{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:17:47Z","timestamp":1788499067243,"version":"build-2803163510"},"reference-count":176,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M733195"],"award-info":[{"award-number":["2023M733195"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025T180824"],"award-info":[{"award-number":["2025T180824"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2023M733195"],"award-info":[{"award-number":["2023M733195"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2025T180824"],"award-info":[{"award-number":["2025T180824"]}],"id":[{"id":"https:\/\/ror.org\/0426zh255","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Surface-enhanced Raman scattering (SERS) technology has attracted growing interest for on-site food safety monitoring, with flexible substrates offering distinct advantages in conformal sampling, portability, and non-destructive analysis. This review systematically summarizes recent advances in flexible SERS substrates for practical food safety applications, covering design strategies including material selection, structural engineering, and performance enhancement, as well as diverse applications such as swabbing-based detection, in situ analysis, enrichment-assisted trace detection, and multiplexed contaminant identification. Challenges and future perspectives are also discussed, focusing on portable instrument adaptation, simplified sample pretreatment, intelligent data analysis, and scalable manufacturing. This review aims to bridge the gap between laboratory research and field deployment, providing valuable insights for the commercialization of flexible SERS technology in real-world food safety monitoring.<\/jats:p>","DOI":"10.3390\/foods15173070","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:24:03Z","timestamp":1788150243000},"page":"3070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flexible SERS Substrates for On-Site Food Safety Monitoring: A Five-Year Progress Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Wenzheng","family":"Ye","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Biological Systems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-0577","authenticated-orcid":false,"given":"Ruiyun","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138402","DOI":"10.1016\/j.foodchem.2024.138402","article-title":"Application, challenges and future prospects of recent nondestructive techniques based on the electromagnetic spectrum in food quality and safety","volume":"441","author":"Fakhlaei","year":"2024","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1080\/10408398.2025.2462721","article-title":"A comprehensive review of analytical techniques for spice quality and safety assessment in the modern food industry","volume":"65","author":"Johnson","year":"2025","journal-title":"Crit. 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