{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T05:25:20Z","timestamp":1786857920970,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/05m2fqn25","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Prebiotic-mediated gut microbiota modulation is a promising approach for obesity management. Red onions have been identified as a potential source of inulin and inulin neoseries oligosaccharides. This study evaluated the in vivo effects of short-chain inulin and inulin neoseries oligosaccharides (SCIINOs) on the fecal microbiota of obese rats and assessed their potential role in obesity attenuation. Male Wistar rats were fed a high-fat diet (HFD) for 16 weeks to induce obesity, while control rats received a normal diet (ND). From weeks 16 to 24, HFD-fed obese rats were randomly assigned to four groups: SCIINOs at 0.5 g\/day, SCIINOs at 1 g\/day, atorvastatin (10 mg\/kg\/day), or no intervention. Obesity status was confirmed by increased body weight, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and higher food and energy intakes. SCIINOs were enzymatically hydrolyzed and purified by yeast treatment and chromatographic methods. After 8 weeks of SCIINO administration (1 g\/day), the fecal microbiota was markedly enriched in Bifidobacterium and Allobaculum, whereas Blautia abundance significantly decreased. SCIINOs also increased taxa negatively associated with obesity-related parameters, including Dubosiella, Rothia, Parabacteroides, Eubacterium, and Coriobacteriaceae UCG-002, which correlated with reductions in body weight, triglycerides, TC, LDL-C, and fasting blood glucose, along with increased high-density lipoprotein cholesterol (HDL-C). In parallel, SCIINOs increased fecal acetate and butyrate levels, which was consistent with the enrichment of Bifidobacterium and butyrate-producing bacteria. Overall, SCIINOs derived from red onions show promise as a prebiotic candidate for obesity attenuation through selective microbiota modulation and enhanced short-chain fatty acid production.<\/jats:p>","DOI":"10.3390\/foods15162841","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:57:46Z","timestamp":1786708666000},"page":"2841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-Chain Inulin and Inulin Neoseries Oligosaccharides from Red Onions Enrich Beneficial Gut Taxa and Attenuate Obesity-Related Outcomes in a Rat Model"],"prefix":"10.3390","volume":"15","author":[{"given":"Supachawadee","family":"Soyprasert","sequence":"first","affiliation":[{"name":"Program in Biotechnology, Multidisciplinary and Interdisciplinary School, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Division of Biochemistry and Biochemical Innovation, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-2985","authenticated-orcid":false,"given":"Kritsakorn","family":"Saninjuk","sequence":"additional","affiliation":[{"name":"School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand"},{"name":"Gut Microbiome Research Group, Mae Fah Luang University, Chiang Rai 57100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalapat","family":"Leangnim","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Biochemical Innovation, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kridsada","family":"Unban","sequence":"additional","affiliation":[{"name":"Division of Food Science and Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chorchat","family":"Lalichatsakul","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Functional Foods for Health and Disease, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattarasritida","family":"Phatthapong","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Functional Foods for Health and Disease, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-0026","authenticated-orcid":false,"given":"Anusorn","family":"Lungkaphin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Functional Foods for Health and Disease, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chartchai","family":"Khanongnuch","sequence":"additional","affiliation":[{"name":"Center of Excellence in Agricultural Innovation for Graduate Entrepreneur, Maejo University, Chiang Mai 50290, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-3277","authenticated-orcid":false,"given":"Apinun","family":"Kanpiengjai","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Biochemical Innovation, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104754","DOI":"10.1016\/j.compbiomed.2021.104754","article-title":"A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity","volume":"136","author":"Safaei","year":"2021","journal-title":"Comput. 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