{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:00:32Z","timestamp":1773662432353,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Background: The aim of our study was to analyze the supply of various forms of genistein (nano, micro, and classic) on the content of four macroelements\u2014calcium, magnesium potassium, and sodium\u2014in the kidneys, brains, hearts, livers, spleens and femurs of rats under conditions of mammary gland neoplasia (induced by 7,12-dimethylbenz[a]anthracene (DMBA)). Methods: Thirty-two 30-day-old Sprague-Dawley rats were included in this study. The animals were randomly assigned to four experimental groups: the control group received only a standard diet (without supplementation), while three groups were supplemented with genistein in different forms\u2014nanoparticles (0.1 mg\/mL; size 92 \u00b1 41 nm), microparticles (0.1 mg\/mL; size 587 \u00b1 83 nm), or macromolecular genistein (0.1 mg\/mL). To induce mammary gland cancer, all rats were administered DMBA. Results: In the presented studies, significant changes in the content of elements in the organs of rats supplemented with various forms of genistein were observed. Of particular importance was the occurrence of soft tissue calcifications caused by the dietary supplementation of rats with various forms of genistein, ranging from the classic form to the nanometric form, in the context of an existing mammary gland neoplastic process. Calcium accumulation occurred in various tissues\u2014the brain (from 252% to 449%); the heart (from 159% to 661%); the liver (from 90% to 613%), regardless of the form of genistein; and the spleen (by 127%) and femurs (by 294%) only in the case of nanogenistein supplementation\u2014compared to rats from the control group not supplemented with any form of genistein in conditions of induced mammary gland cancer. Conclusions: Genistein supplementation in cancer conditions affects mineral homeostasis in rats.<\/jats:p>","DOI":"10.3390\/foods15061040","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:10:43Z","timestamp":1773655843000},"page":"1040","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genistein Supplementation Affects Mineral Homeostasis in Rats with Mammary Cancer"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-0663","authenticated-orcid":false,"given":"Dorota","family":"Skrajnowska","sequence":"first","affiliation":[{"name":"Department of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-5073","authenticated-orcid":false,"given":"Arkadiusz","family":"Szterk","sequence":"additional","affiliation":[{"name":"ASLAB Science, Fort S\u0142u\u017cew 1\/9, 02-787 Warsaw, Poland"},{"name":"Department of Pharmacology and Toxicology, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-4546","authenticated-orcid":false,"given":"Karol","family":"Ofiara","sequence":"additional","affiliation":[{"name":"ASLAB Science, Fort S\u0142u\u017cew 1\/9, 02-787 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Strus","sequence":"additional","affiliation":[{"name":"ASLAB Science, Fort S\u0142u\u017cew 1\/9, 02-787 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-2352","authenticated-orcid":false,"given":"Barbara","family":"Bobrowska-Korczak","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Food Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2174\/187152012803833107","article-title":"Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on Its ADME","volume":"12","author":"Yang","year":"2012","journal-title":"Anticancer Agents Med. 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