{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:49:26Z","timestamp":1774543766560,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Health Minister","award":["IZS PLV 02\/25 RC"],"award-info":[{"award-number":["IZS PLV 02\/25 RC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Ensuring the safety of gluten-free foods is essential for individuals with coeliac disease and other gluten-related disorders, for whom even minimal gluten exposure can cause adverse effects; this study aimed to evaluate the long-term compliance of gluten-free labeled foods marketed in Italy. A total of 4139 pre-packaged gluten-free products were collected between 2015 and 2024 and analyzed using validated analytical methods. Products were categorized into macro-categories: cereal-based foods, processed non-cereal-based foods, confectionery, flours, baby foods, and dietary supplements. A descriptive analysis and risk modeling were generated to visualize relative risks. Overall non-compliance remained consistently very low (&lt;1%) throughout the 10-year period, with an average rate of 0.27% and minor peaks in 2016 and 2018. The highest frequencies of gluten contamination were observed in cereal-based products and flours-particularly corn flour-while occasional non-compliance occurred in some processed non-cereal-based foods and confectionery; no non-compliance was detected in baby foods or dietary supplements. These findings are reassuring and consistent with, or better than, available EU data, confirming the effectiveness of current control systems and highlighting the importance of continuous monitoring, validated analytical methods and effective allergen management strategies. Strengthened collaboration among regulators and manufacturers remains essential to prevent cross-contamination and protect consumer health.<\/jats:p>","DOI":"10.3390\/foods15071144","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:10:24Z","timestamp":1774537824000},"page":"1144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ensuring Gluten-Free Safety: A Descriptive Analysis of Laboratory Results and Quality Control"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8353-5136","authenticated-orcid":false,"given":"Roberta","family":"Giugliano","sequence":"first","affiliation":[{"name":"National Reference Centre for the Detection of Substances and Products Causing Allergies or Intolerances in Food (CReNaRiA), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D\u2019Aosta, Piazza Borgo Pila 39\/24, 16129 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Migone","sequence":"additional","affiliation":[{"name":"National Reference Centre for the Detection of Substances and Products Causing Allergies or Intolerances in Food (CReNaRiA), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D\u2019Aosta, Piazza Borgo Pila 39\/24, 16129 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Saccheggiani","sequence":"additional","affiliation":[{"name":"National Reference Centre for the Detection of Substances and Products Causing Allergies or Intolerances in Food (CReNaRiA), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D\u2019Aosta, Piazza Borgo Pila 39\/24, 16129 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9336-1324","authenticated-orcid":false,"given":"Simona","family":"Mella","sequence":"additional","affiliation":[{"name":"National Reference Centre for the Detection of Substances and Products Causing Allergies or Intolerances in Food (CReNaRiA), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D\u2019Aosta, Piazza Borgo Pila 39\/24, 16129 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6597-475X","authenticated-orcid":false,"given":"Elisabetta","family":"Razzuoli","sequence":"additional","affiliation":[{"name":"National Reference Centre for the Detection of Substances and Products Causing Allergies or Intolerances in Food (CReNaRiA), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D\u2019Aosta, Piazza Borgo Pila 39\/24, 16129 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1080\/10408398.2019.1651689","article-title":"Gluten-Related Disorders: Celiac Disease, Wheat Allergy, and Nonceliac Gluten Sensitivity","volume":"60","author":"Cabanillas","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Roszkowska, A., Pawlicka, M., Mroczek, A., Ba\u0142abuszek, K., and Nieradko-Iwanicka, B. (2019). Non-Celiac Gluten Sensitivity: A Review. Medicina, 55.","DOI":"10.3390\/medicina55060222"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1080\/07853890.2021.1990392","article-title":"Gastrointestinal Microbiome and Gluten in Celiac Disease","volume":"53","author":"Wu","year":"2021","journal-title":"Ann. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Cenni, S., Sesenna, V., Boiardi, G., Casertano, M., Russo, G., Reginelli, A., Esposito, S., and Strisciuglio, C. (2023). The Role of Gluten in Gastrointestinal Disorders: A Review. Nutrients, 15.","DOI":"10.3390\/nu15071615"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41575-021-00552-z","article-title":"The Global Burden of Coeliac Disease: Opportunities and Challenges","volume":"19","author":"Makharia","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/ageing\/27.4.535","article-title":"Coeliac Disease in Old Age: \u2018A Catch in the Rye\u2019","volume":"27","author":"Beaumont","year":"1998","journal-title":"Age Ageing"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrgastro.2015.131","article-title":"Extraintestinal Manifestations of Coeliac Disease","volume":"12","author":"Leffler","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","article-title":"Coeliac Disease","volume":"399","author":"Catassi","year":"2022","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/20469047.2018.1504431","article-title":"Coeliac Disease","volume":"39","author":"Singh","year":"2019","journal-title":"Paediatr. Int. Child Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","article-title":"Coeliac Disease","volume":"391","author":"Lebwohl","year":"2018","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/bmj.281.6250.1258","article-title":"Is Coeliac Disease Underdiagnosed?","volume":"281","author":"Swinson","year":"1980","journal-title":"Br. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","article-title":"European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020","volume":"70","author":"Husby","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and Management of Adult Coeliac Disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease","volume":"54","author":"Husby","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised Criteria for Diagnosis of Coeliac Disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition","volume":"65","author":"Guandalini","year":"1990","journal-title":"Arch. Dis. Child."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"bmjopen-2017-017678","DOI":"10.1136\/bmjopen-2017-017678","article-title":"Prevalence of Positive Coeliac Disease Serology and HLA Risk Genotypes in a Multiethnic Population of Adults in Canada: A Cross-Sectional Study","volume":"7","author":"Jamnik","year":"2017","journal-title":"BMJ Open"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bustamante, M.\u00c1., Fern\u00e1ndez-Gil, M.P., Churruca, I., Miranda, J., Lasa, A., Navarro, V., and Sim\u00f3n, E. (2017). Evolution of Gluten Content in Cereal-Based Gluten-Free Products: An Overview from 1998 to 2016. Nutrients, 9.","DOI":"10.3390\/nu9010021"},{"key":"ref_18","unstructured":"(2026, March 17). Italian Foods Labeled as Gluten-Free Found to Have Small Amounts of Gluten Contamination. Available online: https:\/\/www.massgeneral.org\/children\/celiac-disease\/italian-foods-labeled-as-glutenfree-found-to-have-small-amounts-of-gluten-contamination."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/MEG.0000000000002739","article-title":"Performance Assessment of a New G12\/A1 Antibody-Based Rapid ELISA Using Commercially Available and Gluten-Spiked Food Samples","volume":"36","author":"Verma","year":"2024","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Verma, A.K., Gatti, S., Galeazzi, T., Monachesi, C., Padella, L., Del Baldo, G., Annibali, R., Lionetti, E., and Catassi, C. (2017). Gluten Contamination in Naturally or Labeled Gluten-Free Products Marketed in Italy. Nutrients, 9.","DOI":"10.3390\/nu9020115"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cgh.2019.06.013","article-title":"Increased Prevalence of Celiac Disease in School-Age Children in Italy","volume":"18","author":"Gatti","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_22","unstructured":"(2026, February 15). RIDASCREEN\u00ae Gliadin\u2014Food & Feed Analysis. Available online: https:\/\/food.r-biopharm.com\/it\/prodotti\/ridascreen-gliadin\/."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wieser, H., Ruiz-Carnicer, \u00c1., Segura, V., Comino, I., and Sousa, C. (2021). Challenges of Monitoring the Gluten-Free Diet Adherence in the Management and Follow-Up of Patients with Celiac Disease. Nutrients, 13.","DOI":"10.3390\/nu13072274"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jada.2010.03.014","article-title":"Gluten Contamination of Grains, Seeds, and Flours in the United States: A Pilot Study","volume":"110","author":"Thompson","year":"2010","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Caio, G., Volta, U., Sapone, A., Leffler, D.A., De Giorgio, R., Catassi, C., and Fasano, A. (2019). Celiac Disease: A Comprehensive Current Review. BMC Med., 17.","DOI":"10.1186\/s12916-019-1380-z"},{"key":"ref_26","first-page":"75","article-title":"Control of Nutritive Allergens in a Hospitality Kitchen","volume":"61","year":"2020","journal-title":"Sci. J. \u201cMeat Technol.\u201d"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2621.2007.01599.x","article-title":"Gluten Contamination of Cereal Foods in Canada","volume":"43","author":"McKinnon","year":"2008","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_28","unstructured":"(2025, February 10). Aspetti Epidemiologici Nel Mondo. Available online: https:\/\/www.epicentro.iss.it\/celiachia\/epidemiologia-mondo."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez, J.M., Est\u00e9vez, V., Bascu\u00f1\u00e1n, K., Ayala, J., and Araya, M. (2022). Commercial Oats in Gluten-Free Diet: A Persistent Risk for Celiac Patients. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.986282"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"113231","DOI":"10.1016\/j.fct.2022.113231","article-title":"Risk of Consuming Products with or without Precautionary Wheat or Gluten Labelling for Persons with Coeliac Disease","volume":"166","author":"Rasmussen","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Farage, P., Zandonadi, R.P., Gandolfi, L., Pratesi, R., Falcomer, A.L., Ara\u00fajo, L.S., Nakano, E.Y., and Ginani, V.C. (2019). Accidental Gluten Contamination in Traditional Lunch Meals from Food Services in Brasilia, Brazil. 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