{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:59:19Z","timestamp":1790600359778,"version":"4.1.0"},"reference-count":82,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Psyllium has long been used to improve satiety and control weight. Leek and dill leaves are abundant in bioactive substances that have been confirmed to have anti-inflammatory and antioxidant properties. Our goal was to assess the hepatoprotective effects of two formulae (dill and psyllium or leek and psyllium) against oxidative stress and inflammatory markers in a metabolic dysfunction-associated steatotic liver disease (MASLD) rat model. Twenty four rats were used in this study. Rats were given a high-fat, high-sucrose diet (HF\/HS), a Western diet, to create a MASLD model. The two formulae showed lower levels of serum alanine transaminase and aspartate transaminase, as well as a preventive effect against obesity, as shown by lower levels of leptin (with changes of 60.57 and 67.14%, respectively) and body weight gain (with changes of 25.57 and 29.04%, respectively). The two formulae resulted in a reduction in blood glucose, insulin, cholesterol, triglycerides, oxidative markers, and inflammatory markers upon feeding on the HF\/HS diet. The histological evaluation in rats treated with the two formulae revealed reduced hepatic vacuolization and lobular inflammation. The two formulations reduced the mRNA expression of nuclear factor-kappa B (NF-\u03baB) while increasing the mRNA expression of nuclear erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1). The results indicated the potential efficacy of the two prepared formulations in alleviating and preventing MASLD in the rat model evaluated.<\/jats:p>","DOI":"10.3390\/foods15193447","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:35:59Z","timestamp":1790595359000},"page":"3447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant-Based Functional Formulae Mitigate Western Diet-Induced MASLD by Modulating Hepatic Oxidative Stress, Inflammation as Well as Nrf-2\/HO-1 and NF-\u03baB Gene Expression"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-000X","authenticated-orcid":false,"given":"Rasha S.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Sciences, National Research Centre, Cairo 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-4202","authenticated-orcid":false,"given":"Karem","family":"Fouda","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Sciences, National Research Centre, Cairo 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-4687","authenticated-orcid":false,"given":"Noha E.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Microbial Biotechnology, National Research Centre, Cairo 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lehoczki, A., Cs\u00edp\u0151, T., Lip\u00e9cz, \u00c1., Major, D., Fazekas-Pongor, V., Cs\u00edk, B., M\u00f3zes, N., Feh\u00e9r, \u00c1., D\u00f3sa, N., and \u00c1rva, D. 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