{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:30:40Z","timestamp":1793640640749,"version":"4.5.1"},"reference-count":151,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Provincial Key Research and Development Program","award":["ZDYF2025SXLH005"],"award-info":[{"award-number":["ZDYF2025SXLH005"]}]},{"name":"Yunnan Province Agricultural Basic Research Joint Foundation","award":["202101BD070001-028"],"award-info":[{"award-number":["202101BD070001-028"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960075"],"award-info":[{"award-number":["31960075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["31960075"],"award-info":[{"award-number":["31960075"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Yunnan Ten Thousand Talents Plan Young &amp; Elite Talents Project","award":["YNWR-QNBJ-2020-178"],"award-info":[{"award-number":["YNWR-QNBJ-2020-178"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Alpinia oxyphylla Miquel is a perennial medicinal plant widely cultivated in the provinces of Fujian, Guangdong, and Hainan in China. The dried mature fruit of A. oxyphylla, officially recorded as Alpiniae Oxyphyllae Fructus in the pharmacopoeia of the People\u2019s Republic of China (since 2012), is one of the four primary southern medicinal materials in traditional Chinese medicine (TCM). In TCM, the fruit is traditionally used to support kidney function, regulate urination, and alleviate gastrointestinal disorders such as diarrhea. Its continued use across Southeast Asia underscores its enduring ethnopharmacological relevance. The plant is rich in bioactive constituents, including terpenoids, flavonoids, diphenylheptanes, and sterols, which exhibit diverse biological activities, including antioxidant, anti-inflammatory, anticancer, neuroprotective, and gastrointestinal protective effects. Information on Alpinia oxyphylla was collected from multiple databases, including Web of Science, Google Scholar, PubMed, Baidu Scholar, ScienceDirect, CNKI, and the Pharmacopoeia of the People\u2019s Republic of China. The search strategy included keywords related to A. oxyphylla, its chemical constituents, biological activities, pharmacological effects, traditional medicinal uses, and safety. A bibliometric analysis of 217 English-language publications (2014\u20132025) using CiteSpace revealed a marked increase in global research interest, with keyword clustering and burst analyses highlighting oxidative stress, Alzheimer\u2019s disease, and cognitive enhancement as emerging research hotspots. Moreover, 692 patents were identified, demonstrating substantial technological innovation related to A. oxyphylla, particularly in essential oil formulations, functional foods, and health-promoting applications. Overall, this review integrates phytochemical, pharmacological, bibliometric, and patent perspectives to provide a holistic understanding of A. oxyphylla and its medicinal fruit, offering a solid scientific foundation for future research, standardization, and translational development.<\/jats:p>","DOI":"10.3390\/foods15071212","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:09:54Z","timestamp":1775138994000},"page":"1212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Diversity, Mechanistic Pharmacology, and Therapeutic Potential of Alpinia oxyphylla"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0602-3609","authenticated-orcid":false,"given":"Taixia","family":"Chen","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Institute of Biofabrication Research, College of Science, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Shahidin","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Research Center for Agricultural Chemistry, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Jiangsu Co-Innovation Center for Modern Production Technology, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Development and Utilization of Food and Medicinal Resources, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Agricultural Chemistry, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Development and Utilization of Food and Medicinal Resources, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Center for Agricultural Chemistry, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Development and Utilization of Food and Medicinal Resources, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3963-5113","authenticated-orcid":false,"given":"Xiaoyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biofabrication Research, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Research Center for Agricultural Chemistry, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Development and Utilization of Food and Medicinal Resources, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Biofabrication Research, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Research Center for Agricultural Chemistry, College of Science, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Development and Utilization of Food and Medicinal Resources, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-3617","authenticated-orcid":false,"given":"Chengting","family":"Zi","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Institute of Biofabrication Research, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Research Center for Agricultural Chemistry, College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Development and Utilization 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