{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:32:25Z","timestamp":1782124345898,"version":"3.54.5"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1170871; 1180059"],"award-info":[{"award-number":["1170871; 1180059"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Lycium minutifolium J. Remy (Solanaceae) is commonly used as an infusion in traditional medicine to treat stomach pain, meteorism, intestinal disorders, stomach ailments, and other severe problems including prostate cancer and stomach cancer. From the EtOAc extract of L. minutifolium bark five known metabolites were isolated using chromatographic techniques. The gastroprotective effects of the EtOAc fraction and edible infusion extract of the bark were assayed on the hydrochloric acid (HCl)\/EtOH induced gastric ulcer model in mice to support the traditional use of the plant. The EtOAc extract and the edible infusion showed gastroprotective effect at dose of 100 mg\/kg reducing lesions by 31% and 64%, respectively. The gastroprotective action mechanisms of the edible infusion at a single oral dose of 100 mg\/kg were evaluated suggesting that prostaglandins, sulfhydryl groups, and nitric oxide are involved in the mode of gastroprotective action. The UHPLC analysis coupled to high-resolution mass spectrometry of the edible infusion showed the presence of twenty-three compounds. Our results can support the gastroprotective properties of the edible infusion extract, and at least can validate in part, the ethnopharmacological uses of the plant.<\/jats:p>","DOI":"10.3390\/foods9050565","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T06:41:20Z","timestamp":1588660880000},"page":"565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Isolation, Gastroprotective Effects and Untargeted Metabolomics Analysis of Lycium Minutifolium J. Remy (Solanaceae)"],"prefix":"10.3390","volume":"9","author":[{"given":"Stephanie","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, 8320000 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-4891","authenticated-orcid":false,"given":"Mariano Walter","family":"Pertino","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica de Productos Naturales, Instituto de Qu\u00edmica de Recursos Naturales, Universidad de Talca, 3460000 Talca, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Arcos","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas, Universidad Andres Bello, Campus Vi\u00f1a del Mar, Quillota 980, Vi\u00f1a del Mar, 2531098 Valparaiso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Reichert","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas, Universidad Andres Bello, Campus Vi\u00f1a del Mar, Quillota 980, Vi\u00f1a del Mar, 2531098 Valparaiso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-968X","authenticated-orcid":false,"given":"Javier","family":"Echeverria","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias del Ambiente, Facultad de Qu\u00edmica y Biolog\u00eda, Universidad de Santiago de Chile, 9170022 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-3123","authenticated-orcid":false,"given":"Mario","family":"Simirgiotis","sequence":"additional","affiliation":[{"name":"Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, 5090000 Valdivia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Borquez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias B\u00e1sicas, Universidad de Antofagasta, Av Coloso S-N, 1240000 Antofagasta, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad Andres Bello, Sazi\u00e9 2315, 8370092 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5246-1368","authenticated-orcid":false,"given":"Carlos","family":"Areche","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias, Universidad de Chile, 8320000 Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas, Universidad Andres Bello, Campus Vi\u00f1a del Mar, Quillota 980, Vi\u00f1a del Mar, 2531098 Valparaiso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"key":"ref_1","unstructured":"Mozsik, G.Y., Abdel-Salam, O.M.E., and Szolcsanyi, J. 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