{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:03:34Z","timestamp":1773468214101,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002571","name":"Woosuk University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002571","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Alcohol hangover is a significant health concern worldwide. Java water-dropwort (Oenanthe javanica) has been traditionally used in East Asia for treating hepatitis, jaundice, and alcohol hangovers. This study evaluated the effects of java water-dropwort extract formulation on alcohol metabolism and hangover symptoms. A randomized, double-blind, placebo-controlled crossover trial was conducted with 36 healthy adults aged 19\u201340 years. Participants received either java water-dropwort extract formulation (8.71 mL equivalent to 6.69 g raw material) or placebo 30 min before alcohol consumption (0.8 g\/kg body weight, 20.1% soju). Blood alcohol and acetaldehyde concentrations were measured at multiple time points up to 15 h post consumption. Hangover symptoms were assessed using the Alcohol Hangover Severity Scale and Acute Hangover Scale. A total of 36 participants were enrolled, and 33 completed the study per protocol. Blood alcohol area under the curve (AUC) was significantly lower in the java water-dropwort group (58.626 vs. 66.194 mmol\u00b7h\/L, p = 0.008). Blood acetaldehyde AUC was also significantly reduced (69.794 vs. 88.205 mg\u00b7h\/dL, p = 0.031). Hangover symptom scores in the test group were significantly lower than those in the placebo group (4.030 vs. 8.606, p = 0.026). No adverse events occurred. Java water-dropwort extract effectively enhanced alcohol metabolism and improved hangover symptoms, offering potential therapeutic value for hangover management.<\/jats:p>","DOI":"10.3390\/foods15061003","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:23:03Z","timestamp":1773307383000},"page":"1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Java Water-Dropwort (Oenanthe javanica) Extract on Alcohol Metabolism and Hangover Symptoms: A Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8078-1155","authenticated-orcid":false,"given":"Young-Sik","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Herbology, College of Korean Medicine, Woosuk University, Jeonju 55338, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-4201","authenticated-orcid":false,"given":"Chan-Hun","family":"Jung","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Jeonju 54810, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-4618","authenticated-orcid":false,"given":"Seon-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Jeonju 54810, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungyung","family":"Chai","sequence":"additional","affiliation":[{"name":"Research Institute, MediCRO Co., Ltd., Anyang 14067, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-7071","authenticated-orcid":false,"given":"Hongjun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Formula Science, College of Korean Medicine, Woosuk University, Jeonju 55338, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Risnita, S., Iseric, E., Zijlstra, M.N., Stock, A.K., and Verster, J.C. 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