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However, systematic comparisons of flavor and chemical profiles across mainstream cultivars remain lacking. This study systematically analyzed the flavor characteristics, volatile\/non-volatile metabolic profiles, and antioxidant activity of six mainstream CRP cultivars. A total of 455 volatile organic compounds (VOCs) were identified, among which terpenoids showed distinct cultivar-specific accumulation and strongly affected aroma; 35 key VOCs were screened as pivotal contributors to distinct aroma profiles. Untargeted metabolomics identified 1289 non-volatile metabolites, among which polymethoxyflavones and flavonoid glycosides exhibited significant cultivar-specific accumulation. The six CRP cultivars showed five distinct metabolic accumulation patterns, which significantly affected the differences in bioactive compound accumulation and flavor formation among different cultivars. This study reveals the aroma formation basis and metabolic features of mainstream CRP cultivars, offering insights into CRP functional food development and genetic breeding.<\/jats:p>","DOI":"10.3390\/foods15122090","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:25:17Z","timestamp":1781083517000},"page":"2090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated Flavoromics and Metabolomics Reveal Aroma and Bioactive Characteristics of Six Mainstream Citri Reticulatae Pericarpium Cultivars"],"prefix":"10.3390","volume":"15","author":[{"given":"Luxin","family":"Xie","sequence":"first","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"},{"name":"Pharmacy School, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Dong","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Qin","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Shang","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"},{"name":"Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanpeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Pharmacy School, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Pharmacy School, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-3577","authenticated-orcid":false,"given":"Shouwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China"},{"name":"Jiangxi Key Laboratory for Sustainable Utilization of Chinese Materia Medica Resources, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shi, M., Guo, Q., Xiao, Z., Xiao, Y., and Feng, K. (2024). Recent Advances in the Health Benefits and Application of Tangerine Peel (Citri Reticulatae Pericarpium): A Review. Foods, 13.","DOI":"10.3390\/foods13131978"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101798","DOI":"10.1016\/j.fochx.2024.101798","article-title":"FT-NIR Combined with Machine Learning Was Used to Rapidly Detect the Adulteration of Pericarpium Citri Reticulatae (Chenpi) and Predict the Adulteration Concentration","volume":"24","author":"Chen","year":"2024","journal-title":"Food Chem. X"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jeong, S.H., Park, M.Y., Bhosale, P.B., Abusaliya, A., Won, C.K., Park, K.I., Kim, E., Heo, J.D., Kim, H.W., and Ahn, M. (2023). Potential Antioxidant and Anti-Inflammatory Effects of Lonicera japonica and Citri Reticulatae Pericarpium Polyphenolic Extract (LCPE). Antioxidants, 12.","DOI":"10.3390\/antiox12081582"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113514","DOI":"10.1016\/j.foodres.2023.113514","article-title":"Integrated Metabolomics and Network Pharmacology to Reveal Antioxidant Mechanisms and Potential Pharmacological Ingredients of Citrus Herbs","volume":"174","author":"Cao","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"103653","DOI":"10.1016\/j.arabjc.2021.103653","article-title":"Study on Flavonoid and Bioactivity Features of the Pericarp of Citri Reticulatae \u2018chachi\u2019 during Storage","volume":"15","author":"Liang","year":"2022","journal-title":"Arab. J. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wang, F., Chen, L., Chen, H., Yan, Z., and Liu, Y. (2022). Discovery of the Key Active Compounds in Citri Reticulatae Pericarpium (Citrus reticulata \u201cChachi\u201d) and Their Therapeutic Potential for the Treatment of COVID-19 Based on Comparative Metabolomics and Network Pharmacology. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1048926"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature25447","article-title":"Genomics of the Origin and Evolution of Citrus","volume":"554","author":"Wu","year":"2018","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/pca.3496","article-title":"UPLC-Q-TOF-MS with Chemometrics Approach Analysis of Nonvolatile Compounds for Medicinal Citrus Reticulata with Cultivar and Areas Variations","volume":"36","author":"Yang","year":"2025","journal-title":"Phytochem. Anal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.foodchem.2016.05.141","article-title":"Discrimination of Citrus reticulata Blanco and Citrus reticulata \u2018Chachi\u2019 by Gas Chromatograph-Mass Spectrometry Based Metabolomics Approach","volume":"212","author":"Duan","year":"2016","journal-title":"Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wang, F., Chen, L., Chen, H., Chen, S., and Liu, Y. (2019). Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata \u201cDahongpao\u201d) Using UPLC-ESI-MS\/MS. Molecules, 24.","DOI":"10.3390\/molecules24152680"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11104-024-06613-x","article-title":"Pilot Study Assessing Effects of Selected Soil Factors on the Accumulation of Hesperidin, Nobiletin and Tangeretin in Pericarps of Citrus reticulata \u2018Chachi\u2019","volume":"503","author":"Ma","year":"2024","journal-title":"Plant Soil"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.29219\/fnr.v65.7526","article-title":"The Mechanism and Candidate Compounds of Aged Citrus Peel (chenpi) Preventing Chronic Obstructive Pulmonary Disease and Its Progression to Lung Cancer","volume":"65","author":"Zhou","year":"2021","journal-title":"Food Nutr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kim, S.S., Kim, H.-J., Park, K.J., Kang, S.B., Park, Y., Han, S.-G., Kim, M., Song, Y.H., and Kim, D.-S. (2022). Metabolomic Profiling of Citrus unshiu during Different Stages of Fruit Development. Plants, 11.","DOI":"10.3390\/plants11070967"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, W., Fu, X., Zhang, Y., Chen, X., Feng, T., Xiong, C., and Nie, Q. (2024). Metabolome Comparison of Sichuan Dried Orange Peels (Chenpi) Aged for Different Years. Horticulturae, 10.","DOI":"10.3390\/horticulturae10040421"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1270\/jsbbs.21065","article-title":"Recent Applications of Metabolomics in Plant Breeding","volume":"72","author":"Sakurai","year":"2022","journal-title":"Breed. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1016\/j.cell.2022.06.029","article-title":"Metabolic Analysis as a Driver for Discovery, Diagnosis, and Therapy","volume":"185","author":"DeBerardinis","year":"2022","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100500","DOI":"10.1016\/j.fochx.2022.100500","article-title":"Emerging Applications of Metabolomics in Food Science and Future Trends","volume":"16","author":"Wu","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"130697","DOI":"10.1016\/j.foodchem.2021.130697","article-title":"Application of Metabolomics for Revealing the Interventional Effects of Functional Foods on Metabolic Diseases","volume":"367","author":"Fu","year":"2022","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"139227","DOI":"10.1016\/j.foodchem.2024.139227","article-title":"Metabolomics Applications for Plant-Based Foods Origin Tracing, Cultivars Identification and Processing: Feasibility and Future Aspects","volume":"449","author":"Liang","year":"2024","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"112562","DOI":"10.1016\/j.scienta.2023.112562","article-title":"Molecular Mechanisms Underlying Postharvest Physiology and Metabolism of Fruit and Vegetables through Multi-Omics Technologies","volume":"324","author":"Habibi","year":"2024","journal-title":"Sci. Hortic."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100836","DOI":"10.1016\/j.cofs.2022.100836","article-title":"Insights into Metabolomics in Quality Attributes of Postharvest Fruit","volume":"45","author":"Yun","year":"2022","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10068-021-00917-9","article-title":"Mass Spectrometry Based Metabolomics Approach on the Elucidation of Volatile Metabolites Formation in Fermented Foods: A Mini Review","volume":"30","author":"Park","year":"2021","journal-title":"Food Sci. Biotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"138957","DOI":"10.1016\/j.foodchem.2024.138957","article-title":"Evaluation of Aroma Characteristics of Penaeus vannamei with Different Drying Methods Using HS-SPME-GC-MS, MMSE-GC-MS, and Sensory Evaluation","volume":"449","author":"Shi","year":"2024","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1016\/j.apsb.2023.05.021","article-title":"Metabolomics in Drug Research and Development: The Recent Advances in Technologies and Applications","volume":"13","author":"Pang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120721","DOI":"10.1016\/j.indcrop.2025.120721","article-title":"A Multi-Omics Fusion of Metabolomics, Lipidomics, and Flavoromics to Analyze the Effect of Enzyme Treatment on Tobacco Quality","volume":"226","author":"Hao","year":"2025","journal-title":"Ind. Crops Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104794","DOI":"10.1016\/j.tifs.2024.104794","article-title":"Machine Learning and Flavoromics-Based Research Strategies for Determining the Characteristic Flavor of Food: A Review","volume":"154","author":"Cai","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41538-025-00628-z","article-title":"Metabolomics and Sensomics Reveal Non-Volatile Flavor Dynamics in Summer\u2013Autumn Steamed Green Tea Flakes Processing","volume":"9","author":"Ni","year":"2025","journal-title":"npj Sci. Food"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100586","DOI":"10.1016\/j.fochx.2023.100586","article-title":"Aroma Characteristics of Wuyi Rock Tea Prepared from 16 Different Tea Plant Varieties","volume":"17","author":"Yue","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.molp.2024.04.012","article-title":"WTV2.0: A High-Coverage Plant Volatilomics Method with a Comprehensive Selective Ion Monitoring Acquisition Mode","volume":"17","author":"Yuan","year":"2024","journal-title":"Mol. Plant"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102434","DOI":"10.1016\/j.fochx.2025.102434","article-title":"Integrated Widely Targeted Metabolomics and Flavoromics Reveal Processing-Driven Dynamic Changes in Functional Metabolites of Eucommia ulmoides Leaf Tea","volume":"27","author":"Lin","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_31","unstructured":"(2023). Sensory Evaluation for Pubei Chenpi (Standard No. T\/CAI 041-2023)."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"143896","DOI":"10.1016\/j.ijbiomac.2025.143896","article-title":"Identification and Functional Analysis of Terpene Synthases Revealing the Aroma Variations among Different Chrysanthemum indicum var. aromaticum Ploidy Germplasm","volume":"312","author":"Yuan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114942","DOI":"10.1016\/j.foodres.2024.114942","article-title":"Comparison and Identification of Aroma Components in 21 Kinds of Frankincense with Variety and Region Based on the Odor Intensity Characteristic Spectrum Constructed by HS\u2013SPME\u2013GC\u2013MS Combined with E-Nose","volume":"195","author":"Chen","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Mas, M.C., Rambla, J.L., L\u00f3pez-Gresa, M.P., Bl\u00e1zquez, M.A., and Granell, A. (2019). Volatile Compounds in Citrus Essential Oils: A Comprehensive Review. Front. Plant Sci., 10.","DOI":"10.3389\/fpls.2019.00012"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bergman, M.E., Davis, B., and Phillips, M.A. (2019). Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action. Molecules, 24.","DOI":"10.3390\/molecules24213961"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"138616","DOI":"10.1016\/j.foodchem.2024.138616","article-title":"Flavor Characterization of Citri Reticulatae Pericarpium (Citrus reticulata \u2018Chachiensis\u2019) with Different Aging Years via Sensory and Metabolomic Approaches","volume":"443","author":"Liu","year":"2024","journal-title":"Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Liu, H., Zheng, W., Xu, J., Zhou, L., Zong, M., Wang, S., Wang, Y., Zhang, W., Zuo, H., and Liu, S. (2025). Multi-Omics Provides Insights into the Genetic Influence on Characteristic Aroma Formation of Xinhui Chenpi. Hortic. Plant J., in press.","DOI":"10.1016\/j.hpj.2025.05.016"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102617","DOI":"10.1016\/j.fochx.2025.102617","article-title":"Metabolomics Analysis Reveals Dynamic Changes of Volatile and Non-Volatile Metabolites during the Scenting Process of Jasmine Tea","volume":"28","author":"Gu","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"uhaf015","DOI":"10.1093\/hr\/uhaf015","article-title":"Genomic Origin of Citrus reticulata \u201cUnshiu\u201d","volume":"12","author":"Liu","year":"2025","journal-title":"Hortic. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"122970","DOI":"10.1016\/j.carbpol.2024.122970","article-title":"Effects of aging on the fine structure, chain conformation, and morphology of Chenpi polysaccharides","volume":"349","author":"Xu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"144995","DOI":"10.1016\/j.foodchem.2025.144995","article-title":"Flavor Characterization of Aged Citri Reticulatae Pericarpium from Core Regions: An Integrative Approach Utilizing GC-IMS, GC\u2013MS, E-Nose, E-Tongue, and Chemometrics","volume":"490","author":"Liu","year":"2025","journal-title":"Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1182\/blood-2025-6828","article-title":"Hesperadin, an Aurora B Kinase Inhibitor, Synergizes with Chidamide to Suppress T-Cell Acute Lymphoblastic Leukemia by Targeting c-MYC","volume":"146","author":"Chen","year":"2025","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"107048","DOI":"10.1016\/j.jff.2025.107048","article-title":"Hesperidin Blocks the Gastritis-to-Gastric Cancer Cascade: Multi-Pathway Regulation and Mechanism","volume":"134","author":"Deng","year":"2025","journal-title":"J. Funct. Foods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1080\/10408398.2022.2030297","article-title":"Nobiletin as a Chemopreventive Natural Product against Cancer, a Comprehensive Review","volume":"63","author":"Chen","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11236","DOI":"10.1021\/acs.jafc.2c02927","article-title":"Tangeretin Protects Mice from Alcohol-Induced Fatty Liver by Activating Mitophagy through the AMPK\u2013ULK1 Pathway","volume":"70","author":"Guo","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1039\/D4FO01704H","article-title":"Sinensetin, a Polymethoxyflavone from Citrus Fruits, Ameliorates LPS-Induced Acute Lung Injury by Suppressing Txnip\/NLRP3\/Caspase-1\/GSDMD Signaling-Mediated Inflammatory Responses and Pyroptosis","volume":"15","author":"Xu","year":"2024","journal-title":"Food Funct."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"154285","DOI":"10.1016\/j.phymed.2022.154285","article-title":"5-Demethylnobiletin: Insights into Its Pharmacological Activity, Mechanisms, Pharmacokinetics and Toxicity","volume":"104","author":"Ding","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"10050","DOI":"10.1021\/acs.jafc.3c01881","article-title":"Heptamethoxyflavone Alleviates Metabolic Syndrome in High-Fat Diet-Fed Mice by Regulating the Composition, Function, and Metabolism of Gut Microbiota","volume":"71","author":"Feng","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"151611","DOI":"10.1016\/j.bbrc.2025.151611","article-title":"An Integrated Approach of Transcriptomics, Network Pharmacology and Molecular Docking Uncovers the Mechanisms of 5,6,7,4\u2032-Tetramethoxyflavone in Treating Cervical Cancer","volume":"760","author":"You","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2321615121","DOI":"10.1073\/pnas.2321615121","article-title":"Neofunctionalization of an OMT Cluster Dominates Polymethoxyflavone Biosynthesis Associated with the Domestication of Citrus","volume":"121","author":"Peng","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1038\/s41467-024-48235-y","article-title":"An Integrated Multi-Omics Approach Reveals Polymethoxylated Flavonoid Biosynthesis in Citrus reticulata cv. Chachiensis","volume":"15","author":"Wen","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"138964","DOI":"10.1016\/j.foodchem.2024.138964","article-title":"Short-Term Steaming during Processing Impacts the Quality of Citri Reticulatae \u2018Chachi\u2019 Peel","volume":"447","author":"Chen","year":"2024","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"116089","DOI":"10.1016\/j.foodres.2025.116089","article-title":"Metabolite Profiling and \u2018Dryness\u2019-like Effect Analysis of \u2018Chenpi\u2019 Plant Tea (Citri Reticulatae Pericarpium Peel) with and without Steaming Processing","volume":"206","author":"Lan","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"118266","DOI":"10.1016\/j.indcrop.2024.118266","article-title":"Comparative Analysis of Citri reticulatae pericarpium: Revealing the Nonvolatile Compounds Transformation and Optimizing Drying Processes","volume":"212","author":"Sun","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1038\/s41588-023-01516-6","article-title":"Pangenome Analysis Provides Insight into the Evolution of the Orange Subfamily and a Key Gene for Citric Acid Accumulation in Citrus Fruits","volume":"55","author":"Huang","year":"2023","journal-title":"Nat. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"129499","DOI":"10.1016\/j.foodchem.2021.129499","article-title":"Comparative Profiling and Natural Variation of Polymethoxylated Flavones in Various Citrus Germplasms","volume":"354","author":"Peng","year":"2021","journal-title":"Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1080\/10408398.2020.1870035","article-title":"Citrus Flavonoids and Their Antioxidant Evaluation","volume":"62","author":"Wang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Li, L.-J., Tan, W.-S., Li, W.-J., Zhu, Y.-B., Cheng, Y.-S., and Ni, H. (2019). Citrus Taste Modification Potentials by Genetic Engineering. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246194"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101697","DOI":"10.1016\/j.xplc.2026.101697","article-title":"Evolutionary Origin of Neohesperidoside, a Bitter Metabolite, and Its Potential Role in Biotic Defense and Citrus Dissemination","volume":"7","author":"Li","year":"2026","journal-title":"Plant Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"118889","DOI":"10.1016\/j.bbamcr.2020.118889","article-title":"Aminoacyl-tRNA Synthetases and Amino Acid Signaling","volume":"1868","author":"Yu","year":"2021","journal-title":"Biochim. Biophys. Acta BBA-Mol. Cell Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pbi.2017.08.003","article-title":"Functions of ABC Transporters in Plant Growth and Development","volume":"41","author":"Do","year":"2018","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/jipb.13919","article-title":"Optimizing Carbon and Nitrogen Metabolism in Plants: From Fundamental Principles to Practical Applications","volume":"67","author":"Liu","year":"2025","journal-title":"J. Integr. Plant Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-arplant-050213-040251","article-title":"Sucrose Metabolism: Gateway to Diverse Carbon Use and Sugar Signaling","volume":"65","author":"Ruan","year":"2014","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1021\/acssynbio.4c00383","article-title":"Advances in Flavonoid and Derivative Biosynthesis: Systematic Strategies for the Construction of Yeast Cell Factories","volume":"13","author":"Wang","year":"2024","journal-title":"ACS Synth. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"102884","DOI":"10.1016\/j.fochx.2025.102884","article-title":"Revealing the Dynamic Changes in the Metabolites and Sensory Quality of Citri Reticulatae Pericarpium during Aging Using Feature-Based Molecular Networks and Metabolomics","volume":"29","author":"Xu","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"138531","DOI":"10.1016\/j.foodchem.2024.138531","article-title":"Recent Advances in the Authentication (Geographical Origins, Varieties and Aging Time) of Tangerine Peel (Citri reticulatae Pericarpium): A Review","volume":"442","author":"Li","year":"2024","journal-title":"Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"113093","DOI":"10.1016\/j.postharvbio.2024.113093","article-title":"Insight into Role of Nicotinamide Involved in Energy Metabolism and Redox Homeostasis: A Case Study in Strawberry","volume":"217","author":"Mao","year":"2024","journal-title":"Postharvest Biol. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Leonardi, R., and Jackowski, S. (2007). Biosynthesis of Pantothenic Acid and Coenzyme A. EcoSal Plus, 2.","DOI":"10.1128\/ecosalplus.3.6.3.4"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tplants.2008.03.003","article-title":"Building Lipid Barriers: Biosynthesis of Cutin and Suberin","volume":"13","author":"Pollard","year":"2008","journal-title":"Trends Plant Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"He, M., Qin, C.-X., Wang, X., and Ding, N.-Z. (2020). Plant Unsaturated Fatty Acids: Biosynthesis and Regulation. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.00390"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/jipb.13054","article-title":"Contribution of Phenylpropanoid Metabolism to Plant Development and Plant\u2013Environment Interactions","volume":"63","author":"Dong","year":"2021","journal-title":"J. Integr. Plant Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1078\/0176-1617-01169","article-title":"Purine and Pyrimidine Nucleotide Metabolism in Higher Plants","volume":"160","author":"Stasolla","year":"2003","journal-title":"J. Plant Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"118054","DOI":"10.1016\/j.foodres.2025.118054","article-title":"Elucidation of the Diverse Molecular Signatures and Transformation Pathways of Flavor Metabolites in Age-Stratified Citri reticulatae pericarpium (ChenPi) and Their Enzymatic Hydrolysates: A Perspective from the Flavor Space","volume":"225","author":"Wu","year":"2026","journal-title":"Food Res. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/fft2.506","article-title":"Unveiling the Potentials and Action Mechanisms of Citri reticulatae Pericarpium as an Anti-Inflammatory Food","volume":"6","author":"Li","year":"2025","journal-title":"Food Front."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.molp.2024.10.009","article-title":"Genomic and Metabolomic Insights into the Selection and Differentiation of Bioactive Compounds in Citrus","volume":"17","author":"Liang","year":"2024","journal-title":"Mol. Plant"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"140806","DOI":"10.1016\/j.foodchem.2024.140806","article-title":"Targeted\/Untargeted Metabolomics and Antioxidant Properties Distinguish Citrus reticulata \u2018Chachi\u2019 from Citrus reticulata Blanco","volume":"462","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"143053","DOI":"10.1016\/j.foodchem.2025.143053","article-title":"Differentiation of Citri Reticulatae Pericarpium Varieties via HPLC Fingerprinting of Polysaccharides Combined with Machine Learning","volume":"473","author":"Zhong","year":"2025","journal-title":"Food Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Yang, M., Jiang, Z., Wen, M., Wu, Z., Zha, M., Xu, W., and Zhang, L. (2022). Chemical Variation of Chenpi (Citrus Peels) and Corresponding Correlated Bioactive Compounds by LC-MS Metabolomics and Multibioassay Analysis. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.825381"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"118324","DOI":"10.1016\/j.foodres.2025.118324","article-title":"Metabolomics Combined with Extraction Optimization and Biochemical Assays Revealed Flavonoids and in Vitro and in Vivo Antioxidant Activity of Ponkan Chenpi","volume":"227","author":"Wang","year":"2026","journal-title":"Food Res. Int."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/12\/2090\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:33:16Z","timestamp":1781087596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/12\/2090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":79,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["foods15122090"],"URL":"https:\/\/doi.org\/10.3390\/foods15122090","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]}}}