{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T19:56:28Z","timestamp":1794254188657,"version":"4.9.0"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Juniperus phoenicea L. is a popular plant in alternative medicine, particularly in the steppe and highland regions of western Algeria. The present study focuses on characterizing the essential oil of Juniperus phoenicea growing spontaneously in the Ain El Orak region of El Bayadh province, where it is a valuable resource. The essential oil yield obtained by hydrodistillation was 0.98%, and its characterization by GC-MS revealed 46 compounds, predominantly \u03b1-Terpinolene at 21.29%, Limonene at 14.68%, Terpinene 4-ol at 12.04%, \u03b2-Myrcene at 9.93%, and \u03b2-Pinene at 7.31%. The study of the anti-radical activity against DPPH showed an IC50 value of approximately 0.23 mg\/mL. The evaluation of the anti-ulcer property on experimentally induced ulcers in mice through oral administration of ethanol demonstrated excellent protection of the gastric mucosa, with 48.07%, 54.87%, and 81.92% protection for doses of 50, 100, and 200 mg\/kg, respectively, comparable to omeprazole at 72.40%. The hepatoprotective activity against toxicity induced by intraperitoneal injection of a 250 mg\/kg dose of paracetamol in mice showed a protective effect expressed by the decrease in serum levels of AST (260.33 \u00b1 9.69 IU\/L) and ALT (56.22 \u00b1 9.63 IU\/L) to values comparable to the those of the physiological group, especially for the 300 mg\/kg dose of the essential oil of J. phoenicea.<\/jats:p>","DOI":"10.3390\/foods15101667","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:05:22Z","timestamp":1778501122000},"page":"1667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Juniperus phoenicea L. Essential Oil from Ain El Orak (Algeria): Chemical Analysis by GC\/MS, In Vitro Antioxidant and In Vivo\/In Silico Gastroprotective and Hepatoprotective Effects"],"prefix":"10.3390","volume":"15","author":[{"given":"Meriem","family":"Medjekane","sequence":"first","affiliation":[{"name":"Institute of Life and Natural Sciences, Nour Bachir University Center of El-Bayadh, El-Bayadh 32000, Algeria"},{"name":"Laboratory of Experimental Pathological Research, Department of Nutrition and Food Sciences, Hassiba Benbouali University of Chlef, Ouled Fares, Chlef 02010, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-7935","authenticated-orcid":false,"given":"Yacine","family":"Nait Bachir","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural and Life Sciences, University Saad Dahlab\u2013Blida 1, Blida 09000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-6763","authenticated-orcid":false,"given":"Zohra Douaa","family":"Benyahlou","sequence":"additional","affiliation":[{"name":"Laboratory of Technology and Solid Properties (LTPS), Faculty of Sciences and Technology, Abdelhamid Ibn Badis University of Mostaganem, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzia","family":"Nemar","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathological Research, Department of Nutrition and Food Sciences, Hassiba Benbouali University of Chlef, Ouled Fares, Chlef 02010, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Housseyn","family":"Medjahed","sequence":"additional","affiliation":[{"name":"Institute of Life and Natural Sciences, Nour Bachir University Center of El-Bayadh, El-Bayadh 32000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safia Ali","family":"Haimoud","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathological Research, Department of Nutrition and Food Sciences, Hassiba Benbouali University of Chlef, Ouled Fares, Chlef 02010, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Sadoud","sequence":"additional","affiliation":[{"name":"Laboratory of Beneficial Microorganisms, Functional Food and Health, Department of Food Science, Faculty of Nature and Life Science, Abdelhamid Ibn Badis University, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Naas","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Life and Natural Sciences, University of Relizane, Relizane 48000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Nehari","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Bio-Resources, Department of Nutrition and Food Sciences, Faculty of Life and Natural Sciences, Hassiba Benbouali University of Chlef, Ouled Fares, Chlef 02010, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messouda","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Institute of Life and Natural Sciences, Nour Bachir University Center of El-Bayadh, El-Bayadh 32000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaima","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Institute of Life and Natural Sciences, Nour Bachir University Center of El-Bayadh, El-Bayadh 32000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-358X","authenticated-orcid":false,"given":"Abdelkader","family":"Chouaih","sequence":"additional","affiliation":[{"name":"Laboratory of Technology and Solid Properties (LTPS), Faculty of Sciences and Technology, Abdelhamid Ibn Badis University of Mostaganem, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Foligni","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Promoting of the Quality of Life, San Raffaele University Rome, Via Val Cannuta 247, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e13446","DOI":"10.1111\/jfpp.13446","article-title":"Formulation of stable microcapsules suspensions content Salvia officinalis extract for its antioxidant activity preservation","volume":"42","author":"Zafour","year":"2018","journal-title":"J. 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