{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:50:23Z","timestamp":1785408623632,"version":"3.56.0"},"reference-count":68,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31801559"],"award-info":[{"award-number":["31801559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["31801559"],"award-info":[{"award-number":["31801559"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation Boosting Action Plan for Rural Revitalization of Shandong Province","award":["2024TZXD007"],"award-info":[{"award-number":["2024TZXD007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>As important sources of prebiotics, natural plant polysaccharides have been widely investigated owing to their excellent anti-inflammatory, anti-tumor, immunomodulatory, and gut microbiota-regulating effects. This study explored the anti-tumor effects and underlying mechanisms of garlic polysaccharides (GP-1) in a mouse model of azoxymethane\/dextran sulfate sodium-induced colitis-associated colon tumorigenesis. GP-1, identified as a typical fructan (molecular weight: 3583 Da) with (2\u21921) and (2\u21926) linkages, significantly improved survival rate, reduced colon tumor burden, and alleviated intestinal bleeding in tumor mice. Furthermore, intestinal damage was significantly attenuated, as evidenced by enhanced barrier integrity, downregulated pro-inflammatory cytokines, and elevated antioxidant enzyme activities. GP-1 also inhibited aberrant epithelial proliferation by suppressing Ki67 protein expression. Multi-omics analyses revealed that these benefits might be associated with gut microbiota and metabolite remodeling, as well as transcriptional suppression of key inflammatory\/tumorigenic pathways. Our findings highlighted the inhibitory effect of GP-1 on colon tumorigenesis and supported its potential as a gut-health-promoting functional food ingredient.<\/jats:p>","DOI":"10.3390\/foods15111901","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:57:43Z","timestamp":1779962263000},"page":"1901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Garlic Polysaccharides Ameliorate AOM\/DSS-Induced Colon Tumorigenesis: A Multi-Omics Mechanistic Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Yongqiu","family":"Qi","sequence":"first","affiliation":[{"name":"Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-6273","authenticated-orcid":false,"given":"Zhenjia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiteng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai\u2019an 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135196","DOI":"10.1016\/j.foodchem.2022.135196","article-title":"Supplementation of quinoa peptides alleviates colorectal cancer and restores gut microbiota in AOM\/DSS-treated mice","volume":"408","author":"Fan","year":"2023","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"131759","DOI":"10.1016\/j.foodchem.2021.131759","article-title":"Protective effects of non-extractable phenolics from strawberry against inflammation and colon cancer in vitro","volume":"374","author":"Huang","year":"2022","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","article-title":"Risk of colorectal cancer in patients with ulcerative colitis: A meta-analysis of population-based cohort studies","volume":"10","author":"Jess","year":"2012","journal-title":"Clin. 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