{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:03:08Z","timestamp":1789707788587,"version":"4.0.1"},"reference-count":135,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Plan Project of Jilin Province, China","award":["YDZJ202604QYCX009"],"award-info":[{"award-number":["YDZJ202604QYCX009"]}]},{"name":"Jilin Provincial Natural Science Foundation","award":["20260102175JC"],"award-info":[{"award-number":["20260102175JC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Obesity\u2013depression comorbidity involves interconnected metabolic dysfunction, chronic low-grade inflammation, oxidative stress, neuroendocrine dysregulation, gut microbial dysbiosis, and impaired gut\u2013brain communication. Edible and medicinal mushrooms provide nutrients and diverse bioactive compounds, including polysaccharides, terpenoids, nucleosides, sterols, peptides, and phenolic compounds. This narrative review integrates evidence on representative mushroom species, cultivation and fermentation factors affecting their composition, major bioactive compounds and biosynthetic pathways, gut\u2013brain axis-related mechanisms, and opportunities for functional food development. Evidence derived predominantly from in vitro and animal studies suggests that mushroom-derived bioactive compounds may modulate gut microbial composition, intestinal barrier integrity, inflammatory and oxidative pathways, lipid and glucose metabolism, and neuroendocrine signaling. An exploratory database-based analysis further mapped predicted candidate molecular targets associated with inflammatory, metabolic, and neural processes. From a food science perspective, the compositional diversity of mushrooms and their compatibility with cultivation, fermentation, extraction, and formulation provide opportunities for developing conventional foods, functional foods, nutraceuticals, and standardized products. Overall, edible and medicinal mushrooms show promise as food and nutraceutical resources, but their translation into evidence-based functional products requires improved standardization, safety and bioavailability assessments, and well-designed human trials.<\/jats:p>","DOI":"10.3390\/foods15183265","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:58:59Z","timestamp":1789545539000},"page":"3265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Compounds from Edible and Medicinal Mushrooms in Obesity\u2013Depression Comorbidity: Gut\u2013Brain Axis Mechanisms and Functional Food Perspectives"],"prefix":"10.3390","volume":"15","author":[{"given":"Wang","family":"Li","sequence":"first","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongze","family":"Chi","sequence":"additional","affiliation":[{"name":"Jilin Provincial Drug Review and Inspection Center, Changchun 130000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmin","family":"Hu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Chengde Academy of Agriculture and Forestry Sciences, Chengde 067000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Sciences, Changchun University of Technology, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Li","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueting","family":"Dai","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990\u20132021, with forecasts to 2050: A forecasting study for the Global Burden of Disease Study 2021","volume":"405","author":"Ng","year":"2025","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","article-title":"Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Ferrari","year":"2024","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"120299","DOI":"10.1016\/j.jad.2025.120299","article-title":"Global, regional and national burden of anxiety and depression disorders from 1990 to 2021, and forecasts up to 2040","volume":"393","author":"Zhang","year":"2026","journal-title":"J. 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