Exposed to Tumor Necrosis Factor-\u03b1 (TNF-\u03b1)","volume":"58","author":"Trombetta","year":"2010","journal-title":"J. Agric. Food Chem."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/4\/688\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T05:17:24Z","timestamp":1771132644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/4\/688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["foods15040688"],"URL":"https:\/\/doi.org\/10.3390\/foods15040688","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]}}}