{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:10:04Z","timestamp":1793823004225,"version":"4.6.1"},"reference-count":233,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"USDA-National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2022-38821-37357"],"award-info":[{"award-number":["2022-38821-37357"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Hypertension is a major controllable risk factor associated with cardiovascular disease, myocardial infarction, stroke, heart failure, and end-stage diabetes. While commercial antihypertensive drugs are effective in managing high blood pressure, they often come with a range of side effects. Additionally, individuals who begin anti-hypertensive treatment may need to continue these medications throughout their lifetime. In response to these challenges, recent studies have focused on the potential of antihypertensive peptides and hydrolysates derived from food proteins. Food protein-derived peptides and hydrolysates help lower blood pressure (hypertension) primarily by inhibiting the renin\u2013angiotensin system (RAS). Some peptides or protein hydrolysates derived from milk and fish have been proven to be safe and effective anti-hypertensive products, and they are currently on the market. The bioactive peptides and hydrolysates derived from plant proteins with a long history of safe consumption are generally considered safe and have shown some advantages over animal protein-derived peptides. This review provides an up-to-date overview of plant protein-derived antihypertensive peptides and hydrolysates, covering their ACE- and renin-inhibiting activities and mechanisms, in vivo and clinical evidence, bioavailability, production and commercialization challenges, and perspectives for future research.<\/jats:p>","DOI":"10.3390\/foods15050900","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:19:21Z","timestamp":1772720361000},"page":"900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antihypertensive Peptides and Hydrolysates Derived from Plant Proteins and Their Bioavailability"],"prefix":"10.3390","volume":"15","author":[{"given":"Seyi David","family":"Adebayo","sequence":"first","affiliation":[{"name":"Department of Family and Consumer Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9345-3005","authenticated-orcid":false,"given":"Sukanya","family":"Poddar","sequence":"additional","affiliation":[{"name":"Department of Family and Consumer Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-8278","authenticated-orcid":false,"given":"Jianmei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Family and Consumer Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, February 20). Hypertension. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hypertension."},{"key":"ref_2","unstructured":"Fryar, C.D., Kit, B., Carroll, M.D., and Afful, J. (2025, September 08). Hypertension Prevalence, Awareness, Treatment, and Control among Adults Age 18 and Older: United States, August 2021\u2013August 2023, Available online: https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db511.htm."},{"key":"ref_3","unstructured":"(2026, February 20). Centers for Disease Control and Prevention Multiple Cause of Death Data on CDC WONDER, Available online: https:\/\/wonder.cdc.gov\/mcd.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1161\/CIR.0000000000001258","article-title":"Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory from the American Heart Association","volume":"150","author":"Kazi","year":"2024","journal-title":"Circulation"},{"key":"ref_5","unstructured":"Fountain, J.H., Kaur, J., and Lappin, S.L. (2023). Renin Angiotensin System. Physiology, StatPearls Publishing."},{"key":"ref_6","unstructured":"Khalil, H., and Zeltser, R. (2023). Antihypertensive Medications. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.peptides.2008.02.005","article-title":"The Antihypertensive Effect of Peptides: A Novel Alternative to Drugs?","volume":"29","author":"Hong","year":"2008","journal-title":"Peptides"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s42485-023-00106-8","article-title":"Comprehensive Review on Some Food-Derived Bioactive Peptides with Anti-Hypertension Therapeutic Potential for Angiotensin-Converting Enzyme (ACE) Inhibition","volume":"14","author":"Olalere","year":"2023","journal-title":"J. Proteins Proteom."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12648","DOI":"10.1111\/jfbc.12648","article-title":"Food Protein-Derived Renin-Inhibitory Peptides: In Vitro and in Vivo Properties","volume":"43","author":"Aluko","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1021\/acs.jafc.1c06289","article-title":"Bioactive Peptides: From Basic Research to Clinical Trials and Commercialization","volume":"70","author":"Duffuler","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jff.2019.04.050","article-title":"Regulatory Requirements of Bioactive Peptides (Protein Hydrolysates) from Food Proteins","volume":"58","author":"Chalamaiah","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18014","DOI":"10.1038\/nrdp.2018.14","article-title":"Hypertension","volume":"4","author":"Oparil","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_13","first-page":"547809","article-title":"Essential Hypertension: An Approach to Its Etiology and Neurogenic Pathophysiology","volume":"2013","year":"2013","journal-title":"Int. J. Hypertens."},{"key":"ref_14","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/HYPERTENSIONAHA.124.24137","article-title":"Closing the Gap in Global Disparities in Hypertension Control","volume":"82","author":"Mishra","year":"2025","journal-title":"Hypertension"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","article-title":"Global Epidemiology, Health Burden and Effective Interventions for Elevated Blood Pressure and Hypertension","volume":"18","author":"Zhou","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1681\/ASN.2006111199","article-title":"A Population-Based, Prospective Study of Blood Pressure and Risk for End-Stage Renal Disease in China","volume":"18","author":"Reynolds","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The Global Epidemiology of Hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/jamacardio.2019.5306","article-title":"Sex Differences in Blood Pressure Trajectories Over the Life Course","volume":"5","author":"Ji","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_20","unstructured":"Ostchega, Y., Fryar, C.D., Nwankwo, T., and Nguyen, D.T. (2025, September 08). Hypertension Prevalence among Adults Aged 18 and over: United States, 2017\u20132018, Available online: https:\/\/stacks.cdc.gov\/view\/cdc\/87559."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.1161\/CIR.0000000000000534","article-title":"Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association","volume":"136","author":"Carnethon","year":"2017","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/HYPERTENSIONAHA.115.06853","article-title":"Effects of Different Dietary Interventions on Blood Pressure","volume":"67","author":"Gay","year":"2016","journal-title":"Hypertension"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/jch.13535","article-title":"Salt-Induced Effects on Microvascular Function: A Critical Factor in Hypertension Mediated Organ Damage","volume":"21","author":"Marketou","year":"2019","journal-title":"J. Clin. Hypertens."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R546","DOI":"10.1152\/ajpregu.00491.2005","article-title":"Role of Potassium in Regulating Blood Flow and Blood Pressure","volume":"290","author":"Haddy","year":"2006","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7326\/0003-4819-136-7-200204020-00006","article-title":"Effect of Aerobic Exercise on Blood Pressure","volume":"136","author":"Whelton","year":"2002","journal-title":"Ann. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/IJNRD.S39739","article-title":"Obesity, Hypertension, and Chronic Kidney Disease","volume":"7","author":"Hall","year":"2014","journal-title":"Int. J. Nephrol. Renov. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"(1997). The Trials of Hypertension Prevention Collaborative Research Group Effects of Weight Loss and Sodium Reduction Intervention on Blood Pressure and Hypertension Incidence in Overweight People with High-Normal Blood Pressure: The Trials of Hypertension Prevention, Phase II. Arch. Intern. Med., 157, 657\u2013667.","DOI":"10.1001\/archinte.1997.00440270105009"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1056\/NEJM200101043440101","article-title":"Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet","volume":"344","author":"Sacks","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.1997.03540440058033","article-title":"Effects of Oral Potassium on Blood Pressure: Meta-Analysis of Randomized Controlled Clinical Trials","volume":"277","author":"Whelton","year":"1997","journal-title":"JAMA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1016\/S2468-2667(17)30003-8","article-title":"The Effect of a Reduction in Alcohol Consumption on Blood Pressure: A Systematic Review and Meta-Analysis","volume":"2","author":"Roerecke","year":"2017","journal-title":"Lancet Public Health"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"(1997). The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch. Intern. Med., 157, 2413\u20132446.","DOI":"10.1001\/archinte.1997.00440420033005"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.HYP.0000253780.36691.4f","article-title":"Aliskiren Reduces Blood Pressure and Suppresses Plasma Renin Activity in Combination with a Thiazide Diuretic, an Angiotensin-Converting Enzyme Inhibitor, or an Angiotensin Receptor Blocker","volume":"49","author":"Barton","year":"2007","journal-title":"Hypertension"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/s41371-018-0149-8","article-title":"The Role of Aliskiren in the Management of Hypertension and Major Cardiovascular Outcomes: A Systematic Review and Meta-Analysis","volume":"33","author":"Bjerre","year":"2019","journal-title":"J. Hum. Hypertens."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phrs.2017.07.026","article-title":"Antihypertensive Drugs","volume":"124","author":"Laurent","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mancia, G., Grassi, G., Rosei, E.A., Dominiczak, A., and Kjeldsen, S. (2019). Manual of Hypertension of the European Society of Hypertension, CRC Press. [3rd ed.].","DOI":"10.1201\/9780429199189"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3109\/07853890.2015.1078905","article-title":"Nutraceuticals for Blood Pressure Control","volume":"47","author":"Sirtori","year":"2015","journal-title":"Ann. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"177866","DOI":"10.1016\/j.ejphar.2025.177866","article-title":"Clinical Significance of Intervention in the Renin-Angiotensin-Aldosterone-Apelinergic System","volume":"1003","author":"Wagenaar","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"131152","DOI":"10.1016\/j.ijbiomac.2024.131152","article-title":"A Novel Angiotensin I-Converting Enzyme Inhibitory Peptide from Walnut (Juglans Sigillata) Protein Hydrolysates and Its Evaluation in Ang II-Induced HUVECs and Hypertensive Rats","volume":"266","author":"Xie","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1021\/bi00815a005","article-title":"Isolation of Bradykinin-Potentiating Peptides from Bothrops Jararaca Venom","volume":"9","author":"Ferreira","year":"1970","journal-title":"Biochemistry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/1541-4337.12711","article-title":"Activity and Bioavailability of Food Protein-Derived Angiotensin-I-Converting Enzyme\u2013Inhibitory Peptides","volume":"20","author":"Xue","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10989-019-09823-5","article-title":"A Review on Bioactive Peptides: Physiological Functions, Bioavailability and Safety","volume":"26","author":"Bhandari","year":"2020","journal-title":"Int. J. Pept. Res. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cofs.2014.09.005","article-title":"Bioactive Peptides and Protein Hydrolysates: Research Trends and Challenges for Application as Nutraceuticals and Functional Food Ingredients","volume":"1","year":"2015","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Liao, W., Sun, G., Xu, D., Wang, Y., Lu, Y., Sun, J., Xia, H., and Wang, S. (2021). The Blood-Pressure-Lowering Effect of Food-Protein-Derived Peptides: A Meta-Analysis of Recent Clinical Trials. Foods, 10.","DOI":"10.3390\/foods10102316"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.afnr.2016.10.003","article-title":"Protein Hydrolysates and Biopeptides: Production, Biological Activities, and Applications in Foods and Health Benefits. A Review","volume":"Volume 81","year":"2017","journal-title":"Advances in Food and Nutrition Research"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.crfs.2022.10.031","article-title":"Advances in the Stability Challenges of Bioactive Peptides and Improvement Strategies","volume":"5","author":"Pei","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Daskaya-Dikmen, C., Yucetepe, A., Karbancioglu-Guler, F., Daskaya, H., and Ozcelik, B. (2017). Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants. Nutrients, 9.","DOI":"10.3390\/nu9040316"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00394-008-0710-2","article-title":"Bioactive Peptides and Proteins from Foods: Indication for Health Effects","volume":"47","author":"Roos","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"130494","DOI":"10.1016\/j.foodchem.2021.130494","article-title":"Isolation and Functionalities of Bioactive Peptides from Fruits and Vegetables: A Reviews","volume":"366","author":"Sosalagere","year":"2022","journal-title":"Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jfutfo.2022.03.003","article-title":"Review on Plant-Derived Bioactive Peptides: Biological Activities, Mechanism of Action and Utilizations in Food Development","volume":"2","author":"Fan","year":"2022","journal-title":"J. Future Foods"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cofs.2021.01.002","article-title":"In Vivo Bioactivities of Food Protein-Derived Peptides\u2014A Current Review","volume":"39","author":"Daroit","year":"2021","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Garbacz, K., Wawrzykowski, J., Czelej, M., Czernecki, T., and Wa\u015bko, A. (2023). Recent Trends in the Application of Oilseed-Derived Protein Hydrolysates as Functional Foods. Foods, 12.","DOI":"10.3390\/foods12203861"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0308-8146(00)00337-X","article-title":"Characteristics and Composition of Different Seed Oils and Flours","volume":"74","author":"Taha","year":"2001","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.foodchem.2006.08.012","article-title":"Peanut Protein Concentrate: Production and Functional Properties as Affected by Processing","volume":"103","author":"Yu","year":"2007","journal-title":"Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"113545","DOI":"10.1016\/j.lwt.2022.113545","article-title":"The Influence of Enzymatic Pretreatment of Chickpea on Properties of Protein Nanoparticles Prepared by Heat Treatment","volume":"163","author":"Antov","year":"2022","journal-title":"LWT"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1111\/ijfs.17466","article-title":"Emerging Protein Sources and Novel Extraction Techniques: A Systematic Review on Sustainable Approaches","volume":"59","author":"Jain","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21776\/ub.jtp.2024.025.01.1","article-title":"Study of Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from Ficus pumila var. awkeotsang Seeds Hydrolysate","volume":"25","author":"Ningrum","year":"2024","journal-title":"J. Teknol. Pertan."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Poddar, S., and Yu, J. (2024). Angiotensin-Converting Enzyme and Renin-Inhibitory Activities of Protein Hydrolysates Produced by Alcalase Hydrolysis of Peanut Protein. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137463"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"115254","DOI":"10.1016\/j.lwt.2023.115254","article-title":"Identification and Mechanistic Study of Four Novel ACE Inhibitory Peptides from Maize Germ Protein Hydrolysates","volume":"186","author":"Liu","year":"2023","journal-title":"LWT"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100147","DOI":"10.1016\/j.fochms.2022.100147","article-title":"Inhibition Kinetics, Molecular Docking, and Stability Studies of the Effect of Papain-Generated Peptides from Palm Kernel Cake Proteins on Angiotensin-Converting Enzyme (ACE)","volume":"5","author":"Zarei","year":"2022","journal-title":"Food Chem. Mol. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100047","DOI":"10.1016\/j.fochms.2021.100047","article-title":"Enzymatic Hydrolysis and Microbial Fermentation: The Most Favorable Biotechnological Methods for the Release of Bioactive Peptides","volume":"3","author":"Aguilar","year":"2021","journal-title":"Food Chem. Mol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jaoac\/70.1.147","article-title":"Acid Hydrolysis of Proteins for Chromatographic Analysis of Amino Acids","volume":"70","author":"Zumwalt","year":"1987","journal-title":"J. AOAC Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"H121","DOI":"10.1111\/j.1750-3841.2009.01145.x","article-title":"Characterization and ACE-Inhibitory Activity of Amaranth Proteins","volume":"74","author":"Tiengo","year":"2009","journal-title":"J. Food Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1021\/jf500849u","article-title":"Savinase, the Most Suitable Enzyme for Releasing Peptides from Lentil (Lens culinaris Var. Castellana) Protein Concentrates with Multifunctional Properties","volume":"62","author":"Frias","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Goyal, N., Hajare, S.N., and Gautam, S. (2023). Release of an Encrypted, Highly Potent ACE-Inhibitory Peptide by Enzymatic Hydrolysis of Moth Bean (Vigna aconitifolia) Protein. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1167259"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1021\/jf505037p","article-title":"HPLC-Q-TOF-MS Identification of Antioxidant and Antihypertensive Peptides Recovered from Cherry (Prunus cerasus L.) Subproducts","volume":"63","author":"Endermann","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/1541-4337.12326","article-title":"Biotechnological Applications of Proteases in Food Technology","volume":"17","author":"Tavano","year":"2018","journal-title":"Comp. Rev. Food Sci. Food Safe"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1002\/jsfa.7509","article-title":"Relationships between the Structure of Wheat Gluten and ACE Inhibitory Activity of Hydrolysate: Stepwise Multiple Linear Regression Analysis","volume":"96","author":"Zhang","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3923\/ajft.2009.226.240","article-title":"Optimization of Enzymatic Hydrolysis of Defatted Sesame Flour by Different Proteases and Their Effect on the Functional Properties of the Resulting Protein Hydrolysate","volume":"4","author":"Kanu","year":"2009","journal-title":"Am. J. Food Technol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3746\/pnf.2025.30.4.379","article-title":"Two Optimized Cysteine Protease-Aided Protein Hydrolysates of Soybean Tempeh Inhibit Angiotensin-Converting Enzyme Activity In Vitro","volume":"30","author":"Sukrasno","year":"2025","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.foodhyd.2017.10.022","article-title":"Effect of Ethanol on the Solubilization of Hydrophobic Molecules by Sodium Caseinate","volume":"77","author":"Qu","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1021\/acs.analchem.0c02194","article-title":"Organic Solvents for Enhanced Proteolysis of Stable Proteins for Hydrogen\u2013Deuterium Exchange Mass Spectrometry","volume":"92","author":"Guo","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1111\/1750-3841.15902","article-title":"Desalination of Duck Egg White by Biocoagulation to Obtain Peptide-ferrous Chelate as Iron Delivery System: Preparation, Characterization, and Fe2+ Release Evaluation in Vitro","volume":"86","author":"Shi","year":"2021","journal-title":"J. Food Sci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ratnaningsih, E., Reynard, R., Khoiruddin, K., Wenten, I.G., and Boopathy, R. (2021). Recent Advancements of UF-Based Separation for Selective Enrichment of Proteins and Bioactive Peptides\u2014A Review. Appl. Sci., 11.","DOI":"10.3390\/app11031078"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1021\/acs.joc.3c01494","article-title":"Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis","volume":"89","author":"Kekessie","year":"2024","journal-title":"J. Org. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Chakrabarti, S., Guha, S., and Majumder, K. (2018). Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients, 10.","DOI":"10.3390\/nu10111738"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jff.2013.01.024","article-title":"Purification and Hypotensive Activity of Rapeseed Protein-Derived Renin and Angiotensin Converting Enzyme Inhibitory Peptides","volume":"5","author":"He","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.foodres.2012.12.003","article-title":"Renin and Angiotensin Converting Enzyme Inhibition with Antioxidant Properties of African Yam Bean Protein Hydrolysate and Reverse-Phase HPLC-Separated Peptide Fractions","volume":"52","author":"Ajibola","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.foodres.2013.11.015","article-title":"Blood Pressure Lowering Effects of Australian Canola Protein Hydrolysates in Spontaneously Hypertensive Rats","volume":"55","author":"Alashi","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s11746-011-1841-9","article-title":"Kinetics of Enzyme Inhibition and Antihypertensive Effects of Hemp Seed (Cannabis sativa L.) Protein Hydrolysates","volume":"88","author":"Girgih","year":"2011","journal-title":"J. Americ. Oil Chem. Soc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2621.2000.tb16049.x","article-title":"Classification and Antihypertensive Activity of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Food Proteins","volume":"65","author":"Iroyukifujita","year":"2000","journal-title":"J. Food Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0162-3109(99)00118-6","article-title":"LKPNM: A Prodrug-Type ACE-Inhibitory Peptide Derived from Fish Protein","volume":"44","author":"Fujita","year":"1999","journal-title":"Immunopharmacology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0271-5317(04)00058-2","article-title":"Angiotensin I\u2013Converting Enzyme Inhibitory Peptides Derived from Food Proteins and Their Physiological and Pharmacological Effects","volume":"24","author":"Li","year":"2004","journal-title":"Nutr. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"478","DOI":"10.33003\/fjs-2020-0402-140","article-title":"Renin-Inhibitory Bioactive Peptides with Antihypertensive Property: A Review","volume":"4","author":"Saliu","year":"2020","journal-title":"Fudma J. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"128719","DOI":"10.1016\/j.foodchem.2020.128719","article-title":"Recently Isolated Food-Derived Antihypertensive Hydrolysates and Peptides: A Review","volume":"346","author":"Kaur","year":"2021","journal-title":"Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.foodchem.2017.02.039","article-title":"Antihypertensive Peptides from Animal Products, Marine Organisms, and Plants","volume":"228","author":"Lee","year":"2017","journal-title":"Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wei, Y., Liu, Y., Li, Y., Wang, X., Zheng, Y., Xu, J., Sang, S., and Liu, Y. (2022). A Novel Antihypertensive Pentapeptide Identified in Quinoa Bran Globulin Hydrolysates: Purification, In Silico Characterization, Molecular Docking with ACE and Stability against Different Food-Processing Conditions. Nutrients, 14.","DOI":"10.3390\/nu14122420"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"113613","DOI":"10.1016\/j.lwt.2022.113613","article-title":"In Vitro Gastrointestinal Digestion Study and Identification of Novel Angiotensin I-Converting Enzyme Inhibitory Peptide from Broccoli (Brassica oleracea)","volume":"164","author":"Zhang","year":"2022","journal-title":"LWT"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zhu, Q., Xue, J., Wang, P., Wang, X., Zhang, J., Fang, X., He, Z., and Wu, F. (2023). Identification of a Novel ACE Inhibitory Hexapeptide from Camellia Seed Cake and Evaluation of Its Stability. Foods, 12.","DOI":"10.3390\/foods12030501"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"100324","DOI":"10.1016\/j.focha.2023.100324","article-title":"Health-Promoting Activities of Moringa Oleifera Lam. Seeds Protein Hydrolysates and Its Ultra-Filtered Peptide Fractions","volume":"2","author":"Liu","year":"2023","journal-title":"Food Chem. Adv."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"8994","DOI":"10.1039\/D1FO01103K","article-title":"Antihypertensive Activity of the ACE\u2013Renin Inhibitory Peptide Derived from Moringa oleifera Protein","volume":"12","author":"Ma","year":"2021","journal-title":"Food Funct."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"107702","DOI":"10.1016\/j.fbio.2025.107702","article-title":"The Antihypertensive Activity of Lotus Seed Protein Hydrolysates and the Identification of Antihypertensive Peptides","volume":"73","author":"Tian","year":"2025","journal-title":"Food Biosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11130-025-01426-4","article-title":"Perilla Frutescens Seeds as a Source of Antihypertensive Peptides: Discovery of Novel Tetrapeptides with ACE Inhibitory Activity","volume":"80","author":"Hung","year":"2025","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Zhang, L., Pan, D., Shao, L., Zheng, Y., Hao, W., Kan, Y., Cao, J., Yu, H., and Liu, J. (2023). Oil Palm Kernel Globulin Antihypertensive Peptides: Isolation and Characterization, ACE Inhibition Mechanisms, Zinc-Chelating Activity, Security and Stability. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1225256"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105604","DOI":"10.1016\/j.jff.2023.105604","article-title":"Peptides Isolated from Black Soybean Synergistically Inhibit the Activity of Angiotensin Converting Enzyme (ACE)","volume":"106","author":"Shao","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10909","DOI":"10.1021\/acs.jafc.4c00609","article-title":"Two Novel Angiotensin-Converting Enzyme (ACE) Inhibitory and ACE2 Upregulating Peptides from the Hydrolysate of Pumpkin (Cucurbita moschata) Seed Meal","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wu, F., Luo, X., Zhang, Y., Wang, P., Chang, Y., He, Z., and Liu, X. (2023). Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya Grandis. Nutrients, 15.","DOI":"10.3390\/nu15102374"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"101135","DOI":"10.1016\/j.crfs.2025.101135","article-title":"Identification of Novel Angiotensin I-Converting Enzyme Inhibitory Peptides from Walnut (Juglans Sigillata Dode) Protein Hydrolysates and Their Vascular Endothelial Protective Properties: In Silico and in Vitro Studies","volume":"11","author":"Xiong","year":"2025","journal-title":"Curr. Res. Food Sci."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhang, Y., Qi, Q., Liang, F., Wang, N., Chen, Q., Li, X., Sun, S., Wang, X., and Bai, K. (2023). Preparation and Activity Evaluation of Angiotensin-I Converting Enzyme Inhibitory Peptides from Protein Hydrolysate of Mulberry Leaf. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1064526"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.procbio.2023.03.006","article-title":"Purification and Molecular Docking of Angiotensin Converting Enzyme-Inhibitory Peptides Derived from Corn Gluten Meal Hydrolysate and from in Silico Gastrointestinal Digestion","volume":"129","author":"Wongngam","year":"2023","journal-title":"Process Biochem."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Wang, X., Guo, M., Yan, X., Zhuang, Y., Sun, Y., and Li, J. (2022). Two Novel Antihypertensive Peptides Identified in Millet Bran Glutelin-2 Hydrolysates: Purification, In Silico Characterization, Molecular Docking with ACE and Stability in Various Food Processing Conditions. Foods, 11.","DOI":"10.3390\/foods11091355"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00044-023-03167-y","article-title":"Characterization of Novel Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from Taiwan Red Quinoa (Chenopodium formosanum Koidz.) Seed Proteins Using Two Sequential Bioassay-Guided Fractionations","volume":"33","author":"Suleman","year":"2024","journal-title":"Med. Chem. Res."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, J., Cheng, C., Zheng, Y., Li, H., Zhu, Z., Yan, Y., Hao, W., and Qin, N. (2023). Study on the In Silico Screening and Characterization, Inhibition Mechanisms, Zinc-Chelate Activity, and Stability of ACE-Inhibitory Peptides Identified in Naked Oat Bran Albumin Hydrolysates. Foods, 12.","DOI":"10.3390\/foods12112268"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Dai, H., He, M., Hu, G., Li, Z., Al-Romaima, A., Wu, Z., Liu, X., and Qiu, M. (2023). Discovery of ACE Inhibitory Peptides Derived from Green Coffee Using In Silico and In Vitro Methods. Foods, 12.","DOI":"10.3390\/foods12183480"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Prangthip, P., Panbangred, W., and Reamtong, O. (2023). Potential Antihypertensive Activity of Novel Peptides from Green Basil Leaves. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-04098-2"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.procbio.2024.01.022","article-title":"Inhibitory Activity of Angiotensin-I Converting Enzyme (ACE-I) from Partially Purified Phaseolus Lunatus Peptide Fractions","volume":"139","year":"2024","journal-title":"Process Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"135082","DOI":"10.1016\/j.foodchem.2022.135082","article-title":"Novel Antihypertensive Peptides from Lupin Protein Hydrolysate: An in-Silico Identification and Molecular Docking Studies","volume":"407","author":"Fadimu","year":"2023","journal-title":"Food Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"439","DOI":"10.47836\/ifrj.30.2.14","article-title":"ACE-Inhibitory Activity of Seed Storage Proteins and Hydrolysates from Job\u2019s Tears (Coix lacryma-jobi L.)","volume":"30","author":"Sarnthima","year":"2023","journal-title":"Int. Food Res. J."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Llontop-Bernab\u00e9, K.S., Intiquilla, A., Ramirez-Veliz, C., Santos, M., Jim\u00e9nez-Aliaga, K., Zavaleta, A.I., Paterson, S., and Hern\u00e1ndez-Ledesma, B. (2025). Production of Multifunctional Hydrolysates from the Lupinus Mutabilis Protein Using a Micrococcus Sp. PC7 Protease. BioTech, 14.","DOI":"10.3390\/biotech14020032"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e107921","DOI":"10.1590\/fst.107921","article-title":"Isolation, Purification and Bioactivity of ACE Inhibitory Peptides from Peach Kernel Protein Enzymatic Hydrolysate","volume":"42","author":"Wang","year":"2022","journal-title":"Food Sci. Technol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Chaipoot, S., Punfa, W., Ounjaijean, S., Phongphisutthinant, R., Kulprachakarn, K., Parklak, W., Phaworn, L., Rotphet, P., and Boonyapranai, K. (2022). Antioxidant, Anti-Diabetic, Anti-Obesity, and Antihypertensive Properties of Protein Hydrolysate and Peptide Fractions from Black Sesame Cake. Molecules, 28.","DOI":"10.3390\/molecules28010211"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"145011","DOI":"10.1016\/j.foodchem.2025.145011","article-title":"ACE-Inhibitory Peptides from Morchella Esculenta: Screening, Kinetics, and Molecular Dynamics Simulation","volume":"490","author":"Zeng","year":"2025","journal-title":"Food Chem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Shi, A., Liu, H., Liu, L., Hu, H., Wang, Q., and Adhikari, B. (2014). Isolation, Purification and Molecular Mechanism of a Peanut Protein-Derived ACE-Inhibitory Peptide. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111188"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1021\/jf000695n","article-title":"Hypotensive and Physiological Effect of Angiotensin Converting Enzyme Inhibitory Peptides Derived from Soy Protein on Spontaneously Hypertensive Rats","volume":"49","author":"Wu","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e12572","DOI":"10.1111\/jfbc.12572","article-title":"Molecular Interactions, Bioavailability, and Cellular Mechanisms of Angiotensin-Converting Enzyme Inhibitory Peptides","volume":"43","author":"Fan","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"118131","DOI":"10.1016\/j.lwt.2025.118131","article-title":"Structure-Activity Relationship Analysis of the ACE Inhibitory Activity of Three Walnut Protein Hydrolysates and Elucidation of the ACE Inhibitory Mechanism of Its Derived Peptides","volume":"228","author":"Zhang","year":"2025","journal-title":"LWT"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1263\/jbb.106.310","article-title":"Angiotensin-I Converting Enzyme (ACE) Inhibitory Mechanism of Tripeptides Containing Aromatic Residues","volume":"106","author":"Kobayashi","year":"2008","journal-title":"J. Biosci. Bioeng."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Li, J., Liu, Z., Zhao, Y., Zhu, X., Yu, R., Dong, S., and Wu, H. (2018). Novel Natural Angiotensin Converting Enzyme (ACE)-Inhibitory Peptides Derived from Sea Cucumber-Modified Hydrolysates by Adding Exogenous Proline and a Study of Their Structure\u2013Activity Relationship. Mar. Drugs, 16.","DOI":"10.3390\/md16080271"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Ma, M., Feng, Y., Miao, Y., Shen, Q., Tang, S., Dong, J., Zhang, J.Z.H., and Zhang, L. (2023). Revealing the Sequence Characteristics and Molecular Mechanisms of ACE Inhibitory Peptides by Comprehensive Characterization of 160,000 Tetrapeptides. Foods, 12.","DOI":"10.3390\/foods12081573"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1093\/oxfordjournals.jbchem.a132692","article-title":"Stereospecificity of Peptidyl Dipeptide Hydrolase (Angiotensin I-Converting Enzyme)","volume":"86","author":"Oshima","year":"1979","journal-title":"J. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/bi00605a004","article-title":"13C Nuclear Magnetic Resonance Study of the Cis-Trans Isomerism in X-Pro-Pro Tripeptides","volume":"17","author":"London","year":"1978","journal-title":"Biochemistry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/BTT.S54056","article-title":"Does the Cis\/Trans Configuration of Peptide Bonds in Bioactive Tripeptides Play a Role in ACE-1 Enzyme Inhibition?","volume":"8","author":"Valjakka","year":"2014","journal-title":"Biol. Targets Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00217-014-2271-3","article-title":"Angiotensin-I-Converting Enzyme Inhibitory, Antimicrobial, and Antioxidant Effect of Bioactive Peptides Obtained from Different Varieties of Common Beans (Phaseolus vulgaris L.) with in Vivo Antihypertensive Activity in Spontaneously Hypertensive Rats","volume":"239","year":"2014","journal-title":"Eur. Food Res. Technol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jff.2015.01.031","article-title":"Kinetics of in Vitro Renin and Angiotensin Converting Enzyme Inhibition by Chicken Skin Protein Hydrolysates and Their Blood Pressure Lowering Effects in Spontaneously Hypertensive Rats","volume":"14","author":"Onuh","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ncpneph0444","article-title":"Mechanisms of Disease: The Tissue Kallikrein\u2013Kinin System in Hypertension and Vascular Remodeling","volume":"3","author":"Madeddu","year":"2007","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9854","DOI":"10.1021\/jf201911p","article-title":"Blood Pressure Lowering Effect of a Pea Protein Hydrolysate in Hypertensive Rats and Humans","volume":"59","author":"Li","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s00726-011-0833-2","article-title":"Quantitative Structure\u2013Activity Relationship Modeling of Renin-Inhibiting Dipeptides","volume":"42","author":"Udenigwe","year":"2012","journal-title":"Amino Acids"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jff.2009.01.009","article-title":"Kinetics of the Inhibition of Renin and Angiotensin I-Converting Enzyme by Flaxseed Protein Hydrolysate Fractions","volume":"1","author":"Udenigwe","year":"2009","journal-title":"J. Funct. Foods"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/ijfs.13449","article-title":"High-pressure Microfluidisation Pretreatment Disaggregate Peanut Protein Isolates to Prepare Antihypertensive Peptide Fractions","volume":"52","author":"Gong","year":"2017","journal-title":"Int. J. Food Sci. Tech."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.procbio.2024.01.014","article-title":"Identification of Novel Renin Inhibitory Peptides from Tartary Buckwheat Albumin Hydrolysates by Molecular Docking","volume":"138","author":"Li","year":"2024","journal-title":"Process Biochem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"103635","DOI":"10.1016\/j.jff.2019.103635","article-title":"Identification of Antihypertensive Peptides from Mung Bean Protein Hydrolysate and Their Effects in Spontaneously Hypertensive Rats","volume":"64","author":"Sonklin","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.3390\/nu7095358","article-title":"Structural and Antihypertensive Properties of Enzymatic Hemp Seed Protein Hydrolysates","volume":"7","author":"Malomo","year":"2015","journal-title":"Nutrients"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"103683","DOI":"10.1016\/j.jff.2019.103683","article-title":"Identification of Renin Inhibitors Peptides from Amaranth Proteins by Docking Protocols","volume":"64","author":"Nardo","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e13090","DOI":"10.1111\/jfbc.13090","article-title":"Antihypertensive and Antioxidant Activities of Enzymatic Wheat Bran Protein Hydrolysates","volume":"44","author":"Zou","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/fsn3.740","article-title":"Antioxidant Properties, ACE\/Renin Inhibitory Activities of Pigeon Pea Hydrolysates and Effects on Systolic Blood Pressure of Spontaneously Hypertensive Rats","volume":"6","author":"Olagunju","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jsfa.8543","article-title":"In Vitro Renin\u2013Angiotensin System Inhibition and in Vivo Antihypertensive Activity of Peptide Fractions from Lima Bean (Phaseolus lunatus L.)","volume":"98","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/hr.2013.79","article-title":"Effects of Black Soy Peptide Supplementation on Blood Pressure and Oxidative Stress: A Randomized Controlled Trial","volume":"36","author":"Kwak","year":"2013","journal-title":"Hypertens. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"104255","DOI":"10.1016\/j.jff.2020.104255","article-title":"The Soybean Bioactive Peptide VHVV Alleviates Hypertension-Induced Renal Damage in Hypertensive Rats via the SIRT1-PGC1\u03b1\/Nrf2 Pathway","volume":"75","author":"Tsai","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"123138","DOI":"10.1016\/j.ijbiomac.2023.123138","article-title":"Purification, Molecular Docking and in Vivo Analyses of Novel Angiotensin-Converting Enzyme Inhibitory Peptides from Protein Hydrolysate of Moth Bean (Vigna aconitifolia (Jacq.) M\u00e0rechal) Seeds","volume":"230","author":"Bhadkaria","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jff.2016.05.016","article-title":"Angiotensin I-Converting Enzyme Inhibitory and Antihypertensive Properties of Potato and Rapeseed Protein-Derived Peptides","volume":"25","author":"Streng","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_140","first-page":"1313","article-title":"Structures and Activity of Angiotensin-Converting Enzyme Inhibitors in an \u03b1-Zein Hydrolysate","volume":"55","author":"Miyoshi","year":"1991","journal-title":"Agric. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/food.200390081","article-title":"Isolation and Characterization of Angiotensin I-converting Enzyme Inhibitory Peptides from Wheat Gliadin Hydrolysate","volume":"47","author":"Motoi","year":"2003","journal-title":"Nahrung"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.jff.2013.07.013","article-title":"Angiotensin-I Converting Enzyme (ACE) Inhibitory Tripeptides from Rice Protein Hydrolysate: Purification and Characterization","volume":"5","author":"Chen","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_143","first-page":"275","article-title":"Antihypertensive Effect of Rice Protein Hydrolysate with in Vitro Angiotensin I-Converting Enzyme Inhibitory Activity in Spontaneously Hypertensive Rats","volume":"16","author":"Li","year":"2007","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.lwt.2016.08.047","article-title":"A Novel Antioxidant and ACE Inhibitory Peptide from Rice Bran Protein: Biochemical Characterization and Molecular Docking Study","volume":"75","author":"Wang","year":"2017","journal-title":"LWT"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-143-1-200507050-00004","article-title":"Effect of Soybean Protein on Blood Pressure: A Randomized, Controlled Trial","volume":"143","author":"He","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Ogawa, Y., Shobako, N., Fukuhara, I., Satoh, H., Kobayashi, E., Kusakari, T., Suwa, M., Matsumoto, M., and Ishikado, A. (2019). Rice Bran Supplement Containing a Functional Substance, the Novel Peptide Leu-Arg-Ala, Has Anti-Hypertensive Effects: A Double-Blind, Randomized, Placebo-Controlled Study. Nutrients, 11.","DOI":"10.3390\/nu11040726"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"130690","DOI":"10.1016\/j.foodchem.2021.130690","article-title":"Identification of Novel Antihypertensive Peptides from Wine Lees Hydrolysate","volume":"366","author":"Bravo","year":"2022","journal-title":"Food Chem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"137537","DOI":"10.1016\/j.foodchem.2023.137537","article-title":"Two Novel Angiotensin I-Converting Enzyme Inhibitory Peptides from Garlic Protein: In Silico Screening, Stability, Antihypertensive Effects in Vivo and Underlying Mechanisms","volume":"435","author":"Xiang","year":"2024","journal-title":"Food Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.clnu.2019.05.016","article-title":"Virgin Olive Oil (Unfiltered) Extract Contains Peptides and Possesses ACE Inhibitory and Antihypertensive Activity","volume":"39","author":"Margalef","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.12938\/bmfh.2020-001","article-title":"Influence of Fermented Soy Protein Consumption on Hypertension and Gut Microbial Modulation in Spontaneous Hypertensive Rats","volume":"39","author":"Daliri","year":"2020","journal-title":"Biosci. Microbiota Food Health"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Ch\u00e1vez-Ontiveros, J., Reyes-Moreno, C., Ram\u00edrez-Torres, G.I., Figueroa-Salcido, O.G., Ar\u00e1mburo-G\u00e1lvez, J.G., Montoya-Rodr\u00edguez, A., Ontiveros, N., and Cuevas-Rodr\u00edguez, E.O. (2022). Extrusion Improves the Antihypertensive Potential of a Kabuli Chickpea (Cicer arietinum L.) Protein Hydrolysate. Foods, 11.","DOI":"10.3390\/foods11172562"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Figueroa-Salcido, O.G., Ar\u00e1mburo-G\u00e1lvez, J.G., Mora-Melgem, J.A., Camacho-Cervantes, D.L., Gracia-Valenzuela, M.H., Cuevas-Rodr\u00edguez, E.O., and Ontiveros, N. (2024). Alcalase-Based Chickpea (Cicer arietinum L.) Protein Hydrolysates Efficiently Reduce Systolic Blood Pressure in Spontaneously Hypertensive Rats. Foods, 13.","DOI":"10.3390\/foods13081216"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/09637480500407461","article-title":"In Vitro Intestinal Transport and Antihypertensive Activity of ACE Inhibitory Pea and Whey Digests","volume":"56","author":"Vermeirssen","year":"2005","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Hernndez-Ledesma, B. (2013). Antihypertensive Peptides from Food Proteins. Bioactive Food Peptides in Health and Disease, InTech.","DOI":"10.5772\/3318"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1021\/jf026186y","article-title":"Isolation and Antihypertensive Effect of Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Spinach Rubisco","volume":"51","author":"Yang","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e12571","DOI":"10.1111\/jfbc.12571","article-title":"Influence of Peptide Characteristics on Their Stability, Intestinal Transport, and in Vitro Bioavailability: A Review","volume":"43","author":"Wang","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_157","unstructured":"Caballero, B., Allen, L., and Prentice, A. (2013). Protein Digestion and Bioavailability. Encyclopedia of Human Nutrition, Elsevier. [4th ed.]."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Ozorio, L., Mellinger-Silva, C., Cabral, L.M.C., Jardin, J., Boudry, G., and Dupont, D. (2020). The Influence of Peptidases in Intestinal Brush Border Membranes on the Absorption of Oligopeptides from Whey Protein Hydrolysate: An Ex Vivo Study Using an Ussing Chamber. Foods, 9.","DOI":"10.3390\/foods9101415"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.2527\/1990.6893011x","article-title":"Intestinal Absorption of Protein Hydrolysis Products: A Review","volume":"68","author":"Webb","year":"1990","journal-title":"J. Anim. Sci."},{"key":"ref_160","unstructured":"Abumrad, N.A., Nassi, F., and Marcus, A. (2016). Digestion and Absorption of Dietary Fat, Carbohydrate, and Protein. Fordtran\u2019s Gastrointestinal and Liver Disease, US Elsevier Health."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bpg.2016.02.007","article-title":"Physiology of Intestinal Absorption and Secretion","volume":"30","author":"Kiela","year":"2016","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1111\/1750-3841.13840","article-title":"Identification of Potent ACE Inhibitory Peptides from Wild Almond Proteins","volume":"82","author":"Mirzapour","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.foodchem.2016.10.087","article-title":"Identification, Functional Gastrointestinal Stability and Molecular Docking Studies of Lentil Peptides with Dual Antioxidant and Angiotensin I Converting Enzyme Inhibitory Activities","volume":"221","author":"Frias","year":"2017","journal-title":"Food Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1016\/j.foodchem.2013.04.064","article-title":"LC\u2013MS\/MS Coupled with QSAR Modeling in Characterising of Angiotensin I-Converting Enzyme Inhibitory Peptides from Soybean Proteins","volume":"141","author":"Gu","year":"2013","journal-title":"Food Chem."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Amigo, L., and Hern\u00e1ndez-Ledesma, B. (2020). Current Evidence on the Bioavailability of Food Bioactive Peptides. Molecules, 25.","DOI":"10.3390\/molecules25194479"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1034\/j.1600-0773.2002.900601.x","article-title":"Transport of Peptidomimetic Drugs by the Intestinal Di\/Tri-peptide Transporter, PepT1","volume":"90","author":"Brodin","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0168-3659(01)00427-8","article-title":"Dipeptide Model Prodrugs for the Intestinal Oligopeptide Transporter. Affinity for and Transport via hPepT1 in the Human Intestinal Caco-2 Cell Line","volume":"76","author":"Nielsen","year":"2001","journal-title":"J. Control. Release"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nsmb.2860","article-title":"Selectivity Mechanism of a Bacterial Homolog of the Human Drug-Peptide Transporters PepT1 and PepT2","volume":"21","author":"Guettou","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-5173(00)00564-0","article-title":"A Rapid Screening System to Determine Drug Affinities for the Intestinal Dipeptide Transporter 2: Affinities of ACE Inhibitors","volume":"210","author":"Moore","year":"2000","journal-title":"Int. J. Pharm."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.addr.2016.07.007","article-title":"Oral Absorption of Peptides and Nanoparticles across the Human Intestine: Opportunities, Limitations and Studies in Human Tissues","volume":"106","author":"Lundquist","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1023\/A:1016246629130","article-title":"Transport of Peptidomimetic Renin Inhibitors Across Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for Self-Enhancement of Paracellular Transport Route","volume":"12","author":"Walter","year":"1995","journal-title":"Pharm. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.idairyj.2007.09.006","article-title":"Bioavailability of the Antihypertensive Peptide LHLPLP: Transepithelial Flux of HLPLP","volume":"18","author":"Ramos","year":"2008","journal-title":"Int. Dairy J."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpharm.2005.01.022","article-title":"Current Strategies Used to Enhance the Paracellular Transport of Therapeutic Polypeptides across the Intestinal Epithelium","volume":"294","author":"Johnston","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.peptides.2004.06.009","article-title":"Transport of Angiotensin Peptides across the Caco-2 Monolayer","volume":"25","author":"Chua","year":"2004","journal-title":"Peptides"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0014-2999(94)90714-5","article-title":"Novel Central Action of Des-Asp-Angiotensin I","volume":"257","author":"Sim","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.foodchem.2017.09.032","article-title":"Charge and Hydrophobicity of Casein Peptides Influence Transepithelial Transport and Bioavailability","volume":"245","author":"Wang","year":"2018","journal-title":"Food Chem."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1365-2222.1999.00462.x","article-title":"Peptidases: Structure, Function and Modulation of Peptide-mediated Effects in the Human Lung","volume":"29","author":"Hulsmann","year":"1999","journal-title":"Clin Exp. Allergy"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1248\/bpb.23.427","article-title":"Depressor Effect of Wheat Germ Hydrolysate and Its Novel Angiotensin I-Converting Enzyme Inhibitory Peptide, Ile-Val-Tyr, and the Metabolism in Rat and Human Plasma","volume":"23","author":"Matsui","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nchembio.1907","article-title":"A Biomimetic Approach for Enhancing the in Vivo Half-Life of Peptides","volume":"11","author":"Penchala","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1021\/acs.jafc.1c07438","article-title":"Metabolic Fate and Bioavailability of Food-Derived Peptides: Are Normal Peptides Passed through the Intestinal Layer to Exert Biological Effects via Proposed Mechanisms?","volume":"70","author":"Sato","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ab.2011.02.037","article-title":"Application of 13C Stable Isotope Labeling Liquid Chromatography\u2013Multiple Reaction Monitoring\u2013Tandem Mass Spectrometry Method for Determining Intact Absorption of Bioactive Dipeptides in Rats","volume":"414","author":"Nakashima","year":"2011","journal-title":"Anal. Biochem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/jn\/137.4.953","article-title":"Angiotensin Converting Enzyme Inhibitory Peptides from a Lactotripeptide-Enriched Milk Beverage Are Absorbed Intact into the Circulation1","volume":"137","author":"Foltz","year":"2007","journal-title":"J. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1021\/acs.jafc.8b06896","article-title":"Amount of Collagen in the Meat Contained in Japanese Daily Dishes and the Collagen Peptide Content in Human Blood after Ingestion of Cooked Fish Meat","volume":"67","author":"Asai","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"104","DOI":"10.31665\/JFB.2018.2145","article-title":"Identification of Food-Derived Peptides in Human Blood after Ingestion of Corn and Wheat Gluten Hydrolysates","volume":"2","author":"Ejima","year":"2018","journal-title":"J. Food Bioact."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1021\/jf300497p","article-title":"Identification of Food-Derived Elastin Peptide, Prolyl-Glycine (Pro-Gly), in Human Blood after Ingestion of Elastin Hydrolysate","volume":"60","author":"Shigemura","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_186","first-page":"155","article-title":"Presence of Aspartic Dipeptides with \u03b2 Peptide Bond and\/or D-Aspartyl Residue in Rat Blood after Ingestion of Porcine Liver Protein Hydrolysate","volume":"2","author":"Ejima","year":"2019","journal-title":"Bioact. Compd. Health Dis."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/psc.568","article-title":"Tissue Distribution of Antihypertensive Dipeptide, Val-Tyr, after Its Single Oral Administration to Spontaneously Hypertensive Rats","volume":"10","author":"Matsui","year":"2004","journal-title":"J. Pept. Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/clpt.1982.59","article-title":"Captopril Kinetics","volume":"31","author":"Duchin","year":"1982","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1248\/bpb.35.422","article-title":"Distribution of Prolylhydroxyproline and Its Metabolites after Oral Administration in Rats","volume":"35","author":"Kawaguchi","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Shigemura, Y., Iwasaki, Y., Tateno, M., Suzuki, A., Kurokawa, M., Sato, Y., and Sato, K. (2018). A Pilot Study for the Detection of Cyclic Prolyl-Hydroxyproline (Pro-Hyp) in Human Blood after Ingestion of Collagen Hydrolysate. Nutrients, 10.","DOI":"10.3390\/nu10101356"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"103395","DOI":"10.1016\/j.jff.2019.05.051","article-title":"Identification of Angiotensin Converting Enzyme 2 (ACE2) up-Regulating Peptides from Pea Protein Hydrolysate","volume":"60","author":"Liao","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41538-019-0050-z","article-title":"Pyroglutamyl Leucine, a Peptide in Fermented Foods, Attenuates Dysbiosis by Increasing Host Antimicrobial Peptide","volume":"3","author":"Shirako","year":"2019","journal-title":"npj Sci. Food"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"M\u0142ynarska, E., Wasiak, J., Gajewska, A., Bili\u0144ska, A., Ste\u0107, G., Jasi\u0144ska, J., Rysz, J., and Franczyk, B. (2024). Gut Microbiota and Gut\u2013Brain Axis in Hypertension: Implications for Kidney and Cardiovascular Health\u2014A Narrative Review. Nutrients, 16.","DOI":"10.3390\/nu16234079"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"a034173","DOI":"10.1101\/cshperspect.a034173","article-title":"Vagus Nerve Stimulation and the Cardiovascular System","volume":"10","author":"Capilupi","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1096\/fj.201700333RR","article-title":"Characterization of Soy-deprestatin, a Novel Orally Active Decapeptide That Exerts Antidepressant-like Effects via Gut\u2013Brain Communication","volume":"32","author":"Mori","year":"2018","journal-title":"FASEB J."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tifs.2019.12.022","article-title":"Safety Considerations on Food Protein-Derived Bioactive Peptides","volume":"96","author":"Liu","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1177\/10915818221100700","article-title":"Safety Assessment of Plant-Derived Proteins and Peptides as Used in Cosmetics","volume":"41","author":"Burnett","year":"2022","journal-title":"Int. J. Toxicol."},{"key":"ref_198","unstructured":"Food and Drug Administration (2025, November 27). Authorized Health Claims That Meet the Significant Scientific Agreement (SSA) Standard, Available online: https:\/\/www.fda.gov\/food\/nutrition-food-labeling-and-critical-foods\/authorized-health-claims-meet-significant-scientific-agreement-ssa-standard."},{"key":"ref_199","unstructured":"(2026, February 21). Agriculture and Agri-Food Canada Canada\u2019s Regulatory System for Foods with Health Benefits\u2014An Overview for Industry. Available online: https:\/\/agriculture.canada.ca\/en\/sector\/food-processing-industry\/regulatory-requirements\/health-benefits."},{"key":"ref_200","unstructured":"(2025, November 28). Regulation (EC) No 1924\/2006 of the European Parliament and of the Council of 20 December 2006 on Nutrition and Health Claims Made on Foods, Available online: https:\/\/www.legislation.gov.uk\/eur\/2006\/1924\/contents."},{"key":"#cr-split#-ref_201.1","unstructured":"EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck, D., Bohn, T., Castenmiller, J., de Henauw, S., Hirsch-Ernst, K.I., Maciuk, A., Mangelsdorf, I., McArdle, H.J., and Naska, A. (2024). Guidance on the Scientific Requirements for an Application for Authorisation of a Novel Food in the Context of Regulation"},{"key":"#cr-split#-ref_201.2","unstructured":"(EU) 2015\/2283. EFSA J., 22, e8961."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"115988","DOI":"10.1016\/j.lwt.2024.115988","article-title":"Effect of Limited Hydrolysis with Endopeptidase on Bitterness Properties of Wheat Gluten Hydrolysates","volume":"198","author":"Zhang","year":"2024","journal-title":"LWT"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Sun, X., Zheng, J., Liu, B., Huang, Z., and Chen, F. (2022). Characteristics of the Enzyme-Induced Release of Bitter Peptides from Wheat Gluten Hydrolysates. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1022257"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.1021\/jf0495035","article-title":"Hydrophobicity of Bitter Peptides from Soy Protein Hydrolysates","volume":"52","author":"Cho","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1111\/j.1750-3841.2007.00610.x","article-title":"Evaluation of Bitterness in Enzymatic Hydrolysates of Soy Protein Isolate by Taste Dilution Analysis","volume":"73","author":"Seo","year":"2008","journal-title":"J. Food Sci."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Sawicki, T., Jab\u0142o\u0144ska, M., Danielewicz, A., and Przyby\u0142owicz, K.E. (2024). Phenolic Compounds Profile and Antioxidant Capacity of Plant-Based Protein Supplements. Molecules, 29.","DOI":"10.3390\/molecules29092101"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2408150","DOI":"10.1002\/advs.202408150","article-title":"Toward Diverse Plant Proteins for Food Innovation","volume":"11","author":"Kim","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1111\/ijfs.15163","article-title":"An Arginine Aminopeptidase from Marine Bacillus Axarquiensis SWJSX8 and Its Application in Improving Pumpkin Seed Protein Hydrolysis","volume":"56","author":"Lei","year":"2021","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1111\/1541-4337.13050","article-title":"Review on the Release Mechanism and Debittering Technology of Bitter Peptides from Protein Hydrolysates","volume":"21","author":"Liu","year":"2022","journal-title":"Comp. Rev. Food Sci. Food Safe"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"e70195","DOI":"10.1002\/mnfr.70195","article-title":"Randomized Controlled Trial: Effects of a Bitter-Tasting Pea Protein Hydrolysate Intervention With Low Degree of Hydrolyzation on Energy Intake in Moderately Overweight Male Subjects","volume":"69","author":"Gradl","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"e15932","DOI":"10.1111\/jfpp.15932","article-title":"Characterization of Bioactive Peptides Produced from Green Lentil (Lens culinaris) Seed Protein Concentrate Using Alcalase and Flavourzyme in Single and Sequential Hydrolysis","volume":"45","author":"Rezvankhah","year":"2021","journal-title":"Food Process. Preserv."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"S605","DOI":"10.1111\/j.1750-3841.2007.00475.x","article-title":"Physicochemical and Bitterness Properties of Enzymatic Pea Protein Hydrolysates","volume":"72","author":"Humiski","year":"2007","journal-title":"J. Food Sci."},{"key":"ref_213","unstructured":"Toldr\u00e1, F., and Wu, J. (2021). Encapsulation Technology for Protection and Delivery of Bioactive Peptides. Biologically Active Peptides, Elsevier."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1111\/ijfs.14031","article-title":"Bioactive Phaseolus Lunatus Peptides Release from Maltodextrin\/Gum Arabic Microcapsules Obtained by Spray Drying after Simulated Gastrointestinal Digestion","volume":"54","author":"Cian","year":"2019","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s11947-015-1472-5","article-title":"The Effect of Rapeseed Protein Structural Modification on Microstructural Properties of Peptide Microcapsules","volume":"8","author":"Wang","year":"2015","journal-title":"Food Bioprocess Technol."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Du, T., Xu, J., Zhu, S., Yao, X., Guo, J., and Lv, W. (2022). Effects of Spray Drying, Freeze Drying, and Vacuum Drying on Physicochemical and Nutritional Properties of Protein Peptide Powder from Salted Duck Egg White. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1026903"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1080\/07373937.2021.1906695","article-title":"Encapsulation of Dairy Protein Hydrolysates: Recent Trends and Future Prospects","volume":"39","author":"Giroldi","year":"2021","journal-title":"Dry. Technol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"e4662","DOI":"10.1002\/fsn3.4662","article-title":"Spray-Dried Wheat Gluten Protein Hydrolysate Microcapsules: Physicochemical Properties, Retention of Antioxidant Capability, and Release Behavior Under Simulated Gastrointestinal Digestion Conditions","volume":"13","author":"GanjiVtan","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/07373937.2019.1689399","article-title":"Spray-Drying Encapsulation of Protein Hydrolysates and Bioactive Peptides: Opportunities and Challenges","volume":"38","author":"Sarabandi","year":"2020","journal-title":"Dry. Technol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/07373937.2022.2089162","article-title":"Spray Freeze Drying for Protein Encapsulation: Impact of the Formulation to Morphology and Stability","volume":"41","author":"Baldelli","year":"2023","journal-title":"Dry. Technol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"110099","DOI":"10.1016\/j.foodcont.2023.110099","article-title":"Spray Freeze Drying\u2014A Synergistic Drying Technology and Its Applications in the Food Industry to Preserve Bioactive Compounds","volume":"155","author":"Chhabra","year":"2024","journal-title":"Food Control"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"4765463","DOI":"10.1155\/2017\/4765463","article-title":"Response Surface Optimisation for the Production of Antioxidant Hydrolysates from Stone Fish Protein Using Bromelain","volume":"2017","author":"Auwal","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-P\u00e9rez, V., Jim\u00e9nez-Mart\u00ednez, C., Gonz\u00e1lez-Escobar, J.L., and Corzo-R\u00edos, L.J. (2024). Exploring the Impact of Encapsulation on the Stability and Bioactivity of Peptides Extracted from Botanical Sources: Trends and Opportunities. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1423500"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"103522","DOI":"10.1016\/j.cis.2025.103522","article-title":"Gum Arabic-Protein Coacervation: Recent Advances for Improved Functionality and Food Applications","volume":"342","author":"Khubber","year":"2025","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Mankan, E., Karakas, C.Y., Saroglu, O., Mzoughi, M., Sagdic, O., and Karadag, A. (2025). Food-Grade Liposome-Loaded Delivery Systems: Current Trends and Future Perspectives. Foods, 14.","DOI":"10.3390\/foods14172978"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/02652040400026434","article-title":"Ionotropic Alginate Beads for Controlled Intestinal Protein Delivery: Effect of Chitosan and Barium Counter-Ions on Entrapment and Release","volume":"22","author":"Bhopatkar","year":"2005","journal-title":"J. Microencapsul."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"102787","DOI":"10.1016\/j.fochx.2025.102787","article-title":"Encapsulation of Bioactive Peptides Derived from Sargassum Angustifolium Algae Using Calcium Alginate and Chia Gum","volume":"29","author":"Jafarirad","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3390\/polysaccharides5030028","article-title":"Antihypertensive Amaranth Protein Hydrolysates Encapsulation in Alginate\/Pectin Beads: Influence on Bioactive Properties upon In Vitro Digestion","volume":"5","author":"Aguilar","year":"2024","journal-title":"Polysaccharides"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ijbiomac.2020.12.143","article-title":"Release of Encapsulated Bioactives Influenced by Alginate Viscosity under In-Vitro Gastrointestinal Model","volume":"170","author":"Abraham","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Ten Have, G.A.M., Van Der Pijl, P.C., Kies, A.K., and Deutz, N.E.P. (2015). Enhanced Lacto-Tri-Peptide Bio-Availability by Co-Ingestion of Macronutrients. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130638"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.foodres.2017.06.002","article-title":"Quantification of Egg Ovalbumin Hydrolysate-Derived Anti-Hypertensive Peptides in an in Vitro Model Combining Luminal Digestion with Intestinal Caco-2 Cell Transport","volume":"99","author":"Grootaert","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Aatif, M. (2023). Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies. 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