{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:08:02Z","timestamp":1778519282610,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2024YFD2100701"],"award-info":[{"award-number":["2024YFD2100701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Natural Science Foundation Project","award":["24JCQNJC02020"],"award-info":[{"award-number":["24JCQNJC02020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Hyperlipidemia-associated obesity is frequently accompanied by hepatic injury, bile acid dysregulation, gut microbial remodeling, and anxiety-like behavioral alterations. As emerging functional food ingredients, postbiotics and dietary herbs (DH) may provide practical dietary strategies for metabolic health management, but the most suitable postbiotic form and its compatibility with DH remain unclear. In this study, FB 3-14-derived postbiotics were first screened in vitro for cholesterol micellar binding. Inactivated bacterial cells (Postcell) exhibited the strongest cholesterol-binding capacity and were therefore selected for in vivo validation, alone or in combination with DH, in a high-fat, high-cholesterol (HFHC) mouse model. Consistently, Postcell showed superior efficacy in attenuating body weight gain, jejunal triglyceride accumulation, and hepatic dysfunction compared with other postbiotic forms. Importantly, Postcell_DH exerted broader metabolic benefits, including reductions in weight gain, food efficiency, bile acid dysregulation, and neuroinflammation. Multi-omics analysis further indicated that these effects may be mediated through remodeling of the gut microbiota and metabolome, particularly pathways involved in bile acid and tryptophan metabolism. Notably, Clostridioides and taurochenodeoxycholate-7-sulfate were negatively associated with total cholesterol (TC) and leptin, whereas Clostridium_sensu_stricto_1 and 3-Hydroxyindolin-2-1-sulfate were negatively correlated with brain inflammatory level, lipid, and bile acid-related index. This study supports a practical postbiotic\u2013herbal combination strategy relevant to functional food and dietary supplement development for hyperlipidemia-associated metabolic disturbances.<\/jats:p>","DOI":"10.3390\/foods15101679","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:39:32Z","timestamp":1778513972000},"page":"1679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Effect of Bifidobacterium longum Postbiotics and Dietary Herbs on Ameliorating Metabolic Disturbances in Hyperlipidemic Mice"],"prefix":"10.3390","volume":"15","author":[{"given":"Yi","family":"Sun","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Yue","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoxin","family":"Cui","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-8831","authenticated-orcid":false,"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-1916","authenticated-orcid":false,"given":"Dancai","family":"Fan","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Lv","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China"},{"name":"Research Institute of Public Health, Nankai University, Tianjin 300071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120939","DOI":"10.1016\/j.carbpol.2023.120939","article-title":"Gut microbiota-metabolic axis insight into the hyperlipidemic effect of lotus seed resistant starch in hyperlipidemic mice","volume":"314","author":"Zeng","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Xu, F., Yu, Z., Liu, Y., Du, T., Yu, L., Tian, F., Chen, W., and Zhai, Q. (2023). A High-Fat, High-cholesterol diet promotes intestinal inflammation by exacerbating gut microbiome dysbiosis and bile acid disorders in cholecystectomy. Nutrients, 15.","DOI":"10.3390\/nu15173829"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.tjnut.2023.05.026","article-title":"Stigmasterol protects against steatohepatitis induced by high-fat and high-cholesterol diet in mice by enhancing the alternative bile acid synthesis pathway","volume":"153","author":"Xin","year":"2023","journal-title":"J. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1880240","article-title":"Akkermansia muciniphila and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption in rats","volume":"13","author":"Higarza","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1186\/s12967-025-06927-z","article-title":"Postbiotics as a novel intervention for obesity management and improving metabolic parameters: A systematic review and meta-analysis of animal studies","volume":"23","author":"Nazarinejad","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ismael, M., Wu, J., Yang, H., and Zhong, Q. (2026). Impact of dietary interventions with Schleiferilactobacillus harbinensis Z171, its exopolysaccharide, and postbiotics on hepatic cholesterol metabolism in high-fat diet-fed mouse model. Foods, 15.","DOI":"10.3390\/foods15040666"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/jam.14276","article-title":"Postbiotics produced at laboratory and industrial level as potential functional food ingredients with the capacity to protect mice against Salmonella infection","volume":"127","author":"Dunand","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41538-022-00167-x","article-title":"Regulation of viable\/inactivated\/lysed probiotic Lactobacillus plantarum H6 on intestinal microbiota and metabolites in hypercholesterolemic mice","volume":"6","author":"Li","year":"2022","journal-title":"npj Sci. Food"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105999","DOI":"10.1016\/j.fbio.2025.105999","article-title":"Effects of viable Lacticaseibacillus paracasei K56 and its derived postbiotics on obesity and inflammation induced by a high-fat diet","volume":"65","author":"Wu","year":"2025","journal-title":"Food Biosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103108","DOI":"10.1016\/j.fbio.2023.103108","article-title":"Harnessing the potential of postbiotics derived from Bacillus coagulans: A promising avenue for obesity management via the gut-liver axis","volume":"56","author":"Chen","year":"2023","journal-title":"Food Biosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/10408398.2020.1738333","article-title":"Postbiotics: A novel strategy in food allergy treatment","volume":"61","author":"Abbasi","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1080\/10408398.2021.1895061","article-title":"The biological activities of postbiotics in gastrointestinal disorders","volume":"62","author":"Abbasi","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jare.2024.12.002","article-title":"Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity","volume":"75","author":"Luo","year":"2024","journal-title":"J. Adv. Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Liu, J.-J., Wei, F., Wang, Y.-D., Liu, J., Xu, B.-L., Ma, S.-C., and Yang, J.-B. (2025). Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer\u2019s disease. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1461177"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bae, G.Y., Ko, K., Yang, E., Park, S.-S., Suh, H.J., and Hong, K.-B. (2023). Combined effects of Ziziphus jujuba, Dimocarpus longan, and Lactuca sativa on sleep-related behaviors through GABAergic signaling. Foods, 13.","DOI":"10.3390\/foods13010001"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/fft2.185","article-title":"Excessive consumption of the sugar rich longan fruit promoted the development of nonalcoholic fatty liver disease via mediating gut dysbiosis","volume":"4","author":"Wu","year":"2023","journal-title":"Food Front."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Jeon, H.J., You, S.H., Nam, E.H., Truong, V.L., Bang, J.H., Bae, Y.J., Rarison, R.H.G., Kim, S.K., Jeong, W.S., and Jung, Y.H. (2023). Red ginseng dietary fiber promotes probiotic properties of Lactiplantibacillus plantarum and alters bacterial metabolism. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1139386"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1039\/D4FO05503A","article-title":"Mulberry-derived postbiotics alleviate LPS-induced intestinal inflammation and modulate gut microbiota dysbiosis","volume":"16","author":"Abbas","year":"2025","journal-title":"Food Funct."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tek, E., Duran, N., Colak, E.Y., Duran, G.G., Kutlu, T., Bayraktar, H.S., Dagli, S., and Demir, M. (2025). The effects of postbiotics and glycyrrhetinic acid on immune response and inflammation-related genes during H. pylori eradication therapy. BMC Microbiol., 26.","DOI":"10.1186\/s12866-025-04191-1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"116064","DOI":"10.1016\/j.foodres.2025.116064","article-title":"Combined traditional Chinese medicine and probiotics (TCMP) alleviates lipid accumulation and improves metabolism in high-fat diet mice via the microbiota-gut-liver axis","volume":"207","author":"Liu","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"156655","DOI":"10.1016\/j.phymed.2025.156655","article-title":"Renshen Zhuye decoction ameliorates high-fat diet-induced obesity and insulin resistance by modulating gut microbiota and metabolic homeostasis","volume":"141","author":"Luo","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2623578","DOI":"10.1080\/19490976.2026.2623578","article-title":"A novel exopolysaccharide from Lactiplantibacillus plantarum H6 improves cholesterol metabolism via Muribaculum-mediated activation of the enterohepatic FXR\u2013FGF15 axis","volume":"18","author":"Li","year":"2026","journal-title":"Gut Microbes"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Dong, H., Ren, X., Song, Y., Zhang, J., Zhuang, H., Peng, C., Zhao, J., Shen, J., Yang, J., and Zang, J. (2024). Assessment of multifunctional activity of a postbiotic preparation derived from Lacticaseibacillus paracasei postbiotic-P6. Foods, 13.","DOI":"10.20944\/preprints202405.0186.v1"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kou, R., Wang, J., Li, A., Wang, Y., Zhang, B., Liu, J., Sun, Y., and Wang, S. (2023). Ameliorating effects of Bifidobacterium longum subsp. infantis FB3-14 against high-fat-diet-induced obesity and gut microbiota disorder. Nutrients, 15.","DOI":"10.3390\/nu15194104"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ziarno, M., Zareba, D., Scibisz, I., and Kozlowska, M. (2023). Exploring the cholesterol-modifying abilities of Lactobacilli cells in digestive models and dairy products. Microorganisms, 11.","DOI":"10.20944\/preprints202305.0766.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1194\/jlr.R088989","article-title":"Microbial impact on cholesterol and bile acid metabolism: Current status and future prospects","volume":"60","author":"Kriaa","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"103952","DOI":"10.1016\/j.fbio.2024.103952","article-title":"In vitro assessment of antioxidant, antidiabetic, and cholesterol-modulating abilities of lactic acid bacteria: Implications for metabolic health and functional foods","volume":"59","author":"Qayyum","year":"2024","journal-title":"Food Biosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1021\/acs.jafc.3c08527","article-title":"Bifidobacterium breve protects the intestinal epithelium and mitigates inflammation in colitis via regulating the gut microbiota\u2013cholic acid pathway","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"G\u0142owacka, P., Oszajca, K., Pudlarz, A., Szemraj, J., and Witusik-Perkowska, M. (2024). Postbiotics as molecules targeting cellular events of aging brain\u2014The role in pathogenesis, prophylaxis and treatment of neurodegenerative diseases. Nutrients, 16.","DOI":"10.3390\/nu16142244"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"157403","DOI":"10.1016\/j.phymed.2025.157403","article-title":"Systematic review and pharmacological insights of ginsenoside Rf: Current status and future perspectives","volume":"148","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"107260","DOI":"10.1016\/j.fbio.2025.107260","article-title":"Nuciferine alleviates cognitive impairment by modulating endoplasmic reticulum stress in D-galactose-induced aging mice","volume":"71","author":"Yang","year":"2025","journal-title":"Food Biosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1002\/ptr.8528","article-title":"Nuciferine exerts anti-inflammatory effects in mice with non-alcoholic steatohepatitis by regulating the miR-23a-3p-SIRT1-NF-\u03baB pathway and Akkermansia muciniphila-extracellular vesicles","volume":"39","author":"Zhu","year":"2025","journal-title":"Phytother. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Kwon, D., Yun, C., Kim, J.-H., Kim, K.-M., Bae, G.Y., Yang, M.H., Lee, Y.-H., and Jung, Y.-S. (2025). Anti-obesity effects of narirutin and hesperidin in immature Citrus reticulata extract via AMPK activation in high-fat diet-fed mice. Food Sci. Human. Wellness, 15.","DOI":"10.26599\/FSHW.2025.9250649"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100671","DOI":"10.1016\/j.prmcm.2025.100671","article-title":"Neuroprotective potential of hesperidin in alcohol withdrawal syndrome: A preclinical study in Swiss albino mice","volume":"16","author":"Mehdiya","year":"2025","journal-title":"Pharmacol. Res. -Mod. Chin. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"127429","DOI":"10.1016\/j.foodchem.2020.127429","article-title":"Effect of thermal processing on free and bound phenolic compounds and antioxidant activities of hawthorn","volume":"332","author":"Li","year":"2020","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"118943","DOI":"10.1016\/j.jep.2024.118943","article-title":"Taxus chinensis (Pilg.) Rehder fruit attenuates aging behaviors and neuroinflammation by inhibiting microglia activation via TLR4\/NF-\u03baB\/NLRP3 pathway","volume":"337","author":"Meimei","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"108694","DOI":"10.1016\/j.intimp.2022.108694","article-title":"Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-\u03baB and MAPK signaling pathways in vivo and in vitro","volume":"108","author":"Su","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1055\/s-0041-1731707","article-title":"Role of FXR in bile acid and metabolic homeostasis in NASH: Pathogenetic concepts and therapeutic opportunities","volume":"41","author":"Radun","year":"2021","journal-title":"Proc. Semin. Liver Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"G537","DOI":"10.1152\/ajpgi.00311.2017","article-title":"Bile acid profiles within the enterohepatic circulation in a diabetic rat model after bariatric surgeries","volume":"314","author":"Wei","year":"2018","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41522-022-00358-0","article-title":"Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation","volume":"8","author":"Aguirre","year":"2022","journal-title":"npj Biofilms Microbiomes"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40168-023-01471-8","article-title":"Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice","volume":"11","author":"Pan","year":"2023","journal-title":"Microbiome"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"113005","DOI":"10.1016\/j.celrep.2023.113005","article-title":"The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis","volume":"42","author":"Miyamoto","year":"2023","journal-title":"Cell Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105876","DOI":"10.1016\/j.ebiom.2025.105876","article-title":"Gut microbiota regulates exercise-induced hormetic modulation of cognitive function","volume":"119","author":"Cintado","year":"2025","journal-title":"EBioMedicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"109469","DOI":"10.1016\/j.envint.2025.109469","article-title":"Organophosphate pesticides modulate gut microbiota and influence bile acid metabolism in an in vitro fermentation model","volume":"199","author":"Zheng","year":"2025","journal-title":"Environ. Int."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/10\/1679\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:08:45Z","timestamp":1778515725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/10\/1679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["foods15101679"],"URL":"https:\/\/doi.org\/10.3390\/foods15101679","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]}}}