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This study aimed to optimize and compare the extraction of phenolic compounds from the residual biomass of andiroba (Carapa guianensis) using the conventional method with methanol as the solvent, and a green chemistry method via ultrasound using ethanol as the solvent. The optimization of the extraction variables (time, mass\/volume ratio, and ethanol concentration) was performed using a Central Composite Rotatable Design (CCRD 23) combined with the desirability function. The established optimal conditions were an extraction time of 26.78 min, a mass\/volume ratio of 86.46 mg\/mL, and an ethanol concentration of 32.5%. The conventional method achieved a higher yield of total phenolic compounds (TPC) (109.05 mg GAE\/mL) and total flavonoid compounds (TFC) (38.18 mg GAE\/mL) compared to the ultrasound-assisted method (UAE) (82.64 and 26.27 mg GAE\/mL, respectively). LC-MS analysis revealed a diversity of extracted bioactive molecules. Both methodologies yielded extracts with good in vitro antioxidant activity (DPPH and ABTS). In the antimicrobial assay, the extracts demonstrated an unprecedented bacteriostatic effect for this residue, inhibiting the growth of the Gram-positive bacterium Staphylococcus aureus at concentrations ranging from 43.83% to 52.67%, with no activity against Gram-negative bacteria. The optimization demonstrated that the industrial residue of andiroba still contains a significant concentration of bioactive compounds. These findings confirm the bioeconomic potential of this by-product for the formulation of high-value-added bio-inputs, with promising applications in the development of smart packaging or bioactive food coatings.<\/jats:p>","DOI":"10.3390\/foods15152641","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:55:41Z","timestamp":1785225341000},"page":"2641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Valorization of Carapa guianensis By-Products: Extraction Optimization and Antimicrobial and Antioxidant Activity"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-1233","authenticated-orcid":false,"given":"Vinicius Sid\u00f4nio Vale","family":"Moraes","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos (PPGCTA), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Vieira","family":"Pantoja","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos (PPGCTA), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Aparecido Ferreira de","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioquimica, Instituto Butantan, S\u00e3o Paulo 05503-900, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em\u00eddio","family":"Beraldo-Neto","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioquimica, Instituto Butantan, S\u00e3o Paulo 05503-900, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuelle da Silva","family":"Prudente","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Biotecnologia Aplicada a Agropecu\u00e1ria (PPGBAA), Bel\u00e9m 66077-830, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnatt Allan Rocha de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos (PPGCTA), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, Par\u00e1, Brazil"},{"name":"Faculdade de Nutri\u00e7\u00e3o (FANUT), Instituto de Sa\u00fade, Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-4502","authenticated-orcid":false,"given":"Luiza Helena da Silva","family":"Martins","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos (PPGCTA), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, Par\u00e1, Brazil"},{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Biotecnologia Aplicada a Agropecu\u00e1ria (PPGBAA), Bel\u00e9m 66077-830, Par\u00e1, Brazil"},{"name":"Instituto de Sa\u00fade e Produ\u00e7\u00e3o Animal (ISPA), Universidade Federal Rural da Amaz\u00f4nia (UFRA), Bel\u00e9m 66077-830, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia de F\u00e1tima Henriques","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancia e Tecnologia de Alimentos (PPGCTA), Universidade Federal do Par\u00e1 (UFPA), Rua Augusto Corr\u00eaa, Bel\u00e9m 66075-900, Par\u00e1, 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