{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:43:48Z","timestamp":1775439828867,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yongfu County People\u2019s Government to Beijing University of Chinese Medicine","award":["BUCM-2023-JS-KF-044"],"award-info":[{"award-number":["BUCM-2023-JS-KF-044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disease worldwide with complex pathogenesis and no approved specific therapy. Siraitia grosvenorii is a widely used medicinal and edible herb, yet its efficacy and underlying mechanisms against MAFLD remain poorly defined. This study explored the protective effects and potential mechanisms of aqueous extract of Siraitia grosvenorii (AESG) on MAFLD. Based on ultra-high-performance liquid chromatography-linear trap quadrupole orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap-MS) analysis, 38 components in AESG were tentatively assigned, with tetracyclic triterpene saponins being the most abundant. In high-fat diet (HFD)-induced MAFLD mice, AESG significantly attenuated body weight gain, reduced plasma total cholesterol (T-CHO) and low-density lipoprotein cholesterol (LDL-C) levels, and dramatically decreased hepatic triglyceride (TG) accumulation from 0.0141 mmol\/g in the model group to 0.0063 mmol\/g in the low-dose AESG group, corresponding to a reduction of 55.00%. AESG also alleviated plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, and improved hepatocyte steatosis. Furthermore, AESG restored HFD-induced gut dysbiosis by enriching beneficial bacteria including Akkermansia and suppressing harmful bacteria such as Ruminococcus. In free fatty acids (FFA) stimulated HepG2 cells, AESG suppressed de novo lipogenesis via downregulating Fatty Acid Synthase (FASN), Acetyl-CoA Carboxylase (ACC) and Sterol Regulatory Element-Binding Protein 1c (SREBP1c), and enhanced antioxidant capacity via activating the Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)\/Heme Oxygenase 1 (HO-1)\/Sirtuin 1 (SIRT1) pathway, thereby attenuating lipid accumulation and oxidative stress. In conclusion, AESG ameliorates MAFLD by inhibiting lipogenesis, improving oxidative stress, and regulating gut microbiota. These findings support Siraitia grosvenorii as a promising natural dietary intervention for MAFLD prevention and adjuvant therapy.<\/jats:p>","DOI":"10.3390\/foods15071241","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:19:32Z","timestamp":1775434772000},"page":"1241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aqueous Extract of Siraitia\u00a0grosvenorii Alleviates MAFLD by Modulating Metabolism and Maintaining Gut Homeostasis in High-Fat Diet Fed Mice"],"prefix":"10.3390","volume":"15","author":[{"given":"Hong","family":"Li","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixian","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxiu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zailin","family":"Liang","sequence":"additional","affiliation":[{"name":"Agricultural and Rural Bureau of Yongfu County, Guilin 541000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[{"name":"Agricultural and Rural Bureau of Yongfu County, Guilin 541000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusheng","family":"Mo","sequence":"additional","affiliation":[{"name":"Agricultural and Rural Bureau of Yongfu County, Guilin 541000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengli","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106507","DOI":"10.1016\/j.phrs.2022.106507","article-title":"Toll-like receptors and metabolic (dysfunction)-associated fatty liver disease","volume":"185","author":"Khanmohammadi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20420188221139101","DOI":"10.1177\/20420188221139101","article-title":"MAFLD: What 2 years of the redefinition of fatty liver disease has taught us","volume":"13","author":"Grabherr","year":"2022","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.4093\/dmj.2024.0541","article-title":"Metabolic dysfunction-associated steatotic liver disease in type 2 diabetes mellitus: A review and position statement of the fatty liver research group of the Korean Diabetes Association","volume":"48","author":"Bae","year":"2024","journal-title":"Diabetes Metab. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.amjmed.2023.03.010","article-title":"Cardiovascular disease risk and statin use among adults with metabolic dysfunction associated fatty liver disease","volume":"136","author":"Yeoh","year":"2023","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e565","DOI":"10.1212\/WNL.0000000000200770","article-title":"Association of nonalcoholic fatty liver disease and fibrosis with incident dementia and cognition: The Rotterdam study","volume":"99","author":"Xiao","year":"2022","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41581-021-00519-y","article-title":"Association of metabolic dysfunction-associated fatty liver disease with kidney disease","volume":"18","author":"Wang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1002\/imt2.76","article-title":"Decoding the role of immune T cells: A new territory for improvement of metabolic-associated fatty liver disease","volume":"2","author":"Liu","year":"2023","journal-title":"Imeta"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Qu, W., Ma, T., Cai, J., Zhang, X., Zhang, P., She, Z., Wan, F., and Li, H. (2021). Liver fibrosis and MAFLD: From molecular aspects to novel pharmacological strategies. Front. Med., 8.","DOI":"10.3389\/fmed.2021.761538"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.tcb.2020.05.004","article-title":"Endoplasmic reticulum (ER) stress response failure in diseases","volume":"30","author":"Bhattarai","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"157250","DOI":"10.1016\/j.phymed.2025.157250","article-title":"Mogroside V: Molecular mechanisms and therapeutic applications","volume":"148","author":"He","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wang, S., Cui, K., Liu, J., Hu, J., Yan, K., Xiao, P., Lu, Y., Yang, X., and Liang, X. (2022). Mogroside-rich extract from Siraitia grosvenorii fruits ameliorates high-fat diet-induced obesity associated with the modulation of gut microbiota in mice. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.870394"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1039\/C8FO01486H","article-title":"AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet\/streptozotocin-induced diabetic mice","volume":"10","author":"Liu","year":"2019","journal-title":"Food Funct."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"105326","DOI":"10.1016\/j.tiv.2022.105326","article-title":"Mogroside V exerts anti-inflammatory effects on fine particulate matter-induced inflammation in porcine alveolar macrophages","volume":"80","author":"Shen","year":"2022","journal-title":"Toxicol. In Vitro"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1039\/D2FO02179J","article-title":"Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice","volume":"14","author":"Lu","year":"2023","journal-title":"Food Funct."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.tem.2021.04.008","article-title":"Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease","volume":"32","author":"Lim","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101372","DOI":"10.1016\/j.gendis.2024.101372","article-title":"Transcription factors, metabolic dysfunction-associated fatty liver disease, and therapeutic implications","volume":"12","author":"Hu","year":"2025","journal-title":"Genes Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.tem.2022.03.005","article-title":"SGLT-2 inhibitors and GLP-1 receptor agonists in metabolic dysfunction-associated fatty liver disease","volume":"33","author":"Moon","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"112955","DOI":"10.1016\/j.ecoenv.2021.112955","article-title":"Exposure to PM2. 5 during pregnancy causes lung inflammation in the offspring: Mechanism of action of mogrosides","volume":"228","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"133205","DOI":"10.1016\/j.foodchem.2022.133205","article-title":"Enzymatic hydrolyzation of mogrosides in Luo Han Guo extract by NKA-adsorbed snailase improves its sensory profile","volume":"390","author":"Su","year":"2022","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"129938","DOI":"10.1016\/j.foodchem.2021.129938","article-title":"Selective enzymatic \u03b1-1, 6-monoglucosylation of mogroside IIIE for the bio-creation of \u03b1-siamenoside I, a potential high-intensity sweetener","volume":"359","author":"Xu","year":"2021","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4103\/abr.abr_21_22","article-title":"Atorvastatin and flaxseed effects on biochemical indices and hepatic fat of NAFLD model in rats","volume":"12","author":"Eslami","year":"2023","journal-title":"Adv. Biomed. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120051","DOI":"10.1016\/j.carbpol.2022.120051","article-title":"Amelioration of hydrolyzed guar gum on high-fat diet-induced obesity: Integrated hepatic transcriptome and metabolome","volume":"297","author":"Fu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155379","DOI":"10.1016\/j.metabol.2022.155379","article-title":"Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis","volume":"139","author":"Gu","year":"2023","journal-title":"Metabolism"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41577-024-01103-8","article-title":"Adipokines: Masterminds of metabolic inflammation","volume":"25","author":"Tilg","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"340104","DOI":"10.1016\/j.aca.2022.340104","article-title":"Detecting inflammation in the diabetic mice with a fluorescence lifetime-based probe","volume":"1221","author":"Cheng","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev-physiol-042222-024353","article-title":"Orchestration of the adipose tissue immune landscape by adipocytes","volume":"86","author":"Bradley","year":"2024","journal-title":"Annu. Rev. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41392-022-01178-6","article-title":"The evolving view of thermogenic fat and its implications in cancer and metabolic diseases","volume":"7","author":"Yin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102537","DOI":"10.1016\/j.media.2022.102537","article-title":"Conditional GANs based system for fibrosis detection and quantification in Hematoxylin and Eosin whole slide images","volume":"81","author":"Naglah","year":"2022","journal-title":"Med. Image Anal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155703","DOI":"10.1016\/j.phymed.2024.155703","article-title":"Morroniside delays the progression of non-alcoholic steatohepatitis by promoting AMPK-mediated lipophagy","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"153739","DOI":"10.1016\/j.phymed.2021.153739","article-title":"Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis","volume":"92","author":"Huang","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"111196","DOI":"10.1016\/j.foodres.2022.111196","article-title":"Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease","volume":"156","author":"Zhang","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8960","DOI":"10.1039\/D1FO01039E","article-title":"Lycopene modulates lipid metabolism in rats and their offspring under a high-fat diet","volume":"12","author":"Cao","year":"2021","journal-title":"Food Funct."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"151912","DOI":"10.1016\/j.bbrc.2025.151912","article-title":"Mogroside V prevents ethanol-induced hangover and liver damage by reducing oxidative stress, steatosis and inflammation","volume":"766","author":"Ai","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"\u010cakar, U., \u010colovi\u0107, M., Milenkovi\u0107, D., Pagnacco, M., Maksimovi\u0107, J., Krsti\u0107, D., and \u0110or\u0111evi\u0107, B. (2025). Strawberry and drupe fruit wines antioxidant activity and protective effect against induced oxidative stress in rat synaptosomes. Antioxidants, 14.","DOI":"10.3390\/antiox14020155"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113629","DOI":"10.1016\/j.biopha.2022.113629","article-title":"Microbiota modulation and anti-obesity effects of fermented Pyrus ussuriensis Maxim extract against high-fat diet-induced obesity in rats","volume":"154","author":"Boby","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s40104-025-01284-9","article-title":"Advances in understanding the role of gut microbiota in fat deposition and lipid metabolism","volume":"16","author":"Zhong","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"112891","DOI":"10.1016\/j.biopha.2022.112891","article-title":"Effect of dendrobium mixture in alleviating diabetic cognitive impairment associated with regulating gut microbiota","volume":"149","author":"Zheng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"127599","DOI":"10.1016\/j.micres.2023.127599","article-title":"Ant may well destroy a whole dam: Glycans of colonic mucus barrier disintegrated by gut bacteria","volume":"281","author":"Li","year":"2024","journal-title":"Microbiol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2152307","DOI":"10.1080\/19490976.2022.2152307","article-title":"Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion","volume":"14","author":"Paone","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"110467","DOI":"10.1016\/j.foodres.2021.110467","article-title":"Regulatory effects of Lactobacillus fermented black barley on intestinal microbiota of NAFLD rats","volume":"147","author":"Zhu","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41538-024-00349-9","article-title":"Lauric-\u03b1-linolenic lipids modulate gut microbiota, preventing obesity, insulin resistance and inflammation in high-fat diet mice","volume":"8","author":"Huang","year":"2024","journal-title":"npj Sci. Food"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"128317","DOI":"10.1016\/j.micres.2025.128317","article-title":"Akkermansia muciniphila: A key player in gut microbiota-based disease modulation","volume":"301","author":"Shaheen","year":"2025","journal-title":"Microbiol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143315","DOI":"10.1016\/j.ijbiomac.2025.143315","article-title":"Simulated gut microbiota fermentation of polysaccharide extracts from Ganoderma lucidum and Ganoderma neo-japonicum","volume":"310","author":"Ayimbila","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"155413","DOI":"10.1016\/j.phymed.2024.155413","article-title":"Gut microbiota-dependent modulation of pre-metastatic niches by Jianpi Yangzheng decoction in the prevention of lung metastasis of gastric cancer","volume":"128","author":"Zhu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"115099","DOI":"10.1016\/j.ecoenv.2023.115099","article-title":"Pectin alleviates the pulmonary inflammatory response induced by PM2. 5 from a pig house by modulating intestinal microbiota","volume":"261","author":"Tang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12967-021-02839-w","article-title":"The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life","volume":"19","author":"Kaczmarczyk","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","article-title":"The cellular and functional complexity of thermogenic fat","volume":"22","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ejphar.2019.02.044","article-title":"Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice","volume":"854","author":"Shankar","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/JOE-20-0472","article-title":"SAHA induces white fat browning and rectifies metabolic dysfunctions via activation of ZFPs","volume":"249","author":"Ma","year":"2021","journal-title":"J. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/db20-1210","article-title":"l-Theanine activates the browning of white adipose tissue through the AMPK\/\u03b1-ketoglutarate\/Prdm16 axis and ameliorates diet-induced obesity in mice","volume":"70","author":"Peng","year":"2021","journal-title":"Diabetes"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e50085","DOI":"10.15252\/embr.202050085","article-title":"Chronic cold exposure enhances glucose oxidation in brown adipose tissue","volume":"21","author":"Wang","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejphar.2006.09.011","article-title":"Bifendate treatment attenuates hepatic steatosis in cholesterol\/bile salt-and high-fat diet-induced hypercholesterolemia in mice","volume":"552","author":"Pan","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmet.2024.09.012","article-title":"Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity","volume":"37","author":"Sakamoto","year":"2025","journal-title":"Cell Metab."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Seebacher, F., Zeigerer, A., Kory, N., and Krahmer, N. (2020). Hepatic lipid droplet homeostasis and fatty liver disease. Seminars in Cell & Developmental Biology, Elsevier.","DOI":"10.1016\/j.semcdb.2020.04.011"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"122047","DOI":"10.1016\/j.biomaterials.2023.122047","article-title":"Self-assembling polymer-based short chain fatty acid prodrugs ameliorate non-alcoholic steatohepatitis and liver fibrosis","volume":"295","author":"Shashni","year":"2023","journal-title":"Biomaterials"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/7\/1241\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:45:12Z","timestamp":1775436312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/7\/1241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,5]]},"references-count":58,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["foods15071241"],"URL":"https:\/\/doi.org\/10.3390\/foods15071241","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,5]]}}}