{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:41:30Z","timestamp":1785426090380,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research and Development Fund, Burapha University","award":["YR2568\/15"],"award-info":[{"award-number":["YR2568\/15"]}]},{"award":["YR2568\/15"],"award-info":[{"award-number":["YR2568\/15"]}],"id":[{"id":"https:\/\/ror.org\/01ff74m36","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Lactic Acid Bacteria (LAB)-derived antimicrobial compounds are recognized as a promising source of novel antimicrobial agents, particularly for the treatment of Methicillin-Resistant Staphylococcus aureus (MRSA), where the mode of action and associated cellular effects remain largely unexplored. This study aims to evaluate antibacterial activity of Limosilactobacillus fermentum YTPP05 isolated from pickled radish against MRSA. Upon the initial antibacterial evaluations, it was found that strain YTPP05 inhibited the growth of MRSA isolates. Multiplex PCR identified multiple resistance genes in our MRSA strains, including mecA, blaZ, and aacA genes, aligning with antibacterial susceptibility profiles determined by the disc diffusion assay. An agar overlay assay showed that YTPP05 possessed antibacterial potential, with the largest inhibition zone diameters of 40.83 \u00b1 8.43 mm, while the inhibition zones of the Cell Free Supernatant (CFS) of YTPP05 by an agar well diffusion were 27.16 \u00b1 2.93 mm against the MRSA isolates. The minimum inhibitory concentration and minimum bactericidal concentration of YTPP05-derived CFS were 125 mg\/mL. Scanning Electron Microscopy (SEM) demonstrated YTPP05 extracts caused cell membrane disruption, bubble-like protrusion, and cell lysis. Collectively, this study highlights the anti-MRSA potential of YTPP05 as an alternative antimicrobial agent for combating MRSA infections.<\/jats:p>","DOI":"10.3390\/foods15081431","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:37:42Z","timestamp":1776677862000},"page":"1431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial Potential of Limosilactobacillus fermentum YTPP05 Against Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.3390","volume":"15","author":[{"given":"Pimnipa","family":"Pornjirawittayakul","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peerapat","family":"Krittanan","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittipot","family":"Sirichaiwetchakoon","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Biopharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surachat","family":"Buddhisa","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-2480","authenticated-orcid":false,"given":"Nattaphol","family":"Prakobkaew","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismini","family":"Nakouti","sequence":"additional","affiliation":[{"name":"Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-5903","authenticated-orcid":false,"given":"Glyn","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7020-5910","authenticated-orcid":false,"given":"Churat","family":"Weeraphan","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6771-5362","authenticated-orcid":false,"given":"Htun Htun","family":"Win","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjawan","family":"Dunkhunthod","sequence":"additional","affiliation":[{"name":"Thai Tradition Medicine Program, Faculty of Nursing and Allied Health Sciences, Phetchaburi Rajabhat University, Phetchaburi 76000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-8666","authenticated-orcid":false,"given":"Yothin","family":"Teethaisong","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, Chon Buri 20131, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref_1","first-page":"388","article-title":"Staphylococcus aureus Contamination during Food Preparation, Processing and Handling","volume":"5","author":"Mahmoud","year":"2014","journal-title":"Int. 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