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H.L.Li fruit is a bioactive dietary resource, yet its effects on intestinal inflammation and the associated microbial, metabolic, and host responses remain poorly understood. This study characterized P. fortuneana fruit extract (PFE) and evaluated its protective effects in a dextran sodium sulfate (DSS)-induced colitis model using microbiota, metabolomic, and transcriptomic analyses. Chemical profiling confirmed the presence of representative phenolic acids, flavonoids, and condensed tannins in PFE. Administered before and during 2.5% DSS exposure, PFE reduced disease activity, attenuated colon shortening and the elevated spleen index, and improved colonic histopathological appearance. PFE also reduced IL-6 and increased IL-10 and serum GSH-Px levels, while high-dose PFE decreased TNF-\u03b1. It restored ZO-1 expression, increased colonic diamine oxidase levels, and tended to increase Occludin expression. PFE increased microbial diversity and evenness, reduced Turicibacter and Ruminococcus, and increased Prevotella and Jeotgalicoccus. Non-targeted metabolomics identified changes in selected cecal bile acid- and lipid-related metabolites, whereas transcriptomic and protein analyses implicated bile secretion- and PPAR-related responses, accompanied by increased ASBT, PPAR\u03b3, and NLRP6 expression. Collectively, these findings demonstrate the protective effects of PFE against DSS-induced colitis and support its further investigation as a potential food-derived bioactive ingredient for intestinal health.<\/jats:p>","DOI":"10.3390\/foods15193528","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:15:18Z","timestamp":1790928918000},"page":"3528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic-Rich Extract from Pyracantha fortuneana Fruit Alleviates DSS-Induced Colitis in Mice: Insights from Gut Microbiota, Metabolomic, and Transcriptomic Analyses"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-6587","authenticated-orcid":false,"given":"Hang","family":"Xu","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Purification and Application of Plant Anticancer Active Ingredients, College of Chemistry and Life 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colitis","volume":"402","author":"Honap","year":"2023","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal cancer in inflammatory bowel disease: Mechanisms and management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1039\/D2FO02781J","article-title":"Tieguanyin extracts ameliorated DSS-induced mouse colitis by suppressing inflammation and regulating intestinal microbiota","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dzi\u0105bowska-Grabias, K., Sztanke, M., Zaj\u0105c, P., Celejewski, M., Kurek, K., Szkutnicki, S., Korga, P., Bulikowski, W., and Sztanke, K. (2021). Antioxidant therapy in inflammatory bowel diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10030412"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2021.08.047","article-title":"The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair","volume":"161","author":"Kuo","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Schoultz, I., and Keita, \u00c5.V. (2020). The intestinal barrier and current techniques for the assessment of gut permeability. Cells, 9.","DOI":"10.3390\/cells9081909"},{"key":"ref_7","first-page":"102809","article-title":"Oat bran ameliorated DSS-induced mice colitis by suppressing inflammation and enriching beneficial metabolites derived from gut microbiota","volume":"27","author":"Gu","year":"2026","journal-title":"J. Agric. Food Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115430","DOI":"10.1016\/j.biopha.2023.115430","article-title":"Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism","volume":"167","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/imm.12930","article-title":"Immune regulation by microbiome metabolites","volume":"154","author":"Kim","year":"2018","journal-title":"Immunology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2020.01.021","article-title":"Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation","volume":"27","author":"Sinha","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e2406917","DOI":"10.1002\/advs.202406917","article-title":"Bifidobacterium pseudolongum-derived bile acid from dietary carvacrol and thymol supplementation attenuates colitis via cGMP-PKG-mTORC1 pathway","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1039\/D3FO01771K","article-title":"Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2\/glycine\/mTOR\/PPAR-\u03b3 signaling pathway","volume":"14","author":"Guo","year":"2023","journal-title":"Food Funct."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1039\/D2FO01347A","article-title":"Protective effect of traditional Korean fermented soybean foods (doenjang) on a dextran sulfate sodium-induced colitis mouse model","volume":"13","author":"Yang","year":"2022","journal-title":"Food Funct."},{"key":"ref_15","first-page":"101641","article-title":"Polyphenol-protein particles: A nutraceutical breakthrough in nutrition and food science","volume":"19","author":"Muntaha","year":"2025","journal-title":"J. Agric. Food Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"130509","DOI":"10.1016\/j.foodchem.2021.130509","article-title":"Physicochemical, biological properties, and flavour profile of Rosa roxburghii Tratt, Pyracantha fortuneana, and Rosa laevigata Michx fruits: A comprehensive review","volume":"366","author":"Li","year":"2022","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jff.2016.01.028","article-title":"Characterization of active constituents in Pyracantha fortuneana fruit extract and their effects on hyperlipidaemia, obesity, and oxidative stress in rodents","volume":"22","author":"Xu","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106838","DOI":"10.1016\/j.jff.2025.106838","article-title":"Protective effects and potential mechanisms of Pyracantha fortuneana fruit extract on chemotherapy-induced thrombocytopenia revealed by transcriptomic analysis","volume":"128","author":"Xu","year":"2025","journal-title":"J. Funct. Foods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1039\/C9FO01599J","article-title":"The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats","volume":"10","author":"Xu","year":"2019","journal-title":"Food Funct."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115383","DOI":"10.1016\/j.lwt.2023.115383","article-title":"Effects of different drying methods on the physicochemical and functional properties of Pyracantha fortuneana (Maxim.) LI Fruit","volume":"187","author":"Xu","year":"2023","journal-title":"LWT"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"105767","DOI":"10.1016\/j.phrs.2021.105767","article-title":"Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism","volume":"171","author":"Dong","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sabater, C., Calvete-Torre, I., Ruiz, L., and Margolles, A. (2022). Arabinoxylan and pectin metabolism in Crohn\u2019s disease microbiota: An in silico study. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137093"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wen, X., Peng, H., Zhang, H., He, Y., Guo, F., Bi, X., Liu, J., and Sun, Y. (2024). Wheat bran polyphenols ameliorate DSS-induced ulcerative colitis in mice by suppressing MAPK\/NF-\u03baB inflammasome pathways and regulating intestinal microbiota. Foods, 13.","DOI":"10.3390\/foods13020225"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Li, D., Yang, J., Yang, Y., Liu, J., Li, H., Li, R., Cao, C., Shi, L., Wu, W., and He, K. (2021). A timely review of cross-kingdom regulation of plant-derived microRNAs. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.613197"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jnutbio.2018.03.026","article-title":"The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells","volume":"57","author":"Hou","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Villani, V., and Gismondi, A. (2026). Malva sylvestris flower extract exhibits antineoplastic potential against human colon cancer cell lines and induces CDK2 transcript instability via plant miR160-5p. Nutrients, 18.","DOI":"10.3390\/nu18030495"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1039\/D3FO04277D","article-title":"Gut microbiota modulation and effects of a diet enriched in apple pomace on inflammation in a DSS-induced colitis mouse model","volume":"15","author":"Sabater","year":"2024","journal-title":"Food Funct."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"118050","DOI":"10.1016\/j.jep.2024.118050","article-title":"A multi-omics study reveals the therapeutic effect of Linderae Radix water extract on irritable bowel syndrome (IBS-D)","volume":"328","author":"Ouyang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155897","DOI":"10.1016\/j.phymed.2024.155897","article-title":"Artemisia argyi polyphenols attenuates DSS-induced colitis in mice by regulating the structural composition of gut microbiota","volume":"132","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00535-017-1384-4","article-title":"Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease","volume":"53","author":"Nishino","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113797","DOI":"10.1016\/j.foodres.2023.113797","article-title":"The attenuating effect of fermented soymilk on DSS-induced colitis in mice by suppressing immune response and modulating gut microbiota","volume":"176","author":"Sun","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"110530","DOI":"10.1016\/j.foodres.2021.110530","article-title":"Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota","volume":"147","author":"Li","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1631\/jzus.B2100988","article-title":"Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress","volume":"23","author":"Wang","year":"2022","journal-title":"J. Zhejiang Univ.-Sci. B"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2249152","DOI":"10.1080\/19490976.2023.2249152","article-title":"The curious case of Prevotella copri","volume":"15","author":"Abdelsalam","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/acs.jafc.2c06697","article-title":"Coprococcus eutactus, a potent probiotic, alleviates colitis via acetate-mediated IgA response and microbiota restoration","volume":"71","author":"Yang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"108238","DOI":"10.1016\/j.pharmthera.2022.108238","article-title":"Bile acid metabolism and signaling, the microbiota, and metabolic disease","volume":"237","author":"Cai","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.3748\/wjg.v27.i24.3609","article-title":"Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis","volume":"27","author":"Yang","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI107233","article-title":"Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man","volume":"52","author":"Soloway","year":"1973","journal-title":"J. Clin. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phymed.2017.01.009","article-title":"Serum metabolomics analysis reveals that obvious cardioprotective effects of low dose Sini decoction against isoproterenol-induced myocardial injury in rats","volume":"31","author":"Zhou","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/gutjnl-2020-321173","article-title":"Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis","volume":"70","author":"Pujo","year":"2021","journal-title":"Gut"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"121350","DOI":"10.1016\/j.jep.2026.121350","article-title":"Berberine alleviates DSS-induced colitis by modulating macrophage phenotype via PPAR-\u03b3\/mTOR\/HIF-1\u03b1 signaling pathway","volume":"362","author":"He","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mohapatra, S.K., Guri, A.J., Climent, M., Vives, C., Carbo, A., Horne, W.T., Hontecillas, R., and Bassaganya-Riera, J. (2010). Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010215"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00018-024-05124-3","article-title":"Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes","volume":"81","author":"Becerril","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"154452","DOI":"10.1016\/j.phymed.2022.154452","article-title":"Qing-Chang-Hua-Shi granule ameliorates DSS-induced colitis by activating NLRP6 signaling and regulating Th17\/Treg balance","volume":"107","author":"Cheng","year":"2022","journal-title":"Phytomedicine"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/19\/3528\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:40:36Z","timestamp":1790930436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/15\/19\/3528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":46,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["foods15193528"],"URL":"https:\/\/doi.org\/10.3390\/foods15193528","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]}}}