{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:55:30Z","timestamp":1791982530887,"version":"4.4.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Tridax procumbens L. is a medicinal plant and used as a drink to treat bronchial catarrh, diarrhea, dysentery and liver diseases. In this study, we evaluated the potential use of T. procumbens to treat hyperuricemia, oxidative stress, and bacterial infection. Ethyl acetate extract of this plant was separated to different fractions by column chromatography (CC) using chloroform and methanol as eluents and subjected to xanthine oxidase (XO) inhibitory, antioxidant, and antibacterial assays. The results showed that the F45\u201347 fraction exhibited the strongest XO inhibitory activity (IC50 = 133.17 \u00b5g\/mL), while the F48\u201350 fraction possessed maximum antioxidant activity assessed by DPPH (2,2-diphenyl-2-picrylhydrazyl) and ABTS (2,2\u2019-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) assays (IC50 = 0.51 and 1.04 mg\/mL, respectively). In addition, the F4\u20135 fraction presented the most effective inhibition on the growth of Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Proteus mirabilis. Gas chromatography-mass spectrophotometry (GS-MS) and liquid chromatography-electrospray ionization-mass spectrophotometry (LC-ESI-MS) results revealed that fatty acids, glycerides, and flavonoids were the major compounds of the F45\u201347 fraction. Glycerides, triose sugar alcohols, and fatty acids were dominant compounds of the F48\u201350 fraction, while sterols were principal components of the F4\u20135 fraction. This study indicated that T. procumbens had potent inhibitory effects on XO inhibitory, antioxidant, and antibacterial activities. These biological activities may be attributed to the presence of fatty acids, flavonoids, and sterols in this plant. It is suggested that T. procumbens can be utilized as a healthy source to develop beverages and foods to treat antihyperuricemia, oxidative stress, and bacterial infection.<\/jats:p>","DOI":"10.3390\/foods8010021","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T04:10:16Z","timestamp":1547179816000},"page":"21","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Antihyperuricemia, Antioxidant, and Antibacterial Activities of Tridax procumbens L."],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-301X","authenticated-orcid":false,"given":"Yusuf","family":"Andriana","sequence":"first","affiliation":[{"name":"Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan"},{"name":"Development Center for Appropriate Technology, Indonesian Institute of Sciences, Jl. KS. Tubun No. 5 Subang, Jawa Barat 41213, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-5698","authenticated-orcid":false,"given":"Tran Dang","family":"Xuan","sequence":"additional","affiliation":[{"name":"Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Ngoc","family":"Quy","sequence":"additional","affiliation":[{"name":"Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-0917","authenticated-orcid":false,"given":"Truong Ngoc","family":"Minh","sequence":"additional","affiliation":[{"name":"Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Mai","family":"Van","sequence":"additional","affiliation":[{"name":"Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Duc","family":"Viet","sequence":"additional","affiliation":[{"name":"Graduate School for International Development and Cooperation, Hiroshima University, Hiroshima 739-8529, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0367-326X(00)00296-3","article-title":"A new flavonoid from the aerial parts of Tridax procumbens","volume":"72","author":"Ali","year":"2001","journal-title":"Fitoterapia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jep.2015.12.051","article-title":"An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo","volume":"181","author":"Kpodar","year":"2016","journal-title":"J. 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