{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:04:36Z","timestamp":1785423876002,"version":"3.56.0"},"reference-count":87,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472365"],"award-info":[{"award-number":["32472365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32472365"],"award-info":[{"award-number":["32472365"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017948","name":"Chongqing Academy of Science and Technology","doi-asserted-by":"publisher","award":["CSTB2023TIAD-KPX0030"],"award-info":[{"award-number":["CSTB2023TIAD-KPX0030"]}],"id":[{"id":"10.13039\/100017948","id-type":"DOI","asserted-by":"publisher"}]},{"award":["CSTB2023TIAD-KPX0030"],"award-info":[{"award-number":["CSTB2023TIAD-KPX0030"]}],"id":[{"id":"https:\/\/ror.org\/01gnzp994","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Chongqing Modern Agricultural Industry Technology System","award":["CQMAITS202513"],"award-info":[{"award-number":["CQMAITS202513"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The liver, a by-product of livestock processing, is abundant in protein and serves as an excellent precursor for bioactive and taste-active peptides. However, comprehensive reviews on its valorization remain limited. This review summarizes recent advances in utilizing liver as a source of bioactive peptides (BPs) and taste-active peptides (TAPs). It systematically outlines the composition of liver and preparation methods of liver-derived peptides, discusses the diverse bioactivities of peptides from livestock liver and its taste characteristics, and also examines current challenges along with future perspectives. Liver-derived peptides possess various bioactivities, such as antioxidant, anti-inflammatory, antihypertensive, and metabolism-regulatory activities. Meanwhile, they can elicit the umami, sweet, and bitter taste primarily through different taste transduction receptors. The bioactive and taste properties of peptides are closely related to molecular weight, hydrophobicity, and composition of peptides. Furthermore, ultrasound treatment and the Maillard reaction are effective methods for improving the taste characteristics of liver-derived peptides. However, current research on liver-derived peptides remains limited by inefficient screening and prediction of BPs, low bioavailability, and a narrow focus on TAPs. Overall, this review provides a theoretical reference for high-value utilization of liver-derived peptides from livestock by-products.<\/jats:p>","DOI":"10.3390\/foods15142497","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:05:58Z","timestamp":1784077558000},"page":"2497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver-Derived Peptides from Livestock Processing By-Products: Insights into Generation, Bioactivity, and Taste Properties"],"prefix":"10.3390","volume":"15","author":[{"given":"Zhilin","family":"Chen","sequence":"first","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"},{"name":"Westa College, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4840-3685","authenticated-orcid":false,"given":"Ahmed H.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"},{"name":"Department Food Science and Technology, Faculty of Agriculture, Qena University, Qena 83523, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Food Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100910","DOI":"10.1016\/j.cogsc.2024.100910","article-title":"Meat by-products as a source of bioactive peptides and functional ingredients: Regulatory and safety barriers to valorization","volume":"47","author":"Gagaoua","year":"2024","journal-title":"Curr. Opin. Green Sustain. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.tifs.2021.02.033","article-title":"Values-added utilization of protein and hydrolysates from animal processing by-product livers: A review","volume":"110","author":"Zou","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s43555-024-00038-4","article-title":"Strategies for Porcine Liver Valorization as a Source of Food Ingredients","volume":"2","author":"Saguer","year":"2024","journal-title":"Curr. Food Sci. Technol. Rep."},{"key":"ref_4","first-page":"4435","article-title":"Comparison of nutrients between donkey liver and pig liver, chicken liver and goose liver","volume":"9","author":"Zhang","year":"2018","journal-title":"J. Food Saf. Qual."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104037","DOI":"10.1016\/j.jprot.2020.104037","article-title":"Peptidomic analysis of antioxidant peptides from porcine liver hydrolysates using SWATH-MS","volume":"232","author":"Borrajo","year":"2021","journal-title":"J. Proteom."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106744","DOI":"10.1016\/j.fbio.2025.106744","article-title":"Anti-inflammatory and lipid metabolism regulatory effects of porcine liver protein-derived peptides: Preparation, verification and identification","volume":"69","author":"Miao","year":"2025","journal-title":"Food Biosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"147276","DOI":"10.1016\/j.foodchem.2025.147276","article-title":"Enhanced flavor and modified structure of Maillard reaction products from chicken liver protein hydrolysate through composite fermentation pretreatment","volume":"498","author":"Chen","year":"2026","journal-title":"Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107031","DOI":"10.1016\/j.ultsonch.2024.107031","article-title":"Effects of ultrasonic waves of different powers on the physicochemical properties, functional characteristics, and ultrastructure of bovine liver peptides","volume":"110","author":"Duan","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.crfs.2020.11.002","article-title":"The identification and characterisation of novel bioactive peptides derived from porcine liver","volume":"3","author":"Pearman","year":"2020","journal-title":"Curr. Res. Food Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115240","DOI":"10.1016\/j.foodres.2024.115240","article-title":"Effect of ultrasound and enzymatic pre-treatments on the profile of bioactive peptides of beef liver hydrolysates","volume":"197","author":"Gallego","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1007\/s12649-021-01464-4","article-title":"In-Vivo Anti-anaemic Effects of Bioactive Compounds Prepared from Chicken Liver Using Biotechnological Tools","volume":"12","author":"Chakka","year":"2021","journal-title":"Waste Biomass Valoriz."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Juknien\u0117, I., Zaborskien\u0117, G., Jankauskien\u0117, A., and Ma\u010dionien\u0117, I. (2023). Antimicrobial and Antioxidant Properties of Bovine Livers and Hearts Hydrolysates. Appl. Sci., 13.","DOI":"10.3390\/app132413142"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lu, Y., Zhou, M., Lou, A., Gao, D., Li, Z., Gao, M., Han, S., Liu, F., Xu, F., and Qi, X. (2025). Pig liver peptide KITGLGVK ameliorates alcoholic liver disease through the gut\u2013liver axis: Focus on the SCFA\/NRF2\/xCT\/GPX4, BA\/FXR\/SREBP1c and pyruvate\u2013TCA cycle pathways. Food Sci. Hum. Wellness.","DOI":"10.26599\/FSHW.2025.9250660"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"127369","DOI":"10.1016\/j.foodchem.2020.127369","article-title":"Effects of ultrasound pretreatment on the extent of Maillard reaction and the structure, taste and volatile compounds of chicken liver protein","volume":"331","author":"Chen","year":"2020","journal-title":"Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"113468","DOI":"10.1016\/j.foodres.2023.113468","article-title":"Pork organs as a potential source of flavour-related substances","volume":"173","author":"Mora","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_16","first-page":"26","article-title":"Comparative Studies of Amino Acid, Fatty Acids and Proximal Chemical Composition Content of Donkey, Dog, Camel, Beef and Goat Liver","volume":"24","author":"Bayomy","year":"2019","journal-title":"Agric. Food Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104125","DOI":"10.1016\/j.tifs.2023.104125","article-title":"Chicken slaughterhouse by-products: A source of protein hydrolysates to manage non-communicable diseases","volume":"139","author":"Mulero","year":"2023","journal-title":"Trends Food Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"\u010cubo\u0148, J., Hlebov\u00e1, M., and Ha\u0161\u010d\u00edk, P. (2022). Meat and Liver Quality of Overfed Duck, Slovak University of Agriculture in Nitra.","DOI":"10.15414\/2022.9788055224978"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rodrigues, L.S., Silva, J.A.R.d., Silva, W.C.d., Silva, \u00c9.B.R.d., Belo, T.S., Sousa, C.E.L., Rodrigues, T.C.G.d.C., Silva, A.G.M.e., Prates, J.A.M., and Louren\u00e7o-J\u00fanior, J.d.B. (2024). A Review of the Nutritional Aspects and Composition of the Meat, Liver and Fat of Buffaloes in the Amazon. Animals, 14.","DOI":"10.3390\/ani14111618"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cordeiro, A.R.R.d.A., Bezerra, T.K.A., and Madruga, M.S. (2022). Valuation of Goat and Sheep By-Products: Challenges and Opportunities for Their Use. Animals, 12.","DOI":"10.3390\/ani12233277"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107738","DOI":"10.4254\/wjh.v17.i8.107738","article-title":"Vitamin A toxicity and hepatic pathology: A comprehensive review","volume":"17","author":"Pestalardo","year":"2025","journal-title":"World J. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Du, G.-H. (2018). Vitamin B. Natural Small Molecule Drugs from Plants, Springer.","DOI":"10.1007\/978-981-10-8022-7"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, F., Li, X., and Wei, Y. (2023). Selenium and Selenoproteins in Health. Biomolecules, 13.","DOI":"10.3390\/biom13050799"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zang, L., Zhu, H., Wang, K., Liu, Y., Yu, F., and Zhao, W. (2022). Not Just Anticoagulation-New and Old Applications of Heparin. Molecules, 27.","DOI":"10.3390\/molecules27206968"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4254\/wjh.v15.i2.180","article-title":"Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy","volume":"15","author":"Zhang","year":"2023","journal-title":"World J. Hepatol."},{"key":"ref_26","first-page":"100047","article-title":"Enzymatic hydrolysis and microbial fermentation: The most favorable biotechnological methods for the release of bioactive peptides","volume":"3","author":"Aguilar","year":"2021","journal-title":"Food Chem."},{"key":"ref_27","first-page":"100281","article-title":"Graphing the Green route: Enzymatic hydrolysis in sustainable decomposition","volume":"7","author":"Singh","year":"2024","journal-title":"Curr. Res. Microb. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109389","DOI":"10.1016\/j.foodres.2020.109389","article-title":"Antioxidant activity and peptidomic analysis of porcine liver hydrolysates using alcalase, bromelain, flavourzyme and papain enzymes","volume":"137","author":"Borrajo","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Borrajo, P., L\u00f3pez-Pedrouso, M., Franco, D., Pateiro, M., and Lorenzo, J.M. (2020). Antioxidant and Antimicrobial Activity of Porcine Liver Hydrolysates Using Flavourzyme. Appl. Sci., 10.","DOI":"10.3390\/app10113950"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"103036","DOI":"10.1016\/j.fbio.2023.103036","article-title":"Identification of hepatoprotective peptides from porcine liver and its interaction with ethanol metabolizing enzymes in vitro","volume":"55","author":"Wang","year":"2023","journal-title":"Food Biosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109123","DOI":"10.1016\/j.foodres.2020.109123","article-title":"Workflow towards the generation of bioactive hydrolysates from porcine products by combining in silico and in vitro approaches","volume":"132","author":"Bechaux","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Sun, J., Zhou, C., Cao, J., He, J., Sun, Y., Dang, Y., Pan, D., and Xia, Q. (2022). Purification and Characterization of Novel Antioxidative Peptides From Duck Liver Protein Hydrolysate as Well as Their Cytoprotection Against Oxidative Stress in HepG2 Cells. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.848289"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"116718","DOI":"10.1016\/j.lwt.2024.116718","article-title":"Bovine liver hydrolysates based on six proteases: Physicochemical properties, emulsification characteristics, antioxidant capacity assessment, and peptide identification","volume":"208","author":"Duan","year":"2024","journal-title":"LWT"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s13197-022-05571-5","article-title":"Antioxidant and angiotensin-I-converting enzyme (ACE-I) inhibitory activities of protein hydrolysates derived from water buffalo (Bubalus bubalis) liver","volume":"60","author":"Maheswarappa","year":"2023","journal-title":"J. Food Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1007\/s13197-015-1920-2","article-title":"In-vitro antioxidant and antibacterial properties of fermentatively and enzymatically prepared chicken liver protein hydrolysates","volume":"52","author":"Chakka","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Du, Y., Chen, Z., Wei, H., Zhu, S., and Cai, K. (2022). Isolation and Identification of Antioxidative Peptide from Goose Liver Hydrolysate to Ameliorate Alcohol-Mediated Oxidative Stress Damage in HHL-5 Hepatocytes. Molecules, 27.","DOI":"10.3390\/molecules27217151"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10068-017-0166-3","article-title":"Antioxidant properties of porcine liver proteins hydrolyzed using Monascus purpureus","volume":"26","author":"Yu","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"114479","DOI":"10.1016\/j.lwt.2023.114479","article-title":"Preparation and characterization of duck liver-derived antioxidant peptides based on LC-MS\/MS, molecular docking, and machine learning","volume":"175","author":"Fan","year":"2023","journal-title":"LWT"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1007\/s11694-024-03035-2","article-title":"Use of poultry by-products: Production of functional ingredients with high bioactive value through the use of ultrasound-assisted enzymatic hydrolysis","volume":"19","year":"2025","journal-title":"J. Food Meas. Charact."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e13091","DOI":"10.1111\/jfbc.13091","article-title":"Ultrasound treatment on the structure of goose liver proteins and antioxidant activities of its enzymatic hydrolysate","volume":"44","author":"Zhao","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"117458","DOI":"10.1016\/j.lwt.2025.117458","article-title":"Effect of low-frequency ultrasound pretreatment on taste substances in chicken liver by fermentation","volume":"218","author":"Wang","year":"2025","journal-title":"LWT"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"136351","DOI":"10.1016\/j.foodchem.2023.136351","article-title":"Valorisation of pork by-products to obtain antioxidant and antihypertensive peptides","volume":"423","author":"Lorenzo","year":"2023","journal-title":"Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Islam, M., Huang, Y., Islam, S., Fan, B., Tong, L., and Wang, F. (2022). Influence of the Degree of Hydrolysis on Functional Properties and Antioxidant Activity of Enzymatic Soybean Protein Hydrolysates. Molecules, 27.","DOI":"10.3390\/molecules27186110"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.ijbiomac.2020.10.060","article-title":"Use of Alcalase in the production of bioactive peptides: A review","volume":"165","author":"Siar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"145917","DOI":"10.1016\/j.foodchem.2025.145917","article-title":"Upcycling shrimp processing by-products into dual-functional peptides: Insights into bioactivity and flavor","volume":"493","author":"Chen","year":"2025","journal-title":"Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"142178","DOI":"10.1016\/j.foodchem.2024.142178","article-title":"Comparative analysis of different pretreatments and hydrolysis conditions for the generation of taste-related substances in pork liver hydrolyzates","volume":"467","author":"Mora","year":"2025","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"15693","DOI":"10.1021\/acs.jafc.4c02362","article-title":"Sequential Enzymatic Hydrolysis and Ultrasound Pretreatment of Pork Liver for the Generation of Bioactive and Taste-Related Hydrolyzates","volume":"72","author":"Mora","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.foodchem.2018.02.159","article-title":"Structural characteristics of low bitter and high umami protein hydrolysates prepared from bovine muscle and porcine plasma","volume":"257","author":"Fu","year":"2018","journal-title":"Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Peres Fabbri, L., Cavallero, A., Vidotto, F., and Gabriele, M. (2024). Bioactive Peptides from Fermented Foods: Production Approaches, Sources, and Potential Health Benefits. Foods, 13.","DOI":"10.3390\/foods13213369"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ijbiomac.2019.08.062","article-title":"Modifying the structure, emulsifying and rheological properties of water-soluble protein from chicken liver by low-frequency ultrasound treatment","volume":"139","author":"Zou","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"128417","DOI":"10.1016\/j.foodchem.2020.128417","article-title":"Structural and antimicrobial properties of Maillard reaction products in chicken liver protein hydrolysate after sonication","volume":"343","author":"Chen","year":"2021","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gani, A., and Ashwar, B.A. (2021). Bioactive Peptides Derived from Different Sources. Food Biopolymers: Structural, Functional and Nutraceutical Properties, Springer International Publishing.","DOI":"10.1007\/978-3-030-27061-2"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.26599\/FSHW.2023.9250041","article-title":"Identification and the molecular mechanism of novel duck liver-derived anti-inflammatory peptides in lipopolysaccharide-induced RAW264.7 cell model","volume":"13","author":"Fan","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_54","first-page":"150","article-title":"Isolation, Identification and Activity of Anti-inflammatory Peptides Derived from Duck Liver Protein Hydrolysate","volume":"44","author":"Laidi","year":"2023","journal-title":"Food Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1021\/acs.jafc.7b01403","article-title":"Protective Effects of Functional Chicken Liver Hydrolysates against Liver Fibrogenesis: Antioxidation, Anti-inflammation, and Antifibrosis","volume":"65","author":"Chen","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s42452-025-07464-6","article-title":"Natural plant antioxidants for food preservation and emerging trends in nutraceutical applications","volume":"7","author":"Parveen","year":"2025","journal-title":"Discov. Appl. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Juknien\u0117, I., Zaborskien\u0117, G., and Stankevi\u010dien\u0117, J. (2024). Identification for Antioxidant Peptides in Porcine Liver and Heart Hydrolysates Using SWATH-MS Analysis. Processes, 12.","DOI":"10.3390\/pr12122944"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sar\u0131ta\u015f, S., Portocarrero, A.C.M., Miranda L\u00f3pez, J.M., Lombardo, M., Koch, W., Raposo, A., El-Seedi, H.R., de Brito Alves, J.L., Esatbeyoglu, T., and Karav, S. (2024). The Impact of Fermentation on the Antioxidant Activity of Food Products. Molecules, 29.","DOI":"10.3390\/molecules29163941"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103744","DOI":"10.1016\/j.fbio.2024.103744","article-title":"Recent advances of hepatoprotective peptides: Production, structure, mechanisms, and interactions with intestinal microbiota","volume":"58","author":"Zhong","year":"2024","journal-title":"Food Biosci."},{"key":"ref_60","first-page":"342","article-title":"Research Progress on Preparation, Activity Analysis, and Structure-activity Relationship of Visceral Bioactive Peptides from Livestock and Poultry","volume":"40","author":"Yuting","year":"2024","journal-title":"Mod. Food Sci. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Silvestrini, A., Meucci, E., Ricerca, B.M., and Mancini, A. (2023). Total Antioxidant Capacity: Biochemical Aspects and Clinical Significance. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310978"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.peptides.2010.11.024","article-title":"Isolation, purification and characterization of antioxidant peptidic fractions from a bovine liver sarcoplasmic protein thermolysin hydrolyzate","volume":"32","author":"Rai","year":"2011","journal-title":"Peptides"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"132833","DOI":"10.1016\/j.ijbiomac.2024.132833","article-title":"Unlocking the potential of chicken liver byproducts: Identification of antioxidant peptides through in silico approaches and anti-aging effects of a selected peptide in Caenorhabditis elegans","volume":"272","author":"Chen","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1111\/ijfs.12471","article-title":"Antioxidant activities of chicken liver hydrolysates by pepsin treatment","volume":"49","author":"Chou","year":"2014","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_65","unstructured":"Bravo-Diaz, C. (2022). Amino Acids, Amino Acid Derivatives and Peptides as Antioxidants. Lipid Oxidation in Food and Biological Systems: A Physical Chemistry Perspective, Springer International Publishing."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/cmdc.202000996","article-title":"The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products","volume":"16","author":"Wang","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"115300","DOI":"10.1016\/j.addr.2024.115300","article-title":"Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers","volume":"208","author":"Stephens","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"12510","DOI":"10.1039\/D2FO02223K","article-title":"Peptides and protein hydrolysates exhibiting anti-inflammatory activity: Sources, structural features and modulation mechanisms","volume":"13","author":"Guadix","year":"2022","journal-title":"Food Funct."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"02","DOI":"10.54393\/pbmj.v6i04.858","article-title":"Hypertension: Causes, Symptoms, Treatment and Prevention: Hypertension: Treatment and Prevention","volume":"6","author":"Mazhar","year":"2023","journal-title":"Pak. Biomed. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated mechanisms of MASLD pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.foodchem.2014.03.052","article-title":"Effects of chicken-liver hydrolysates on lipid metabolism in a high-fat diet","volume":"160","author":"Yang","year":"2014","journal-title":"Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"104023","DOI":"10.1016\/j.psj.2024.104023","article-title":"Valorization of broiler edible byproducts: A chicken-liver hydrolysate with hepatoprotection against binge drinking","volume":"103","author":"Lin","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.5713\/ajas.18.0571","article-title":"Identification of duck liver-expressed antimicrobial peptide 2 and characterization of its bactericidal activity","volume":"32","author":"Hong","year":"2019","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut\u2013liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"127678","DOI":"10.1016\/j.foodchem.2020.127678","article-title":"New insights into the structure-activity relationships of antioxidative peptide PMRGGGGYHY","volume":"337","author":"Wu","year":"2021","journal-title":"Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Xiang, H., Song, W., Hao, S., and Sun-Waterhouse, D. (2026). Unlocking the Potential of Taste and Taste-active Peptides: Bridging Structural Characteristics and Biological Activities with Food and Pharmaceutical Applications. J. Future Foods, in press.","DOI":"10.1016\/j.jfutfo.2025.12.020"},{"key":"ref_77","unstructured":"Zhou, H. (2023). Study on Preparation and Umami Mechanism of Taste Peptides from Chicken Liver and Fish Bone Paste. [Master\u2019s Thesis, Jiangsu University]."},{"key":"ref_78","unstructured":"Ahmad, R., Kim, J., Hutchings, S., Subbaraj, A., and Hannaford, R. (2024). Kokumi Flavour Peptide Production from Beef Offal Co-Products, AMPC."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/ijfs.14037","article-title":"Valorisation of protein hydrolysates from animal by-products: Perspectives on bitter taste and debittering methods: A review","volume":"54","author":"Fu","year":"2019","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"145028","DOI":"10.1016\/j.foodchem.2025.145028","article-title":"Discovery of novel umami peptides and their bitterness masking effects from yellowfin tuna (Thunnus albacares) via peptidomics, multisensory evaluation, and molecular docking approaches","volume":"489","author":"Wei","year":"2025","journal-title":"Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1080\/10408398.2019.1691500","article-title":"Maillard reaction products derived from food protein-derived peptides: Insights into flavor and bioactivity","volume":"60","author":"Fu","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"15906","DOI":"10.1021\/acs.jafc.4c02871","article-title":"Generation of Olfactory Compounds in Cat Food Attractants: Chicken Liver-Derived Protein Hydrolysates and Their Contribution to Enhancing Palatability","volume":"72","author":"Wei","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"148082","DOI":"10.1016\/j.foodchem.2026.148082","article-title":"Research advances and outlook of bioactive peptides: Integrating artificial intelligence, molecular simulation, and instrumental analysis techniques","volume":"506","author":"Cao","year":"2026","journal-title":"Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"104845","DOI":"10.1016\/j.tifs.2024.104845","article-title":"Artificial intelligence in food bioactive peptides screening: Recent advances and future prospects","volume":"156","author":"Chang","year":"2025","journal-title":"Trends Food Sci. Technol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"149640","DOI":"10.1016\/j.foodchem.2026.149640","article-title":"Plastein reaction improves the ADH-stabilizing activity and digestive stability of chicken hydrolysate: The critical role of hydrophobic peptides","volume":"519","author":"Xiao","year":"2026","journal-title":"Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.crfs.2022.10.031","article-title":"Advances in the stability challenges of bioactive peptides and improvement strategies","volume":"5","author":"Pei","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wang, X., Yang, Z., Zhang, W., Xing, L., Luo, R., and Cao, S. (2024). Obstacles, research progress, and prospects of oral delivery of bioactive peptides: A comprehensive review. Front. 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