{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:29Z","timestamp":1792789289241,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mahasarakham University","id":[{"id":"https:\/\/ror.org\/0453j3c58","id-type":"ROR","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/0453j3c58","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Naringin is a naturally occurring flavanone glycoside found in citrus fruits that has been widely studied for its antioxidant and anti-inflammatory activities. The precise mechanisms by which naringin exerts protective effects against ischemic stroke are not yet fully understood. To address this gap, the current study examined the efficacy of naringin administration (100 mg\/kg BW) in an experimental rat model involving permanent right middle cerebral artery occlusion (Rt.MCAO). Administration of naringin significantly improved neurological performance while reducing cerebral infarct volume and brain edema following ischemic injury. Histopathological evaluation further demonstrated that naringin preserved neuronal density in the cerebral cortex and hippocampus, indicating protection against ischemia-induced neuronal degeneration. In parallel, naringin attenuated glial activation, as evidenced by reduced expression of ionized calcium-binding adapter molecule 1 (Iba1) and glial fibrillary acidic protein (GFAP), accompanied by suppression of the pro-inflammatory mediators interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2). Furthermore, naringin restored redox homeostasis by lowering malondialdehyde (MDA) levels and preserving the activities of the endogenous antioxidant enzymes catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and mitochondrial superoxide dismutase (mitochondrial SOD). A significant reduction in myeloperoxidase (MPO) activity further supported its ability to alleviate oxidative stress and inflammatory responses. Our findings indicate that naringin has neuroprotective effects in experimental ischemic stroke. These effects were associated with improved antioxidant defenses and reduced neuroinflammatory responses. However, further preclinical studies are needed to confirm the underlying mechanisms, optimal treatment conditions, and long-term effects.<\/jats:p>","DOI":"10.3390\/foods15193449","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:35:59Z","timestamp":1790595359000},"page":"3449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Citrus Flavonoid Naringin Confers Neuroprotection Against Cerebral Ischemia by Enhancing Endogenous Antioxidant Capacity and Suppressing Neuroinflammation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-0933","authenticated-orcid":false,"given":"Ratchaniporn","family":"Kongsui","sequence":"first","affiliation":[{"name":"Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-9941","authenticated-orcid":false,"given":"Nut","family":"Palachai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mahasarakham University, Maha Sarakham 44000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araya","family":"Supawat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mahasarakham University, Maha Sarakham 44000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-4677","authenticated-orcid":false,"given":"Sitthisak","family":"Thongrong","sequence":"additional","affiliation":[{"name":"Division of Anatomy, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-3843","authenticated-orcid":false,"given":"Jinatta","family":"Jittiwat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mahasarakham University, Maha Sarakham 44000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0038-1649503","article-title":"Global Burden of Stroke","volume":"38","author":"Katan","year":"2018","journal-title":"Semin. Neurol."},{"key":"ref_2","unstructured":"(2024). GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurol., 23, 973\u20131003."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1161\/CIR.0000000000001412","article-title":"2026 Heart Disease and Stroke Statistics: A Report of US and Global Data from the American Heart Association","volume":"153","author":"Palaniappan","year":"2026","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World Stroke Organization: Global Stroke Fact Sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int. J. Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e73533","DOI":"10.2196\/73533","article-title":"Smart Device-Based Therapy on Hand Motor Function Improvement in Stroke Survivors During Rehabilitation: Scoping Review","volume":"12","author":"Krumina","year":"2025","journal-title":"JMIR Rehabil. Assist. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13561-026-00727-x","article-title":"A systematic review on indirect costs related to loss of productivity after stroke","volume":"16","year":"2026","journal-title":"Health Econ. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/eurjcn\/zvag015","article-title":"The hidden cost of informal care: A commentary on productivity loss, gender inequality, and the invisible workforce of stroke carers","volume":"25","author":"Bartoli","year":"2026","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.2174\/1381612826666200708133912","article-title":"Pathophysiology of Ischemic Stroke: Role of Oxidative Stress","volume":"26","author":"Rojas","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Long, Z., Zhu, Y., Zhao, H., Liao, S., and Liu, C. (2025). Ferroptosis in ischemic stroke: Mechanisms, pathological implications, and therapeutic strategies. Front. Neurosci., 19.","DOI":"10.3389\/fnins.2025.1623485"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1038\/s41598-025-85957-5","article-title":"Comprehensive analysis of bioinformatics identification TST, SQOR and NRDC is mitochondria-related biomarkers of ischemic cerebral apoplexy","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Salaudeen, M.A., Bello, N., Danraka, R.N., and Ammani, M.L. (2024). Understanding the Pathophysiology of Ischemic Stroke: The Basis of Current Therapies and Opportunity for New Ones. Biomolecules, 14.","DOI":"10.3390\/biom14030305"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5815843","DOI":"10.1155\/2022\/5815843","article-title":"Pathophysiology of Ischemic Stroke: Noncoding RNA Role in Oxidative Stress","volume":"2022","author":"Su","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shen, X., Chen, L., Shen, L., Chen, S., Mu, S., Chen, L., Wang, S., and Li, Z. (2025). Inflammatory biomarkers in cerebral venous thrombosis versus ischemic stroke: A network meta-analysis. Front. Neurol., 16, Erratum in Front Neurol.\u00a02026, 16, 1769992. https:\/\/doi.org\/10.3389\/fneur.2025.1769992.","DOI":"10.3389\/fneur.2025.1634369"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Gong, Z., Guo, J., Liu, B., Guo, Y., Cheng, C., Jiang, Y., Liang, N., Hu, M., Song, T., and Yang, L. (2023). Mechanisms of immune response and cell death in ischemic stroke and their regulation by natural compounds. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1287857"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tips.2020.11.010","article-title":"Targeting the Immune System for Ischemic Stroke","volume":"42","author":"Zhang","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.2174\/1570159X21666230718104634","article-title":"The Relationship of Astrocytes and Microglia with Different Stages of Ischemic Stroke","volume":"21","author":"Liang","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/cns.13620","article-title":"Microglial\/Macrophage polarization and function in brain injury and repair after stroke","volume":"27","author":"Lyu","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jurga, A.M., Paleczna, M., Kadluczka, J., and Kuter, K.Z. (2021). Beyond the GFAP-Astrocyte Protein Markers in the Brain. Biomolecules, 11.","DOI":"10.3390\/biom11091361"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"He, T., Yang, G.Y., and Zhang, Z. (2022). Crosstalk of Astrocytes and Other Cells during Ischemic Stroke. Life, 12.","DOI":"10.3390\/life12060910"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hou, M., Wei, D., Wang, Y., Zhang, X., and Yao, Z. (2025). Protective effects of naringenin and naringin in organ ischemia\/reperfusion injuries: A comprehensive narrative review. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1701726"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kazmierczak, T., Cyboran-Mikolajczyk, S., Trochanowska-Pauk, N., Walski, T., Nowicka, P., and Bonarska-Kujawa, D. (2025). Insights on the Mechanisms of the Protective Action of Naringenin, Naringin and Naringin Dihydrochalcone on Blood Cells in Terms of Their Potential Anti-Atherosclerotic Activity. Molecules, 30.","DOI":"10.3390\/molecules30030547"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Stabrauskiene, J., Kopustinskiene, D.M., Lazauskas, R., and Bernatoniene, J. (2022). Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071686"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12017-019-08590-2","article-title":"Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents","volume":"22","author":"Garabadu","year":"2020","journal-title":"Neuromolecular Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Tungmunnithum, D., Thongboonyou, A., Pholboon, A., and Yangsabai, A. (2018). Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview. Medicines, 5.","DOI":"10.3390\/medicines5030093"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yoo, K.Y., Won, M.H., Ahn, J.H., and Park, J.H. (2025). Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury. Biology, 14.","DOI":"10.3390\/biology14091153"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Emran, T.B., Islam, F., Nath, N., Sutradhar, H., Das, R., Mitra, S., Alshahrani, M.M., Alhasaniah, A.H., and Sharma, R. (2022). Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint. Life, 13.","DOI":"10.3390\/life13010099"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Adams, J.A., Uryash, A., Mijares, A., Eltit, J.M., and Lopez, J.R. (2025). Endothelial and Cardiovascular Effects of Naringin: A Systematic Review. Nutrients, 17.","DOI":"10.3390\/nu17162658"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12017-023-08771-0","article-title":"Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia-Reperfusion Model of Rats","volume":"26","author":"Yilmaz","year":"2024","journal-title":"Neuromolecular Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9029","DOI":"10.1007\/s12035-018-1027-7","article-title":"Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation","volume":"55","author":"Feng","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3892\/br.2024.1773","article-title":"In vivo protective effects of 6-gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti-apoptotic pathways","volume":"20","author":"Kongsui","year":"2024","journal-title":"Biomed. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102062","DOI":"10.1016\/j.toxrep.2025.102062","article-title":"Naringin ameliorates high-fat diet-induced hepatotoxicity and dyslipidemia in experimental rat model via modulation of anti-oxidant enzymes, AMPK and SERBP-1c signaling pathways","volume":"14","author":"Sarkar","year":"2025","journal-title":"Toxicol. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3708497","DOI":"10.1155\/2019\/3708497","article-title":"Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression","volume":"2019","author":"Pengnet","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1204709","DOI":"10.1155\/2019\/1204709","article-title":"Baihui Point Laser Acupuncture Ameliorates anti-inCognitive Impairment, Motor Deficit, and Neuronal Loss Partly via Antioxidant and Anti-Inflammatory Effects in an Animal Model of Focal Ischemic Stroke","volume":"2019","author":"Jittiwat","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Palachai, N., Supawat, A., Kongsui, R., Klimaschewski, L., and Jittiwat, J. (2025). Galangin\u2019s Neuroprotective Role: Targeting Oxidative Stress, Inflammation, and Apoptosis in Ischemic Stroke in a Rat Model of Permanent Middle Cerebral Artery Occlusion. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26051847"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"119842","DOI":"10.1016\/j.lfs.2021.119842","article-title":"Dihydrocapsaicin effectively mitigates cerebral ischemia-induced pathological changes in vivo, partly via antioxidant and anti-apoptotic pathways","volume":"283","author":"Jittiwat","year":"2021","journal-title":"Life Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3892\/br.2023.1608","article-title":"Ameliorative effects of 6-gingerol in cerebral ischemia are mediated via the activation of antioxidant and anti-inflammatory pathways","volume":"18","author":"Kongsui","year":"2023","journal-title":"Biomed. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/br.2023.1602","article-title":"Pinostrobin alleviates chronic restraint stress-induced cognitive impairment by modulating oxidative stress and the function of astrocytes in the hippocampus of rats","volume":"18","author":"Thongrong","year":"2023","journal-title":"Biomed. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0021-9258(18)56216-5","article-title":"Photometric determination of catalase activity","volume":"187","author":"Goldblith","year":"1950","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Maida, C.D., Norrito, R.L., Rizzica, S., Mazzola, M., Scarantino, E.R., and Tuttolomondo, A. (2024). Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202404.1239.v1"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zeng, L., Hu, S., Zeng, L., Chen, R., Li, H., Yu, J., and Yang, H. (2023). Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion. Brain Sci., 13.","DOI":"10.3390\/brainsci13071007"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, H., Yiqiang, Z., Cai, J., and Guo, J. (2025). Immune-mediated blood-brain barrier disruption after ischemic stroke: Mechanisms and therapeutic targets. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1716041"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.hest.2020.09.001","article-title":"Behavioral tests in rodent models of stroke","volume":"1","author":"Ruan","year":"2020","journal-title":"Brain Hemorrhages"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e17166","DOI":"10.1016\/j.heliyon.2023.e17166","article-title":"The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases","volume":"9","author":"Adetunji","year":"2023","journal-title":"Heliyon"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lu, Y., Li, D.H., Xu, J.M., and Zhou, S. (2024). Role of naringin in the treatment of atherosclerosis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1451445"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2009.06.056","article-title":"Protective effect of naringin against ischemic reperfusion cerebral injury: Possible neurobehavioral, biochemical and cellular alterations in rat brain","volume":"616","author":"Gaur","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0028-3908(02)00093-X","article-title":"The 2-oxopyrrolidinacetamide piracetam reduces infarct brain volume induced by permanent middle cerebral artery occlusion in male rats","volume":"43","author":"Tortiglione","year":"2002","journal-title":"Neuropharmacology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2017.09.013","article-title":"Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways","volume":"1676","author":"Yang","year":"2017","journal-title":"Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1161\/01.STR.31.9.2112","article-title":"Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients","volume":"31","author":"Kessler","year":"2000","journal-title":"Stroke"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3892\/br.2024.1888","article-title":"Effect of galangin on oxidative stress, antioxidant defenses and mitochondrial dynamics in a rat model of focal cerebral ischemia","volume":"22","author":"Supawat","year":"2025","journal-title":"Biomed. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., and Ge, J. (2022). The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1047550"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.2147\/JIR.S461795","article-title":"Microglia in Ischemic Stroke: Pathogenesis Insights and Therapeutic Challenges","volume":"17","author":"Shui","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Patabendige, A., Singh, A., Jenkins, S., Sen, J., and Chen, R. (2021). Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084280"},{"key":"ref_56","first-page":"3492058","article-title":"Naringin Regulates Microglia BV-2 Activation and Inflammation via the JAK\/STAT3 Pathway","volume":"2022","author":"Li","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3892\/mmr.2026.13805","article-title":"Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2\/STAT3 signaling pathway","volume":"33","author":"Wu","year":"2026","journal-title":"Mol. Med. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.5114\/aoms.2019.84854","article-title":"Naringin attenuates high glucose-induced injuries and inflammation by modulating the leptin-JAK2\/STAT3 pathway in H9c2 cardiac cells","volume":"17","author":"Luo","year":"2021","journal-title":"Arch. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/17520363.2024.2389038","article-title":"IL-6 and stroke recurrence in ischemic stroke","volume":"18","author":"Jiang","year":"2024","journal-title":"Biomark. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106909","DOI":"10.1016\/j.psj.2026.106909","article-title":"The role of cyclooxygenase-2 in oxidative stress and inflammation: Implications for poultry health and production","volume":"105","author":"Xiao","year":"2026","journal-title":"Poult. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Xiao, L., Huang, Y., Wu, L., Zeng, S., Qiu, C., Li, X., Xie, L., and Wu, D. (2025). The role of inflammation in Ischemic stroke: From biomarker to treatment. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1608353"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"28630","DOI":"10.1021\/acsomega.1c03066","article-title":"Naringin as Sustained Delivery Nanoparticles Ameliorates the Anti-inflammatory Activity in a Freund\u2019s Complete Adjuvant-Induced Arthritis Model","volume":"6","author":"Mohanty","year":"2021","journal-title":"ACS Omega"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5551\/jat.65842","article-title":"Association between Serum Interleukin-6 Levels and Long-term Outcomes after Ischemic Stroke: A Prospective Cohort Study","volume":"33","author":"Arai","year":"2026","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"115772","DOI":"10.1016\/j.bcp.2023.115772","article-title":"Spatial and temporal mapping of neuron-microglia interaction modes in acute ischemic stroke","volume":"216","author":"Dou","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Chen, S., Chen, H., Du, Q., and Shen, J. (2020). Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00433"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.4103\/1673-5374.332130","article-title":"Myeloperoxidase: A new target for the treatment of stroke?","volume":"17","author":"Wang","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e70268","DOI":"10.1002\/mco2.70268","article-title":"Oxidative Stress: Signaling Pathways, Biological Functions, and Disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Grujicic, J., and Allen, A.R. (2025). Manganese Superoxide Dismutase: Structure, Function, and Implications in Human Disease. Antioxidants, 14.","DOI":"10.3390\/antiox14070848"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Thongrong, S., Kongsui, R., Klimaschewski, L., and Jittiwat, J. (2025). Modulatory Potential of Alpinetin on Inflammation, Oxidative Stress, Apoptosis, and Mitochondrial Dynamics in a Rat Middle Cerebral Artery Occlusion Model of Ischemic Stroke. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262311329"},{"key":"ref_70","first-page":"1474","article-title":"Naringin Supplementation Reduces Inflammatory Processes in the Cerebellum in Brain Ischemia of Rats","volume":"25","author":"Babacanoglu","year":"2025","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e12040","DOI":"10.1590\/1414-431x2022e12040","article-title":"Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK\/Nrf2 signaling pathway in vitro","volume":"55","author":"Wu","year":"2022","journal-title":"Braz. J. Med. Biol. 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