{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:41:23Z","timestamp":1785436883291,"version":"3.56.0"},"reference-count":36,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31701698"],"award-info":[{"award-number":["31701698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["31701698"],"award-info":[{"award-number":["31701698"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008870","name":"Shanghai Municipal Commission of Agriculture and Rural Affairs","doi-asserted-by":"crossref","award":["2024-02-08-00-12-F00033"],"award-info":[{"award-number":["2024-02-08-00-12-F00033"]}],"id":[{"id":"10.13039\/501100008870","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2024-02-08-00-12-F00033"],"award-info":[{"award-number":["2024-02-08-00-12-F00033"]}],"id":[{"id":"https:\/\/ror.org\/05ckt8b96","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["22Y42201400"],"award-info":[{"award-number":["22Y42201400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"award":["22Y42201400"],"award-info":[{"award-number":["22Y42201400"]}],"id":[{"id":"https:\/\/ror.org\/03kt66j61","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund, ECSFR, CAFS","award":["2024YC03"],"award-info":[{"award-number":["2024YC03"]}]},{"award":["2024YC03"],"award-info":[{"award-number":["2024YC03"]}],"id":[{"id":"https:\/\/ror.org\/04hqqqx81","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020199","name":"Liaoning Academy of Agricultural Sciences","doi-asserted-by":"crossref","award":["2026JC4037"],"award-info":[{"award-number":["2026JC4037"]}],"id":[{"id":"10.13039\/501100020199","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2026JC4037"],"award-info":[{"award-number":["2026JC4037"]}],"id":[{"id":"https:\/\/ror.org\/03vnb1535","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Glycidol, a probable human carcinogen, remains an under-investigated process contaminant in soy sauce. This study developed a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS\/MS) method for its determination in this complex condiment. The approach combined chemical derivatization with p-Dimethylaminophenol hydrochloride for analyte stabilization with an optimized sample pretreatment using a custom-packed activated carbon solid-phase extraction (SPE) cartridge effectively removed matrix interferences, and performing the derivatization at pH 6.5 prevented conversion of 2- and 3-monochloropropanediol (2-MCPD and 3-MCPD) into glycidol, ensuring high specificity and accuracy. This approach shows broad linearity from 1 to at least 100 ng\/mL (R2 = 0.9993), and demonstrates excellent performance, with a limit of detection and quantification of 0.5 ng\/mL and 1.0 ng\/mL, respectively. Application to commercial samples (n = 11) confirmed the presence of glycidol, highlighting the need for its monitoring. This work provides a robust analytical tool essential for supporting food safety surveillance of this contaminant in fermented foods.<\/jats:p>","DOI":"10.3390\/foods15071220","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:19:32Z","timestamp":1775434772000},"page":"1220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of Glycidol in Soy Sauce Using p-Dimethylaminophenol Derivatization Coupled with Liquid Chromatography-Tandem Mass Spectrometry"],"prefix":"10.3390","volume":"15","author":[{"given":"Yifan","family":"Zhao","sequence":"first","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"},{"name":"College of Food Science and Engineering, Dalian Ocean University, Dalian 116034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Wang","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"},{"name":"School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-511X","authenticated-orcid":false,"given":"Hai","family":"Chi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Protection and Utilization of Aquatic Germplasm Resource, Liaoning Ocean and Fisheries Science Research Institute, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-6194","authenticated-orcid":false,"given":"Guangxin","family":"Yang","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Shen","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"Fan","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Tian","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6648-0778","authenticated-orcid":false,"given":"Mian Hasnain","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-2133","authenticated-orcid":false,"given":"Cong","family":"Kong","sequence":"additional","affiliation":[{"name":"East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106875","DOI":"10.1016\/j.jfca.2024.106875","article-title":"Fats and oils contaminants: An analysis of EU RASFF notifications from 1999 to 2023","volume":"137","author":"Eissa","year":"2025","journal-title":"J. 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