{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:01:49Z","timestamp":1793372509080,"version":"4.5.0"},"reference-count":70,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing High-level Talent Project","award":["19008024075"],"award-info":[{"award-number":["19008024075"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32472269"],"award-info":[{"award-number":["32472269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["32472269"],"award-info":[{"award-number":["32472269"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Human milk (HM) represents the physiological reference for infant digestion, whereas infant formulas (IFs) differ in protein composition and lipid architecture. This study compared the gastric and intestinal digestion of HM, five commercial IFs, whole milk powder (WMP), and protein ingredients using a standardized infant in vitro model. Protein hydrolysis was assessed through digestibility and residual subunit patterns, and lipid digestion was evaluated through free fatty acid release and fatty acid profiling. Gastric digestion revealed pronounced differences driven by intrinsic structure and processing, whereas intestinal digestion reduced these disparities, although distinct subunit patterns persisted. Lipid analyses showed clear source-dependent separation before digestion and partial convergence during intestinal lipolysis. Several IFs containing structured lipid and vegetable-oil systems showed intestinal fatty acid or free fatty acid profiles closer to HM than WMP, whereas samples with stronger bovine-fat signatures remained more distinct. Overall, the results demonstrate that digestion-product patterns provide mechanistic insight into structure-driven digestion behavior in complex dairy-based matrices, beyond compositional comparison alone.<\/jats:p>","DOI":"10.3390\/foods15172999","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:59:23Z","timestamp":1787741963000},"page":"2999","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated Protein\u2013Lipid Digestion Profiles of Human Milk, Infant Formulas, and Dairy Ingredients Under Infant In Vitro Digestion"],"prefix":"10.3390","volume":"15","author":[{"given":"Bingyu","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qi","sequence":"additional","affiliation":[{"name":"Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuteng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"An","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vizzari, G., Morniroli, D., Ceroni, F., Verduci, E., Consales, A., Colombo, L., Cerasani, J., Mosca, F., and Giann\u00ec, M.L. (2021). Human milk, more than simple nourishment. Children, 8.","DOI":"10.3390\/children8100863"},{"key":"ref_2","first-page":"1","article-title":"Is infant immunity actively suppressed or immature?","volume":"5","author":"Gervassi","year":"2014","journal-title":"Virol. Res. Treat."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4081\/pmc.2017.155","article-title":"Human milk: Composition and health benefits","volume":"39","author":"Mosca","year":"2017","journal-title":"Pediatr. Med. Chir."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Carr, L.E., Virmani, M.D., Rosa, F., Munblit, D., Matazel, K.S., Elolimy, A.A., and Yeruva, L. (2021). Role of human milk bioactives on infants\u2019 gut and immune health. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.604080"},{"key":"ref_5","unstructured":"U.S. Food and Drug Administration (2026, March 15). Infant Formula Nutrient Specifications, Available online: https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-B\/part-107\/subpart-D\/section-107.100."},{"key":"ref_6","unstructured":"Codex Alimentarius Commission (2024). Standard for Infant Formula and Formulas for Special Medical Purposes Intended for Infants, Codex Alimentarius Commission."},{"key":"ref_7","unstructured":"(2021). National Food Safety Standard: Infant Formula (Standard No. GB 10765-2021). Available online: http:\/\/openstd.samr.gov.cn."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104536","DOI":"10.1016\/j.jfca.2022.104536","article-title":"How to adjust \u03b1-lactalbumin and \u03b2-casein ratio in milk protein formula to give a similar digestion pattern to human milk?","volume":"110","author":"Huang","year":"2022","journal-title":"J. Food Compos. Anal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/nutrit\/nuy004","article-title":"Applications for \u03b1-lactalbumin in human nutrition","volume":"76","author":"Layman","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"106787","DOI":"10.1016\/j.foodhyd.2021.106787","article-title":"In vitro dynamic digestion of model infant formulae containing lactoferrin and medium chain triacylglycerols","volume":"118","author":"Furtado","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1432-1033.1991.tb15801.x","article-title":"Molecular cloning and sequence analysis of bovine lactotransferrin","volume":"196","author":"Pierce","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0161-5890(03)00152-4","article-title":"Lactoferrin\u2014A multifunctional protein with antimicrobial properties","volume":"40","author":"Farnaud","year":"2003","journal-title":"Mol. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e13337","DOI":"10.1111\/1541-4337.13337","article-title":"Whey protein hydrolysates and infant formulas: Effects on physicochemical and biological properties","volume":"23","author":"Li","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Feng, L., Ye, W., Zhang, K., Qu, D., Liu, W., Wu, M., and Han, J. (2022). In vitro digestion characteristics of hydrolyzed infant formula and its effects on the growth and development in mice. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.912207"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.1021\/acs.jafc.1c01760","article-title":"Simulated in vitro infant gastrointestinal digestion of infant formulas containing different fat sources and human milk: Differences in lipid profiling and free fatty acid release","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/sj.ejcn.1601470","article-title":"Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas","volume":"56","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, Q., Xu, Y., Liu, Y., Qian, F., Mu, G., and Zhu, X. (2022). Effects of proteins and mineral ions on the physicochemical properties of 1,3-dioleoyl-2-palmitoylglycerol emulsion to mimic a liquid infant formula. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.808351"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.3168\/jds.2022-22763","article-title":"Efficient in vitro digestion of lipids and proteins in bovine milk fat globule membrane ingredient (MFGMi) and whey-casein infant formula with added MFGMi","volume":"106","author":"Chitchumroonchokchai","year":"2023","journal-title":"J. Dairy Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131878","DOI":"10.1016\/j.foodchem.2021.131878","article-title":"Heat-induced unfolding facilitates plant protein digestibility during in vitro static infant digestion","volume":"375","author":"Tang","year":"2022","journal-title":"Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"144675","DOI":"10.1016\/j.foodchem.2025.144675","article-title":"Effect of hybrid animal-plant milk blends on metabolomic profiles, antioxidant capacities, and protein digestibility for potential infant nutrition applications","volume":"487","author":"Zamzam","year":"2025","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"144758","DOI":"10.1016\/j.foodchem.2025.144758","article-title":"Evaluating allergenicity of protein fragments and peptides in partially hydrolysed infant formulas available in Hong Kong","volume":"487","author":"Lau","year":"2025","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"145297","DOI":"10.1016\/j.foodchem.2025.145297","article-title":"Quantitative analysis of seven free short-chain fatty acids in infant formula using GC-MS\/MS","volume":"491","author":"Zhu","year":"2025","journal-title":"Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"135762","DOI":"10.1016\/j.foodchem.2023.135762","article-title":"Comparison of phospholipid composition and microstructure of milk fat globules contained in human milk and infant formulae","volume":"415","author":"Liu","year":"2023","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"140850","DOI":"10.1016\/j.foodchem.2024.140850","article-title":"Lipidomics of sheep and goat milk-based infant formulae during in vitro dynamic digestion","volume":"461","author":"Casula","year":"2024","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"142797","DOI":"10.1016\/j.foodchem.2025.142797","article-title":"Improving fat globule structure to narrow metabolite gap between human milk and infant formulae","volume":"471","author":"Sun","year":"2025","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"131704","DOI":"10.1016\/j.foodchem.2021.131704","article-title":"Digestibility of proteins in camel milk in comparison to bovine and human milk using an in vitro infant gastrointestinal digestion system","volume":"374","author":"Zou","year":"2022","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.foodchem.2017.07.145","article-title":"A first step towards a consensus static in vitro model for simulating full-term infant digestion","volume":"240","author":"Bourlieu","year":"2018","journal-title":"Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.tifs.2019.07.009","article-title":"Natural products for glycaemic control: Polyphenols as inhibitors of alpha-amylase","volume":"91","author":"Sun","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1021\/jf304094p","article-title":"Model for human milk fat substitute evaluation based on triacylglycerol composition profile","volume":"61","author":"Zou","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108785","DOI":"10.1016\/j.foodhyd.2023.108785","article-title":"Mechanism of fat globule size and surface composition regulating in vitro dynamic digestion, absorption and transport of structured emulsions","volume":"142","author":"Hou","year":"2023","journal-title":"Food Hydrocoll."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"129830","DOI":"10.1016\/j.foodchem.2021.129830","article-title":"Improved estimation of in vitro protein digestibility of different foods using size exclusion chromatography","volume":"358","author":"Rieder","year":"2021","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"104810","DOI":"10.1016\/j.idairyj.2020.104810","article-title":"The effect of pre-treatment of protein ingredients for infant formula on their in vitro gastro-intestinal behaviour","volume":"110","author":"Corrigan","year":"2020","journal-title":"Int. Dairy J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1017\/S0007114524001260","article-title":"Comparison of protein digestibility of human milk and infant formula using the INFOGEST method under infant digestion conditions","volume":"132","author":"Komatsu","year":"2024","journal-title":"Br. J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Abrahamse, E., Thomassen, G.G., Renes, I.B., Wierenga, P.A., and Hettinga, K.A. (2022). Gastrointestinal protein hydrolysis kinetics: Opportunities for further infant formula improvement. Nutrients, 14.","DOI":"10.3390\/nu14071512"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Abdoul-Aziz, S.K.A., Zhang, Y., and Wang, J. (2021). Milk odd and branched chain fatty acids in dairy cows: A review on dietary factors and its consequences on human health. Animals, 11.","DOI":"10.3390\/ani11113210"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Carta, S., Correddu, F., Battacone, G., Pulina, G., and Nudda, A. (2022). Comparison of milk odd- and branched-chain fatty acids among human, dairy species and artificial substitutes. Foods, 11.","DOI":"10.3390\/foods11244118"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.foodres.2017.12.049","article-title":"Digestion of milk proteins: Comparing static and dynamic in vitro digestion systems with in vivo data","volume":"118","author":"Egger","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107368","DOI":"10.1016\/j.foodhyd.2021.107368","article-title":"Protein structure in model infant milk formulas impacts their kinetics of hydrolysis under in vitro dynamic digestion","volume":"126","author":"Halabi","year":"2022","journal-title":"Food Hydrocoll."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113860","DOI":"10.1016\/j.foodres.2023.113860","article-title":"Digestive properties and peptide profiles exhibited significant differences between skim camel milk and bovine milk powder after static in vitro simulated infant gastrointestinal digestion","volume":"178","author":"Jiang","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"132884","DOI":"10.1016\/j.foodchem.2022.132884","article-title":"Structural and chemical changes induced by temperature and pH hinder the digestibility of whey proteins","volume":"387","author":"Accardo","year":"2022","journal-title":"Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1039\/C9FO02097G","article-title":"Lysine blockage of milk proteins in infant formula impairs overall protein digestibility and peptide release","volume":"11","author":"Zenker","year":"2020","journal-title":"Food Funct."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dupont, D., and Tom\u00e9, D. (2020). Milk proteins: Digestion and absorption in the gastrointestinal tract. Milk Proteins, Academic Press.","DOI":"10.1016\/B978-0-12-815251-5.00020-7"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"107025","DOI":"10.1016\/j.ultsonch.2024.107025","article-title":"Effects of ultrasound pretreatment on the structure, IgE binding capacity, functional properties and bioactivity of whey protein hydrolysates via multispectroscopy and peptidomics revealed","volume":"110","author":"Pang","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101360","DOI":"10.1016\/j.fochx.2024.101360","article-title":"Characterisation and comparison of enzymatically prepared donkey milk whey protein hydrolysates","volume":"22","author":"Wei","year":"2024","journal-title":"Food Chem. X"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"126514","DOI":"10.1016\/j.foodchem.2020.126514","article-title":"Impact of caseins and whey proteins ratio and lipid content on in vitro digestion and ex vivo absorption","volume":"319","author":"Saha","year":"2020","journal-title":"Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"134840","DOI":"10.1016\/j.foodchem.2022.134840","article-title":"Impact of casein-to-whey protein ratio on gastric emptying, proteolysis, and peptidome profile of fermented milk during in vitro dynamic gastrointestinal digestion in preschool children","volume":"405","author":"Zhang","year":"2023","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"106599","DOI":"10.1016\/j.foodhyd.2021.106599","article-title":"Gastric colloidal behaviour of milk protein as a tool for manipulating nutrient digestion in dairy products and protein emulsions","volume":"115","author":"Ye","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"108515","DOI":"10.1016\/j.foodhyd.2023.108515","article-title":"Decalcification strongly affects in vitro gastrointestinal digestion of bovine casein micelles under infant, adult and elderly conditions","volume":"139","author":"Wang","year":"2023","journal-title":"Food Hydrocoll."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109610","DOI":"10.1016\/j.foodhyd.2023.109610","article-title":"Formation of casein micelles simulating human milk casein composition from bovine caseins: Micellar structure and in vitro infant gastrointestinal digestion","volume":"149","author":"Yang","year":"2024","journal-title":"Food Hydrocoll."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Roy, D., Ye, A., Moughan, P.J., and Singh, H. (2020). Composition, structure, and digestive dynamics of milk from different species: A review. Front. Nutr., 7.","DOI":"10.3389\/fnut.2020.577759"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jnutbio.2015.05.003","article-title":"Human, donkey and cow milk differently affects energy efficiency and inflammatory state by modulating mitochondrial function and gut microbiota","volume":"26","author":"Trinchese","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.3168\/jds.S0022-0302(97)76235-0","article-title":"Effect of homogenization pressure on the milk fat globule membrane proteins","volume":"80","author":"Richter","year":"1997","journal-title":"J. Dairy Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"108847","DOI":"10.1016\/j.foodres.2019.108847","article-title":"The adhesion of homogenized fat globules to proteins is increased by milk heat treatment and acidic pH: Quantitative insights provided by AFM force spectroscopy","volume":"129","author":"Obeid","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.3168\/jds.S0022-0302(05)72868-X","article-title":"Size distribution of fat globules in human colostrum, breast milk, and infant formula","volume":"88","author":"Michalski","year":"2005","journal-title":"J. Dairy Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nutres.2020.08.002","article-title":"Digestion of human milk fat in healthy infants","volume":"83","author":"He","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104882","DOI":"10.1016\/j.idairyj.2020.104882","article-title":"Milk protein coagulation under gastric conditions: A review","volume":"113","author":"Huppertz","year":"2021","journal-title":"Int. Dairy J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3168\/jds.2021-21177","article-title":"Kinetics of pepsin-induced hydrolysis and the coagulation of milk proteins","volume":"105","author":"Yang","year":"2022","journal-title":"J. Dairy Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.foodres.2016.11.025","article-title":"Lipid droplets coated with milk fat globule membrane fragments: Microstructure and functional properties as a function of pH","volume":"91","author":"Lopez","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.foodhyd.2016.03.018","article-title":"On the role of bile salts in the digestion of emulsified lipids","volume":"60","author":"Sarkar","year":"2016","journal-title":"Food Hydrocoll."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.foodres.2018.05.040","article-title":"Digestion fates of different edible oils vary with their composition specificities and interactions with bile salts","volume":"111","author":"Ye","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.idairyj.2019.01.005","article-title":"Comparison of bovine milk fat and vegetable fat for infant formula: Implications for infant health","volume":"92","author":"Hageman","year":"2019","journal-title":"Int. Dairy J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1021\/acs.jafc.1c08029","article-title":"Similarity index for the fat fraction between breast milk and infant formulas","volume":"70","author":"Hokkanen","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2014). Scientific opinion on the essential composition of infant and follow-on formulae. EFSA J., 12, 3760.","DOI":"10.2903\/j.efsa.2014.3760"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.plefa.2013.03.002","article-title":"Review of sn-2 palmitate oil implications for infant health","volume":"89","author":"Lifshitz","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jcis.2020.10.101","article-title":"Morphology of bile salts micelles and mixed micelles with lipolysis products, from scattering techniques and atomistic simulations","volume":"587","author":"Pabois","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.foodchem.2013.09.092","article-title":"Tandem mass spectrometric analysis of human milk triacylglycerols from normal weight and overweight mothers on different diets","volume":"146","author":"Linderborg","year":"2014","journal-title":"Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.foodchem.2016.11.139","article-title":"A comparative study of triacylglycerol composition in Chinese human milk within different lactation stages and imported infant formula by SFC coupled with Q-TOF-MS","volume":"221","author":"Tu","year":"2017","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.foodchem.2017.04.122","article-title":"Triacylglycerol regioisomers in human milk resolved with an algorithmic novel electrospray ionization tandem mass spectrometry method","volume":"233","author":"Kallio","year":"2017","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1021\/acs.jafc.8b01085","article-title":"Fatty acid profile and the sn-2 position distribution in triacylglycerols of breast milk during different lactation stages","volume":"66","author":"Qi","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Liu, L., Lin, S., Ma, S., Sun, Y., Li, X., and Liang, S. (2022). A comparative analysis of lipid digestion in human milk and infant formulas based on simulated in vitro infant gastrointestinal digestion. 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