{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:01:30Z","timestamp":1790071290646,"version":"4.0.1"},"reference-count":149,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Gamma-aminobutyric acid (GABA), a non-protein amino acid widely present in plant-based foods, has gained considerable attention for its diverse physiological effects and underlying mechanisms. As a functional dietary component, GABA has been reported to exhibit antihypertensive activity in preclinical and preliminary human studies, with proposed mechanisms including angiotensin-converting enzyme (ACE) inhibition and modulation of sympathetic outflow. In nematode models, GABA has been observed to alleviate aging-related oxidative stress by enhancing antioxidant enzymes (e.g., SOD, CAT) and reducing lipofuscin accumulation. It may also alleviate certain menopausal symptoms based on limited human trial data, potentially through regulation of autonomic nervous system balance and reduction in vasomotor disturbances. Its anxiolytic and sleep-promoting effects are linked to GABAergic neurotransmission via GABAA\/B receptors, which suppresses hypothalamic\u2013pituitary\u2013adrenal (HPA) axis hyperactivity. GABA also shows anticancer potential in cell-based assays by disrupting tumor cell cycles and metastasis pathways, while its antidiabetic role in preclinical models involves pancreatic \u03b2-cell protection and glucose homeostasis regulation. Despite the wide range of proposed physiological benefits, safety assessments indicate that GABA is generally well-tolerated at typical dietary supplement doses (\u2264300 mg\/day), with higher intakes (up to 3000 mg\/day) permitted in some regulatory frameworks, supporting its use in functional foods. Future research should focus on optimizing GABA-enriched food production and elucidating dose-related mechanisms for personalized nutrition.<\/jats:p>","DOI":"10.3390\/foods15183323","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:12:09Z","timestamp":1789999929000},"page":"3323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Physiological Effects and Mechanisms of Gamma-Aminobutyric Acid in Food Systems"],"prefix":"10.3390","volume":"15","author":[{"given":"Mingcan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-5261","authenticated-orcid":false,"given":"Tabussam","family":"Tufail","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105646","DOI":"10.1016\/j.fbio.2024.105646","article-title":"Increasing gamma-aminobutyric acid (GABA) production by Lactiplantibacillus plantarum via ultrasonication: Optimization, kinetic model, ATPase activity, and cell permeability","volume":"63","author":"Chen","year":"2025","journal-title":"Food Biosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111801","DOI":"10.1016\/j.foodres.2022.111801","article-title":"Enrichment of gamma-aminobutyric acid in foods: From conventional methods to innovative technologies","volume":"162","author":"Sun","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/07388551.2020.1869688","article-title":"Microbial production of gamma-aminobutyric acid: Applications, state-of-the-art achievements, and future perspectives","volume":"41","author":"Luo","year":"2021","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e05526","DOI":"10.1016\/j.heliyon.2020.e05526","article-title":"\u03b3-Aminobutyric acid found in fermented foods and beverages: Current trends","volume":"6","author":"Sahab","year":"2020","journal-title":"Heliyon"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.3390\/nu16172983","article-title":"Efficacy of Food Supplement Based on Monacolins, \u03b3-Oryzanol, and \u03b3-Aminobutyric Acid in Mild Dyslipidemia: A Randomized, Double-Blind, Parallel-Armed, Placebo-Controlled Clinical Trial","volume":"16","author":"Morone","year":"2024","journal-title":"Nutrients"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/19476337.2021.1905721","article-title":"Effects of high-temperature cooking on the gamma-aminobutyric acid content and antioxidant capacity of germinated brown rice (Oryza sativa L.)","volume":"19","author":"Toyoizumi","year":"2021","journal-title":"CyTA-J. Food"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3390\/nutraceuticals4020015","article-title":"The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention","volume":"4","author":"Almutairi","year":"2024","journal-title":"Nutraceuticals"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Cui, Y., Miao, K., Niyaphorn, S., and Qu, X. (2020). Production of Gamma-Aminobutyric Acid from Lactic Acid Bacteria: A Systematic Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030995"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"107788","DOI":"10.1016\/j.fbio.2025.107788","article-title":"Exogenous GABA increases the accumulation of bioactive compounds in broccoli sprouts under NaCl stress by modulating their biosynthesis and gene expression","volume":"74","author":"Wang","year":"2025","journal-title":"Food Biosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11936","DOI":"10.1073\/pnas.1822067116","article-title":"GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity","volume":"116","author":"Hwang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12171","DOI":"10.1021\/acs.jafc.1c02933","article-title":"Transcriptome analysis reveals the molecular mechanism of GABA accumulation during quinoa (Chenopodium quinoa Willd.) germination","volume":"69","author":"Zhang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1002\/jsfa.14373","article-title":"Ultrasound combined with alternating anaerobic and aerobic treatment elicited gamma-aminobutyric acid accumulation in mulberry leaves","volume":"105","author":"Xie","year":"2025","journal-title":"J. Sci. Food Agric."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/B978-0-444-64057-4.00013-2","article-title":"\u0393-Aminobutyric Acid (GABA): Biosynthesis, Role, Commercial Production, and Applications","volume":"57","author":"Rashmi","year":"2018","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.3390\/foods10102448","article-title":"Integrated Analysis of Metabolome and Volatile Profiles of Germinated Brown Rice from the Japonica and Indica Subspecies","volume":"10","author":"Zhou","year":"2021","journal-title":"Foods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3390\/foods11070912","article-title":"Rice Bran Stabilisation and Oil Extraction Using the Microwave-Assisted Method and Its Effects on GABA and Gamma-Oryzanol Compounds","volume":"11","author":"Reis","year":"2022","journal-title":"Foods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1002\/jsfa.70444","article-title":"Mechanistic insights into ultrasound-induced gamma-aminobutyric acid accumulation in coffee leaves: A comprehensive study on the synthesis pathways, signal molecules, and transcriptome","volume":"106","author":"Sun","year":"2026","journal-title":"J. Sci. Food Agric."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e12324","DOI":"10.1111\/jfbc.12324","article-title":"\u03b3-amino butyric acid-enriched barley bran lowers adrenocorticotropic hormone and corticosterone levels in immobilized stressed rats","volume":"41","author":"Pichiah","year":"2017","journal-title":"J. Food Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/10942912.2018.1446025","article-title":"Impact of extraction parameters and their optimization on the nutraceuticals and antioxidant properties of aqueous extract mulberry leaf","volume":"21","author":"Tchabo","year":"2018","journal-title":"Int. J. Food Prop."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1111\/ijfs.15664","article-title":"Effect of Levilactobacillus brevis TISTR 860 and Lactiplantibacillus plantarum TISTR 951 on gamma-aminobutyric acid content in fermented rice flour and rice noodles (Kanomjeen)","volume":"57","author":"Chittrakhani","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1002\/jsfa.10924","article-title":"The fermentation properties and microbial diversity of soy sauce fermented by germinated soybean","volume":"101","author":"Zhao","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.3390\/molecules24152678","article-title":"An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid","volume":"24","author":"Ngo","year":"2019","journal-title":"Molecules"},{"key":"ref_22","first-page":"8852","article-title":"Gamma-aminobutyric acid (GABA): A comprehensive review of dietary sources, enrichment technologies, processing effects, health benefits, and its applications","volume":"19","author":"Hou","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e19721","DOI":"10.1590\/fst.19721","article-title":"Germination of five Indonesian brown rice: Evaluation of antioxidant, bioactive compounds, fatty acids and pasting properties","volume":"42","author":"Munarko","year":"2021","journal-title":"Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"111450","DOI":"10.1016\/j.foodres.2022.111450","article-title":"Study on zinc accumulation, bioavailability, physicochemical and structural characteristics of brown rice combined with germination and zinc fortification","volume":"158","author":"Zhang","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"143033","DOI":"10.1016\/j.foodchem.2025.143033","article-title":"Enrichment of GABA content in brown rice through heating and humidifying treatment: Quantification via TLC-ImageJ method","volume":"473","author":"Bai","year":"2025","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103251","DOI":"10.1016\/j.jcs.2021.103251","article-title":"Metabolite profiling reveals the metabolic features of the progenies resulting from the low phytic acid rice (Oryza sativa L.) mutant","volume":"100","author":"Zhou","year":"2021","journal-title":"J. Cereal Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ultsonch.2017.08.029","article-title":"Enhancement of gama-aminobutyric acid (GABA) and other health-related metabolites in germinated red rice (Oryza sativa L.) by ultrasonication","volume":"40","author":"Ding","year":"2018","journal-title":"Ultrason. Sonochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"100379","DOI":"10.1016\/j.ijgfs.2021.100379","article-title":"Effect of germination on nutritional and bioactive properties of red rice grains and its application in cupcake production","volume":"25","author":"Hoffmann","year":"2021","journal-title":"Int. J. Gastron. Food Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/ijfs.15105","article-title":"Effects of soaking and sprouting on bioactive compounds of black and red pigmented rice cultivars","volume":"57","author":"Islam","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.foodchem.2017.09.128","article-title":"Effects of controlled germination on selected physicochemical and functional properties of whole-wheat flour and enhanced \u03b3-aminobutyric acid accumulation by ultrasonication","volume":"243","author":"Ding","year":"2018","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3390\/molecules23092244","article-title":"Effects of germination on protein, \u03b3-aminobutyric acid, phenolic acids, and antioxidant capacity in wheat","volume":"23","author":"Kim","year":"2018","journal-title":"Molecules"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103359","DOI":"10.1016\/j.jcs.2021.103359","article-title":"Influence of pretreatments combined with extrusion on \u03b3-amino butyric acid, nutritional composition and physicochemical properties of foxtail millet (Setaria italica)","volume":"102","author":"Mushtaq","year":"2021","journal-title":"J. Cereal Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/foods9030296","article-title":"Sprouted Barley Flour as a Nutritious and Functional Ingredient","volume":"9","author":"Rico","year":"2020","journal-title":"Foods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e13471","DOI":"10.1111\/jfbc.13471","article-title":"Effect ofLactobacillus plantarumfermented barley on plasma glycolipids and insulin sensitivity in subjects with metabolic syndrome","volume":"44","author":"Pan","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/10408398.2021.1972926","article-title":"Health-promoting properties of barley: A review of nutrient and nutraceutical composition, functionality, bioprocessing, and health benefits","volume":"63","author":"Zhang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_36","first-page":"236","article-title":"Optimization of germination time and temperature to maximize the content of bioactive compounds and the antioxidant activity of purple corn (Zea mays L.) by response surface methodology","volume":"76","author":"Frias","year":"2017","journal-title":"Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.lwt.2016.09.029","article-title":"Improvement in beta-carotene, vitamin B2, GABA, free amino acids and isoflavones in yellow and black soybeans upon germination","volume":"75","author":"Huang","year":"2017","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1007\/s13197-020-04423-4","article-title":"Beans germination as a potential tool for GABA-enriched tofu production","volume":"57","author":"Vann","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1590\/1678-457X.0080","article-title":"GABA (\u03b3-aminobutyric acid) production, antioxidant activity in some germinated dietary seeds and the effect of cooking on their GABA content","volume":"36","author":"Tiansawang","year":"2016","journal-title":"Food Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00217-006-0300-6","article-title":"Kinetics of free protein amino acids, free non-protein amino acids and trigonelline in soybean (Glycine max L.) and lupin (Lupinus angustifolius L.) sprouts","volume":"224","author":"Kuo","year":"2006","journal-title":"Eur. Food Res. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jsfa.3778","article-title":"Effects of cultivar and culture conditions on \u03b3-aminobutyric acid accumulation in germinated fava beans (Vicia faba L.)","volume":"90","author":"Li","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.lwt.2019.05.049","article-title":"Changes in the chemical composition and bioactive compounds of chickpea (Cicer arietinum L.) fortified by germination","volume":"111","author":"Ferreira","year":"2019","journal-title":"LWT"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.foodchem.2016.01.037","article-title":"Dual effects of slightly acidic electrolyzed water (SAEW) treatment on the accumulation of \u03b3-aminobutyric acid (GABA) and rutin in germinated buckwheat","volume":"201","author":"Hao","year":"2016","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.17221\/185\/2016-CJFS","article-title":"Free Amino Acids, Fatty Acids, and Phenolic Compounds in Tartary Buckwheat of Different Hull Colour","volume":"35","author":"Peng","year":"2017","journal-title":"Czech. J. Food Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.foodres.2017.11.021","article-title":"Grape and wine amino acid composition from Carignan noir grapevines growing under rainfed conditions in the Maule Valley, Chile: Effects of location and rootstock","volume":"105","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.postharvbio.2012.08.005","article-title":"Catabolism of GABA in apple fruit: Subcellular localization and biochemical characterization of two \u03b3-aminobutyrate transaminases","volume":"75","author":"Trobacher","year":"2013","journal-title":"Postharvest Biol. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.scienta.2017.01.042","article-title":"Changes in physicochemical properties of mulberry fruits (Morus alba L.) during ripening","volume":"217","author":"Lee","year":"2017","journal-title":"Sci. Hortic."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111912","DOI":"10.1016\/j.postharvbio.2022.111912","article-title":"Long-term cold storage affects metabolites, antioxidant activities, and ripening and stress-related genes of kiwifruit cultivars","volume":"189","author":"Choi","year":"2022","journal-title":"Postharvest Biol. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.postharvbio.2010.03.003","article-title":"\u0393-Aminobutyric acid (GABA) accumulation in four strawberry cultivars in response to elevated CO2 storage","volume":"57","author":"Deewatthanawong","year":"2010","journal-title":"Postharvest Biol. Technol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1080\/09637486.2016.1198888","article-title":"Methyl-inositol, \u03b3-aminobutyric acid and other health benefit compounds in the aril of litchi","volume":"67","author":"Wu","year":"2016","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3390\/agronomy11061204","article-title":"Antioxidant properties, \u03b3-aminobutyric acid (GABA) content, and physicochemical characteristics of tomato cultivars","volume":"11","author":"Tilahun","year":"2021","journal-title":"Agronomy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.foodchem.2016.07.167","article-title":"Influence of cold stress on contents of soluble sugars, vitamin C and free amino acids including gamma-aminobutyric acid (GABA) in spinach (Spinacia oleracea)","volume":"215","author":"Yoon","year":"2017","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"103522","DOI":"10.1016\/j.jfca.2020.103522","article-title":"Determination of free amino acids in five commercial sweetpotato cultivars by hydrophilic interaction liquid chromatography-mass spectrometry","volume":"92","author":"Qiu","year":"2020","journal-title":"J. Food Compos. Anal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"103711","DOI":"10.1016\/j.jfca.2020.103711","article-title":"Formation of \u03b3-aminobutyric acid (GABA) during the natural lactic acid fermentation of cucumber","volume":"96","author":"Moore","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/14620316.2013.11513021","article-title":"Varietal differences in the chlorogenic acid, anthocyanin, soluble sugar, organic acid, and amino acid concentrations of eggplant fruit","volume":"88","author":"Mori","year":"2013","journal-title":"J. Hortic. Sci. Biotechnol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.foodres.2014.05.026","article-title":"Presence and variation of \u03b3-aminobutyric acid and other free amino acids in cocoa beans from different geographical origins","volume":"63","author":"Marseglia","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"108655","DOI":"10.1016\/j.lwt.2019.108655","article-title":"Investigation of free amino acids, bioactive and neuroactive compounds in different types of tea and effect of black tea processing","volume":"117","year":"2020","journal-title":"LWT"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jfca.2013.03.005","article-title":"Determination of amino acids in white, green, black, oolong, pu-erh teas and tea products","volume":"31","author":"Horanni","year":"2013","journal-title":"J. Food Compos. Anal."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1021\/jf801795m","article-title":"Determination of theanine, GABA, and other amino acids in green, oolong, black, and Pu-erh teas with dabsylation and high-performance liquid chromatography","volume":"56","author":"Syu","year":"2008","journal-title":"J. Agric. Chem. Food"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"111093","DOI":"10.1016\/j.postharvbio.2019.111093","article-title":"Effects of high N2\/CO2 in package treatment on polyamine-derived 4-Aminobutyrate (GABA) biosynthesis in cold-stored white mushrooms (Agaricus bisporus)","volume":"162","author":"Chen","year":"2020","journal-title":"Postharvest Biol. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1021\/jf505410a","article-title":"Analysis and Evaluation of Tasty Components in the Pileus and Stipe of Lentinula edodes at Different Growth Stages","volume":"63","author":"Chen","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"133714","DOI":"10.1016\/j.foodchem.2022.133714","article-title":"The yield, nutritional value, umami components and mineral contents of the first-flush and second-flush Pleurotus pulmonarius mushrooms grown on three forestry wastes","volume":"397","author":"Wang","year":"2022","journal-title":"Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3390\/foods11091325","article-title":"Metabolite profiling of chestnut (Castanea crenata) according to origin and harvest time using 1H NMR spectroscopy","volume":"11","author":"Yu","year":"2022","journal-title":"Foods"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e15777","DOI":"10.1111\/jfpp.15777","article-title":"Ultrasonication increases \u03b3-aminobutyric acid accumulation in coffee leaves and affects total phenolic content and angiotensin-converting enzyme inhibitory activity","volume":"45","author":"Ji","year":"2021","journal-title":"J. Food Process. Preserv."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.3390\/nu15214700","article-title":"Bifidobacterium breve CCFM1025 Improves Sleep Quality via Regulating the Activity of the HPA Axis: A Randomized Clinical Trial","volume":"15","author":"Lan","year":"2023","journal-title":"Nutrients"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"125960","DOI":"10.1016\/j.foodchem.2019.125960","article-title":"The necessity of walnut proteolysis based on evaluation after in vitro simulated digestion: ACE inhibition and DPPH radical-scavenging activities","volume":"311","author":"Liu","year":"2020","journal-title":"Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1039\/D1FO00427A","article-title":"The necessity of enzymatically hydrolyzing walnut protein to exert antihypertensive activity based on in vitro simulated digestion and in vivo verification","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"L\u00e9gat, L., Brouwers, S., Smolders, I.J., and Dupont, A.G. (2017). Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors. Front. Neurosci., 11.","DOI":"10.3389\/fnins.2017.00346"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/nu14030545","article-title":"The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action","volume":"14","author":"Grosso","year":"2022","journal-title":"Nutrients"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41440-018-0196-0","article-title":"Importance of AT1 and AT2 receptors in the nucleus of the solitary tract in cardiovascular responses induced by a high-fat diet","volume":"42","author":"Speretta","year":"2019","journal-title":"Hypertens. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e12545","DOI":"10.1111\/jfbc.12545","article-title":"Efficacy of new beverage made of dates vinegar and garlic juice in improving serum lipid profile parameters and inflammatory biomarkers of mildly hyperlipidemic adults: A double-blinded, randomized, placebo-controlled study","volume":"42","author":"Ali","year":"2018","journal-title":"J. Food Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/10641960902977908","article-title":"Anti-Hypertensive Effect of \u03b3-Aminobutyric Acid (GABA)-Rich Chlorella on High-Normal Blood Pressure and Borderline Hypertension in Placebo-Controlled Double Blind Study","volume":"31","author":"Shimada","year":"2009","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3136\/nskkk.51.79","article-title":"Hypotensive effect of fermented milk containing \u03b3-aminobutyric acid (GABA) in subjects with high normal blood pressure","volume":"51","author":"Kajimoto","year":"2004","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"133064","DOI":"10.1016\/j.foodchem.2022.133064","article-title":"Cold atmospheric plasma treatment improves the \u03b3-aminobutyric acid content of buckwheat seeds providing a new anti-hypertensive functional ingredient","volume":"388","author":"Chen","year":"2022","journal-title":"Food Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jtcme.2014.11.022","article-title":"Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure","volume":"6","author":"Nishimura","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"102603","DOI":"10.1016\/j.jbc.2022.102603","article-title":"Angiotensin-converting enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver","volume":"298","author":"Chen","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1002\/jsfa.10939","article-title":"Antihypertensive effect of rapeseed peptides and their potential in improving the effectiveness of captopril","volume":"101","author":"Wang","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"112033","DOI":"10.1016\/j.foodres.2022.112033","article-title":"Calcium-chelating improved zein peptide stability, cellular uptake, and bioactivity by influencing the structural characterization","volume":"162","author":"Qu","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1039\/D0FO00151A","article-title":"The milk macromolecular peptide: Preparation and evaluation of antihypertensive activity in rats","volume":"11","author":"Cui","year":"2020","journal-title":"Food Funct."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1039\/D1FO02779D","article-title":"Highly stable, antihypertensive, and antioxidative peptide production from Apostichopus japonicus by integrated enzymatic membrane reactor and nanofilter-purification mechanism","volume":"13","author":"Quaisie","year":"2022","journal-title":"Food Funct."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e13276","DOI":"10.1111\/jfpp.13276","article-title":"Effects of ultrasound pretreatment on enzymolysis of sodium caseinate protein: Kinetic study, angiotensin-converting enzyme inhibitory activity, and the structural characteristics of the hydrolysates","volume":"41","author":"Abdualrahman","year":"2017","journal-title":"J. Food Process. Preserv."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"132400","DOI":"10.1016\/j.foodchem.2022.132400","article-title":"Exogenous GABA improves the antioxidant and anti-aging ability of silkworm (Bombyx mori)","volume":"383","author":"Tu","year":"2022","journal-title":"Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"108636","DOI":"10.1016\/j.plaphy.2024.108636","article-title":"Root uptake of cereal benzoxazinoids grants resistance to root-knot nematode invasion in white clover","volume":"210","author":"Hama","year":"2024","journal-title":"Plant Physiol. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ijbiomac.2020.03.206","article-title":"Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton","volume":"155","author":"Hui","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/cpr.12257","article-title":"Zinc oxide nanoparticles inhibit expression of manganese superoxide dismutase via amplification of oxidative stress, in murine photoreceptor cells","volume":"49","author":"Guo","year":"2016","journal-title":"Cell Prolif."},{"key":"ref_86","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"116470","DOI":"10.1016\/j.neuroimage.2019.116470","article-title":"Task-related measures of short-interval intracortical inhibition and GABA levels in healthy young and older adults: A multimodal TMS-MRS study","volume":"208","author":"Cuypers","year":"2020","journal-title":"NeuroImage"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"9178","DOI":"10.1021\/acs.jafc.9b00705","article-title":"AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans","volume":"67","author":"Peng","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e14456","DOI":"10.1111\/jfbc.14456","article-title":"Responses of bitter melon saponins to oxidative stress and aging via the IIS pathway linked with sir-2.1 and hlh-30","volume":"46","author":"Zhang","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"102958","DOI":"10.1016\/j.jcs.2020.102958","article-title":"Localization of amino acids in germinated rice grain: Gamma-aminobutyric acid and essential amino acids production approach","volume":"93","author":"Kamjijam","year":"2020","journal-title":"J. Cereal Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: Impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1166\/jbn.2010.1130","article-title":"New Perspective of GABA as an Inhibitor of Formation of Advanced Lipoxidation End-Products: It\u2019s Interaction with Malondiadehyde","volume":"6","author":"Deng","year":"2010","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1556-276X-8-190","article-title":"Comparison of taurine, GABA, Glu, and Asp as scavengers of malondialdehyde in vitro and in vivo","volume":"8","author":"Deng","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1021\/acs.jafc.8b02293","article-title":"Protective Effect and Mechanism of Theanine on Lipopolysaccharide-Induced Inflammation and Acute Liver Injury in Mice","volume":"66","author":"Wang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12986-018-0299-2","article-title":"Protective effects of \u03b3-aminobutyric acid against H2O2-induced oxidative stress in RIN-m5F pancreatic cells","volume":"15","author":"Tang","year":"2018","journal-title":"Nutr. Metab."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"11967","DOI":"10.1080\/10408398.2022.2098244","article-title":"Molecular bases for the use of functional foods in the management of healthy aging: Berries, curcumin, virgin olive oil and honey; three realities and a promise","volume":"63","author":"Xiao","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/ijnp\/pyac066","article-title":"Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study","volume":"26","author":"Tran","year":"2023","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Gilfarb, R.A., and Leuner, B. (2022). GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan. Front. Behav. Neurosci., 16.","DOI":"10.3389\/fnbeh.2022.802530"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1176\/appi.ajp.2014.14070918","article-title":"Ovarian hormone fluctuation, neurosteroids, and HPA axis dysregulation in perimenopausal depression: A novel heuristic model","volume":"172","author":"Gordon","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Edinoff, A.N., Odisho, A.S., Lewis, K., Kaskas, A., Hunt, G., Cornett, E.M., Kaye, A.D., Kaye, A., Morgan, J., and Barrilleaux, P.S. (2021). Brexanolone, a GABA A Modulator, in the Treatment of Postpartum Depression in Adults: A Comprehensive Review. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.699740"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"104512","DOI":"10.1016\/j.psyneuen.2019.104512","article-title":"The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause","volume":"112","author":"Kimball","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.maturitas.2016.01.015","article-title":"Modeling menopause: The utility of rodents in translational behavioral endocrinology research","volume":"87","author":"Koebele","year":"2016","journal-title":"Maturitas"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.semcdb.2021.04.021","article-title":"Coming of age in the frontal cortex: The role of puberty in cortical maturation","volume":"118","author":"Delevich","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.clnesp.2023.09.773","article-title":"GABA in rice bran extract (GRBE) improves relaxation effects on depressive-like behavior in mice model","volume":"58","author":"Jeong","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41538-025-00369-z","article-title":"Limosilactobacillus reuteri fermented brown rice alleviates anxiety improves cognition and modulates gut microbiota in stressed mice","volume":"9","author":"Tyagi","year":"2025","journal-title":"npj Sci. Food"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3390\/nu13051728","article-title":"Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder","volume":"13","author":"Johnson","year":"2021","journal-title":"Nutrients"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/13880209.2018.1557698","article-title":"GABA and l-theanine mixture decreases sleep latency and improves NREM sleep","volume":"57","author":"Kim","year":"2019","journal-title":"Pharm. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/biof.5520260305","article-title":"Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans","volume":"26","author":"Higashiguchi","year":"2006","journal-title":"BioFactors"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.08.055","article-title":"The renin angiotensin system and the brain: New developments","volume":"46","author":"Farag","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"H1200","DOI":"10.1152\/ajpheart.00216.2018","article-title":"Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states","volume":"315","author":"Dampney","year":"2018","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10068-016-0076-9","article-title":"Effect of oral \u03b3-aminobutyric acid (GABA) administration on sleep and its absorption in humans","volume":"25","author":"Yamatsu","year":"2016","journal-title":"Food Sci. Biotechnol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"25675","DOI":"10.1021\/acs.jafc.4c07140","article-title":"Metabolomic Analysis Reveals the Linkage between Sleep-Enhancing Effects and Metabolite Biomarkers and Pathways of Different Casein Hydrolysates in Chronic Unpredictable Mild Stressed Mice","volume":"72","author":"Qian","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jff.2018.04.001","article-title":"Theanine supplementation prevents liver injury and heat shock response by normalizing hypothalamic-pituitaryadrenal axis hyperactivity in mice subjected to whole body heat stress","volume":"45","author":"Wang","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13311-017-0600-5","article-title":"Gut Microbiota and the Neuroendocrine System","volume":"15","author":"Farzi","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"105563","DOI":"10.1016\/j.jff.2023.105563","article-title":"Oligopeptide of RDPEER from watermelon seeds prevents heat stress-induced liver injury by suppressing oxidative stress and inflammation responses","volume":"105","author":"Chen","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/br.2023.1598","article-title":"Agarwood essential oil inhalation exerts antianxiety and antidepressant effects via the regulation of Glu\/GABA system homeostasis","volume":"18","author":"Wang","year":"2023","journal-title":"Biomed. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.autneu.2016.06.006","article-title":"Angiotensin II acting on PVN induces sympathoexcitation and pressor responses via the PI3K-dependent pathway","volume":"198","author":"Buttler","year":"2016","journal-title":"Auton. Neurosci. Basic Clin."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/nu17071242","article-title":"Diet, Eating Habits, and Lifestyle Factors Associated with Adequate Sleep Duration in Children and Adolescents Living in 5 Mediterranean Countries: The DELICIOUS Project","volume":"17","author":"Godos","year":"2025","journal-title":"Nutrients"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5694\/j.1326-5377.1988.tb112773.x","article-title":"Does anxiety reduce the secretion rate of secretory IgA in saliva?","volume":"148","author":"Graham","year":"1988","journal-title":"Med. J. Aust."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbr.2016.04.049","article-title":"Sleep-promoting effects of the GABA\/5-HTP mixture in vertebrate models","volume":"310","author":"Hong","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/nu17091491","article-title":"Efficacy and Tolerability of a Chemically Characterized Scutellaria lateriflora L. Extract-Based Food Supplement for Sleep Management: A Single-Center, Controlled, Randomized, Crossover, Double-Blind Clinical Trial","volume":"17","author":"Morone","year":"2025","journal-title":"Nutrients"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.21037\/apm-21-2798","article-title":"The combined use of gamma-aminobutyric acid and walnut peptide enhances sleep in mice","volume":"10","author":"Chen","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Jongkees, B.J., Immink, M.A., Finisguerra, A., and Colzato, L.S. (2018). Transcutaneous Vagus Nerve Stimulation (tVNS) Enhances Response Selection During Sequential Action. Front. Psychol., 9.","DOI":"10.3389\/fpsyg.2018.01159"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/cne.24337","article-title":"GABAA Receptor Subunits in the Human Amygdala and Hippocampus: Immunohistochemical Distribution of 7 Subunits","volume":"526","author":"Stefanits","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/acsomega.7b00425","article-title":"BBB: Permeable Conjugate of Exogenic GABA","volume":"2","author":"Li","year":"2017","journal-title":"ACS Omega"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuropharm.2018.06.029","article-title":"Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex","volume":"139","author":"Ozaita","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"108505","DOI":"10.1016\/j.pharmthera.2023.108505","article-title":"GABAergic modulation of sleep-wake states","volume":"249","author":"Oishi","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"110568","DOI":"10.1016\/j.celrep.2022.110568","article-title":"Principles of GABAergic signaling in developing cortical network dynamics","volume":"38","author":"Kirmse","year":"2022","journal-title":"Cell Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3892\/ol.2021.12744","article-title":"GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors","volume":"21","author":"Soejima","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"106116","DOI":"10.1016\/j.biocel.2021.106116","article-title":"ABAT targeted by miR-183-5p regulates cell functions in liver cancer","volume":"141","author":"Han","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e1908291","DOI":"10.1002\/adma.201908291","article-title":"Multifunctional Bio-Nanocomposite Coatings for Perishable Fruits","volume":"32","author":"Jung","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e2102079","DOI":"10.1002\/advs.202102079","article-title":"Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABAAR-Dependent TRIM21 Modulation of Src Expression","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"141750","DOI":"10.1016\/j.foodchem.2024.141750","article-title":"GABA (\u03b3-aminobutyric acid) enrichment and detection methods in cereals: Unlocking sustainable health benefits","volume":"464","author":"Tufail","year":"2025","journal-title":"Food Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.3168\/jds.2019-17757","article-title":"Effect of \u03b3-aminobutyric acid-rich yogurt on insulin sensitivity in a mouse model of type 2 diabetes mellitus","volume":"103","author":"Li","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/biom15030399","article-title":"Role of \u03b3-Aminobutyric acid (GABA) as an inhibitory neurotransmitter in diabetes management: Mechanisms and therapeutic implications","volume":"15","author":"Barakat","year":"2025","journal-title":"Biomolecules"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"107217","DOI":"10.1016\/j.jff.2026.107217","article-title":"The potential application of a ketogenic diet in type 1 diabetes mellitus and multiple sclerosis","volume":"138","author":"Zhang","year":"2026","journal-title":"J. Funct. Foods"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.2337\/db13-1385","article-title":"Combined therapy with GABA and proinsulin\/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting beta-cell replication in newly diabetic NOD mice","volume":"63","author":"Tian","year":"2014","journal-title":"Diabetes"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"12620","DOI":"10.1080\/10408398.2023.2255666","article-title":"Insights into the cellular, molecular, and epigenetic targets of gamma-aminobutyric acid against diabetes: A comprehensive review on its mechanisms","volume":"64","author":"Sun","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11130-025-01382-z","article-title":"Cynarin Counteracts Lipotoxicity in Pancreatic \u03b2-Cells Via Inhibiting Palmitate-Induced Apoptosis and Linoleic Acid-Provoked Ferroptosis","volume":"80","author":"Wang","year":"2025","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1021\/acsomega.7b01988","article-title":"Effect of \u03b3-Aminobutyric Acid-Chitosan Nanoparticles on Glucose Homeostasis in Mice","volume":"3","author":"Liu","year":"2018","journal-title":"ACS Omega"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5540118","DOI":"10.1155\/2023\/5540118","article-title":"Health Benefits of Okara for the Management of Diabetes Mellitus","volume":"2023","author":"Lesa","year":"2023","journal-title":"J. Food Qual."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Hinton, T., Jelinek, H.F., Viengkhou, V., Johnston, G.A., and Matthews, S. (2019). Effect of GABA-fortified oolong tea on reducing stress in a university student cohort. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00027"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/13880209.2018.1563621","article-title":"Analysis of the protective effects of \u03b3-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice","volume":"57","author":"Yang","year":"2019","journal-title":"Pharm. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3988\/jcn.2018.14.3.291","article-title":"Safety and efficacy of gamma-aminobutyric acid from fermented rice germ in patients with insomnia symptoms: A randomized, double-blind trial","volume":"14","author":"Byun","year":"2018","journal-title":"J. Clin. Neurol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"8109621","DOI":"10.1155\/2018\/8109621","article-title":"The effects of fermented laminaria japonica on short-term working memory and physical fitness in the elderly","volume":"2018","author":"Reid","year":"2018","journal-title":"Evid.-Based Complement Altern. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"D1179","DOI":"10.1093\/nar\/gkaa962","article-title":"Global Substance Registration System: Consistent scientific descriptions for substances related to health","volume":"49","author":"Peryea","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1530\/acta.0.0930149","article-title":"Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man","volume":"93","author":"Cavagnini","year":"1980","journal-title":"Eur. J. Endocrinol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0024-3205(76)90146-6","article-title":"Pharmacological manipulation of gamma-aminobuytyric acid (GABA) in morphine analgesia, tolerance and physical dependence","volume":"18","author":"Ho","year":"1976","journal-title":"Life Sci."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/18\/3323\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:15:32Z","timestamp":1790068532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/18\/3323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":149,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["foods15183323"],"URL":"https:\/\/doi.org\/10.3390\/foods15183323","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]}}}