{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:19:55Z","timestamp":1785331195724,"version":"3.55.0"},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["project AGL2015-67995-C3-2 and grant IJCI-2015-26789"],"award-info":[{"award-number":["project AGL2015-67995-C3-2 and grant IJCI-2015-26789"]}]},{"DOI":"10.13039\/100012964","name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","award":["LR15CBBC05"],"award-info":[{"award-number":["LR15CBBC05"]}],"id":[{"id":"10.13039\/100012964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180\u2013250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment.<\/jats:p>","DOI":"10.3390\/foods9060804","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T11:00:56Z","timestamp":1592478056000},"page":"804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-8598","authenticated-orcid":false,"given":"Amani","family":"Taamalli","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Sciences, University of Hafr Al Batin, P.O. Box 1803, Hafr Al Batin 39524, Saudi Arabia"},{"name":"Laboratoire de Biotechnologie de l\u2019Olivier, Centre de Biotechnologie de Borj-Cedria, B.P.901, Hammam-Lif 2050, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouar","family":"Feriani","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-3070","authenticated-orcid":false,"given":"Jes\u00fas","family":"Lozano-Sanchez","sequence":"additional","affiliation":[{"name":"Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, Edificio BioRegi\u00f3n, 18016 Granada, Spain"},{"name":"Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakhdar","family":"Ghazouani","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afoua","family":"El Mufti","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Salah","family":"Allagui","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax 3018, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Segura-Carretero","sequence":"additional","affiliation":[{"name":"Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, Edificio BioRegi\u00f3n, 18016 Granada, Spain"},{"name":"Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Mhamdi","sequence":"additional","affiliation":[{"name":"Laboratoire de Biotechnologie de l\u2019Olivier, Centre de Biotechnologie de Borj-Cedria, B.P.901, Hammam-Lif 2050, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-6676","authenticated-orcid":false,"given":"David","family":"Arr\u00e1ez-Roman","sequence":"additional","affiliation":[{"name":"Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, Edificio BioRegi\u00f3n, 18016 Granada, Spain"},{"name":"Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"ref_1","first-page":"135","article-title":"Enzymatic and non-enzymatic antioxidants in selected Piper species","volume":"41","author":"Karthikeyan","year":"2003","journal-title":"Indian J. Exp. Biol."},{"key":"ref_2","unstructured":"Pereira Rodrigues, O. (2013). Characterization of Phenolic Constituents of Medicinal Plants and Evaluation of Pharmacological Activities: Focus in Antioxidant and Anti-Inflammatory Properties, University of Salamanca-Faculty of Pharmacy."},{"key":"ref_3","first-page":"162","article-title":"Hepatoprotective activity of Ficus carica Linn. leaf extract against carbon tetrachloride-induced hepatotoxicity in rats","volume":"15","author":"Krishna","year":"2007","journal-title":"Daru"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2329-6631.1000127","article-title":"Effect of Microbially Synthesized Eicosapentaenoic Acid on Carbon Tetrachloride Induced Hepatotoxicity","volume":"4","author":"Nandakishor","year":"2014","journal-title":"J. Dev. Drugs"},{"key":"ref_5","first-page":"218","article-title":"Hepatoprotective effects of purified oleuropein from olive leaf extract against ethanol-induced damages in the rat","volume":"13","author":"Alirezaei","year":"2012","journal-title":"Iran. J. Vet. Res."},{"key":"ref_6","first-page":"139","article-title":"Role of free radicals in toxic hepatic injury I. Free radical biochemistry","volume":"31","author":"Brent","year":"1993","journal-title":"Clin. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0009-9120(93)90111-I","article-title":"Human disease, free radicals, and the oxidant\/antioxidant balance","volume":"26","author":"Mccord","year":"1993","journal-title":"Clin. Biochem."},{"key":"ref_8","first-page":"57","article-title":"Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis","volume":"34","author":"Koruk","year":"2004","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_9","unstructured":"Venketeshwer, R. (2012). Screening of some traditionally used plants for their hepatoprotective effect. Phytochemicals as Nutraceuticals\u2014Global Approaches to Their Role in Nutrition and Health, InTechOpen."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"598","DOI":"10.5530\/pj.2020.12.89","article-title":"In-vitro Antioxidant and In-Vivo Hepatoprotective Activity of Ethenolic Extract of Tectona grandis Bark Against CCl4 Induced Liver Injury in Rats","volume":"12","author":"Bagali","year":"2020","journal-title":"Pharmacogn J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.22270\/jddt.v10i3.4006","article-title":"Ameliorative effect of hydroalcoholic extracts of Nigella sativa seed against CCl4-induced acute liver injury in rats","volume":"10","author":"Kingsley","year":"2020","journal-title":"J. Drug Deliv. Ther."},{"key":"ref_12","first-page":"238","article-title":"Hepatoprotective studies of floral extracts of Gomphrena serrata L. and piperic acid on CCl 4 induced hepatotoxicity","volume":"10","author":"Vani","year":"2019","journal-title":"Indian J. Nat. Prod. Resour."},{"key":"ref_13","first-page":"152","article-title":"Hepatoprotective studies of aqueous leaf and root extracts of Barringtonia acutangula (L.) Gaertn. against ethanol induced hepatic stress in rats","volume":"19","author":"Rashmi","year":"2020","journal-title":"Indian J. Tradit. Knowl."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1315202","article-title":"Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats","volume":"2020","author":"Fki","year":"2020","journal-title":"Biomed Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Feriani, A., Tir, M., Mar\u00eda, A., Caravaca, G., Contreras, M., Taamalli, A., Segura-Carretero, A., Ghazouani, L., Mufti, A., and Tlili, N. (2020). Zygophyllum album leaves extract prevented hepatic fibrosis in rats, by reducing liver injury and suppressing oxidative stress, inflammation, apoptosis and the TGF-\u03b21\/Smads signaling pathways. Exploring of bioactive compounds using HPLC\u2013DAD\u2013ES. Inflammopharmacology.","DOI":"10.1007\/s10787-020-00700-y"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.jff.2013.03.014","article-title":"Protective effects of phenolic constituents from Cytisus multiflorus, Lamium album L. and Thymus citriodorus on liver cells","volume":"5","author":"Pereira","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1016\/j.chroma.2011.04.053","article-title":"New possibilities for the valorization of olive oil by-products","volume":"1218","author":"Herrero","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"112007","DOI":"10.1016\/j.jep.2019.112007","article-title":"Plants mentioned in the Islamic Scriptures ( Holy Qur \u2019 \u00e2n and Ahadith ): Traditional uses and medicinal importance in contemporary times","volume":"243","author":"Khalifa","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.numecd.2019.07.001","article-title":"Impact of different types of olive oil on cardiovascular risk factors: A systematic review and network meta-analysis","volume":"29","author":"Schwingshackl","year":"2019","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Castej\u00f3n, M.L., Montoya, T., Alarc\u00f3n-de-la-Lastra, C., and S\u00e1nchez-Hidalgo, M. (2020). Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases. Antioxidants, 9.","DOI":"10.3390\/antiox9020149"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., and Bernini, R. (2019). Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.. Nutrients, 11.","DOI":"10.3390\/nu11081776"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/B978-0-444-64057-4.00012-0","article-title":"Olea europaea as Potential Source of Bioactive Compounds for Diseases Prevention","volume":"Volume 57","year":"2018","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/6789704","article-title":"Geographical Characterization of Tunisian Olive Tree Leaves (cv. Chemlali) Using HPLC-ESI-TOF and IT\/MS Fingerprinting with Hierarchical Cluster Analysis","volume":"2018","author":"Taamalli","year":"2018","journal-title":"J. Anal. Methods Chem."},{"key":"ref_24","first-page":"62","article-title":"Protective Activities of Some Extracts from Olea europaea Leaves towards CCl 4 -Induced Hepatotoxicity in Rats","volume":"4","author":"Soliman","year":"2019","journal-title":"Chem. Res. J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Vidi\u010devi\u0107, S., Jelena, T., Stanojevi\u0107, \u017d., Isakovi\u0107, A., Miti\u0107, D., Risti\u0107, D., and Dekanski, D. (2019). Standardized Olea europaea L. leaf extract exhibits protective activity in carbon tetrachloride-induced acute liver injury in rats: The insight into potential mechanisms. Arch. Physiol. Biochem., 1\u20139.","DOI":"10.1080\/13813455.2018.1550095"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/4398924","article-title":"Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice","volume":"2020","author":"Jemai","year":"2020","journal-title":"Biomed Res. Int."},{"key":"ref_27","first-page":"1","article-title":"Anti -fibrogentic and hepatoprotective potential of methanolic olive extract on cadmium induced toxicity in rats","volume":"15","year":"2018","journal-title":"Life Sci. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.14393\/BJ-v36n1a2020-49960","article-title":"Possible protective effect of olive leaves extract on paracetamol induced hepatotoxicity in male albino rats","volume":"36","author":"Taha","year":"2020","journal-title":"Biosci. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.sjbs.2015.08.011","article-title":"Effect of Olea oleaster and Juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice","volume":"23","author":"Alrobai","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopha.2017.12.101","article-title":"Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis","volume":"98","author":"Elgebaly","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.fct.2017.06.010","article-title":"Olive phenolic compounds attenuate deltamethrin-induced liver and kidney toxicity through regulating oxidative stress, inflammation and apoptosis","volume":"106","author":"Maalej","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Nastic, N., Borras-Linares, I., Lozano-S\u00e1nchez, J., \u0160varc-Gaji\u00b4, J., and Segura-carretero, A. (2020). Comparative assessment of phytochemical profiles of comfrey (Symphytum officinale L.) root extracts Obtained by Different Extraction Techniques. Molecules, 25.","DOI":"10.3390\/molecules25040837"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Camargo, A.D., Parada-Alonso, F., Ib\u00e1\u00f1ez, E., and Cifuentes, A. (2018). Recent applications of on-line supercritical fluid extraction coupled to advanced analytical techniques for compounds extraction and identification. J. Sep. Sci., 1\u201342.","DOI":"10.1002\/jssc.201800729"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.trac.2019.03.016","article-title":"Green extraction techniques in green analytical chemistry","volume":"116","author":"Armenta","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shahidi, F. (2005). Supercritical technologies for further processing of edible oils. Bailey\u2019s Industrial Oil and Fat Products, John Wiley & Sons, Inc.","DOI":"10.1002\/047167849X"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jssc.200500032","article-title":"Analytical determination of polyphenols in olive oils","volume":"28","author":"Cerretani","year":"2005","journal-title":"J. Sep. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.fct.2012.02.090","article-title":"Use of advanced techniques for the extraction of phenolic compounds from Tunisian olive leaves: Phenolic composition and cytotoxicity against human breast cancer cells","volume":"50","author":"Taamalli","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Taamalli, A., Lozano, J., Jebabli, H., Trabelsi, N., Abaza, L., Segura-Carretero, A., Cho, J.Y., and Arraez-Roman, D. (2019). Monitoring the bioactive compounds status in Olea europaea according to collecting period and drying conditions. Energies, 12.","DOI":"10.3390\/en12050947"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tox.2010.04.014","article-title":"Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice","volume":"273","author":"Tipoe","year":"2010","journal-title":"Toxicology"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Levine, R.L., Garland, D., Oliver, C.N., Amici, A., Climent, I., Lenz, A.G., Ahn, B.W., Shaltiel, S., and Stadtman, E.R. (1990). Determination of carbonyl content in oxidatively modified proteins. Methods in Enzymology, Elsevier.","DOI":"10.1016\/0076-6879(90)86141-H"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"ref_42","unstructured":"Packer, L. (1984). Catalase in vitro. Methods in Enzymology, Elsevier."},{"key":"ref_43","unstructured":"Packer, L. (1984). Assays of glutathione peroxidase. Methods in Enzymology, Elsevier."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.lfs.2003.12.019","article-title":"Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells","volume":"75","author":"Kanno","year":"2004","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.sjbs.2014.08.005","article-title":"Influence of olive and rosemary leaves extracts on chemically induced liver cirrhosis in male rats","volume":"22","author":"Shawush","year":"2015","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/0974-8490.122913","article-title":"Protection of CCl 4 -induced liver and kidney damage by phenolic compounds in leaf extracts of Cnestis ferruginea ( de Candolle )","volume":"6","author":"Rahmat","year":"2014","journal-title":"Pharmacognosy Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0940-2993(11)80116-8","article-title":"Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4)","volume":"46","author":"Szende","year":"1994","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_48","first-page":"209","article-title":"Hepatoprotective activity of leaves extract of eichhornia crassipes against CCl4 induced hepatotoxicity albino rats","volume":"1","author":"Dineshkumar","year":"2013","journal-title":"Int. J. Pure Appl. Zool."},{"key":"ref_49","first-page":"1","article-title":"Effects of Rhus tripartitum fruit extract on CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats","volume":"94","author":"Tlili","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_50","first-page":"021","article-title":"Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice","volume":"2","author":"Essawy","year":"2012","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_51","first-page":"1612","article-title":"Carbon tetrachloride-induced hepatotoxicity in rats\u2014Protective role of aqueous leaf extracts of Coccinia grandis","volume":"1","author":"Kumar","year":"2009","journal-title":"Int. J. Pharm. Tech. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0899-9007(00)00570-0","article-title":"Reactive oxygen species in human health and disease","volume":"17","author":"Castro","year":"2001","journal-title":"Nutrition"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0891-5849(97)00159-7","article-title":"Alterations of antioxidant enzyme expression in response to hydrogen peroxide","volume":"24","author":"Rohrdanz","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"24398","DOI":"10.1016\/S0021-9258(18)54242-3","article-title":"Differential regulation of antioxidant enzymes in response to oxidants","volume":"266","author":"Shull","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Szymonik-Lesiuk, S., Czechowska, G., Stryjecka-Zimmer, M., S\u0142omka, M., M\u0104ldro, A., Celi\u0144ski, K., and Wielosz, M. (2003). superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J. Hepatobiliary Pancreat Surg., 309\u2013315.","DOI":"10.1007\/s00534-002-0824-5"},{"key":"ref_56","unstructured":"Catherine, T., Piquet-pellorce, L.M.G.C., and Samson, M. (2016). Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice. Toxicol. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","article-title":"Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy","volume":"14","author":"Li","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jff.2017.07.054","article-title":"Does Eryngium maritimum seeds extract protect against CCl 4 and cisplatin induced toxicity in rats: Preliminary phytochemical screening and assessment of its in vitro and in vivo antioxidant activity and antifibrotic effect","volume":"37","author":"Mejri","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4039753","article-title":"Antifibrogenic influence of Mentha piperita L. essential Oil against CCl 4 -induced liver fibrosis in rats","volume":"2018","author":"Ogaly","year":"2018","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/9\/6\/804\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:40:21Z","timestamp":1760175621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/9\/6\/804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["foods9060804"],"URL":"https:\/\/doi.org\/10.3390\/foods9060804","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,18]]}}}