{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:15:38Z","timestamp":1785402938797,"version":"3.56.0"},"reference-count":53,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research Plan Rural Revitalization Science and Technology Innovation Boosting Action Plan Project of Shandong Province","award":["2022TZXD0026"],"award-info":[{"award-number":["2022TZXD0026"]}]},{"name":"Shandong Province Engineering Technology Research Center for Efficient Utilization of Fruit and Vegetable Resources"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202217"],"award-info":[{"award-number":["32202217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32202217"],"award-info":[{"award-number":["32202217"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Hyperlipidemia is a chronic metabolic disorder driven by impaired lipid homeostasis. In this study, the steam explosion (SE)-assisted extraction was applied to obtain soluble dietary fiber (SDF) from ginger peel residue. Based on single-factor and orthogonal optimization experiments, SE treatment at a material-to-cavity ratio of 2:5 and a pressure of 1.5 MPa for 300 s achieved an SDF extraction yield of 8.20%, representing a 210.60% increase. Structural and physicochemical analyses showed that both SDF and SE-SDF were mainly composed of glucose, galactose and mannose. SE treatment generated a looser and more porous structure and significantly improved the thermal stability, water holding capacity (WHC) and swelling capacity (SC) of SE-SDF increasing by 38.89% and 30.77%, respectively (p &lt; 0.05). In oleic acid\/palmitic acid (OA\/PA)-stimulated HepG2 cells, both SDF and SE-SDF reduced triglyceride (TG) and total cholesterol (TC) levels in a dose-dependent manner, with SE-SDF showing a stronger hypolipidemic activity. Zebrafish experiments further confirmed that 200 \u00b5g\/mL SE-SDF significantly reduced TG and TC levels by 30.58% and 24.89%, respectively, and decreased lipid deposition in the caudal vasculature and liver by 65.59% and 33.86%, respectively. These findings indicate that SE-SDF from ginger peel residue is a promising functional food ingredient for hyperlipidemia prevention.<\/jats:p>","DOI":"10.3390\/foods15152685","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:09:42Z","timestamp":1785398982000},"page":"2685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physicochemical Properties and Hypolipidemic Activity of Soluble Dietary Fiber Extracted from Ginger Peel Residue"],"prefix":"10.3390","volume":"15","author":[{"given":"Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"},{"name":"Jinan Fruit Research Institute, All China Federation of Supply and Marketing Co-Operatives, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxia","family":"Hu","sequence":"additional","affiliation":[{"name":"Jinan Fruit Research Institute, All China Federation of Supply and Marketing Co-Operatives, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-3083","authenticated-orcid":false,"given":"Yuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-1679","authenticated-orcid":false,"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Jinan Fruit Research Institute, All China Federation of Supply and Marketing Co-Operatives, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-1662","authenticated-orcid":false,"given":"Mengxue","family":"Sun","sequence":"additional","affiliation":[{"name":"Jinan Fruit Research Institute, All China Federation of Supply and Marketing Co-Operatives, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Jinan Fruit Research Institute, All China Federation of Supply and Marketing Co-Operatives, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref_1","unstructured":"Hill, M.F., and Bordoni, B. (2021). Hyperlipidemia, StatPearls."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5056\/jnm23096","article-title":"The effect of Clostridium butyricum on gut microbial changes and functional profiles of metabolism in high-fat diet-fed rats depending on age and sex","volume":"30","author":"Choi","year":"2024","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_3","first-page":"47","article-title":"Biomarkers screening and mechanisms analysis of the restraint stress-induced myocardial injury in hyperlipidemia apoe-\/- mice","volume":"40","author":"Chen","year":"2024","journal-title":"J. Forensic Med. Fayixue Zazhi"},{"key":"ref_4","first-page":"20","article-title":"Novel and future lipid-modulating therapies for the prevention of cardiovascular disease","volume":"9","author":"Julia","year":"2023","journal-title":"Nat. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","article-title":"Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4\u00b74 million participants","volume":"387","author":"Zhou","year":"2016","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijcard.2017.12.069","article-title":"Prevalence of dyslipidemia and achievement of low-density lipoprotein cholesterol targets in Chinese adults: A nationally representative survey of 163,641 adults","volume":"260","author":"Zhang","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"115682","DOI":"10.1016\/j.foodres.2025.115682","article-title":"Plant polyphenols as natural bioactives for alleviating lipid metabolism disorder: Mechanisms and application challenges","volume":"203","author":"Wei","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41575-023-00891-z","article-title":"Effects of dietary fibre on metabolic health and obesity","volume":"21","author":"Deehan","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhou, J., and Wu, L. (2022). Modified Highland Barley Regulates Lipid Metabolism and Liver Injury in High Fat and Cholesterol Diet ICR Mice. Foods, 11.","DOI":"10.3390\/foods11244067"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"24680","DOI":"10.1021\/acsomega.3c01121","article-title":"Soluble dietary fibers as antihyperlipidemic agents: A comprehensive review to maximize their health benefits","volume":"8","author":"Alaa","year":"2023","journal-title":"ACS Omega"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14853","DOI":"10.1021\/acs.jafc.3c03923","article-title":"Dietary. Dietary Fiber and its Potential Role in Obesity: A Focus on Modulating the Gut Microbiota","volume":"71","author":"Tian","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","first-page":"64","article-title":"Dietary fiber modification: Structure, physicochemical properties, bioactivities, and application\u2014A review","volume":"21","author":"Tang","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tifs.2022.04.003","article-title":"Effect of steam explosion on phenolics and antioxidant activity in plants: A review","volume":"124","author":"Wan","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1007\/s13197-021-05254-7","article-title":"Physicochemical and structural properties of dietary fiber from Rosa roxburghii pomace by steam explosion","volume":"59","author":"Zhai","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"102517","DOI":"10.1016\/j.fbio.2023.102517","article-title":"Effects of different treatments on composition, physicochemical and biological properties of soluble dietary fiber in buckwheat bran","volume":"53","author":"Ma","year":"2023","journal-title":"Food Biosci."},{"key":"ref_16","first-page":"46","article-title":"Modification of dietary fiber from Tartary buckwheat bran by steam explosion","volume":"42","author":"He","year":"2021","journal-title":"Food Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1080\/10942912.2023.2254014","article-title":"Bio valorization and industrial applications of ginger waste: A review","volume":"26","author":"Gulzar","year":"2023","journal-title":"Int. J. Food Prop."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"109220","DOI":"10.1016\/j.lwt.2020.109220","article-title":"Modification of insoluble dietary fiber from ginger residue through enzymatic treatments to improve its bioactive properties","volume":"125","author":"Wang","year":"2020","journal-title":"LWT"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ma, C., Ni, L.Y., Sun, M.X., Hu, F.X., Guo, Z.B., Zeng, H.L., Sun, W.L., Zhang, M., Wu, M.Y., and Zheng, B.D. (2024). Enhancing the hypolipidemic and functional properties of Flammulina velutipes root dietary fiber via steam explosion. Foods, 13.","DOI":"10.3390\/foods13223621"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"128822","DOI":"10.1016\/j.ijbiomac.2023.128822","article-title":"Structural characterization and prebiotic activity of Bletilla striata polysaccharide prepared by one-step fermentation with Bacillus Licheniformis BJ2022","volume":"258","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hu, F.X., Li, F., Zheng, Z.J., Sun-Waterhouse, D.X., and Wang, Z.S. (2022). Surfactant-Mediated Ultrasonic-Assisted Extraction and Purification of Antioxidants from Chaenomeles speciosa Sweet Nakai for Chemical- and Cell-Based Antioxidant Capacity Evaluation. Molecules, 27.","DOI":"10.3390\/molecules27227970"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ab.2005.07.041","article-title":"Modification of the Lowry assay to measure proteins and phenols in covalently bound complexes","volume":"346","author":"Winters","year":"2005","journal-title":"Anal. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wei, S., Li, M., Zhao, L., Wang, T., Wu, K., and Yang, J. (2024). Fingerprint profiling for quality evaluation and the related biological activity analysis of polysaccharides from liuweizhiji gegen-sangshen beverage. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1431518"},{"key":"ref_24","first-page":"290","article-title":"Size-exclusion chromatography of ultrahigh molecular weight methylcellulose ethers and hydroxypropyl methylcellulose ethers for reliable molecular weight distribution characterization","volume":"13","author":"Li","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.carbpol.2015.07.018","article-title":"Characterization of polysaccharides with antioxidant and immunological activities from Rhizoma Acori Tatarinowii","volume":"133","author":"Zhang","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_26","first-page":"52","article-title":"Physicochemical Properties and in vitro Antioxidant Activity of Mesona chinensis Polysaccharides","volume":"44","author":"Dong","year":"2023","journal-title":"Food Res. Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108221","DOI":"10.1016\/j.foodhyd.2022.108221","article-title":"Modification of coconut residue fiber and its bile salt adsorption mechanism: Action mode of insoluble dietary fibers probed by microrheology","volume":"136","author":"Tan","year":"2023","journal-title":"Food Hydrocoll."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"114011","DOI":"10.1016\/j.lwt.2022.114011","article-title":"Removal of bound polyphenols and its effect on structure, physicochemical and functional properties of insoluble dietary fiber from adzuki bean seed coat","volume":"169","author":"Yin","year":"2022","journal-title":"LWT"},{"key":"ref_29","first-page":"783","article-title":"Study on structure characterization of pectin from the steamed ginseng and the inhibition activity of lipid accumulation in oleic acid-induced HepG2 cells","volume":"159","author":"Jiao","year":"2020","journal-title":"Int. J. Biol. Macromol. Struct. Funct. Interact."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/ATVBAHA.123.318287","article-title":"Zebrafish apob-containing lipoprotein metabolism: A closer look","volume":"44","author":"Moll","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/fft2.310","article-title":"Lactobacillus plantarum J26 postbiotics alleviate high-fat and high-cholesterol diet-induced hypercholesterolemia via regulating the LXR\u03b1-CYP7A1-bile acid-excretion pathway","volume":"4","author":"Zheng","year":"2023","journal-title":"Food Front."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1111\/ijfs.15784","article-title":"Insight into the physicochemical, structural, and invitro hypoglycemic properties of bamboo shoot dietary fibre: Comparison of physical modification methods","volume":"57","author":"Tang","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/ijfs.13329","article-title":"Response surface methodology for optimisation of soluble dietary fibre extraction from sweet potato residue modified by steam explosion","volume":"52","author":"Wang","year":"2017","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1111\/ijfs.16695","article-title":"Effects of steam explosion treatment on the physicochemical properties and biological activities of okara-derived soluble dietary fibre","volume":"58","author":"Li","year":"2023","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.foodhyd.2018.06.027","article-title":"Effect of wheat bran modification by steam explosion on structural characteristics and rheological properties of wheat flour dough","volume":"84","author":"Sui","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"118823","DOI":"10.1016\/j.lwt.2025.118823","article-title":"Effect of steam explosion on structural, physicochemical and functional properties of dietary fiber of tartary buckwheat","volume":"238","author":"Cheng","year":"2025","journal-title":"LWT"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s13197-023-05817-w","article-title":"Extraction and improvement of protein functionality using steam explosion pretreatment: Advances, challenges, and perspectives","volume":"61","author":"Rigueto","year":"2024","journal-title":"J. Food Sci. Technol."},{"key":"ref_38","first-page":"278","article-title":"Extraction of protein from high-temperature peanut meal using combination process with steam flash-explosion, alkaline-extraction and acid-precipitation","volume":"34","author":"Zhang","year":"2013","journal-title":"Sci. Technol. Food Ind."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112450","DOI":"10.1016\/j.foodres.2022.112450","article-title":"Purification, identification and hypolipidemic activities of three novel hypolipidemic peptides from tea protein","volume":"165","author":"Ye","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"135480","DOI":"10.1016\/j.ijbiomac.2024.135480","article-title":"Structural characterization and hypolipidemic activity of a natural polysaccharide from Suaeda salsa L","volume":"279","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_41","first-page":"147","article-title":"Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes","volume":"197","author":"Zhang","year":"2018","journal-title":"Carbohydr. Polym. Sci. Technol. Asp. Ind. Important Polysacch."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.indcrop.2005.01.006","article-title":"Bioprocess preparation of wheat straw fibers and their characterization","volume":"23","author":"Sain","year":"2006","journal-title":"Ind. Crops Prod."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.foodchem.2025.145849","article-title":"Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides","volume":"493","author":"Ye","year":"2025","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"123727","DOI":"10.1016\/j.carbpol.2025.123727","article-title":"Isolation and structural identification of the homogeneous polysaccharide CGPA1 from with wound healing effects","volume":"363","author":"Meng","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.carbpol.2007.04.015","article-title":"Structure, molecularsize and antitumor activities of polysaccharides from mycelia produced infermenter","volume":"70","author":"Huang","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1111\/1541-4337.13244","article-title":"Exploring the partial degradation of polysaccharides: Structure, mechanism, bioactivities, and perspectives","volume":"22","author":"Chen","year":"2023","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105549","DOI":"10.1016\/j.foodhyd.2019.105549","article-title":"Microwave assisted extraction with three modifications on structural and functional properties of soluble dietary fibers from grapefruit peel","volume":"101","author":"Gan","year":"2019","journal-title":"Food Hydrocoll."},{"key":"ref_48","first-page":"154","article-title":"Process of steam explosion assisted superfine grinding on particle size, chemical composition and physico-chemical properties of wheat bran powder","volume":"371","author":"Kong","year":"2020","journal-title":"Powder Technol. Int. J. Sci. Technol. Wet Dry Part. Syst."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3136\/fstr.27.35","article-title":"Effects of steam explosion on yield and properties of soluble dietary fiber from wheat bran","volume":"27","author":"Ma","year":"2021","journal-title":"Food Sci. Technol. Res."},{"key":"ref_50","first-page":"130","article-title":"Superfine grinding improves functional properties and antioxidant capacities of dietary fiber from bran","volume":"78","author":"Zhu","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.foodchem.2010.06.077","article-title":"Dietary fibre and fibre-rich by-products of food processing: Characterisation, technological functionality and commercial applications: A review","volume":"124","author":"Elleuch","year":"2011","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Xing, Y.H., Zhou, Y.M., Kuang, C.Y., Luo, K.Y., Cheng, Y.H., Wang, X.F., and Wang, S.Y. (2014). Structural, physicochemical and functional properties of dietary fibers from tea residue modified by steam explosion. Front. Sustain. Food Syst., 7.","DOI":"10.3389\/fsufs.2023.1326102"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8565","DOI":"10.1021\/jf402004x","article-title":"Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression","volume":"61","author":"Huang","year":"2013","journal-title":"J. Agric. Food Chem."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/15\/2685\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:48:03Z","timestamp":1785401283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/15\/2685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":53,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["foods15152685"],"URL":"https:\/\/doi.org\/10.3390\/foods15152685","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}