{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:43:53Z","timestamp":1790711033844,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["1R01AG076699"],"award-info":[{"award-number":["1R01AG076699"]}]},{"name":"National Institutes of Health","award":["1R03AI17599001"],"award-info":[{"award-number":["1R03AI17599001"]}]},{"name":"National Institutes of Health","award":["1R03 NS13532601"],"award-info":[{"award-number":["1R03 NS13532601"]}]},{"name":"Northeast Ohio Medical University","award":["1R01AG076699"],"award-info":[{"award-number":["1R01AG076699"]}]},{"name":"Northeast Ohio Medical University","award":["1R03AI17599001"],"award-info":[{"award-number":["1R03AI17599001"]}]},{"name":"Northeast Ohio Medical University","award":["1R03 NS13532601"],"award-info":[{"award-number":["1R03 NS13532601"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Bleeding resulting from surgical procedures or trauma, including gunshot wounds, represents a life-threatening health issue. Therefore, the development of safe, effective, and convenient hemostatic agents is critical in securing the \u201cgolden time\u201d to save patients\u2019 lives. Plant-derived compounds and plant extracts have been regarded as promising sources of hemostatic agents in previous studies, regulating hemostatic function with low toxicity and minimal side effects within the human body. Aloe vera-based hydrogels, which are characterized by flexible strength and high functionality, have emerged as a promising platform for wound applications due to their unique biocompatibility features. This study provides a comprehensive exploration of the utilization of thickening agents and natural agents such as xanthan gum, carrageenan, Carbomer, and alginate in applying aloe vera-based hydrogels as a hemostatic. Furthermore, it also tests the use of aloe vera-based hydrogels for therapeutic delivery at wound sites through the incorporation of various antimicrobial agents to extend the utility of the hydrogels beyond hemostasis. Our novel applied research utilizes aloe vera-based hydrogel as an antimicrobial hemostatic agent, providing valuable insights for a wide range of applications and highlighting its potential to enhance hemorrhage control in various emergency scenarios.<\/jats:p>","DOI":"10.3390\/gels10060409","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T11:47:17Z","timestamp":1718797637000},"page":"409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel"],"prefix":"10.3390","volume":"10","author":[{"given":"Bryan","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA"},{"name":"Solon High School, Solon, OH 44139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trae","family":"Hillyer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA"},{"name":"University Hospital and Northeast Ohio Medical University Scholarship Program, Rootstown, OH 44272, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-4733","authenticated-orcid":false,"given":"Woo Shik","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/08998280.2013.11928934","article-title":"Timing and causes of death after injuries","volume":"26","author":"Sobrino","year":"2013","journal-title":"Proc. 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