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In this study, selenium-enriched A. subrufescens (SAS) was cultivated, and its protective effects against alcoholic liver disease (ALD) were investigated, with an emphasis on clarifying the underlying mechanisms. The results showed that the yield and antioxidant capacity of mushrooms in a 10 mg\u00b7kg\u22121 Se treatment group were increased. Nutritional analysis revealed that SAS contained considerable levels of crude protein (350.00 g\u00b7kg\u22121), crude fiber (7.8%), free amino acids (250.20 g\u00b7kg\u22121), and other bioactive constituents. Furthermore, the hepatoprotective effects of AS\/SAS were studied in male Kunming mice with alcohol-induced liver injury. The body growth, liver index, serum and liver biochemical parameters, histopathological features of liver, hepatic mRNA levels and liver metabolomics were investigated. The results demonstrated that SAS significantly reduced hepatic lipid accumulation, enhanced antioxidant capacity, regulated the mRNA expression of key genes involved in lipid metabolism, oxidative stress, and inflammatory responses, and modulated liver metabolic characteristics. These findings provide theoretical evidence for the potential of SAS as a functional food against alcohol-induced liver injury.<\/jats:p>","DOI":"10.3390\/foods15111833","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:07:47Z","timestamp":1779444467000},"page":"1833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional Components and Anti-Alcoholic Liver Disease Activity of Selenium-Enriched Agaricus subrufescens"],"prefix":"10.3390","volume":"15","author":[{"given":"Hua","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Animal Husbandryand Veterinary Medicine, Fujian Academy of Agricultural Sciences, 247 Pu-Dang Road, Fuzhou  350013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0710-0728","authenticated-orcid":false,"given":"Shien","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghong","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichen","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Deng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, College of Life Sciences, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 320002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-4284","authenticated-orcid":false,"given":"Xucong","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghu","family":"Liu","sequence":"additional","affiliation":[{"name":"International College of JUNCAO Science, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105826","DOI":"10.1016\/j.fbio.2025.105826","article-title":"Structural characterization and hypoglycaemic effects on type 2 diabetic mice of Spirulina platensis polysaccharides and Se-modified polysaccharides","volume":"64","author":"Chang","year":"2025","journal-title":"Food Biosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.carbpol.2018.10.088","article-title":"A combination of selenium and polysaccharides: Promising therapeutic potential","volume":"206","author":"Li","year":"2019","journal-title":"Carbohydr. 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