{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:33Z","timestamp":1789016853339,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"crossref","award":["252300423633"],"award-info":[{"award-number":["252300423633"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"crossref","award":["252300420715"],"award-info":[{"award-number":["252300420715"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009101","name":"Henan Province Key Scientific Research Projects Program for Higher Education Institutions","doi-asserted-by":"publisher","award":["26B220004"],"award-info":[{"award-number":["26B220004"]}],"id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Forestry Science and Technology Promotion Project","award":["YLK202514"],"award-info":[{"award-number":["YLK202514"]}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"crossref","award":["252102110338"],"award-info":[{"award-number":["252102110338"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"crossref","award":["252102320212"],"award-info":[{"award-number":["252102320212"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Ehretia macrophylla fruit is a traditionally used but underutilized functional resource that is noted for its diverse phytochemical composition, which includes flavonoids and polyphenols. However, the systematic metabolic transformations that occur in the fruit during post-harvest storage\u2014particularly those associated with its traditional processing into dark fruit tea\u2014remain largely unknown, limiting efforts to optimize quality and processing strategies. In the study, to address this gap, we employed a widely targeted metabolomics approach based on ultra-performance liquid chromatography\u2013tandem mass spectrometry (UPLC-MS\/MS) to dynamically profile the fruit metabolome across four storage stages (T0, T4, T8, T12). A total of 1101 metabolites were putatively annotated, and day 8 (T8) emerged as a potential pronounced metabolic inflection point. From T8 onward, 30\u201340% of metabolites showed differential accumulation, characterized by a gradual rise in nutrition-relevant lipids, amino acids, and vitamins. In contrast, key antioxidant-related metabolites, including phenolics and flavonoids, increased transiently before T8 but declined sharply thereafter. These coordinated shifts correlated with an increased representation of lipid- and alkaloid-related metabolic pathways, whereas flavonoid-associated features showed a relative decline. Collectively, these findings provide insights into the biochemical processes potentially associated with fruit blackening and the marked decline in antioxidant capacity during traditional processing. Our study provides the first metabolic blueprint connecting traditional processing practices with phased metabolic remodeling, offering a scientific foundation for quality assessment and the development of informed post-harvest strategies for processing E. macrophylla fruit.<\/jats:p>","DOI":"10.3390\/foods15173154","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:23:37Z","timestamp":1788773017000},"page":"3154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of UPLC-MS\/MS-Based Widely Targeted Metabolomics Reveals Metabolic Reprogramming During Post-Harvest Storage of Ehretia macrophylla Fruits"],"prefix":"10.3390","volume":"15","author":[{"given":"Xining","family":"Geng","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Mengyao","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Fengqin","family":"Huang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Shuaizheng","family":"Qi","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Lihua","family":"Xie","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-5185","authenticated-orcid":false,"given":"Meiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Minghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Congping","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4183-834X","authenticated-orcid":false,"given":"Shiping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Germplasm Innovation and Utilization of Eco-Economic Woody Plant, Pingdingshan University, Pingdingshan 467000, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/nutrit\/nuad103","article-title":"Underutilized plants increase biodiversity, improve food and nutrition security, reduce malnutrition, and enhance human health and well-being. Let\u2019s put them back on the plate","volume":"82","author":"Knez","year":"2024","journal-title":"Nutr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cofs.2016.02.002","article-title":"Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects","volume":"8","author":"Zhang","year":"2016","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Alsawaf, S., Alnuaimi, F., Afzal, S., Thomas, R.M., Chelakkot, A.L., Ramadan, W.S., Hodeify, R., Matar, R., Merheb, M., and Siddiqui, S.S. (2022). Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation. Biology, 11.","DOI":"10.3390\/biology11121717"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100836","DOI":"10.1016\/j.cofs.2022.100836","article-title":"Insights into metabolomics in quality attributes of postharvest fruit","volume":"45","author":"Yun","year":"2022","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41597-024-03431-9","article-title":"Haplotype-resolved chromosome-level genome assembly of Ehretia macrophylla","volume":"11","author":"Cheng","year":"2024","journal-title":"Sci. Data"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/ijfs.15005","article-title":"Potential prebiotic functions of a characterised Ehretia macrophylla Wall. fruit polysaccharide","volume":"57","author":"Xu","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_7","unstructured":"He, L. (2018). Separation, Purification, and Activity Study of the Active Components of Ehretia macrophylla Wall Fruit, South China University of Technology."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1111\/1750-3841.15185","article-title":"Phenolic profiles, antioxidant, antiproliferative, and hypoglycemic activities of Ehretia macrophyla Wall. (EMW) fruit","volume":"85","author":"Deng","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107922","DOI":"10.1016\/j.ultsonch.2026.107922","article-title":"Ultrasound-assisted extraction of Ehretia macrophylla wall. Fruit phenolic acids: Process optimization, characterization, and lung protective activities","volume":"131","author":"Fan","year":"2026","journal-title":"Ultrason Sonochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.stem.2022.10.008","article-title":"Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113236","DOI":"10.1016\/j.foodres.2023.113236","article-title":"Uncovering the phenolic diversity of Guabiju fruit: LC-MS\/MS-based targeted metabolomics approach","volume":"173","author":"Spinelli","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Wang, L., Chen, J., Zhang, N., Zhou, W., and Song, Y. (2024). Altitudinal variation of dragon fruit metabolite profiles as revealed by UPLC-MS\/MS-based widely targeted metabolomics analysis. BMC Plant Biol., 24.","DOI":"10.1186\/s12870-024-05011-w"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jiang, L., Lu, M., Rao, T., Liu, Z., Wu, X., and An, H. (2022). Comparative Analysis of Fruit Metabolome Using Widely Targeted Metabolomics Reveals Nutritional Characteristics of Different Rosa roxburghii Genotypes. Foods, 11.","DOI":"10.3390\/foods11060850"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"142844","DOI":"10.1016\/j.foodchem.2025.142844","article-title":"Widely targeted metabolomics analysis reveals dynamic changes in metabolites of \u2019Hass\u2019 avocado during postharvest ripening period","volume":"471","author":"Xin","year":"2025","journal-title":"Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yang, H., Han, T., Wu, Y., Lyu, L., and Wu, W. (2023). Quality analysis and metabolomic profiling of the effects of exogenous abscisic acid on rabbiteye blueberry. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1224245"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113278","DOI":"10.1016\/j.postharvbio.2024.113278","article-title":"Methyl jasmonate delays the browning of litchi pericarp by activating the phenylpropanoid metabolism during cold storage","volume":"219","author":"He","year":"2025","journal-title":"Postharvest Biol. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chen, M., Jiao, S.Q., Xie, L., Geng, X., Qi, S., Fan, J., Cheng, S., Shi, J., and Cao, X. (2024). Integrated physiological, transcriptomic, and metabolomic analyses of drought stress alleviation in Ehretia macrophylla Wall. seedlings by SiO2 NPs (silica nanoparticles). Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1260140"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1271\/bbb.64.882","article-title":"(10E,12Z,15Z)-9-hydroxy-10,12,15-octadecatrienoic acid methyl ester as an anti-inflammatory compound from Ehretia dicksonii","volume":"64","author":"Dong","year":"2000","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110205","DOI":"10.1016\/j.plaphy.2025.110205","article-title":"Diethylaminoethyl octanoate citrate alleviates low temperature stress in wheat seedlings by modulating antioxidative responses","volume":"228","author":"Wang","year":"2025","journal-title":"Plant Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, S., Zhang, H., Yang, L., Zhang, S., and Jiang, H. (2023). Optimization of Ultrasonic-Assisted Extraction Conditions for Bioactive Components and Antioxidant Activity of Poria cocos (Schw.) Wolf by an RSM-ANN-GA Hybrid Approach. Foods, 12.","DOI":"10.3390\/foods12030619"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"14090","DOI":"10.1038\/s41598-024-64877-w","article-title":"Integrated transcriptome and metabolomics analyses revealed key functional genes in Canna indica under Cr stress","volume":"14","author":"Zhu","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhao, K., Chen, Y., Wei, Q., Chen, X., Wan, H., and Sun, C. (2022). Species-Specific Gene Expansion of the Cellulose synthase Gene Superfamily in the Orchidaceae Family and Functional Divergence of Mannan Synthesis-Related Genes in Dendrobium officinale. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.777332"},{"key":"ref_23","unstructured":"(2021). Determination of Total Acid in Foods (Standard No. GB 12456-2021)."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2116\/analsci.24.1593","article-title":"Application of flow injection gradient titration based on the standard addition and dilution procedure to the determination of total acidity in vinegars and soft drinks","volume":"24","author":"Kozak","year":"2008","journal-title":"Anal. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"70899","DOI":"10.1002\/fsn3.70899","article-title":"Synergistic Changes in Ascorbic Acid and Soluble Sugar Contents in Apricot Fruits and the Related Regulatory Mechanisms","volume":"13","author":"He","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12328","DOI":"10.3390\/molecules200712328","article-title":"Study on the spectrophotometric detection of free fatty acids in palm oil utilizing enzymatic reactions","volume":"20","author":"Azeman","year":"2015","journal-title":"Molecules"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kumar, S., Li, G., Huang, X., Ji, Q., Zhou, K., Hou, H., Ke, W., and Yang, J. (2021). Phenotypic, Nutritional, and Antioxidant Characterization of Blanched Oenanthe javanica for Preferable Cultivar. Front. Plant Sci., 12.","DOI":"10.3389\/fpls.2021.639639"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gulcin, \u0130., and Alwasel, S.H. (2025). Fe3+ Reducing Power as the Most Common Assay for Understanding the Biological Functions of Antioxidants. Processes, 13.","DOI":"10.3390\/pr13051296"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101159","DOI":"10.1016\/j.fochx.2024.101159","article-title":"Comprehensive widely targeted metabolomics to decipher the molecular mechanisms of Dioscorea opposita thunb. cv. Tiegun quality formation during harvest","volume":"21","author":"An","year":"2024","journal-title":"Food Chem. X"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"114451","DOI":"10.1016\/j.lwt.2023.114451","article-title":"Metabolic profiles, bioactive compounds and antioxidant activity of rosehips from Xinjiang, China","volume":"174","author":"Sun","year":"2023","journal-title":"LWT"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00204-025-03997-2","article-title":"Antioxidants: A comprehensive review","volume":"99","author":"Gulcin","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"119684","DOI":"10.1016\/j.indcrop.2024.119684","article-title":"Integrated metabolomic and transcriptomic analysis of flavonoid biosynthesis in Ricinus communis L.","volume":"222","author":"Li","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"118365","DOI":"10.1016\/j.indcrop.2024.118365","article-title":"Transcriptome and metabolome analysis reveal the dynamic changes and biosynthesis pathways of alkaloids in Sophora alopecuroides L. under drought stress","volume":"212","author":"Huang","year":"2024","journal-title":"Ind. Crop Prod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2576156","DOI":"10.1080\/10942912.2025.2576156","article-title":"Metabolomic insights into the aging process of Citrus reticulata cv. \u2018Dahongpao\u2019 peel","volume":"28","author":"Zhang","year":"2025","journal-title":"Int. J. Food Prop."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"112169","DOI":"10.1016\/j.foodres.2022.112169","article-title":"Widely targeted metabolomics using UPLC-QTRAP-MS\/MS reveals chemical changes during the processing of black tea from the cultivar Camellia sinensis (L.) O. Kuntze cv. Huangjinya","volume":"162","author":"Zhou","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00216-024-05646-6","article-title":"Effect of different pooled qc samples on data quality during an inter-batch experiment in untargeted UHPLC-HRMS analysis","volume":"417","author":"Ramos","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis: Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/mp\/sst080","article-title":"A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: Application in the study of rice metabolomics","volume":"6","author":"Chen","year":"2013","journal-title":"Mol. Plant"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"W162","DOI":"10.1093\/nar\/gkx449","article-title":"NOREVA: Normalization and evaluation of MS-based metabolomics data","volume":"45","author":"Li","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac051632c","article-title":"Probabilistic quotient normalization as a robust method to account for dilution of complex biological mixtures","volume":"78","author":"Dieterle","year":"2006","journal-title":"Anal. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11306-016-1030-9","article-title":"Non-targeted UHPLC-MS metabolomic data processing methods: A comparative investigation of normalisation, missing value imputation, transformation and scaling","volume":"12","author":"Engel","year":"2016","journal-title":"Metabolomics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"18345","DOI":"10.1021\/acs.jafc.3c07005","article-title":"Integrated transcriptomics and metabolomics analyses provide insights into Qingke in response to cold stress","volume":"71","author":"Xu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: Biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e122436","DOI":"10.3897\/pharmacia.71.e122436","article-title":"UHPLC-HRMS-based profiling and simultaneous quantification of the hydrophilic phenolic compounds from the aerial parts of Hypericum aucheri Jaub. & Spach (Hypericaceae)","volume":"71","author":"Marinov","year":"2024","journal-title":"Pharmacia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"70528","DOI":"10.1111\/1541-4337.70528","article-title":"Keeping Green and Nutritious: A Comprehensive Review on Postharvest Handlings of Broccoli (Brassica oleracea var. italica)","volume":"25","author":"Miao","year":"2026","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, W., Liu, J., Aaqil, M., Zhou, S., Wei, X., Li, L., Chen, Z., Sheng, J., Tian, Y., and Zhao, C. (2026). Changes in the Quality Characteristics of Gastrodia Elata During Traditional Processing: Insights from Multi-Omics Integration. Foods, 15.","DOI":"10.3390\/foods15152704"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41438-020-00362-5","article-title":"Rapid dehydration of grape berries dampens the post-ripening transcriptomic program and the metabolite profile evolution","volume":"7","author":"Zenoni","year":"2020","journal-title":"Hortic. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"112283","DOI":"10.1016\/j.scienta.2023.112283","article-title":"Metabolomic analysis of strawberries at different maturities according to postharvest storage period","volume":"321","author":"Kim","year":"2023","journal-title":"Sci. Hortic."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11101-018-9568-y","article-title":"The antioxidant properties of plant flavonoids: Their exploitation by molecular plant breeding","volume":"17","author":"Aversano","year":"2018","journal-title":"Phytochem. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Qi, X., Zhao, J., Jia, Z., Cao, Z., Liu, C., Li, J., Su, Y., Pan, Y., He, C., and Xu, Y. (2022). Potential Metabolic Pathways and Related Processes Involved in Pericarp Browning for Postharvest Pomegranate Fruits. Horticulturae, 8.","DOI":"10.3390\/horticulturae8100924"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0308-8146(01)00202-3","article-title":"Role of anthocyanin degradation in litchi pericarp browning","volume":"75","author":"Zhang","year":"2001","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chen, Y., Hu, X., Shi, Q., Lu, Y., Yan, J., Wu, D.T., and Qin, W. (2023). Changes in the Fruit Quality, Phenolic Compounds, and Antioxidant Potential of Red-Fleshed Kiwifruit during Postharvest Ripening. Foods, 12.","DOI":"10.3390\/foods12071509"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yu, D., Boughton, B.A., Hill, C.B., Feussner, I., Roessner, U., and Rupasinghe, T.W.T. (2020). Insights Into Oxidized Lipid Modification in Barley Roots as an Adaptation Mechanism to Salinity Stress. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.00001"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Shmuleviz, R., Amato, A., Commisso, M., D\u2019Inca, E., Luzzini, G., Ugliano, M., Fasoli, M., Zenoni, S., and Tornielli, G.B. (2023). Temperature affects organic acid, terpene and stilbene metabolisms in wine grapes during postharvest dehydration. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1107954"},{"key":"ref_55","first-page":"100318","article-title":"Gaseous chlorine dioxide improves Keitt mango quality during postharvest ripening: Enhancing sugar accumulation, terpenoid biosynthesis, and storage performance","volume":"11","author":"Tian","year":"2025","journal-title":"Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100438","DOI":"10.1016\/j.jbc.2021.100438","article-title":"Amino acid-derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development","volume":"296","author":"Parthasarathy","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"102288","DOI":"10.1016\/j.pbi.2022.102288","article-title":"Amino acids and their derivatives mediating defense priming and growth tradeoff","volume":"69","author":"Cai","year":"2022","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Guo, S., Ji, Y., Zheng, Y., Watkins, C.B., Ma, L., Wang, Q., Liang, H., Bai, C., Fu, A., and Li, L. (2023). Transcriptomic, metabolomic, and ATAC-seq analysis reveal the regulatory mechanism of senescence of post-harvest tomato fruit. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1142913"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/17\/3154\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:13:46Z","timestamp":1789013626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/17\/3154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":58,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["foods15173154"],"URL":"https:\/\/doi.org\/10.3390\/foods15173154","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]}}}