{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:05:06Z","timestamp":1789571106310,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Third Institute of Oceanography, Ministry of Natural Resources","award":["2017027"],"award-info":[{"award-number":["2017027"]}]},{"name":"Innovation Research and Development Special Funds of the Municipality\u2013Province\u2013Ministry Co-constructed Program","award":["GJZX-HYSW-2025-01"],"award-info":[{"award-number":["GJZX-HYSW-2025-01"]}]},{"name":"Innovation Research and Development Special Funds of the Municipality\u2013Province\u2013Ministry Co-constructed Program","award":["GJZX-HYSW-2024-09"],"award-info":[{"award-number":["GJZX-HYSW-2024-09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Lactic acid bacterial fermentation offers a mild strategy for tailoring seaweed-derived carbohydrate fractions and strengthening their functional properties. In this study, polysaccharide-rich fractions were recovered from unfermented Gracilariopsis lemaneiformis (GP) and from biomass fermented with two marine-derived lactic acid bacteria, Lacticaseibacillus casei DS31 (GP-D) and Lactiplantibacillus plantarum HJ-S2 (GP-H). Fermentation changed the recovery of total and sulfated carbohydrates and altered monosaccharide profiles. In wild-type N2 worms, GP, GP-D, and GP-H extended mean lifespan by 8.61%, 14.70%, and 21.21%, respectively, and improved heat and oxidative stress survival (median survival +44% and +20% for GP-H, respectively), locomotion, redox homeostasis (SOD activity +19.5%, MDA content \u221273.4% for GP-H), and proteostasis-related phenotypes. Promoter\u2013reporter assays, DAF-16::GFP localization, and transcriptomic profiling identified distinct treatment-associated stress-response programs. Lifespan extension also persisted in a daf-16 loss-of-function background, supporting contributions from complementary longevity networks. Collectively, strain-dependent fermentation reshaped G. lemaneiformis polysaccharide-rich fractions and enhanced their in vivo bioactivity, with GP-H producing the broadest improvement across the measured lifespan and healthspan endpoints.<\/jats:p>","DOI":"10.3390\/foods15183272","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:50:27Z","timestamp":1789566627000},"page":"3272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-3373","authenticated-orcid":false,"given":"Jiaqi","family":"Huang","sequence":"first","affiliation":[{"name":"Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China"},{"name":"Fujian Provincial Key Laboratory of 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