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In this study, ultrasound-assisted extraction (UAE) with ethanol as a green solvent was optimized using a Central Composite Rotational Design (CCRD) with 2 levels (23) and 3 independent variables. The optimal condition (60 % ethanol, solid\u2013liquid ratio 2.5 % m\/v, 26 min) was determined using response surface methodology (RSM), and yielded 9.92 mg GAE\/g of total phenolic content (TPC), with an experimental error of 5.34 % compared to the theoretical model prediction. Under this condition, total flavonoids and tannins were also quantified, reaching 0.38 \u00b1 0.01 mg QE\/g and 4.03 \u00b1 0.10 mg TA\/g, respectively. LC-MS analysis revealed a complex phenolic profile within the extract, confirming the efficiency of UAE in recovering bioactive molecules. Biological assays revealed significant functional properties. Antioxidant activity, evaluated by ABTS and DPPH methods, indicated that the extracts were effective radical scavengers. Antimicrobial assays showed only growth-selective inhibition against Staphylococcus aureus at concentrations of 2.5\u201320 mg\/mL, while no significant activity was observed against Escherichia coli and Pseudomonas spp. These findings highlight the potential of A. murumuru biomass residues as a sustainable source of bioactive compounds with antioxidant activity and a growth inhibitor of S. aureus, reinforcing their possible application in the development of natural additives for food, while contributing to the sustainable bioeconomy of the Amazon.<\/jats:p>","DOI":"10.3390\/foods15081368","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:15:59Z","timestamp":1776244559000},"page":"1368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound-Assisted Green Extraction of Phenolic Compounds from Astrocaryum murumuru Biomass"],"prefix":"10.3390","volume":"15","author":[{"given":"Gabriela Vieira","family":"Pantoja","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos (PPGCTA), Universidade Federal do Par\u00e1, Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Aparecido Ferreira de","family":"Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica do Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em\u00eddio","family":"Beraldo-Neto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica do Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-3077","authenticated-orcid":false,"given":"Lucas Figueiredo da","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas (PPGCF), Instituto de Ci\u00eancias da Sa\u00fade (ICS), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnatt Allan Rocha de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o (FANUT), Instituto de Ci\u00eancias da Sa\u00fade (ICS), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-263X","authenticated-orcid":false,"given":"Gustavo Guadagnucci","family":"Fontanari","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade e Produ\u00e7\u00e3o Animal (ISPA), Universidade Federal Rural da Amaz\u00f4nia (UFRA), Bel\u00e9m 66077-830, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-0860","authenticated-orcid":false,"given":"Daniel Carvalho","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ecologia e Evolu\u00e7\u00e3o, Instituto Butantan, S\u00e3o Paulo 05503-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-4502","authenticated-orcid":false,"given":"Luiza Helena da Silva","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade e Produ\u00e7\u00e3o Animal (ISPA), Universidade Federal Rural da Amaz\u00f4nia (UFRA), Bel\u00e9m 66077-830, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/ind.2021.0005","article-title":"Biofuels and Oils from Amazon Crops: Challenges and Opportunities for the Sustainable Use of Biodiversity Resources","volume":"17","author":"Amarante","year":"2021","journal-title":"Ind. 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