{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:47:42Z","timestamp":1781768862333,"version":"3.54.5"},"reference-count":53,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Vaginal candidiasis poses significant health concerns that affect approximately 75% of women globally and often leads to discomfort and a decrease in quality of life. Traditional treatments, despite their effectiveness, may cause discomfort and adverse effects, such as vaginal discharge, bleeding, and dryness, promoting the exploration of alternative formulations. In this study, we aimed to develop a novel therapeutic approach for the treatment of vaginal candidiasis utilizing oleic acid containing emulgels made from thermoresponsive poloxamer-based hydrogels. These emulgels were designed to provide a sustained release of clotrimazole, an antifungal agent. Incorporating oleic acid enhanced the drug\u2019s solubility and contributed to vaginal health. The formulations were characterized by their rheological properties, in vitro release, mucoadhesion, and spreadability. We conducted rheological measurements on the hydrogels that served as the base for the emulgels, as well as on the emulgels themselves. The emulgels exhibited continuous rheological behavior with changing temperatures, making them suitable for storage at room temperature. With an increasing HPMC content, we achieved enhanced mucoadhesion, which is beneficial for formulations used in body cavities. Moreover, in vitro release studies revealed sustained drug release profiles, which can be adjusted by varying the ratios of poloxamers and HPMC. These findings suggest that the developed emulgels offer a promising therapeutic option for vaginal candidiasis, addressing both the symptoms and the treatment of discomfort.<\/jats:p>","DOI":"10.3390\/gels10110730","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T06:28:32Z","timestamp":1731392912000},"page":"730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Formulation of Emulgels Containing Clotrimazole for the Treatment of Vaginal Candidiasis"],"prefix":"10.3390","volume":"10","author":[{"given":"Zs\u00f3fia","family":"Vilimi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"Kir\u00e1ly","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7658-280X","authenticated-orcid":false,"given":"\u00c1d\u00e1m Tibor","family":"Barna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7653-1065","authenticated-orcid":false,"given":"Zs\u00f3fia Edit","family":"P\u00e1pay","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-5989","authenticated-orcid":false,"given":"L\u00edvia","family":"Budai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Lud\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-3993","authenticated-orcid":false,"given":"Nikolett","family":"K\u00e1llai-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-201X","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Antal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"ref_1","unstructured":"InformedHealth.org (2024, September 24). 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