{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:44:33Z","timestamp":1765233873902,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-73-00091"],"award-info":[{"award-number":["24-73-00091"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Anemia is a global health problem that affects both adults and children, but treatment is hampered by serious side effects, primarily associated with the gastrointestinal tract with oral administration of drugs. In this study, we aimed to develop an oral form of iron compounds using polymethylsilsesquioxane hydrogels. To boost loading efficiency and prolong release, the iron compounds (FeCl3 and ferrous D-Gluconate) are incorporated into a guest\u2013host complex with 2-hydroxypropyl-beta-cyclodextrin. We used PRXD, SEM, EDX mapping, and FTIR to investigate the complex formation, as well as the incorporation of such complexes into hydrogels. The optimal system underlines a combination of ferrous D-Gluconate and HPCD in a 1:1 molar ratio, embedded into a hydrogel with a modest quantity of silicate crosslinks. We demonstrated the slowing of iron release in a gastric media. Mathematical investigation revealed that the Higuchi mechanism releases iron from the hydrogel.<\/jats:p>","DOI":"10.3390\/gels10090564","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T07:45:47Z","timestamp":1725003947000},"page":"564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cyclodextrin\u2014Polymethylsilsesquioxane Combined System as a Perspective Iron Delivery System for Oral Administration"],"prefix":"10.3390","volume":"10","author":[{"given":"Polina","family":"Orlova","sequence":"first","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-6538","authenticated-orcid":false,"given":"Ivan","family":"Meshkov","sequence":"additional","affiliation":[{"name":"Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), Moscow 117393, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-1952","authenticated-orcid":false,"given":"Egor","family":"Latipov","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology of Microelectronics, Russian Academy of Sciences (INM RAS), Moscow 115487, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-3007","authenticated-orcid":false,"given":"Sergey","family":"Vasiliev","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS (FRC PCP MC RAS), Chernogolovka 142432, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-1697","authenticated-orcid":false,"given":"Ivan","family":"Mikheev","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0606-8059","authenticated-orcid":false,"given":"Daria-Maria","family":"Ratova","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2486-3276","authenticated-orcid":false,"given":"Alexandra","family":"Kalinina","sequence":"additional","affiliation":[{"name":"Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), Moscow 117393, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3050-3253","authenticated-orcid":false,"given":"Aziz","family":"Muzafarov","sequence":"additional","affiliation":[{"name":"Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), Moscow 117393, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-4491","authenticated-orcid":false,"given":"Irina","family":"Le-Deygen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120590","DOI":"10.1016\/j.ijpharm.2021.120590","article-title":"Delivery systems for improving iron uptake in anemia","volume":"601","author":"Trivedi","year":"2021","journal-title":"Int. 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