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Se and Zn play crucial roles in maintaining redox balance in the liver. This study evaluated the effects of micronutrient-biofortified chickpea flours as functional ingredients for the prevention and management of MAFLD disturbances. Chickpea seeds were germinated with Na2SeO3, ZnSO4, ZnSeO3, or ZnSO4 + Na2SeO3, processed into flours, and then subjected to gastrointestinal digestion to obtain biofortified-chickpea digests (BCD). SDS-PAGE and FTIR indicated treatment-dependent changes in the protein\/peptide profile and in the structural organization of the digested matrix. Isoflavone content was higher in ZnSO4-BCDs. The oleic acid-induced HepG2 cell model was used to emulate MAFLD conditions. Under preventive conditions, except for ZnSeO3-BCD, all treatments reduce triglyceride accumulation from 17.1 to 38.6%. Non-biofortified (GC) chickpea flour and ZnSeO3-BCD had greater effects on lipolysis and glycerol release. Overall, Se-BCD affected redox regulation 1.2\u20131.3-fold, suggesting potential improvement in lipid utilization. GC and ZnSO4 + Na2SeO3 BCDs decreased triglyceride accumulation (21.1 and 20.5%, respectively) when evaluated post lipid exposure. In both experimental conditions, BCDs significantly reduced IL-6 levels by 25.1 to 34.7%, demonstrating their immunomodulatory potential. Biofortified chickpea flours exhibit complementary and coordinated biological activities against the main metabolic disturbances associated with MAFLD. Zn\/Se-biofortification of chickpea is a valuable strategy for addressing micronutrient deficiencies and for producing functional ingredients to prevent or ameliorate MAFLD-associated disturbances and improve liver health.<\/jats:p>","DOI":"10.3390\/foods15132330","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:41:01Z","timestamp":1782902461000},"page":"2330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventive and Ameliorative Effects of Se- and Zn-Biofortified Chickpeas on MAFLD-Related Metabolic Disturbances"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3690-6690","authenticated-orcid":false,"given":"Emilio","family":"L\u00f3pez-Mill\u00e1n","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey 64849, NL, Mexico"},{"name":"Tecnologico de Monterrey, Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey  64849, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Alberto","family":"Uribe-Echeverr\u00eda","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey 64849, NL, Mexico"},{"name":"Tecnologico de Monterrey, Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey  64849, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-5267","authenticated-orcid":false,"given":"Juli\u00e1n","family":"de la Rosa-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey 64849, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-6832","authenticated-orcid":false,"given":"Marilena","family":"Antunes-Ricardo","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey 64849, NL, Mexico"},{"name":"Tecnologico de Monterrey, Institute for Obesity Research, Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico, Monterrey  64849, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102882","DOI":"10.1016\/j.pmedr.2024.102882","article-title":"The Global Burden of Overweight-Obesity and Its Association with Economic Status, Benefiting from STEPs Survey of WHO Member States: A Meta-Analysis","volume":"46","author":"Islam","year":"2024","journal-title":"Prev. 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