{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:12Z","timestamp":1790662152032,"version":"4.1.0"},"reference-count":280,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SECIHTI","award":["636841"],"award-info":[{"award-number":["636841"]}]},{"name":"SECIHTI","award":["630999"],"award-info":[{"award-number":["630999"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Cellulose is a sustainable biopolymer, being renewable and abundant, non-toxic, biodegradable, and easily functionalizable. However, the development of hydrogels for tissue engineering applications presents significant challenges that require interdisciplinary expertise, given the intricate and dynamic nature of the human body. This paper delves into current research focused on creating advanced cellulose-based hydrogels with tailored mechanical, biological, chemical, and surface properties. These hydrogels show promise in healing, regenerating, and even replacing human tissues and organs. The synthesis of these hydrogels employs a range of innovative techniques, including supramolecular chemistry, click chemistry, enzyme-induced crosslinking, ultrasound, photo radiation, high-energy ionizing radiation, 3D printing, and other emerging methods. In the realm of tissue engineering, various types of hydrogels are explored, such as stimuli-responsive, hybrid, injectable, bio-printed, electrospun, self-assembling, self-healing, drug-releasing, biodegradable, and interpenetrating network hydrogels. Moreover, these materials can be further enhanced by incorporating cell growth factors, biological molecules, or by loading them with cells or drugs. Looking ahead, future research aims to engineer and tailor hydrogels to meet specific needs. This includes exploring safer and more sustainable materials and synthesis techniques, identifying less invasive application methods, and translating these studies into practical applications.<\/jats:p>","DOI":"10.3390\/gels11060438","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T09:43:14Z","timestamp":1749202994000},"page":"438","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cellulose-Based Hybrid Hydrogels for Tissue Engineering Applications: A Sustainable Approach"],"prefix":"10.3390","volume":"11","author":[{"given":"Elizabeth","family":"V\u00e1zquez-Rivas","sequence":"first","affiliation":[{"name":"Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Guadalajara 44430, Jalisco, Mexico"},{"name":"Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Instituto Tecnol\u00f3gico de Toluca, Metepec 52149, Edo. M\u00e9xico, Mexico"},{"name":"Instituto de Ciencias Nucleares, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alberto","family":"Desales-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Instituto Tecnol\u00f3gico de Toluca, Metepec 52149, Edo. M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Horacio","family":"Pacheco-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Instituto Tecnol\u00f3gico de Toluca, Metepec 52149, Edo. 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