{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:30:15Z","timestamp":1788881415023,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","award":["2021\/11965-3"],"award-info":[{"award-number":["2021\/11965-3"]}]},{"name":"S\u00e3o Paulo Research Foundation\u2014FAPESP","award":["#406973\/2022-9"],"award-info":[{"award-number":["#406973\/2022-9"]}]},{"name":"Brazilian Agencies MCTIC\/CNPq","award":["2021\/11965-3"],"award-info":[{"award-number":["2021\/11965-3"]}]},{"name":"Brazilian Agencies MCTIC\/CNPq","award":["#406973\/2022-9"],"award-info":[{"award-number":["#406973\/2022-9"]}]},{"name":"INCT\/Polysaccharides","award":["2021\/11965-3"],"award-info":[{"award-number":["2021\/11965-3"]}]},{"name":"INCT\/Polysaccharides","award":["#406973\/2022-9"],"award-info":[{"award-number":["#406973\/2022-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>This study evaluates the wound-healing process in horses following the application of two treatment modalities: bacterial cellulose hydrogel with alginate (BCAW) and frog skin (FSW) dressings on experimentally induced skin wounds. Throughout the experiment, no clinical abnormalities were noted in the horses, although initial wound assessments indicated edema and sensitivity. Local hemorrhage was observed in some cases on Day 0, with granulation tissue formation evident by Day 14. Epithelialization began around Day 14 but did not reach complete healing in any group by Day 28. The analysis showed no significant differences in skin wound area or wound contraction rates among the treatment groups compared to control wounds (CWs) over the evaluation periods. Histopathological evaluations also indicated no significant differences in inflammatory responses or healing markers, such as fibroblast proliferation and neovascularization in skin wounds across groups. Despite expectations based on prior research in other species, the treatments with BCAW and FSW did not demonstrate substantial pro-healing effects in horses with induced skin wounds. These findings underscore the complexity of equine wound healing and suggest further investigation is needed to optimize treatment strategies in this species and enhance the translational potential for human clinical applications.<\/jats:p>","DOI":"10.3390\/gels11020107","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T04:36:51Z","timestamp":1738557411000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Bacterial Cellulose\/Alginate-Based Hydrogel and Frog Skin Dressings in Equine Skin Wound Healing"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8225-065X","authenticated-orcid":false,"given":"Rita C.","family":"Campebell","sequence":"first","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa B.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssyca L. A.","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz N. A.","family":"Fortes","sequence":"additional","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-5375","authenticated-orcid":false,"given":"Henrique C.","family":"Veado","sequence":"additional","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-9143","authenticated-orcid":false,"given":"Isabel L.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-1076","authenticated-orcid":false,"given":"Bruno S. L.","family":"Dallago","sequence":"additional","affiliation":[{"name":"Hospital Escola de Grandes Animais, Faculdade de Agronomia e Medicina Veterin\u00e1ria (FAV), Universidade de Bras\u00edlia (UnB), \u00c1rea Especial SRB, Galp\u00e3o 4, Granja do Torto 70636-200, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernane S.","family":"Barud","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biopol\u00edmeros e Biomateriais (BIOPOLMAT), Departamento de Qu\u00edmica, Universidade de Araraquara (UNIARA), Araraquara 14800-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Adorno","sequence":"additional","affiliation":[{"name":"Asa Norte Regional Hospital, HRAN, SMHN Q2, Asa Norte, Bras\u00edlia 70710-100, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-1626","authenticated-orcid":false,"given":"Pablo A. 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